JP2009543783A5 - - Google Patents
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- Publication number
- JP2009543783A5 JP2009543783A5 JP2009519541A JP2009519541A JP2009543783A5 JP 2009543783 A5 JP2009543783 A5 JP 2009543783A5 JP 2009519541 A JP2009519541 A JP 2009519541A JP 2009519541 A JP2009519541 A JP 2009519541A JP 2009543783 A5 JP2009543783 A5 JP 2009543783A5
- Authority
- JP
- Japan
- Prior art keywords
- substituted
- alkynyl
- alkoxy
- alkenyl
- cycloalkyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 0 CCNNN(*)*C Chemical compound CCNNN(*)*C 0.000 description 4
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US83057206P | 2006-07-12 | 2006-07-12 | |
| US60/830,572 | 2006-07-12 | ||
| PCT/US2007/015966 WO2008008476A2 (en) | 2006-07-12 | 2007-07-11 | Transducible delivery of nucleic acids by reversible phosphotriester charge neutralization protecting groups |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014217097A Division JP2015062421A (ja) | 2006-07-12 | 2014-10-24 | 可逆的なホスホトリエステル電荷中和保護基による核酸の形質導入可能な送達 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2009543783A JP2009543783A (ja) | 2009-12-10 |
| JP2009543783A5 true JP2009543783A5 (enExample) | 2010-07-08 |
| JP6125741B2 JP6125741B2 (ja) | 2017-05-17 |
Family
ID=38923923
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009519541A Active JP6125741B2 (ja) | 2006-07-12 | 2007-07-11 | 可逆的なホスホトリエステル電荷中和保護基による核酸の形質導入可能な送達 |
| JP2014217097A Pending JP2015062421A (ja) | 2006-07-12 | 2014-10-24 | 可逆的なホスホトリエステル電荷中和保護基による核酸の形質導入可能な送達 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014217097A Pending JP2015062421A (ja) | 2006-07-12 | 2014-10-24 | 可逆的なホスホトリエステル電荷中和保護基による核酸の形質導入可能な送達 |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US20090093425A1 (enExample) |
| EP (1) | EP2046964B1 (enExample) |
| JP (2) | JP6125741B2 (enExample) |
| CN (1) | CN101506368B (enExample) |
| AU (1) | AU2007272906B2 (enExample) |
| CA (1) | CA2659103C (enExample) |
| WO (1) | WO2008008476A2 (enExample) |
Families Citing this family (35)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2009532017A (ja) | 2006-02-10 | 2009-09-10 | ザ レジェンツ オブ ザ ユニヴァースティ オブ カリフォルニア | PTD/CPPSへのdsRNA結合ドメイン融合体によるsiRNAの導入可能な送達 |
| WO2010039543A2 (en) * | 2008-09-23 | 2010-04-08 | Traversa Therapeutics, Inc. | Self delivering bio-labile phosphate protected pro-oligos for oligonucleotide based therapeutics and mediating rna interference |
| US10022454B2 (en) * | 2008-09-23 | 2018-07-17 | Liposciences, Llc | Functionalized phosphorodiamites for therapeutic oligonucleotide synthesis |
| BRPI0923225A2 (pt) | 2008-12-02 | 2016-10-04 | Chiralgen Ltd | metodo para sintese de acidos nucleicos modificados no atomo de fosforo |
| US9260493B2 (en) | 2009-05-07 | 2016-02-16 | The Regents Of The University Of California | Transducible delivery of nucleic acids using modified dsRNA binding domains |
| US20120142763A1 (en) * | 2009-06-01 | 2012-06-07 | The Regents Of The University Of California | Nucleic acid delivery compositions and methods of use thereof |
| EP2451461A4 (en) | 2009-07-06 | 2013-05-29 | Ontorii Inc | NOVEL NUCLEIC ACID PRODRUGS AND METHOD OF USE THEREOF |
| AU2010306940A1 (en) | 2009-10-12 | 2012-06-07 | Smith, Larry | Methods and compositions for modulating gene expression using oligonucleotide based drugs administered in vivo or in vitro |
| WO2011109677A2 (en) * | 2010-03-04 | 2011-09-09 | University Of Louisville Research Foundation, Inc. | Methods of increasing macropinocytosis in cancer cells |
| DK2620428T3 (da) | 2010-09-24 | 2019-07-01 | Wave Life Sciences Ltd | Asymmetrisk hjælpegruppe |
| US9303258B2 (en) * | 2011-04-05 | 2016-04-05 | The Regents Of The University Of California | Method and compositions comprising small RNA agonist and antagonists to modulate inflammation |
| CN107365339A (zh) | 2011-07-19 | 2017-11-21 | 波涛生命科学有限公司 | 合成官能化核酸的方法 |
| JP5435016B2 (ja) | 2011-12-01 | 2014-03-05 | 株式会社デンソー | 半導体装置の製造方法 |
| EP3919620A1 (en) | 2012-05-02 | 2021-12-08 | Sirna Therapeutics, Inc. | Short interfering nucleic acid (sina) compositions |
| DK2872147T3 (da) | 2012-07-13 | 2023-02-20 | Wave Life Sciences Ltd | Fremgangsmåde til fremstilling af kirale oligonukleotider |
| SG11201500243WA (en) | 2012-07-13 | 2015-04-29 | Shin Nippon Biomedical Lab Ltd | Chiral nucleic acid adjuvant |
| WO2014010250A1 (en) | 2012-07-13 | 2014-01-16 | Chiralgen, Ltd. | Asymmetric auxiliary group |
| JP2015529073A (ja) * | 2012-08-20 | 2015-10-05 | ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア | 生物可逆性基を有するポリヌクレオチド |
| WO2014043289A2 (en) | 2012-09-12 | 2014-03-20 | Quark Pharmaceuticals, Inc. | Double-stranded oligonucleotide molecules to ddit4 and methods of use thereof |
| EP2895608B1 (en) | 2012-09-12 | 2018-12-05 | Quark Pharmaceuticals, Inc. | Double-stranded oligonucleotide molecules to p53 and methods of use thereof |
| EP2928877B1 (en) * | 2012-12-06 | 2020-01-22 | Merck Sharp & Dohme Corp. | Disulfide masked prodrug compositions and methods |
| CA2892676A1 (en) * | 2012-12-06 | 2014-06-12 | Merck Sharp & Dohme Corp. | Nucleoside kinase bypass compositions and methods |
| AU2014233198B2 (en) | 2013-03-15 | 2019-06-27 | Sutter West Bay Hospitals | Falz for use as a target for therapies to treat cancer |
| EP3027222A1 (en) | 2013-07-31 | 2016-06-08 | QBI Enterprises Ltd. | Sphingolipid-polyalkylamine-oligonucleotide compounds |
| EP3027223A1 (en) | 2013-07-31 | 2016-06-08 | QBI Enterprises Ltd. | Methods of use of sphingolipid polyalkylamine oligonucleotide compounds |
| KR102522346B1 (ko) | 2013-08-29 | 2023-04-17 | 시티 오브 호프 | 세포침투 콘주게이트 및 이의 사용 방법 |
| EP3095461A4 (en) | 2014-01-15 | 2017-08-23 | Shin Nippon Biomedical Laboratories, Ltd. | Chiral nucleic acid adjuvant having immunity induction activity, and immunity induction activator |
| WO2015108046A1 (ja) | 2014-01-15 | 2015-07-23 | 株式会社新日本科学 | 抗アレルギー作用を有するキラル核酸アジュバンド及び抗アレルギー剤 |
| EP3095459A4 (en) | 2014-01-15 | 2017-08-23 | Shin Nippon Biomedical Laboratories, Ltd. | Chiral nucleic acid adjuvant having antitumor effect and antitumor agent |
| EP3094728B1 (en) | 2014-01-16 | 2022-03-09 | Wave Life Sciences Ltd. | Chiral design |
| GB201410507D0 (en) * | 2014-06-12 | 2014-07-30 | Univ Bath | Drug delivery enhancement agents |
| WO2018035380A1 (en) * | 2016-08-17 | 2018-02-22 | Solstice Biologics, Ltd. | Polynucleotide constructs |
| US11597744B2 (en) | 2017-06-30 | 2023-03-07 | Sirius Therapeutics, Inc. | Chiral phosphoramidite auxiliaries and methods of their use |
| EP3674407A4 (en) | 2017-08-22 | 2022-01-12 | National University Corporation Nagoya University | MODIFIED POLYNUCLEOTIDE |
| US11510939B1 (en) | 2019-04-19 | 2022-11-29 | Apellis Pharmaceuticals, Inc. | RNAs for complement inhibition |
Family Cites Families (39)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4806463A (en) * | 1986-05-23 | 1989-02-21 | Worcester Foundation For Experimental Biology | Inhibition of HTLV-III by exogenous oligonucleotides |
| US5670617A (en) * | 1989-12-21 | 1997-09-23 | Biogen Inc | Nucleic acid conjugates of tat-derived transport polypeptides |
| US6316003B1 (en) * | 1989-12-21 | 2001-11-13 | Whitehead Institute For Biomedical Research | Tat-derived transport polypeptides |
| AU7759291A (en) * | 1990-03-29 | 1991-10-21 | Gilead Sciences, Inc. | Oligonucleotide-transport agent disulfide conjugates |
| US5733523A (en) * | 1990-12-10 | 1998-03-31 | Akzo Nobel N.V. | Targeted delivery of a therapeutic entity using complementary oligonucleotides |
| NZ244306A (en) * | 1991-09-30 | 1995-07-26 | Boehringer Ingelheim Int | Composition for introducing nucleic acid complexes into eucaryotic cells, complex containing nucleic acid and endosomolytic agent, peptide with endosomolytic domain and nucleic acid binding domain and preparation |
| US5955591A (en) * | 1993-05-12 | 1999-09-21 | Imbach; Jean-Louis | Phosphotriester oligonucleotides, amidites and method of preparation |
| US6051429A (en) * | 1995-06-07 | 2000-04-18 | Life Technologies, Inc. | Peptide-enhanced cationic lipid transfections |
| US6017700A (en) * | 1995-08-04 | 2000-01-25 | Bayer Corporation | Cationic oligonucleotides, and related methods of synthesis and use |
| EP0941122B1 (en) * | 1996-08-13 | 2003-10-29 | Chiron Corporation | Compositions for polynucleotide delivery |
| CA2314267A1 (en) * | 1997-12-10 | 1999-06-17 | Washington University | Anti-pathogen system and methods of use thereof |
| US6531590B1 (en) * | 1998-04-24 | 2003-03-11 | Isis Pharmaceuticals, Inc. | Processes for the synthesis of oligonucleotide compounds |
| US6903077B1 (en) * | 1999-01-04 | 2005-06-07 | University Of Vermont And State Agricultural College | Methods and products for delivering nucleic acids |
| US7491805B2 (en) * | 2001-05-18 | 2009-02-17 | Sirna Therapeutics, Inc. | Conjugates and compositions for cellular delivery |
| CA2417454A1 (en) * | 2000-07-31 | 2002-02-07 | Active Motif | Peptide-mediated delivery of molecules into cells |
| CA2425610A1 (en) * | 2000-10-13 | 2002-04-18 | University Of Lausanne | Intracellular delivery of biological effectors by novel transporter peptide sequences |
| EP1386004A4 (en) * | 2001-04-05 | 2005-02-16 | Ribozyme Pharm Inc | MODULATION OF GENE EXPRESSION ASSOCIATED WITH INFLAMMATORY PROLIFERATION AND GROWTH OF NEURITIES BY METHODS INVOLVING NUCLEIC ACID |
| WO2004048545A2 (en) * | 2002-11-26 | 2004-06-10 | University Of Massachusetts | DELIVERY OF siRNAs______________________________________________ |
| US20040147027A1 (en) * | 2003-01-28 | 2004-07-29 | Troy Carol M. | Complex for facilitating delivery of dsRNA into a cell and uses thereof |
| US20060178297A1 (en) * | 2003-01-28 | 2006-08-10 | Troy Carol M | Systems and methods for silencing expression of a gene in a cell and uses thereof |
| US7166692B2 (en) * | 2003-03-04 | 2007-01-23 | Canbrex Bio Science Walkersville, Inc. | Intracellular delivery of small molecules, proteins, and nucleic acids |
| CN1836048A (zh) * | 2003-06-10 | 2006-09-20 | 图尔金株式会社 | 可转导的dna结合蛋白 |
| US20060222657A1 (en) * | 2003-06-20 | 2006-10-05 | Dowdy Steven F | Polypeptide transduction and fusogenic peptides |
| US20050042603A1 (en) * | 2003-07-01 | 2005-02-24 | Allele Biotechnology & Pharmaceuticals, Inc. | Compositions and methods for peptide-assisted transfection |
| AU2004297533B2 (en) * | 2003-10-24 | 2010-04-29 | Gencia Corporation | Methods and compositions for delivering polynucleotides |
| US7514530B2 (en) * | 2004-04-26 | 2009-04-07 | Centre National De La Recherche Scientifique | Peptide carrier for delivering siRNA into mammalian cells |
| CA2565685A1 (en) * | 2004-05-04 | 2005-12-15 | Nastech Pharmaceutical Company Inc. | Compositions and methods for enhancing delivery of nucleic acids into cells and for modifying expression of target genes in cells |
| US20060040882A1 (en) * | 2004-05-04 | 2006-02-23 | Lishan Chen | Compostions and methods for enhancing delivery of nucleic acids into cells and for modifying expression of target genes in cells |
| US20060035815A1 (en) * | 2004-05-04 | 2006-02-16 | Nastech Pharmaceutical Company Inc. | Pharmaceutical compositions for delivery of ribonucleic acid to a cell |
| US20060030003A1 (en) * | 2004-05-12 | 2006-02-09 | Simon Michael R | Composition and method for introduction of RNA interference sequences into targeted cells and tissues |
| US20050288246A1 (en) * | 2004-05-24 | 2005-12-29 | Iversen Patrick L | Peptide conjugated, inosine-substituted antisense oligomer compound and method |
| US7084248B2 (en) * | 2004-07-14 | 2006-08-01 | Gene Tools, Llc | Peptide composition and method for delivering substances into the cytosol of cells |
| US7828046B2 (en) * | 2004-07-21 | 2010-11-09 | Xiao Huang | Hybrid wicking materials for use in high performance heat pipes |
| WO2006023491A2 (en) * | 2004-08-16 | 2006-03-02 | The Cbr Institute For Biomedical Research, Inc. | Method of delivering rna interference and uses thereof |
| US20080027025A1 (en) * | 2004-08-27 | 2008-01-31 | The Regents Of The University Of California | Protection From And Treatment Of Prion Protein Infection |
| US20090098049A1 (en) * | 2004-09-07 | 2009-04-16 | The Regents Of The University Of California | Targeting transducible molecules to specific cell types |
| CN101421301A (zh) * | 2006-02-10 | 2009-04-29 | 加利福尼亚大学董事会 | 通过dsRNA结合域与PTD/CPPS的融合物转导运输siRNA |
| JP2009532017A (ja) * | 2006-02-10 | 2009-09-10 | ザ レジェンツ オブ ザ ユニヴァースティ オブ カリフォルニア | PTD/CPPSへのdsRNA結合ドメイン融合体によるsiRNAの導入可能な送達 |
| US20120142763A1 (en) * | 2009-06-01 | 2012-06-07 | The Regents Of The University Of California | Nucleic acid delivery compositions and methods of use thereof |
-
2007
- 2007-07-11 EP EP07796847.7A patent/EP2046964B1/en not_active Not-in-force
- 2007-07-11 US US11/776,317 patent/US20090093425A1/en not_active Abandoned
- 2007-07-11 CN CN200780030587.9A patent/CN101506368B/zh not_active Expired - Fee Related
- 2007-07-11 WO PCT/US2007/015966 patent/WO2008008476A2/en not_active Ceased
- 2007-07-11 AU AU2007272906A patent/AU2007272906B2/en not_active Ceased
- 2007-07-11 JP JP2009519541A patent/JP6125741B2/ja active Active
- 2007-07-11 CA CA2659103A patent/CA2659103C/en not_active Expired - Fee Related
-
2014
- 2014-10-24 JP JP2014217097A patent/JP2015062421A/ja active Pending
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