JP2009543788A5 - - Google Patents
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- Publication number
- JP2009543788A5 JP2009543788A5 JP2009519562A JP2009519562A JP2009543788A5 JP 2009543788 A5 JP2009543788 A5 JP 2009543788A5 JP 2009519562 A JP2009519562 A JP 2009519562A JP 2009519562 A JP2009519562 A JP 2009519562A JP 2009543788 A5 JP2009543788 A5 JP 2009543788A5
- Authority
- JP
- Japan
- Prior art keywords
- mucormycosis
- composition
- combination
- item
- antifungal agent
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
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- 229940121375 antifungal agent Drugs 0.000 claims description 67
- 239000003429 antifungal agent Substances 0.000 claims description 67
- 206010061418 Zygomycosis Diseases 0.000 claims description 60
- 201000007524 mucormycosis Diseases 0.000 claims description 60
- 239000000203 mixture Substances 0.000 claims description 44
- XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 claims description 30
- 206010017533 Fungal infection Diseases 0.000 claims description 28
- 208000024386 fungal infectious disease Diseases 0.000 claims description 28
- 239000013522 chelant Substances 0.000 claims description 27
- KAESVJOAVNADME-UHFFFAOYSA-N Pyrrole Chemical compound C=1C=CNC=1 KAESVJOAVNADME-UHFFFAOYSA-N 0.000 claims description 26
- APKFDSVGJQXUKY-INPOYWNPSA-N amphotericin B Chemical group O[C@H]1[C@@H](N)[C@H](O)[C@@H](C)O[C@H]1O[C@H]1/C=C/C=C/C=C/C=C/C=C/C=C/C=C/[C@H](C)[C@@H](O)[C@@H](C)[C@H](C)OC(=O)C[C@H](O)C[C@H](O)CC[C@@H](O)[C@H](O)C[C@H](O)C[C@](O)(C[C@H](O)[C@H]2C(O)=O)O[C@H]2C1 APKFDSVGJQXUKY-INPOYWNPSA-N 0.000 claims description 24
- 150000001875 compounds Chemical class 0.000 claims description 24
- 239000000589 Siderophore Substances 0.000 claims description 18
- 229910052742 iron Inorganic materials 0.000 claims description 15
- 239000000797 iron chelating agent Substances 0.000 claims description 14
- 108010049047 Echinocandins Proteins 0.000 claims description 13
- TZXKOCQBRNJULO-UHFFFAOYSA-N Ferriprox Chemical compound CC1=C(O)C(=O)C=CN1C TZXKOCQBRNJULO-UHFFFAOYSA-N 0.000 claims description 13
- PMVSDNDAUGGCCE-TYYBGVCCSA-L Ferrous fumarate Chemical compound [Fe+2].[O-]C(=O)\C=C\C([O-])=O PMVSDNDAUGGCCE-TYYBGVCCSA-L 0.000 claims description 13
- 229960001489 deferasirox Drugs 0.000 claims description 13
- FMSOAWSKCWYLBB-VBGLAJCLSA-N deferasirox Chemical compound C1=CC(C(=O)O)=CC=C1N(N\C(N\1)=C\2C(C=CC=C/2)=O)C/1=C\1C(=O)C=CC=C/1 FMSOAWSKCWYLBB-VBGLAJCLSA-N 0.000 claims description 13
- 229960003266 deferiprone Drugs 0.000 claims description 13
- 150000004291 polyenes Chemical class 0.000 claims description 13
- 241000222122 Candida albicans Species 0.000 claims description 12
- 239000012678 infectious agent Substances 0.000 claims description 12
- VHVPQPYKVGDNFY-DFMJLFEVSA-N 2-[(2r)-butan-2-yl]-4-[4-[4-[4-[[(2r,4s)-2-(2,4-dichlorophenyl)-2-(1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]piperazin-1-yl]phenyl]-1,2,4-triazol-3-one Chemical compound O=C1N([C@H](C)CC)N=CN1C1=CC=C(N2CCN(CC2)C=2C=CC(OC[C@@H]3O[C@](CN4N=CN=C4)(OC3)C=3C(=CC(Cl)=CC=3)Cl)=CC=2)C=C1 VHVPQPYKVGDNFY-DFMJLFEVSA-N 0.000 claims description 8
- 201000002909 Aspergillosis Diseases 0.000 claims description 8
- 208000036641 Aspergillus infections Diseases 0.000 claims description 8
- 206010007134 Candida infections Diseases 0.000 claims description 8
- 108010020326 Caspofungin Proteins 0.000 claims description 8
- 241000235555 Cunninghamella Species 0.000 claims description 8
- 108010021062 Micafungin Proteins 0.000 claims description 8
- 241000235527 Rhizopus Species 0.000 claims description 8
- 240000005384 Rhizopus oryzae Species 0.000 claims description 8
- 235000013752 Rhizopus oryzae Nutrition 0.000 claims description 8
- 201000003984 candidiasis Diseases 0.000 claims description 8
- 229960000730 caspofungin acetate Drugs 0.000 claims description 8
- RFHAOTPXVQNOHP-UHFFFAOYSA-N fluconazole Chemical compound C1=NC=NN1CC(C=1C(=CC(F)=CC=1)F)(O)CN1C=NC=N1 RFHAOTPXVQNOHP-UHFFFAOYSA-N 0.000 claims description 8
- 229960004884 fluconazole Drugs 0.000 claims description 8
- 229960004130 itraconazole Drugs 0.000 claims description 8
- 229960002159 micafungin Drugs 0.000 claims description 8
- PIEUQSKUWLMALL-YABMTYFHSA-N micafungin Chemical compound C1=CC(OCCCCC)=CC=C1C1=CC(C=2C=CC(=CC=2)C(=O)N[C@@H]2C(N[C@H](C(=O)N3C[C@H](O)C[C@H]3C(=O)N[C@H](C(=O)N[C@H](C(=O)N3C[C@H](C)[C@H](O)[C@H]3C(=O)N[C@H](O)[C@H](O)C2)[C@H](O)CC(N)=O)[C@H](O)[C@@H](O)C=2C=C(OS(O)(=O)=O)C(O)=CC=2)[C@@H](C)O)=O)=NO1 PIEUQSKUWLMALL-YABMTYFHSA-N 0.000 claims description 8
- 229960001589 posaconazole Drugs 0.000 claims description 8
- RAGOYPUPXAKGKH-XAKZXMRKSA-N posaconazole Chemical group O=C1N([C@H]([C@H](C)O)CC)N=CN1C1=CC=C(N2CCN(CC2)C=2C=CC(OC[C@H]3C[C@@](CN4N=CN=C4)(OC3)C=3C(=CC(F)=CC=3)F)=CC=2)C=C1 RAGOYPUPXAKGKH-XAKZXMRKSA-N 0.000 claims description 8
- OGUJBRYAAJYXQP-IJFZAWIJSA-N vuw370o5qe Chemical group CC(O)=O.CC(O)=O.C1([C@H](O)[C@@H](O)[C@H]2C(=O)N[C@H](C(=O)N3CC[C@H](O)[C@H]3C(=O)N[C@H](NCCN)[C@H](O)C[C@@H](C(N[C@H](C(=O)N3C[C@H](O)C[C@H]3C(=O)N2)[C@@H](C)O)=O)NC(=O)CCCCCCCC[C@@H](C)C[C@@H](C)CC)[C@H](O)CCN)=CC=C(O)C=C1 OGUJBRYAAJYXQP-IJFZAWIJSA-N 0.000 claims description 8
- 241000222120 Candida <Saccharomycetales> Species 0.000 claims description 7
- UHPMCKVQTMMPCG-UHFFFAOYSA-N 5,8-dihydroxy-2-methoxy-6-methyl-7-(2-oxopropyl)naphthalene-1,4-dione Chemical compound CC1=C(CC(C)=O)C(O)=C2C(=O)C(OC)=CC(=O)C2=C1O UHPMCKVQTMMPCG-UHFFFAOYSA-N 0.000 claims description 4
- 241000293034 Apophysomyces elegans Species 0.000 claims description 4
- 241000228212 Aspergillus Species 0.000 claims description 4
- 241000228193 Aspergillus clavatus Species 0.000 claims description 4
- 241000228197 Aspergillus flavus Species 0.000 claims description 4
- 241001225321 Aspergillus fumigatus Species 0.000 claims description 4
- 241000351920 Aspergillus nidulans Species 0.000 claims description 4
- 241001465318 Aspergillus terreus Species 0.000 claims description 4
- 241000222178 Candida tropicalis Species 0.000 claims description 4
- 241000223205 Coccidioides immitis Species 0.000 claims description 4
- 201000007336 Cryptococcosis Diseases 0.000 claims description 4
- 241000221204 Cryptococcus neoformans Species 0.000 claims description 4
- 241000223218 Fusarium Species 0.000 claims description 4
- 201000002563 Histoplasmosis Diseases 0.000 claims description 4
- 241000144128 Lichtheimia corymbifera Species 0.000 claims description 4
- 241000045365 Microporus <basidiomycete fungus> Species 0.000 claims description 4
- 241000235395 Mucor Species 0.000 claims description 4
- 241000235388 Mucorales Species 0.000 claims description 4
- 206010033767 Paracoccidioides infections Diseases 0.000 claims description 4
- 201000000301 Paracoccidioidomycosis Diseases 0.000 claims description 4
- 241000235645 Pichia kudriavzevii Species 0.000 claims description 4
- 241000235525 Rhizomucor pusillus Species 0.000 claims description 4
- 241000222126 [Candida] glabrata Species 0.000 claims description 4
- 229940091771 aspergillus fumigatus Drugs 0.000 claims description 4
- 210000000988 bone and bone Anatomy 0.000 claims description 4
- 229940095731 candida albicans Drugs 0.000 claims description 4
- 208000032343 candida glabrata infection Diseases 0.000 claims description 4
- 230000002490 cerebral effect Effects 0.000 claims description 4
- 201000003486 coccidioidomycosis Diseases 0.000 claims description 4
- 230000002496 gastric effect Effects 0.000 claims description 4
- 206010033072 otitis externa Diseases 0.000 claims description 4
- 230000002685 pulmonary effect Effects 0.000 claims description 4
- 150000003839 salts Chemical class 0.000 claims description 4
- 210000002620 vena cava superior Anatomy 0.000 claims description 4
- -1 voricoazole Chemical compound 0.000 claims description 4
- 208000031888 Mycoses Diseases 0.000 claims 5
- 238000002560 therapeutic procedure Methods 0.000 claims 2
- 241000222173 Candida parapsilosis Species 0.000 claims 1
- 229940055022 candida parapsilosis Drugs 0.000 claims 1
- 201000010099 disease Diseases 0.000 description 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 2
- 230000002265 prevention Effects 0.000 description 2
- 230000002538 fungal effect Effects 0.000 description 1
- 230000000069 prophylactic effect Effects 0.000 description 1
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US83109906P | 2006-07-13 | 2006-07-13 | |
| US89762007P | 2007-01-26 | 2007-01-26 | |
| US90407507P | 2007-02-27 | 2007-02-27 | |
| PCT/US2007/016065 WO2008008537A2 (en) | 2006-07-13 | 2007-07-13 | Combi) compositions for the treatment of mucormycosis. comprising iron chelator and antifungal agent |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012258262A Division JP2013040212A (ja) | 2006-07-13 | 2012-11-27 | ムコール症および他の真菌性疾患を処置するための組成物および方法 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2009543788A JP2009543788A (ja) | 2009-12-10 |
| JP2009543788A5 true JP2009543788A5 (https=) | 2011-08-11 |
Family
ID=38610625
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009519562A Pending JP2009543788A (ja) | 2006-07-13 | 2007-07-13 | ムコール症および他の真菌性疾患を処置するための組成物および方法 |
| JP2012258262A Pending JP2013040212A (ja) | 2006-07-13 | 2012-11-27 | ムコール症および他の真菌性疾患を処置するための組成物および方法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012258262A Pending JP2013040212A (ja) | 2006-07-13 | 2012-11-27 | ムコール症および他の真菌性疾患を処置するための組成物および方法 |
Country Status (18)
| Country | Link |
|---|---|
| US (1) | US20100129434A1 (https=) |
| EP (2) | EP2412371A1 (https=) |
| JP (2) | JP2009543788A (https=) |
| KR (1) | KR20090036587A (https=) |
| AU (1) | AU2007272781B2 (https=) |
| BR (1) | BRPI0714221A2 (https=) |
| CA (1) | CA2657634A1 (https=) |
| CL (1) | CL2007002026A1 (https=) |
| IL (1) | IL196389A0 (https=) |
| MA (1) | MA30625B1 (https=) |
| MX (1) | MX2009000506A (https=) |
| NO (1) | NO20090565L (https=) |
| NZ (1) | NZ574862A (https=) |
| RU (1) | RU2464024C2 (https=) |
| SG (1) | SG177122A1 (https=) |
| TN (1) | TN2009000004A1 (https=) |
| TW (1) | TWI448285B (https=) |
| WO (1) | WO2008008537A2 (https=) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NZ614255A (en) * | 2009-03-19 | 2015-03-27 | Los Angeles Biomed Res Inst | Vaccine compositions and methods for treatment of mucormycosis and other fungal diseases |
| US8980876B2 (en) | 2010-10-28 | 2015-03-17 | The Procter & Gamble Company | Inhibition of microbial growth by aconitase inhibition |
| MX2015003729A (es) * | 2012-11-12 | 2015-06-15 | Cipla Ltd | Composiciones farmaceuticas de dosis fija que comprende deferasirox y deferiprona. |
| US11229685B2 (en) | 2013-01-29 | 2022-01-25 | Case Western Reserve University | Fungal iron acquisition inhibitors and uses thereof |
| WO2015026852A1 (en) * | 2013-08-19 | 2015-02-26 | Rutgers, The State University Of New Jersey | Method of inducing an anti-retroviral immune response by counter-acting retro-virus induced anti-apoptosis |
| US20170239182A1 (en) * | 2014-08-13 | 2017-08-24 | Mark E. Hayes | Pharmaceutical formulations of and methods to prepare chelating agents for efficient metal removal treatment systems |
| WO2016025611A2 (en) * | 2014-08-13 | 2016-02-18 | Zoneone Pharma, Inc. | Pharmaceutical formulations of chelating agents as a metal removal treatment system |
| EP3344246A4 (en) * | 2015-08-31 | 2019-04-10 | The University of Adelaide | METHOD AND PRODUCTS FOR THE PREVENTION AND / OR TREATMENT OF MICROORGANISM INFECTIONS WITH IRON-CHELATORS AND IRON-FREE PORPHYRINE |
| US10960002B2 (en) | 2016-05-13 | 2021-03-30 | The Brigham And Women's Hospital, Inc. | Volatile metabolite profiles for the diagnosis and treatment of Mucorales fungi |
| FR3095755A1 (fr) * | 2019-05-10 | 2020-11-13 | Balmes Transplantation | Nouveaux médicaments cytoprotecteurs |
| CN113905715B (zh) | 2019-06-28 | 2025-04-15 | 宝洁公司 | 光增强处理方法 |
| JP2023057423A (ja) * | 2021-10-11 | 2023-04-21 | 国立大学法人 熊本大学 | ムコール症治療薬 |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB8329043D0 (en) * | 1983-10-31 | 1983-11-30 | Hider R C | Pharmaceutical compositions |
| US4698431A (en) * | 1985-11-12 | 1987-10-06 | The United States Of America As Represented By The United States Department Of Energy | Hydroxypyridonate chelating agents |
| PH31594A (en) * | 1993-09-30 | 1998-11-03 | Janssen Pharmaceutica Nv | Oral formulations on an antifungal. |
| MY129541A (en) | 1996-06-25 | 2007-04-30 | Novartis Ag | Substituded 3,5-diphenyl-1,2,4-triazoles and their use as pharmaceutical metal chelators |
| WO1999009997A1 (en) * | 1997-08-26 | 1999-03-04 | Board Of Regents, The University Of Texas System | Edta and other chelators with or without antifungal antimicrobial agents for the prevention and treatment of fungal infections |
| EP1223308B1 (de) * | 2000-12-16 | 2007-01-24 | ALSTOM Technology Ltd | Komponente einer Strömungsmaschine |
| GB0223978D0 (en) | 2002-10-15 | 2002-11-20 | Novartis Ag | Organic compound |
| ITMI20022447A1 (it) * | 2002-11-19 | 2004-05-20 | Carlo Ghisalberti | Uso di piridinoni nel trattamento della purpura capillare ed affezioni cutanee correlate. |
| JP2006513235A (ja) * | 2002-12-31 | 2006-04-20 | ネクター セラピューティクス | 真菌感染症療法のためのエアゾール化可能な医薬製剤 |
| WO2004108114A2 (en) * | 2003-03-31 | 2004-12-16 | Dinesh Shantilal Patel | Anti-fungal composition and a process for its manufacture |
| DE10356409B4 (de) * | 2003-11-28 | 2006-12-28 | Biofrontera Discovery Gmbh | Neues Arzneimittel Oxachelin und Derivate |
-
2007
- 2007-07-12 TW TW096125466A patent/TWI448285B/zh not_active IP Right Cessation
- 2007-07-12 CL CL200702026A patent/CL2007002026A1/es unknown
- 2007-07-13 NZ NZ574862A patent/NZ574862A/en not_active IP Right Cessation
- 2007-07-13 WO PCT/US2007/016065 patent/WO2008008537A2/en not_active Ceased
- 2007-07-13 RU RU2009104961/15A patent/RU2464024C2/ru not_active IP Right Cessation
- 2007-07-13 SG SG2011075421A patent/SG177122A1/en unknown
- 2007-07-13 EP EP11003922A patent/EP2412371A1/en not_active Withdrawn
- 2007-07-13 JP JP2009519562A patent/JP2009543788A/ja active Pending
- 2007-07-13 US US12/373,511 patent/US20100129434A1/en not_active Abandoned
- 2007-07-13 BR BRPI0714221-8A patent/BRPI0714221A2/pt not_active IP Right Cessation
- 2007-07-13 EP EP07796874A patent/EP2043636A2/en not_active Withdrawn
- 2007-07-13 CA CA002657634A patent/CA2657634A1/en not_active Abandoned
- 2007-07-13 MX MX2009000506A patent/MX2009000506A/es not_active Application Discontinuation
- 2007-07-13 KR KR1020097002793A patent/KR20090036587A/ko not_active Ceased
- 2007-07-13 AU AU2007272781A patent/AU2007272781B2/en not_active Ceased
-
2009
- 2009-01-08 IL IL196389A patent/IL196389A0/en unknown
- 2009-01-12 TN TN2009000004A patent/TN2009000004A1/fr unknown
- 2009-02-04 MA MA31613A patent/MA30625B1/fr unknown
- 2009-02-05 NO NO20090565A patent/NO20090565L/no not_active Application Discontinuation
-
2012
- 2012-11-27 JP JP2012258262A patent/JP2013040212A/ja active Pending
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