JP2009544280A5 - - Google Patents
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- JP2009544280A5 JP2009544280A5 JP2009519713A JP2009519713A JP2009544280A5 JP 2009544280 A5 JP2009544280 A5 JP 2009544280A5 JP 2009519713 A JP2009519713 A JP 2009519713A JP 2009519713 A JP2009519713 A JP 2009519713A JP 2009544280 A5 JP2009544280 A5 JP 2009544280A5
- Authority
- JP
- Japan
- Prior art keywords
- gene
- deletion
- cfhr1
- gene product
- cfhr3
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US83101806P | 2006-07-13 | 2006-07-13 | |
| US60/831,018 | 2006-07-13 | ||
| US84007306P | 2006-08-23 | 2006-08-23 | |
| US60/840,073 | 2006-08-23 | ||
| PCT/US2007/073514 WO2008008986A2 (en) | 2006-07-13 | 2007-07-13 | Methods and reagents for treatment and diagnosis of vascular disorders and age-related macular degeneration |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2009544280A JP2009544280A (ja) | 2009-12-17 |
| JP2009544280A5 true JP2009544280A5 (https=) | 2010-09-02 |
| JP5431151B2 JP5431151B2 (ja) | 2014-03-05 |
Family
ID=38924245
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009519713A Active JP5431151B2 (ja) | 2006-07-13 | 2007-07-13 | 血管障害および加齢黄斑変性症の治療および診断のための方法および試薬 |
Country Status (11)
| Country | Link |
|---|---|
| US (4) | US7867727B2 (https=) |
| EP (3) | EP2479284B1 (https=) |
| JP (1) | JP5431151B2 (https=) |
| AT (1) | ATE551350T1 (https=) |
| AU (1) | AU2007272335B2 (https=) |
| CA (1) | CA2659392A1 (https=) |
| DK (1) | DK2447275T3 (https=) |
| IL (1) | IL196319A0 (https=) |
| NZ (1) | NZ574046A (https=) |
| SG (1) | SG173371A1 (https=) |
| WO (1) | WO2008008986A2 (https=) |
Families Citing this family (31)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2357254A1 (en) * | 2005-02-14 | 2011-08-17 | University of Iowa Research Foundation | Methods and reagents for treatment and diagnosis of age-related macular degeneration |
| US20080146501A1 (en) * | 2006-02-13 | 2008-06-19 | University Of Iowa Research Foundation | Protective complement proteins and age-related macular degeneration |
| US8012683B2 (en) | 2006-02-13 | 2011-09-06 | University Of Iowa Research Foundation | Variants in complement regulatory genes predict age-related macular degeneration |
| AU2007277125B2 (en) * | 2006-07-26 | 2013-08-01 | Yale University | Diagnosis and treatment of age related macular degeneration |
| EP2217720A4 (en) * | 2007-11-01 | 2010-12-08 | Univ Iowa Res Found | RNA LOCUS ANALYSIS TO ASSESS THE STUNNING FOR AMD AND MPGNII |
| US20090186370A1 (en) * | 2008-01-18 | 2009-07-23 | Ogle Matthew F | Diagnostic biomarkers for vascular aneurysm |
| DE102008049136B4 (de) * | 2008-09-26 | 2012-10-25 | Leibniz-Institut für Naturstoff-Forschung und Infektionsbiologie e.V. | Neue Regulatoren des angeborenen Immunsystems |
| JP2012533562A (ja) * | 2009-07-16 | 2012-12-27 | グラクソ ウェルカム マニュファクチュアリング ピーティーイー リミテッド | 治療法 |
| US20120190578A1 (en) * | 2009-08-06 | 2012-07-26 | Washington University | Plasma Complement Components as Expression Markers for Age-Related Macular Degeneration and Related Phenotypes |
| EP2478377A2 (de) * | 2009-09-14 | 2012-07-25 | Mosaiques Diagnostics And Therapeutics AG | Polypeptidmarker zur diagnostik und beurteilung vaskulärer erkrankungen |
| JP5706612B2 (ja) * | 2009-12-28 | 2015-04-22 | 学校法人 埼玉医科大学 | 加齢黄斑変性症易罹患性の判定マーカー並びに判定方法及び判定キット |
| US20120202708A1 (en) * | 2010-10-14 | 2012-08-09 | Sequenom, Inc. | Complement factor h copy number variants found in the rca locus |
| US9598733B2 (en) * | 2011-02-17 | 2017-03-21 | The Trustees Of Columbia University In The City Of New York | Methods for identifying subjects with a genetic risk for developing IgA nephropathy |
| CA2834676A1 (en) * | 2011-04-29 | 2012-11-01 | University Of Utah Research Foundation | Methods of predicting the development of complement-mediated disease |
| JP2013064616A (ja) * | 2011-09-15 | 2013-04-11 | Osaka Univ | 高度動脈硬化を発症している可能性を検出する方法およびその利用 |
| WO2013150132A2 (de) * | 2012-04-05 | 2013-10-10 | Mosaiques Diagnostics And Therapeutics Ag | Polypeptidmarker zur diagnostik und beurteilung von schlaganfällen |
| GB201301632D0 (en) * | 2013-01-30 | 2013-03-13 | Imp Innovations | Complement System |
| EP2962106A1 (en) * | 2013-02-26 | 2016-01-06 | Roche Diagnostics GmbH | Agents, kits and methods for complement factor h-related protein 1 detection |
| US10202647B2 (en) | 2013-04-12 | 2019-02-12 | The Trustees Of Columbia University In The City Of New York | Mutations in DSTYK cause dominant urinary tract malformations |
| WO2014194213A1 (en) * | 2013-05-30 | 2014-12-04 | University Of Iowa Research Foundation | Specific complement proteins and efficacy of antibody therapy |
| US10155983B2 (en) | 2014-03-31 | 2018-12-18 | Machaon Diagnostics, Inc. | Method of diagnosis of complement-mediated thrombotic microangiopathies |
| JP7199966B2 (ja) | 2015-12-23 | 2023-01-06 | ソルボンヌ ウニベルシテ | CD11b/CD18に対するCFHの結合を阻害する薬剤、およびその使用 |
| CA3023802C (en) | 2016-05-10 | 2025-02-04 | Inserm (Institut De La Sante Et De La Recherche Medicale) | ACTIVATING AGENTS OF THE DIFFERENTIATION CLUSTER 47 FOR USE IN THE TREATMENT OF INFLAMMATION |
| GB201800620D0 (en) | 2018-01-15 | 2018-02-28 | Univ Manchester | C3b Binding Polypeptide |
| EP3791180A1 (en) * | 2018-05-10 | 2021-03-17 | The University Of Manchester | Methods for assessing macular degeneration |
| EP3824095A4 (en) | 2018-07-20 | 2022-04-20 | University of Utah Research Foundation | GENE THERAPY FOR MACULATE GENERATION |
| DE102018120016B4 (de) | 2018-08-16 | 2020-09-03 | Leibniz-Institut für Naturstoff-Forschung und Infektionsbiologie e.V. -Hans-Knöll-Institut- | Modulatoren der Funktion von Faktor H-verwandtem Protein 1 und deren Verwendungen in der Kontrolle von Entzündung |
| WO2020180147A2 (ko) * | 2019-03-07 | 2020-09-10 | (주)레티마크 | 나이관련 황반변성 진단용 복합 마커 및 이의 용도 |
| WO2020210724A1 (en) | 2019-04-10 | 2020-10-15 | University Of Utah Research Foundation | Htra1 modulation for treatment of amd |
| CA3158517A1 (en) * | 2019-10-22 | 2021-04-29 | Applied Genetic Technologies Corporation | Adeno-associated virus (aav)vectors for the treatment of age-related macular degeneration and other ocular diseases and disorders |
| WO2022058447A1 (en) * | 2020-09-16 | 2022-03-24 | The University Of Manchester | Complementome assay |
Family Cites Families (50)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4816567A (en) | 1983-04-08 | 1989-03-28 | Genentech, Inc. | Recombinant immunoglobin preparations |
| NO870613L (no) | 1986-03-05 | 1987-09-07 | Molecular Diagnostics Inc | Deteksjon av mikroorganismer i en prve inneholdende nukleinsyre. |
| US6548640B1 (en) | 1986-03-27 | 2003-04-15 | Btg International Limited | Altered antibodies |
| US6893625B1 (en) | 1986-10-27 | 2005-05-17 | Royalty Pharma Finance Trust | Chimeric antibody with specificity to human B cell surface antigen |
| US5037746A (en) | 1986-12-03 | 1991-08-06 | University Patents, Inc. | RNA ribozyme polymerases, and methods |
| US4987071A (en) | 1986-12-03 | 1991-01-22 | University Patents, Inc. | RNA ribozyme polymerases, dephosphorylases, restriction endoribonucleases and methods |
| US5116742A (en) | 1986-12-03 | 1992-05-26 | University Patents, Inc. | RNA ribozyme restriction endoribonucleases and methods |
| IL85035A0 (en) | 1987-01-08 | 1988-06-30 | Int Genetic Eng | Polynucleotide molecule,a chimeric antibody with specificity for human b cell surface antigen,a process for the preparation and methods utilizing the same |
| ATE243754T1 (de) | 1987-05-21 | 2003-07-15 | Micromet Ag | Multifunktionelle proteine mit vorbestimmter zielsetzung |
| JP2897959B2 (ja) | 1988-05-20 | 1999-05-31 | エフ.ホフマン―ラ ロシュ アクチェンゲゼルシャフト | 固定化された配列特異的プローブ |
| US5530101A (en) | 1988-12-28 | 1996-06-25 | Protein Design Labs, Inc. | Humanized immunoglobulins |
| US5143854A (en) | 1989-06-07 | 1992-09-01 | Affymax Technologies N.V. | Large scale photolithographic solid phase synthesis of polypeptides and receptor binding screening thereof |
| US5859205A (en) | 1989-12-21 | 1999-01-12 | Celltech Limited | Humanised antibodies |
| US5180818A (en) | 1990-03-21 | 1993-01-19 | The University Of Colorado Foundation, Inc. | Site specific cleavage of single-stranded dna |
| US20020032313A1 (en) * | 1991-03-29 | 2002-03-14 | Genentech, Inc. | Vascular endothelial cell growth factor antagonists |
| EP1413587A2 (en) | 1991-05-03 | 2004-04-28 | Washington University | Modified complement system regulator |
| WO1994004679A1 (en) | 1991-06-14 | 1994-03-03 | Genentech, Inc. | Method for making humanized antibodies |
| US5474796A (en) | 1991-09-04 | 1995-12-12 | Protogene Laboratories, Inc. | Method and apparatus for conducting an array of chemical reactions on a support surface |
| ES2136092T3 (es) | 1991-09-23 | 1999-11-16 | Medical Res Council | Procedimientos para la produccion de anticuerpos humanizados. |
| ATE198358T1 (de) | 1992-04-27 | 2001-01-15 | Dartmouth College | Detektion von gensequenzen in biologischen flüssigkeiten |
| EP0681482B1 (en) | 1993-01-22 | 2005-12-07 | University Research Corporation | Localization of therapeutic agents |
| US5667969A (en) | 1993-11-12 | 1997-09-16 | University Research Corporation | Alteration of sequence of a deleterious target molecule by ribozyme catalyzed trans-splicing |
| US5578832A (en) | 1994-09-02 | 1996-11-26 | Affymetrix, Inc. | Method and apparatus for imaging a sample on a device |
| US5556752A (en) | 1994-10-24 | 1996-09-17 | Affymetrix, Inc. | Surface-bound, unimolecular, double-stranded DNA |
| US6706471B1 (en) | 1996-01-24 | 2004-03-16 | Third Wave Technologies, Inc. | Detection of nucleic acid sequences by invader-directed cleavage |
| US6299895B1 (en) | 1997-03-24 | 2001-10-09 | Neurotech S.A. | Device and method for treating ophthalmic diseases |
| US5898031A (en) | 1996-06-06 | 1999-04-27 | Isis Pharmaceuticals, Inc. | Oligoribonucleotides for cleaving RNA |
| EP1500329B1 (en) | 1996-12-03 | 2012-03-21 | Amgen Fremont Inc. | Human antibodies that specifically bind human TNF alpha |
| GB9710475D0 (en) | 1997-05-21 | 1997-07-16 | Zeneca Ltd | Gene silencing |
| US6506559B1 (en) | 1997-12-23 | 2003-01-14 | Carnegie Institute Of Washington | Genetic inhibition by double-stranded RNA |
| NZ507093A (en) | 1998-04-08 | 2003-08-29 | Commw Scient Ind Res Org | Methods and means for reducing the phenotypic expression of a nucleic acid of interest in a plant |
| EP2314700A1 (en) | 1999-01-28 | 2011-04-27 | Medical College of Georgia Research Institute, Inc | Composition and method for in vivo and in vitro attenuation of gene expression using double stranded RNA |
| AU3704500A (en) | 1999-02-19 | 2001-01-22 | University Of Iowa Research Foundation, The | Diagnostics and therapeutics for arterial wall disruptive disorders |
| US20020102581A1 (en) | 1999-02-19 | 2002-08-01 | Hageman Gregory S. | Diagnostics and therapeutics for ocular disorders |
| GB9927444D0 (en) | 1999-11-19 | 2000-01-19 | Cancer Res Campaign Tech | Inhibiting gene expression |
| US7011952B2 (en) | 2000-02-22 | 2006-03-14 | University Of Iowa Research Foundation | Diagnostics and therapeutics for macular degeneration-related disorders |
| PT1309726E (pt) | 2000-03-30 | 2010-03-08 | Whitehead Biomedical Inst | Mediadores de interferência por rna específicos de sequência de rna |
| AU2001261103B2 (en) | 2000-04-29 | 2007-08-23 | University Of Iowa Research Foundation | Diagnostics and therapeutics for macular degeneration-related disorders |
| US6632606B1 (en) | 2000-06-12 | 2003-10-14 | Aclara Biosciences, Inc. | Methods for single nucleotide polymorphism detection |
| US20040259247A1 (en) | 2000-12-01 | 2004-12-23 | Thomas Tuschl | Rna interference mediating small rna molecules |
| AUPR604101A0 (en) | 2001-06-29 | 2001-07-26 | Unisearch Limited | Aptamers |
| WO2003016470A2 (en) | 2001-08-10 | 2003-02-27 | University Of Virginia Patent Foundation | Enhancing the efficacy of immunotherapies by supplementing with complement |
| CN102618644A (zh) * | 2004-11-18 | 2012-08-01 | 耶鲁大学 | 治疗眼病的方法和组合物 |
| EP2357254A1 (en) | 2005-02-14 | 2011-08-17 | University of Iowa Research Foundation | Methods and reagents for treatment and diagnosis of age-related macular degeneration |
| EP2570491A1 (en) | 2005-06-08 | 2013-03-20 | University of Pittsburgh of the Commonwealth System of Higher Education | Susceptibility genes for age-related maculopathy (ARM) on chromosome 10q26 |
| KR20080065657A (ko) | 2005-10-11 | 2008-07-14 | 예일 유니버시티 | 황반 변성 관련 유전자 |
| US20080255000A1 (en) | 2005-11-02 | 2008-10-16 | Dogulu Cigdem F | Method Evolved for Recognition and Testing of Age Related Macular Degeneration (Mert-Armd) |
| US8012683B2 (en) | 2006-02-13 | 2011-09-06 | University Of Iowa Research Foundation | Variants in complement regulatory genes predict age-related macular degeneration |
| US20080146501A1 (en) | 2006-02-13 | 2008-06-19 | University Of Iowa Research Foundation | Protective complement proteins and age-related macular degeneration |
| GB0611606D0 (en) * | 2006-06-13 | 2006-07-19 | Univ Belfast | Protection against and treatment of age related macular degeneration |
-
2007
- 2007-07-13 JP JP2009519713A patent/JP5431151B2/ja active Active
- 2007-07-13 SG SG2011050705A patent/SG173371A1/en unknown
- 2007-07-13 AT AT07812932T patent/ATE551350T1/de active
- 2007-07-13 EP EP12152172.8A patent/EP2479284B1/en not_active Not-in-force
- 2007-07-13 EP EP07812932A patent/EP2046807B1/en active Active
- 2007-07-13 AU AU2007272335A patent/AU2007272335B2/en not_active Ceased
- 2007-07-13 CA CA002659392A patent/CA2659392A1/en not_active Abandoned
- 2007-07-13 NZ NZ574046A patent/NZ574046A/xx not_active IP Right Cessation
- 2007-07-13 WO PCT/US2007/073514 patent/WO2008008986A2/en not_active Ceased
- 2007-07-13 EP EP12152177.7A patent/EP2447275B1/en active Active
- 2007-07-13 DK DK12152177.7T patent/DK2447275T3/en active
- 2007-08-20 US US11/894,667 patent/US7867727B2/en not_active Expired - Fee Related
-
2009
- 2009-01-01 IL IL196319A patent/IL196319A0/en unknown
-
2010
- 2010-11-24 US US12/954,425 patent/US20120040884A1/en not_active Abandoned
-
2014
- 2014-05-15 US US14/279,235 patent/US20150050646A1/en not_active Abandoned
-
2018
- 2018-03-05 US US15/912,379 patent/US20180371547A1/en not_active Abandoned
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