JP2009544660A - 合成プローブによる融合タンパク質の標識化 - Google Patents
合成プローブによる融合タンパク質の標識化 Download PDFInfo
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- G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
- G01N33/581—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances with enzyme label (including co-enzymes, co-factors, enzyme inhibitors or substrates)
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- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
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- C07D239/47—One nitrogen atom and one oxygen or sulfur atom, e.g. cytosine
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- C—CHEMISTRY; METALLURGY
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- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
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- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/10—Transferases (2.)
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/48—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving transferase
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- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
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| CA2553261C (en) | 2004-01-16 | 2014-03-18 | Stefan Barth | Immunokinases |
| WO2007006055A2 (en) | 2005-07-06 | 2007-01-11 | Vascular Pathways Inc. | Intravenous catheter insertion device and method of use |
| EP1800695A1 (en) | 2005-12-21 | 2007-06-27 | Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. | Immuno-RNA-constructs |
| ATE489989T1 (de) | 2007-05-07 | 2010-12-15 | Vascular Pathways Inc | Einführung eines intravenösen katheters und blutentnahmevorrichtung und anwendungsverfahren |
| WO2009013359A2 (en) * | 2007-07-25 | 2009-01-29 | Fraunhofer Gesellschaft Zur Förderung Der Angewandten Forschung E. V. | Self coupling recombinant antibody fusion proteins |
| WO2010031767A2 (en) * | 2008-09-16 | 2010-03-25 | Technische Universität München | Fluorescent-labelled atpases |
| FR2936245B1 (fr) * | 2008-09-23 | 2012-07-06 | Cis Bio Int | Nouveaux substrats d'o6-alkylguanine-adn alkyltransferase et ses mutants. |
| US9872971B2 (en) | 2010-05-14 | 2018-01-23 | C. R. Bard, Inc. | Guidewire extension system for a catheter placement device |
| US10384039B2 (en) | 2010-05-14 | 2019-08-20 | C. R. Bard, Inc. | Catheter insertion device including top-mounted advancement components |
| US9950139B2 (en) | 2010-05-14 | 2018-04-24 | C. R. Bard, Inc. | Catheter placement device including guidewire and catheter control elements |
| US8932258B2 (en) | 2010-05-14 | 2015-01-13 | C. R. Bard, Inc. | Catheter placement device and method |
| US11925779B2 (en) | 2010-05-14 | 2024-03-12 | C. R. Bard, Inc. | Catheter insertion device including top-mounted advancement components |
| US8690833B2 (en) | 2011-01-31 | 2014-04-08 | Vascular Pathways, Inc. | Intravenous catheter and insertion device with reduced blood spatter |
| US9095683B2 (en) | 2011-02-25 | 2015-08-04 | C. R. Bard, Inc. | Medical component insertion device including a retractable needle |
| USD903101S1 (en) | 2011-05-13 | 2020-11-24 | C. R. Bard, Inc. | Catheter |
| JP6522339B2 (ja) | 2011-11-21 | 2019-05-29 | プロメガ コーポレイションＰｒｏｍｅｇａ Ｃｏｒｐｏｒａｔｉｏｎ | カルボキシｘローダミン類似体 |
| NO2788478T3 (enExample) | 2011-12-09 | 2018-01-20 | ||
| US9267117B2 (en) | 2012-03-15 | 2016-02-23 | New England Biolabs, Inc. | Mapping cytosine modifications |
| WO2013139391A1 (en) * | 2012-03-21 | 2013-09-26 | Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. | Novel photoimmunoconjugates for use in photodynamic therapy |
| US9522254B2 (en) | 2013-01-30 | 2016-12-20 | Vascular Pathways, Inc. | Systems and methods for venipuncture and catheter placement |
| US9782568B2 (en) | 2013-02-05 | 2017-10-10 | Vascular Pathways, Inc. | Systems and methods for needle and catheter advancement |
| EP2972229B1 (en) | 2013-03-15 | 2017-12-27 | Promega Corporation | New silicon and germanium dyes for use in genetic identity |
| CN105392897B (zh) | 2013-03-19 | 2020-03-20 | 定向基因组学公司 | 靶序列的富集 |
| WO2016003795A1 (en) | 2014-07-02 | 2016-01-07 | New England Biolabs, Inc. | Universal n-glycan binding reagent |
| WO2016037127A1 (en) | 2014-09-05 | 2016-03-10 | C.R. Bard, Inc. | Catheter insertion device including retractable needle |
| JP2017537657A (ja) | 2014-12-11 | 2017-12-21 | ニユー・イングランド・バイオレイブス・インコーポレイテツド | 標的配列の濃縮 |
| USD903100S1 (en) | 2015-05-01 | 2020-11-24 | C. R. Bard, Inc. | Catheter placement device |
| BR112017024570B1 (pt) | 2015-05-15 | 2022-06-28 | C.R. Bard, Inc | Dispositivo de inserção para inserir um cateter no corpo de um paciente |
| CN113444094B (zh) | 2016-07-20 | 2023-12-22 | 纳莹(上海)生物科技有限公司 | 一种荧光探针及其制备方法和用途 |
| SG11201901968TA (en) | 2016-09-12 | 2019-04-29 | Bard Inc C R | Blood control for a catheter insertion device |
| EP3585471B1 (en) | 2017-03-01 | 2025-01-01 | C. R. Bard, Inc. | Catheter insertion device |
| CN109574880B (zh) | 2017-09-29 | 2022-06-17 | 纳莹(上海)生物科技有限公司 | 一种荧光探针及其制备方法和用途 |
| CN115671504A (zh) | 2018-03-07 | 2023-02-03 | 巴德阿克塞斯系统股份有限公司 | 用于医疗装置插入系统的导丝推进和血液闪回系统 |
| CN110498799B (zh) | 2018-05-18 | 2022-07-05 | 纳莹(上海)生物科技有限公司 | 一种荧光探针及其制备方法和用途 |
| USD921884S1 (en) | 2018-07-27 | 2021-06-08 | Bard Access Systems, Inc. | Catheter insertion device |
| CN111748089B (zh) * | 2019-03-28 | 2023-07-18 | 成都先导药物开发股份有限公司 | 一种生物素标记化合物以及确定化合物结合靶标蛋白的方法 |
| US11390915B2 (en) | 2019-04-26 | 2022-07-19 | New England Biolabs, Inc. | Polynucleotide adapter design for reduced bias |
| CN112386778B (zh) | 2019-08-19 | 2025-02-28 | 贝克顿·迪金森公司 | 中线导管放置装置 |
| US12440652B2 (en) | 2019-09-20 | 2025-10-14 | Bard Peripheral Vascular, Inc. | Intravenous catheter-placement device and method thereof |
| WO2021183921A1 (en) | 2020-03-12 | 2021-09-16 | New England Biolabs, Inc. | A rapid diagnostic test for lamp |
| EP4182687A4 (en) * | 2020-07-20 | 2024-09-11 | Bio-Rad Laboratories, Inc. | IMMUNOASSAY FOR SARS-COV-2 NEUTRALISING ANTIBODIES AND MATERIALS THEREFOR |
| EP4110945A2 (en) | 2020-08-21 | 2023-01-04 | New England Biolabs, Inc. | A rapid diagnostic test for lamp |
| WO2023197015A1 (en) | 2022-04-08 | 2023-10-12 | New England Biolabs, Inc. | Compositions and analysis of dephosphorylated oligoribonucleotides |
| CN118165544B (zh) * | 2022-12-11 | 2025-09-05 | 中国科学院大连化学物理研究所 | 适用于细胞膜动态超分辨成像的五甲川菁染料荧光探针合成与应用 |
| WO2025129193A1 (en) | 2023-12-15 | 2025-06-19 | New England Biolabs, Inc. | Glycosyltransferases and related methods |
| GB202400129D0 (en) | 2024-01-04 | 2024-02-21 | Cambridge Entpr Ltd | Nucleic acid barcodes |
| WO2025224010A1 (en) | 2024-04-24 | 2025-10-30 | Max-Planck-Gesellschaft zur Förderung der Wissenschaften e. V. | Improved o6-alkylguanine-dna alkyltransferase substrates |
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| CZ2002323A3 (cs) * | 1999-07-28 | 2002-05-15 | Aventis Pharmaceuticals Products Inc. | Substituované oxoazaheterocyklylové sloučeniny a farmaceutické prostředky, které je obsahují |
| WO2004031405A1 (en) * | 2002-10-03 | 2004-04-15 | Ecole Polytechnique Federale De Lausanne (Epfl) | Substrates for o6-alkylguanine-dna alkyltransferase |
| WO2005085470A1 (en) | 2004-03-02 | 2005-09-15 | Epfl Ecole Polytechnique Federale De Lausanne | Specific substrates for o6- alkylguanine-dna alkyltransferase |
| WO2006114409A1 (en) * | 2005-04-27 | 2006-11-02 | Covalys Biosciences Ag | Pyrimidines reacting with o6-alkylguanine-dna alkyltransferase |
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