JP2010047616A5 - - Google Patents
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- Publication number
- JP2010047616A5 JP2010047616A5 JP2009274999A JP2009274999A JP2010047616A5 JP 2010047616 A5 JP2010047616 A5 JP 2010047616A5 JP 2009274999 A JP2009274999 A JP 2009274999A JP 2009274999 A JP2009274999 A JP 2009274999A JP 2010047616 A5 JP2010047616 A5 JP 2010047616A5
- Authority
- JP
- Japan
- Prior art keywords
- composition
- disease
- subject
- alzheimer
- coa reductase
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 206010001897 Alzheimer's disease Diseases 0.000 claims 3
- 239000002471 hydroxymethylglutaryl coenzyme A reductase inhibitor Substances 0.000 claims 2
- FJLGEFLZQAZZCD-JUFISIKESA-N (3S,5R)-fluvastatin Chemical compound C12=CC=CC=C2N(C(C)C)C(\C=C\[C@H](O)C[C@H](O)CC(O)=O)=C1C1=CC=C(F)C=C1 FJLGEFLZQAZZCD-JUFISIKESA-N 0.000 claims 1
- 102000013455 Amyloid beta-Peptides Human genes 0.000 claims 1
- 108010090849 Amyloid beta-Peptides Proteins 0.000 claims 1
- SEERZIQQUAZTOL-ANMDKAQQSA-N Cerivastatin Chemical compound COCC1=C(C(C)C)N=C(C(C)C)C(\C=C\[C@@H](O)C[C@@H](O)CC(O)=O)=C1C1=CC=C(F)C=C1 SEERZIQQUAZTOL-ANMDKAQQSA-N 0.000 claims 1
- PCZOHLXUXFIOCF-BXMDZJJMSA-N Lovastatin Chemical group C([C@H]1[C@@H](C)C=CC2=C[C@H](C)C[C@@H]([C@H]12)OC(=O)[C@@H](C)CC)C[C@@H]1C[C@@H](O)CC(=O)O1 PCZOHLXUXFIOCF-BXMDZJJMSA-N 0.000 claims 1
- AJLFOPYRIVGYMJ-INTXDZFKSA-N Mevastatin Chemical compound C([C@H]1[C@@H](C)C=CC2=CCC[C@@H]([C@H]12)OC(=O)[C@@H](C)CC)C[C@@H]1C[C@@H](O)CC(=O)O1 AJLFOPYRIVGYMJ-INTXDZFKSA-N 0.000 claims 1
- 229960002965 Pravastatin Drugs 0.000 claims 1
- TUZYXOIXSAXUGO-PZAWKZKUSA-N Pravastatin Chemical compound C1=C[C@H](C)[C@H](CC[C@@H](O)C[C@@H](O)CC(O)=O)[C@H]2[C@@H](OC(=O)[C@@H](C)CC)C[C@H](O)C=C21 TUZYXOIXSAXUGO-PZAWKZKUSA-N 0.000 claims 1
- RYMZZMVNJRMUDD-HGQWONQESA-N Simvastatin Chemical compound C([C@H]1[C@@H](C)C=CC2=C[C@H](C)C[C@@H]([C@H]12)OC(=O)C(C)(C)CC)C[C@@H]1C[C@@H](O)CC(=O)O1 RYMZZMVNJRMUDD-HGQWONQESA-N 0.000 claims 1
- 229960005370 atorvastatin Drugs 0.000 claims 1
- XUKUURHRXDUEBC-KAYWLYCHSA-N atorvastatin Chemical compound C=1C=CC=CC=1C1=C(C=2C=CC(F)=CC=2)N(CC[C@@H](O)C[C@@H](O)CC(O)=O)C(C(C)C)=C1C(=O)NC1=CC=CC=C1 XUKUURHRXDUEBC-KAYWLYCHSA-N 0.000 claims 1
- 229960005110 cerivastatin Drugs 0.000 claims 1
- 229960003765 fluvastatin Drugs 0.000 claims 1
- 229960004844 lovastatin Drugs 0.000 claims 1
- 210000002569 neurons Anatomy 0.000 claims 1
- 229960002855 simvastatin Drugs 0.000 claims 1
Claims (3)
- アルツハイマー病の危険があるか、またはアルツハイマー病と診断された被験体において、アルツハイマー病を処置または予防するための組成物であって、該組成物は、該被験体の神経細胞においてアミロイドβの産生を阻害するために有効な量のHMG CoAレダクターゼインヒビターを含む、組成物。
- 前記HMG CoAレダクターゼインヒビターが、ロバスタチン、シンバスタチン、フルバスタチン、プラバスタチン、アトルバスタチン、セリバスタチンおよびコンパクチンからなる群より選択される、請求項1に記載の組成物。
- 前記被験体に経口投与されることを特徴とする、請求項1または2に記載の組成物。
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US09/046,235 US6080778A (en) | 1998-03-23 | 1998-03-23 | Methods for decreasing beta amyloid protein |
Related Parent Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2000537538A Division JP2002507564A (ja) | 1998-03-23 | 1999-03-23 | βアミロイドタンパク質を減少させるための方法 |
Publications (2)
Publication Number | Publication Date |
---|---|
JP2010047616A JP2010047616A (ja) | 2010-03-04 |
JP2010047616A5 true JP2010047616A5 (ja) | 2010-10-14 |
Family
ID=21942345
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2000537538A Pending JP2002507564A (ja) | 1998-03-23 | 1999-03-23 | βアミロイドタンパク質を減少させるための方法 |
JP2009274999A Pending JP2010047616A (ja) | 1998-03-23 | 2009-12-02 | βアミロイドタンパク質を減少させるための方法 |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2000537538A Pending JP2002507564A (ja) | 1998-03-23 | 1999-03-23 | βアミロイドタンパク質を減少させるための方法 |
Country Status (6)
Country | Link |
---|---|
US (5) | US6080778A (ja) |
EP (1) | EP1063980A2 (ja) |
JP (2) | JP2002507564A (ja) |
AU (1) | AU759257B2 (ja) |
CA (1) | CA2324999A1 (ja) |
WO (1) | WO1999048488A2 (ja) |
Families Citing this family (58)
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WO1999026657A1 (en) * | 1997-11-25 | 1999-06-03 | Musc Foundation For Research Development | Inhibitors of nitric oxide synthase |
US20080275104A1 (en) * | 1997-11-25 | 2008-11-06 | Musc Foundation For Research Development | Methods of treating juvenile type 1 diabetes mellitus |
US20040072138A1 (en) * | 1997-11-25 | 2004-04-15 | Medical University Of South Carolina | Attenuation of ischemia/reperfusion injury |
US20060141036A1 (en) * | 1997-12-12 | 2006-06-29 | Andrx Labs Llc | HMG-CoA reductase inhibitor extended release formulation |
US20020188012A1 (en) * | 1998-01-28 | 2002-12-12 | Bisgaier Charles Larry | Method for treating Alzheimer's disease |
US6472421B1 (en) * | 1998-11-13 | 2002-10-29 | Nymox Corporation | Methods for treating, preventing, and reducing the risk of the onset of alzheimer's disease using an HMG CoA reductase inhibitor |
JP2002530122A (ja) * | 1998-11-25 | 2002-09-17 | サイオス インコーポレイテッド | アミロイド関連疾患の予防及び治療 |
US20020055529A1 (en) * | 1998-12-02 | 2002-05-09 | Bisgaier Charles Larry | Method for treating alzheimer's disease |
US20020107173A1 (en) * | 1999-11-04 | 2002-08-08 | Lawrence Friedhoff | Method of treating amyloid beta precursor disorders |
EP1225880A2 (en) * | 1999-11-04 | 2002-07-31 | Andrx Corporation | Use of a hmg-coa reductase inhibitor for treating amyloid beta precursor disorders |
AR027878A1 (es) * | 1999-11-05 | 2003-04-16 | Wyeth Corp | Metodos para identificar y utilizar compuestos inhibidores de amiloides |
WO2001056579A1 (en) * | 2000-02-04 | 2001-08-09 | Esperion Therapeutics Inc. | Methods for treating alzheimer's disease |
US7407662B2 (en) * | 2000-06-29 | 2008-08-05 | Lipid Sciences, Inc. | Modified viral particles with immunogenic properties and reduced lipid content |
US7439052B2 (en) * | 2000-06-29 | 2008-10-21 | Lipid Sciences | Method of making modified immunodeficiency virus particles |
US7407663B2 (en) * | 2000-06-29 | 2008-08-05 | Lipid Sciences, Inc. | Modified immunodeficiency virus particles |
AUPQ846900A0 (en) * | 2000-06-29 | 2000-07-27 | Aruba International Pty Ltd | A vaccine |
US20090017069A1 (en) * | 2000-06-29 | 2009-01-15 | Lipid Sciences, Inc. | SARS Vaccine Compositions and Methods of Making and Using Them |
US6982251B2 (en) * | 2000-12-20 | 2006-01-03 | Schering Corporation | Substituted 2-azetidinones useful as hypocholesterolemic agents |
EP1366061A4 (en) * | 2001-02-05 | 2006-04-26 | Andrx Corp | METHOD FOR TREATING BETA AMYLOID PRECURSOR ILLNESSES |
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CA2451633C (en) * | 2001-06-25 | 2010-11-30 | Lipid Sciences, Inc. | Systems and methods using a solvent for the removal of lipids from fluids |
US20030127386A1 (en) * | 2001-06-25 | 2003-07-10 | Bomberger David C. | Hollow fiber contactor systems for removal of lipids from fluids |
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US20050107461A1 (en) * | 2002-03-12 | 2005-05-19 | Tian-Quan Cai | Drug combination therapy |
US20050222122A1 (en) * | 2002-04-02 | 2005-10-06 | Sean Lilienfeld | Statin therapy for enhancing cognitive maintenance |
AU2003259188B2 (en) * | 2002-07-19 | 2008-03-06 | Aryx Therapeutics, Inc. | Materials and methods for treating hypercholesterolemia |
EP1534243A4 (en) * | 2002-08-26 | 2008-08-13 | Lipid Sciences Inc | TREATMENT OF ALZHEIMER WITH ENTLIPIDED PROTEIN PARTICLES |
FR2848452B1 (fr) * | 2002-12-12 | 2007-04-06 | Aventis Pharma Sa | Application des inhibiteurs de recapture intestinale des acides biliaires pour la prevention et le traitement de la maladie d'alzheimer |
US7192944B2 (en) * | 2003-03-07 | 2007-03-20 | Schering Corp. | Substituted azetidinone compounds, processes for preparing the same, formulations and uses thereof |
JP4589919B2 (ja) * | 2003-03-07 | 2010-12-01 | シェーリング コーポレイション | 高コレステロール血症の処置のための、置換アゼチジノン化合物、これらの処方物および使用 |
ATE406364T1 (de) | 2003-03-07 | 2008-09-15 | Schering Corp | Substituierte azetidinon-derivate, deren pharmazeutische formulierungen und deren verwendung zur behandlung von hypercholesterolemia |
MXPA05009976A (es) * | 2003-03-17 | 2005-11-04 | Japan Tobacco Inc | Metodo para incrementar la biodisponibilidad oral del 2-metilpropantioato de s-[2-([[1- 2-etilbutil) ciclohexil] carbonil] amino) fenilo]. |
EP2289507A1 (en) * | 2003-03-17 | 2011-03-02 | Japan Tobacco, Inc. | Pharmaceutical compositions of CETP inhibitors |
TWI393560B (zh) * | 2003-05-02 | 2013-04-21 | Japan Tobacco Inc | 包含s-〔2(〔〔1-(2-乙基丁基)環己基〕羰基〕胺基)苯基〕2-甲基丙烷硫酯及hmg輔酶a還原酶抑制劑之組合 |
US7393826B2 (en) * | 2003-07-03 | 2008-07-01 | Lipid Sciences, Inc. | Methods and apparatus for creating particle derivatives of HDL with reduced lipid content |
JP2007527387A (ja) * | 2003-07-03 | 2007-09-27 | リピッド サイエンシーズ,インコーポレイテッド | 脂質含量の低下したhdlの粒子誘導体を製造するための方法及び装置 |
WO2005079779A1 (en) * | 2003-10-22 | 2005-09-01 | Merz Pharma Gmbh & Co. Kgaa | THE USE OF 1-AMINOCYCLOHEXANE DERIVATIVES TO MODIFY DEPOSITION OF FIBRILLOGENIC Aß PEPTIDES IN AMYLOIDOPATHIES |
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EP1731147A4 (en) * | 2004-03-31 | 2010-06-30 | Kowa Co | EXTERNAL PREPARATION |
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US20060039890A1 (en) * | 2004-08-20 | 2006-02-23 | Renshaw Perry F | Treatment of psychological and cognitive disorders using a cholesterol -lowering agent in combination with an antidepressant |
US8353184B2 (en) * | 2005-01-21 | 2013-01-15 | Sinox Company Ltd. | Tamper indicating padlock |
AU2006251832A1 (en) * | 2005-05-27 | 2006-11-30 | Queen's University At Kingston | Treatment of protein folding disorders |
EP2007385A4 (en) * | 2006-03-23 | 2010-08-18 | Sinai School Medicine | CARDIOVASCULAR COMPOSITION AND ITS USE FOR THE TREATMENT OF MORBUS ALZHEIMER |
WO2008112887A1 (en) * | 2007-03-13 | 2008-09-18 | Musc Foundation For Research Development | Methods of treating juvenile type 1 diabetes mellitus |
TWI432195B (zh) * | 2007-10-03 | 2014-04-01 | Kowa Co | 神經細胞死亡抑制劑 |
ES2330184B1 (es) * | 2008-06-03 | 2010-07-05 | Neuron Biopharma, S.A. | Uso de estatinas como anticonvulsivantes, antiepilepticos y neuroprotectores. |
EP2391370B1 (en) | 2009-02-02 | 2015-06-03 | Galmed Research and Development Ltd. | Methods and compositions for treating alzheimer's disease |
KR102287877B1 (ko) * | 2014-03-13 | 2021-08-11 | 주식회사 하이폭시 | 차전자피를 포함하는 기억력 및 인지기능 증진용 조성물 |
US11027052B2 (en) | 2017-11-22 | 2021-06-08 | HDL Therapuetics, Inc. | Systems and methods for priming fluid circuits of a plasma processing system |
WO2019049705A1 (ja) * | 2017-09-08 | 2019-03-14 | 自然免疫制御技術研究組合 | アルツハイマー症診断装置及び方法 |
JP2021509894A (ja) | 2017-12-28 | 2021-04-08 | エイチディーエル セラピューティクス インコーポレイテッドHdl Therapeutics, Inc. | ヒト血漿から抽出されたpre−β高密度リポタンパク質を保存および投与するための方法 |
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US3692895A (en) * | 1970-09-08 | 1972-09-19 | Norman A Nelson | Method of reducing hypercholesteremia in humans employing a copolymer of polyethylenepolyamine and a bifunctional substance, such as epichlorohydria |
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DE19716120A1 (de) * | 1997-04-17 | 1998-10-22 | Europ Lab Molekularbiolog | Verwendung von cholesterinsenkenden Mitteln |
US5929062A (en) * | 1997-06-19 | 1999-07-27 | University Of Western Ontario | Oxysterol inhibition of dietary cholesterol uptake |
CA2304505A1 (en) * | 1997-09-24 | 1999-04-01 | Nova Molecular, Inc. | Methods for increasing apoe levels for the treatment of neurodegenerative disease |
ES2257824T3 (es) * | 1998-01-28 | 2006-08-01 | Warner-Lambert Company Llc | Metodo para tratar la enfermedad de alzheimer. |
-
1998
- 1998-03-23 US US09/046,235 patent/US6080778A/en not_active Expired - Lifetime
-
1999
- 1999-01-28 US US09/239,387 patent/US6440387B1/en not_active Expired - Fee Related
- 1999-03-23 WO PCT/US1999/006396 patent/WO1999048488A2/en active IP Right Grant
- 1999-03-23 CA CA002324999A patent/CA2324999A1/en not_active Abandoned
- 1999-03-23 EP EP99914084A patent/EP1063980A2/en not_active Withdrawn
- 1999-03-23 JP JP2000537538A patent/JP2002507564A/ja active Pending
- 1999-03-23 AU AU32009/99A patent/AU759257B2/en not_active Ceased
-
2002
- 2002-02-28 US US10/086,398 patent/US20020120003A1/en not_active Abandoned
- 2002-07-14 US US10/198,331 patent/US20020183379A1/en not_active Abandoned
-
2005
- 2005-09-22 US US11/232,844 patent/US20060025469A1/en not_active Abandoned
-
2009
- 2009-12-02 JP JP2009274999A patent/JP2010047616A/ja active Pending
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