JP2010059146A5 - - Google Patents
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- Publication number
- JP2010059146A5 JP2010059146A5 JP2009164606A JP2009164606A JP2010059146A5 JP 2010059146 A5 JP2010059146 A5 JP 2010059146A5 JP 2009164606 A JP2009164606 A JP 2009164606A JP 2009164606 A JP2009164606 A JP 2009164606A JP 2010059146 A5 JP2010059146 A5 JP 2010059146A5
- Authority
- JP
- Japan
- Prior art keywords
- methyl
- acid
- difluorophenyl
- oxirane
- triazol
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000002253 acid Substances 0.000 claims 6
- 150000003839 salts Chemical class 0.000 claims 5
- 238000000034 method Methods 0.000 claims 4
- MUBZPKHOEPUJKR-UHFFFAOYSA-N Oxalic acid Chemical compound OC(=O)C(O)=O MUBZPKHOEPUJKR-UHFFFAOYSA-N 0.000 claims 3
- 150000001735 carboxylic acids Chemical class 0.000 claims 3
- 239000013078 crystal Substances 0.000 claims 3
- -1 2,5-difluorophenyl group Chemical group 0.000 claims 2
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 claims 2
- 238000002425 crystallisation Methods 0.000 claims 2
- 230000008025 crystallization Effects 0.000 claims 2
- 238000004519 manufacturing process Methods 0.000 claims 2
- UTADLCZFMZEZTJ-MAUHNZJOSA-N (Z)-but-2-enedioic acid 1-[[(2R,3S)-2-(2,5-difluorophenyl)-3-methyloxiran-2-yl]methyl]-1,2,4-triazole Chemical compound OC(=O)\C=C/C(O)=O.C[C@@H]1O[C@]1(C=1C(=CC=C(F)C=1)F)CN1N=CN=C1 UTADLCZFMZEZTJ-MAUHNZJOSA-N 0.000 claims 1
- BEKTUCOCSZIKAZ-JIHQIIETSA-N 1-[[(2R,3S)-2-(2,4-difluorophenyl)-3-methyloxiran-2-yl]methyl]-1,2,4-triazole hydrochloride Chemical compound Cl.C[C@@H]1O[C@]1(C=1C(=CC(F)=CC=1)F)CN1N=CN=C1 BEKTUCOCSZIKAZ-JIHQIIETSA-N 0.000 claims 1
- ZKCXUQDSODZSRB-JIHQIIETSA-N 1-[[(2R,3S)-2-(2,4-difluorophenyl)-3-methyloxiran-2-yl]methyl]-1,2,4-triazole oxalic acid Chemical compound OC(=O)C(O)=O.C[C@@H]1O[C@]1(C=1C(=CC(F)=CC=1)F)CN1N=CN=C1 ZKCXUQDSODZSRB-JIHQIIETSA-N 0.000 claims 1
- MGMCXYLTXGCECB-JIHQIIETSA-N 1-[[(2R,3S)-2-(2,5-difluorophenyl)-3-methyloxiran-2-yl]methyl]-1,2,4-triazole hydrochloride Chemical compound Cl.C[C@@H]1O[C@]1(C=1C(=CC=C(F)C=1)F)CN1N=CN=C1 MGMCXYLTXGCECB-JIHQIIETSA-N 0.000 claims 1
- HGXNLNPILNRPSB-JIHQIIETSA-N 1-[[(2R,3S)-2-(2,5-difluorophenyl)-3-methyloxiran-2-yl]methyl]-1,2,4-triazole oxalic acid Chemical compound OC(=O)C(O)=O.C[C@@H]1O[C@]1(C=1C(=CC=C(F)C=1)F)CN1N=CN=C1 HGXNLNPILNRPSB-JIHQIIETSA-N 0.000 claims 1
- 125000004215 2,4-difluorophenyl group Chemical group [H]C1=C([H])C(*)=C(F)C([H])=C1F 0.000 claims 1
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims 1
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims 1
- OFOBLEOULBTSOW-UHFFFAOYSA-N Propanedioic acid Natural products OC(=O)CC(O)=O OFOBLEOULBTSOW-UHFFFAOYSA-N 0.000 claims 1
- 125000003118 aryl group Chemical group 0.000 claims 1
- 229910052799 carbon Inorganic materials 0.000 claims 1
- 125000004432 carbon atom Chemical group C* 0.000 claims 1
- VZCYOOQTPOCHFL-UPHRSURJSA-N maleic acid Chemical compound OC(=O)\C=C/C(O)=O VZCYOOQTPOCHFL-UPHRSURJSA-N 0.000 claims 1
- 239000011976 maleic acid Substances 0.000 claims 1
- 239000003960 organic solvent Substances 0.000 claims 1
- 235000006408 oxalic acid Nutrition 0.000 claims 1
- VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 claims 1
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2009164606A JP5654738B2 (ja) | 2008-08-08 | 2009-07-13 | エポキシトリアゾール誘導体の製造法 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2008205770 | 2008-08-08 | ||
| JP2008205770 | 2008-08-08 | ||
| JP2009164606A JP5654738B2 (ja) | 2008-08-08 | 2009-07-13 | エポキシトリアゾール誘導体の製造法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2010059146A JP2010059146A (ja) | 2010-03-18 |
| JP2010059146A5 true JP2010059146A5 (enrdf_load_stackoverflow) | 2012-08-09 |
| JP5654738B2 JP5654738B2 (ja) | 2015-01-14 |
Family
ID=42186385
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009164606A Active JP5654738B2 (ja) | 2008-08-08 | 2009-07-13 | エポキシトリアゾール誘導体の製造法 |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JP5654738B2 (enrdf_load_stackoverflow) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP6478447B2 (ja) * | 2013-03-29 | 2019-03-06 | 大阪有機化学工業株式会社 | アダマンチル（メタ）アクリレート系化合物の製造方法 |
| WO2015012271A1 (ja) * | 2013-07-25 | 2015-01-29 | 日産化学工業株式会社 | 複素環化合物の製造方法 |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP3008029B2 (ja) * | 1989-09-26 | 2000-02-14 | 武田薬品工業株式会社 | メルカプト化合物の製造法 |
| IE903395A1 (en) * | 1989-09-26 | 1991-04-10 | Takeda Chemical Industries Ltd | Triazole compounds, their production and use |
| JPH04211070A (ja) * | 1990-03-15 | 1992-08-03 | Takeda Chem Ind Ltd | トリアゾール化合物およびその用途 |
| JPH04356471A (ja) * | 1991-03-25 | 1992-12-10 | Takeda Chem Ind Ltd | トリアゾール化合物およびその用途 |
| JPH06279419A (ja) * | 1993-03-31 | 1994-10-04 | Tokyo Tanabe Co Ltd | 新規トリアゾール誘導体及びこれを有効成分とする抗真菌剤 |
| US6884892B2 (en) * | 2002-06-20 | 2005-04-26 | Sumitomo Chemical Company, Limited | Production methods of epoxytriazole derivative and intermediate therefor |
| US7582781B2 (en) * | 2003-07-18 | 2009-09-01 | Kaneka Corporation | Optically active halohydrin derivative and process for producing optically active epoxy alcohol derivative from the same |
| JP4404611B2 (ja) * | 2003-11-27 | 2010-01-27 | 住友化学株式会社 | エポキシトリアゾール化合物の製造方法及びその中間体 |
| JP4651969B2 (ja) * | 2004-04-28 | 2011-03-16 | 株式会社カネカ | エポキシトリアゾール化合物の製造方法 |
| JP2006182766A (ja) * | 2004-11-30 | 2006-07-13 | Sumitomo Chemical Co Ltd | エポキシトリアゾール誘導体およびその中間体の製造方法 |
| JP2006182765A (ja) * | 2004-11-30 | 2006-07-13 | Sumitomo Chemical Co Ltd | エポキシトリアゾール誘導体の製造方法 |
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2009
- 2009-07-13 JP JP2009164606A patent/JP5654738B2/ja active Active