JP2009545645A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2009545645A5 JP2009545645A5 JP2009522326A JP2009522326A JP2009545645A5 JP 2009545645 A5 JP2009545645 A5 JP 2009545645A5 JP 2009522326 A JP2009522326 A JP 2009522326A JP 2009522326 A JP2009522326 A JP 2009522326A JP 2009545645 A5 JP2009545645 A5 JP 2009545645A5
- Authority
- JP
- Japan
- Prior art keywords
- conjugate
- group
- conjugate according
- btm
- formula
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 125000000217 alkyl group Chemical group 0.000 claims 5
- 229910052799 carbon Inorganic materials 0.000 claims 4
- 239000008194 pharmaceutical composition Substances 0.000 claims 3
- 102000004190 Enzymes Human genes 0.000 claims 2
- 108090000790 Enzymes Proteins 0.000 claims 2
- 125000003118 aryl group Chemical group 0.000 claims 2
- 239000012634 fragment Substances 0.000 claims 2
- 238000004519 manufacturing process Methods 0.000 claims 2
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 2
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 2
- 108090000765 processed proteins & peptides Proteins 0.000 claims 2
- IHDBZCJYSHDCKF-UHFFFAOYSA-N 4,6-dichlorotriazine Chemical compound ClC1=CC(Cl)=NN=N1 IHDBZCJYSHDCKF-UHFFFAOYSA-N 0.000 claims 1
- PEEHTFAAVSWFBL-UHFFFAOYSA-N Maleimide Chemical class O=C1NC(=O)C=C1 PEEHTFAAVSWFBL-UHFFFAOYSA-N 0.000 claims 1
- 241000124008 Mammalia Species 0.000 claims 1
- 108091034117 Oligonucleotide Proteins 0.000 claims 1
- 239000002202 Polyethylene glycol Substances 0.000 claims 1
- DZBUGLKDJFMEHC-UHFFFAOYSA-O acridine;hydron Chemical compound C1=CC=CC2=CC3=CC=CC=C3[NH+]=C21 DZBUGLKDJFMEHC-UHFFFAOYSA-O 0.000 claims 1
- 125000000539 amino acid group Chemical group 0.000 claims 1
- 150000001413 amino acids Chemical class 0.000 claims 1
- 239000005557 antagonist Substances 0.000 claims 1
- 125000003710 aryl alkyl group Chemical group 0.000 claims 1
- 125000005605 benzo group Chemical group 0.000 claims 1
- 239000011203 carbon fibre reinforced carbon Substances 0.000 claims 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims 1
- 150000001768 cations Chemical class 0.000 claims 1
- 150000001875 compounds Chemical class 0.000 claims 1
- 230000021615 conjugation Effects 0.000 claims 1
- 239000002532 enzyme inhibitor Substances 0.000 claims 1
- 229940125532 enzyme inhibitor Drugs 0.000 claims 1
- 150000002148 esters Chemical class 0.000 claims 1
- 125000000524 functional group Chemical group 0.000 claims 1
- 125000003827 glycol group Chemical group 0.000 claims 1
- 125000001072 heteroaryl group Chemical group 0.000 claims 1
- SMWDFEZZVXVKRB-UHFFFAOYSA-O hydron;quinoline Chemical compound [NH+]1=CC=CC2=CC=CC=C21 SMWDFEZZVXVKRB-UHFFFAOYSA-O 0.000 claims 1
- 150000002540 isothiocyanates Chemical class 0.000 claims 1
- 125000005647 linker group Chemical group 0.000 claims 1
- 150000008300 phosphoramidites Chemical class 0.000 claims 1
- 229920001223 polyethylene glycol Polymers 0.000 claims 1
- WVIICGIFSIBFOG-UHFFFAOYSA-N pyrylium Chemical compound C1=CC=[O+]C=C1 WVIICGIFSIBFOG-UHFFFAOYSA-N 0.000 claims 1
- 125000001453 quaternary ammonium group Chemical class 0.000 claims 1
- 239000011541 reaction mixture Substances 0.000 claims 1
- 102000005962 receptors Human genes 0.000 claims 1
- 108020003175 receptors Proteins 0.000 claims 1
- 239000007787 solid Substances 0.000 claims 1
- 239000000758 substrate Substances 0.000 claims 1
- 125000001273 sulfonato group Chemical group [O-]S(*)(=O)=O 0.000 claims 1
- 230000008685 targeting Effects 0.000 claims 1
- 125000003396 thiol group Chemical group [H]S* 0.000 claims 1
- ANRHNWWPFJCPAZ-UHFFFAOYSA-M thionine Chemical compound [Cl-].C1=CC(N)=CC2=[S+]C3=CC(N)=CC=C3N=C21 ANRHNWWPFJCPAZ-UHFFFAOYSA-M 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB0615211.0 | 2006-07-31 | ||
| GB0615211A GB0615211D0 (en) | 2006-07-31 | 2006-07-31 | Asymmetric flouro-substituted polymethine dyes |
| PCT/GB2007/002907 WO2008015415A2 (en) | 2006-07-31 | 2007-07-31 | Asymmetric fluoro-substituted polymethine dyes |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2009545645A JP2009545645A (ja) | 2009-12-24 |
| JP2009545645A5 true JP2009545645A5 (enExample) | 2010-08-26 |
| JP5341757B2 JP5341757B2 (ja) | 2013-11-13 |
Family
ID=37006503
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009522326A Expired - Fee Related JP5341757B2 (ja) | 2006-07-31 | 2007-07-31 | 非対称フルオロ置換ポリメチン色素 |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US20090252687A1 (enExample) |
| EP (1) | EP2046895A2 (enExample) |
| JP (1) | JP5341757B2 (enExample) |
| CN (1) | CN101522815A (enExample) |
| GB (1) | GB0615211D0 (enExample) |
| WO (1) | WO2008015415A2 (enExample) |
Families Citing this family (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0718957D0 (en) * | 2007-09-28 | 2007-11-07 | Ge Healthcare Ltd | Optical imaging agents |
| GB0718967D0 (en) * | 2007-09-28 | 2007-11-07 | Ge Healthcare Ltd | Peptide imaging agents |
| WO2009046010A2 (en) * | 2007-10-02 | 2009-04-09 | Charles Brush | Monomethine dyes |
| SG10201706428XA (en) | 2009-02-06 | 2017-09-28 | Beth Israel Deaconess Medical Ct Inc | Charge-balanced imaging agents |
| US10493169B2 (en) | 2009-02-06 | 2019-12-03 | Beth Israel Deaconess Medical Center | Use of charge-balanced imaging agents for determining renal function |
| WO2010126045A1 (ja) * | 2009-04-28 | 2010-11-04 | 和光純薬工業株式会社 | 第４級アンモニウムカチオン含有ピラゾール系シアニン色素 |
| TWI516264B (zh) * | 2010-05-06 | 2016-01-11 | 臺北醫學大學 | 芳香醯喹啉化合物 |
| WO2012001063A1 (en) * | 2010-06-29 | 2012-01-05 | Ge Healthcare As | Dye compositions and dye syntheses |
| DE102010027016A1 (de) | 2010-07-09 | 2012-01-12 | Universitätsklinikum Jena | Steroid-Styrylfarbstoff-Konjugate zur Simulation und direkten lichtoptischen Detektion des Verhaltens von Steroiden im lebenden biologischen Gewebe und in Gegenwart von steroidbindenden Proteinen |
| GB201013808D0 (en) | 2010-08-18 | 2010-09-29 | Ge Healthcare Ltd | Peptide radiotracer compositions |
| WO2012061403A1 (en) * | 2010-11-02 | 2012-05-10 | Life Technologies Corporation | Modified hydrocyanine dyes for the detection of reactive oxygen species |
| EP2831179B1 (en) * | 2012-03-30 | 2016-04-20 | Life Technologies Corporation | Modified nucleic acid binding cyanine dyes for the detection of reactive oxygen species |
| CN104540819B (zh) | 2012-08-28 | 2019-04-19 | 皮尔斯生物科技有限公司 | 苯并吡喃鎓化合物 |
| JP6133431B2 (ja) | 2012-11-24 | 2017-05-24 | ハンジョウ ディーエーシー バイオテック シーオー．，エルティディ．Ｈａｎｇｚｈｏｕ Ｄａｃ Ｂｉｏｔｅｃｈ Ｃｏ．，Ｌｔｄ． | 親水性連結体及び薬物分子と細胞結合分子との共役反応における親水性連結体の使用 |
| CN108852368B (zh) | 2013-03-14 | 2024-01-12 | 普罗菲尤萨股份有限公司 | 氧传感器 |
| GB201314936D0 (en) | 2013-08-21 | 2013-10-02 | Ge Healthcare Ltd | Radiolabelling method |
| GB201322456D0 (en) | 2013-12-18 | 2014-02-05 | Ge Healthcare Ltd | Radiotracer compositions and methods |
| CN104804463B (zh) * | 2015-03-10 | 2016-08-24 | 西安交通大学第一附属医院 | 用于靶向肿瘤组织的近红外荧光染色剂及制备方法和应用 |
| WO2018119204A1 (en) * | 2016-12-21 | 2018-06-28 | Profusa, Inc. | Polymerizable near-ir dyes |
| EP3375353A1 (en) * | 2017-03-16 | 2018-09-19 | Universität Zürich | Photoacoustic imaging of inflamed tissue |
| EP3606927A4 (en) | 2017-04-03 | 2021-03-17 | Massachusetts Institute of Technology | SHORTWAVE NEAR INFRARED POLYMETHINE DYES |
| US11292778B2 (en) | 2017-06-05 | 2022-04-05 | The Regents Of The University Of California | Heterocyclyl polymethine IR chromophores |
| EP3728137A4 (en) * | 2017-12-22 | 2021-12-08 | North Carolina State University | POLYMERIC FLUOROPHORES, COMPOSITIONS INCLUDING THEM, AND THEIR PREPARATION AND USE PROCESSES |
| AU2019293250A1 (en) | 2018-06-27 | 2021-01-07 | Profusa, Inc. | Near-IR glucose sensors |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5658751A (en) * | 1993-04-13 | 1997-08-19 | Molecular Probes, Inc. | Substituted unsymmetrical cyanine dyes with selected permeability |
| US6495692B1 (en) * | 1996-12-10 | 2002-12-17 | Abbott Laboratories | Helium-neon excitable reticulocyte dyes derivable from halolepidines |
| EP1325084A2 (de) * | 1998-12-05 | 2003-07-09 | Otto Samuel Wolfbeis | Pyridin- und chinolin-farbstoffe als marker für biomoleküle, polymere, arzneistoffe und partikel |
| DE19917713A1 (de) * | 1999-04-09 | 2000-10-19 | Diagnostikforschung Inst | Kurzkettige Peptid-Farbstoffkonjugate als Konstrastmittel für die optische Diagnostik |
| EP1917958B1 (en) * | 2000-01-19 | 2012-06-13 | Abbott Laboratories | Improved HIV protease inhibitors pharmaceutical formulations |
| WO2001090253A1 (de) * | 2000-05-23 | 2001-11-29 | Dyomics Gmbh | Stabile nir-marker-farbstoffe auf der basis von benzopyrylium-polymethinen |
| JP4510444B2 (ja) * | 2001-07-10 | 2010-07-21 | ジーイー・ヘルスケア・アクスイェ・セルスカプ | ペプチドベースの化合物 |
| TWI244494B (en) * | 2003-05-14 | 2005-12-01 | Ritek Corp | Optical recording medium dye |
| EP1866387B1 (en) * | 2005-03-09 | 2013-05-08 | Cepheid | Polar dyes |
-
2006
- 2006-07-31 GB GB0615211A patent/GB0615211D0/en not_active Ceased
-
2007
- 2007-07-31 JP JP2009522326A patent/JP5341757B2/ja not_active Expired - Fee Related
- 2007-07-31 WO PCT/GB2007/002907 patent/WO2008015415A2/en not_active Ceased
- 2007-07-31 EP EP07789086A patent/EP2046895A2/en not_active Withdrawn
- 2007-07-31 US US12/375,239 patent/US20090252687A1/en not_active Abandoned
- 2007-07-31 CN CN 200780036717 patent/CN101522815A/zh active Pending
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2009545645A5 (enExample) | ||
| CA1317207C (en) | Solution phase nucleic acid sandwich assay and polynucleotide probes useful therein | |
| CA2256545C (en) | Probe for analysis of nucleic acids | |
| ES2543325T3 (es) | Inhibidores de la actividad de Akt | |
| US10647740B2 (en) | Multisignal labeling reagents and processes and uses therefor | |
| JP2002542365A (ja) | シアニン色素及びその合成法 | |
| JP2000507949A (ja) | ピペラジンおよびピペリジン化合物 | |
| JP2004323839A (ja) | 非対称シアニン色素クエンチャー | |
| JP2003505458A5 (enExample) | ||
| JP2010527922A5 (enExample) | ||
| US20210079034A1 (en) | Fluorescent dyes and methods of use thereof | |
| ES2339337T3 (es) | Reactivos de marcaje, procedimientos de sintesis de dichos reactivos y procedimiento de deteccion de moleculas biologicas. | |
| JP2000503707A (ja) | スルホインドシアニン染料の合成のための化合物及び合成方法 | |
| JPH10503774A (ja) | ピロロ［２，３−ｂ］ピリジンのテトラヒドロピリジニルメチル誘導体 | |
| WO2005014723A1 (en) | Cyanin-type compounds having an alkynyl linker arm | |
| JP6182529B2 (ja) | 副溝結合剤ホスホラミダイトおよび使用方法 | |
| JP2005504790A5 (enExample) | ||
| JP2021020903A (ja) | クマリン系化合物及び関連する方法 | |
| JP2003532724A (ja) | ソマトスタチン誘導体に親和性を有する、ヒダントイン誘導体 | |
| JP4745331B2 (ja) | 標識用試薬、その試薬の合成方法、及び、生体分子の検出法 | |
| CN112898193B (zh) | 一种吲哚芳基砜类衍生物及其制备方法与应用 | |
| CA3121649C (en) | Fluorescent dyes | |
| WO2017114863A1 (en) | 3-(5-fluoroindolyl)-4-arylmaleimide compounds and their use in tumor treatment | |
| AU768137B2 (en) | Probe for analysis of nucleic acids | |
| HK1239658B (en) | Coumarin-based compounds and related methods |