JP2009542683A5 - - Google Patents
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- Publication number
- JP2009542683A5 JP2009542683A5 JP2009518342A JP2009518342A JP2009542683A5 JP 2009542683 A5 JP2009542683 A5 JP 2009542683A5 JP 2009518342 A JP2009518342 A JP 2009518342A JP 2009518342 A JP2009518342 A JP 2009518342A JP 2009542683 A5 JP2009542683 A5 JP 2009542683A5
- Authority
- JP
- Japan
- Prior art keywords
- substituted
- unsubstituted
- member selected
- alkyl
- heterocycloalkyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 125000000592 heterocycloalkyl group Chemical group 0.000 claims 35
- 125000000753 cycloalkyl group Chemical group 0.000 claims 32
- 150000001875 compounds Chemical class 0.000 claims 30
- 125000003118 aryl group Chemical group 0.000 claims 29
- 125000001072 heteroaryl group Chemical group 0.000 claims 27
- 125000000217 alkyl group Chemical group 0.000 claims 26
- 125000004404 heteroalkyl group Chemical group 0.000 claims 24
- 229910052717 sulfur Inorganic materials 0.000 claims 20
- 229910052739 hydrogen Inorganic materials 0.000 claims 16
- 229910052760 oxygen Inorganic materials 0.000 claims 15
- 229910052731 fluorine Inorganic materials 0.000 claims 14
- 229910052757 nitrogen Inorganic materials 0.000 claims 12
- 229910052794 bromium Inorganic materials 0.000 claims 10
- 229910052801 chlorine Inorganic materials 0.000 claims 10
- 150000002500 ions Chemical class 0.000 claims 9
- 125000002252 acyl group Chemical group 0.000 claims 8
- 125000003710 aryl alkyl group Chemical group 0.000 claims 8
- 125000004446 heteroarylalkyl group Chemical group 0.000 claims 8
- 150000003839 salts Chemical class 0.000 claims 6
- 208000002193 Pain Diseases 0.000 claims 5
- 125000003342 alkenyl group Chemical group 0.000 claims 5
- 125000004429 atom Chemical group 0.000 claims 5
- 239000008194 pharmaceutical composition Substances 0.000 claims 5
- 239000000651 prodrug Substances 0.000 claims 5
- 229940002612 prodrug Drugs 0.000 claims 5
- MTCFGRXMJLQNBG-UWTATZPHSA-N D-Serine Chemical compound OC[C@@H](N)C(O)=O MTCFGRXMJLQNBG-UWTATZPHSA-N 0.000 claims 4
- 229930195711 D-Serine Natural products 0.000 claims 4
- 239000003937 drug carrier Substances 0.000 claims 4
- 208000000044 Amnesia Diseases 0.000 claims 3
- 208000026139 Memory disease Diseases 0.000 claims 3
- 208000012902 Nervous system disease Diseases 0.000 claims 3
- 208000025966 Neurological disease Diseases 0.000 claims 3
- 230000006999 cognitive decline Effects 0.000 claims 3
- 208000010877 cognitive disease Diseases 0.000 claims 3
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 3
- 230000006984 memory degeneration Effects 0.000 claims 3
- 208000023060 memory loss Diseases 0.000 claims 3
- 125000004433 nitrogen atom Chemical group N* 0.000 claims 3
- 208000024827 Alzheimer disease Diseases 0.000 claims 2
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical group [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims 2
- 125000003545 alkoxy group Chemical group 0.000 claims 2
- 229910052799 carbon Inorganic materials 0.000 claims 2
- 150000001767 cationic compounds Chemical class 0.000 claims 2
- 125000004122 cyclic group Chemical group 0.000 claims 2
- 208000035475 disorder Diseases 0.000 claims 2
- 229910052736 halogen Inorganic materials 0.000 claims 2
- 150000002367 halogens Chemical class 0.000 claims 2
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 2
- 125000005647 linker group Chemical group 0.000 claims 2
- 230000004770 neurodegeneration Effects 0.000 claims 2
- 208000015122 neurodegenerative disease Diseases 0.000 claims 2
- 150000002892 organic cations Chemical class 0.000 claims 2
- 201000000980 schizophrenia Diseases 0.000 claims 2
- MTCFGRXMJLQNBG-REOHCLBHSA-N (2S)-2-Amino-3-hydroxypropansäure Chemical compound OC[C@H](N)C(O)=O MTCFGRXMJLQNBG-REOHCLBHSA-N 0.000 claims 1
- 208000030507 AIDS Diseases 0.000 claims 1
- 206010003591 Ataxia Diseases 0.000 claims 1
- 208000008035 Back Pain Diseases 0.000 claims 1
- 206010058019 Cancer Pain Diseases 0.000 claims 1
- 208000023890 Complex Regional Pain Syndromes Diseases 0.000 claims 1
- 206010010904 Convulsion Diseases 0.000 claims 1
- DYDCUQKUCUHJBH-UHFFFAOYSA-N D-Cycloserine Natural products NC1CONC1=O DYDCUQKUCUHJBH-UHFFFAOYSA-N 0.000 claims 1
- DYDCUQKUCUHJBH-UWTATZPHSA-N D-Cycloserine Chemical compound N[C@@H]1CONC1=O DYDCUQKUCUHJBH-UWTATZPHSA-N 0.000 claims 1
- 208000032131 Diabetic Neuropathies Diseases 0.000 claims 1
- 208000001640 Fibromyalgia Diseases 0.000 claims 1
- HOKKHZGPKSLGJE-GSVOUGTGSA-N N-Methyl-D-aspartic acid Chemical compound CN[C@@H](C(O)=O)CC(O)=O HOKKHZGPKSLGJE-GSVOUGTGSA-N 0.000 claims 1
- 208000018737 Parkinson disease Diseases 0.000 claims 1
- 208000004983 Phantom Limb Diseases 0.000 claims 1
- 206010056238 Phantom pain Diseases 0.000 claims 1
- 206010036376 Postherpetic Neuralgia Diseases 0.000 claims 1
- MTCFGRXMJLQNBG-UHFFFAOYSA-N Serine Natural products OCC(N)C(O)=O MTCFGRXMJLQNBG-UHFFFAOYSA-N 0.000 claims 1
- 206010002026 amyotrophic lateral sclerosis Diseases 0.000 claims 1
- 229910052789 astatine Inorganic materials 0.000 claims 1
- 238000011260 co-administration Methods 0.000 claims 1
- 230000036461 convulsion Effects 0.000 claims 1
- 201000010099 disease Diseases 0.000 claims 1
- 150000002148 esters Chemical class 0.000 claims 1
- 125000005842 heteroatom Chemical group 0.000 claims 1
- 150000004677 hydrates Chemical class 0.000 claims 1
- 206010027599 migraine Diseases 0.000 claims 1
- 208000004296 neuralgia Diseases 0.000 claims 1
- 230000002981 neuropathic effect Effects 0.000 claims 1
- 208000021722 neuropathic pain Diseases 0.000 claims 1
- 239000002243 precursor Substances 0.000 claims 1
- 208000020431 spinal cord injury Diseases 0.000 claims 1
- 230000005062 synaptic transmission Effects 0.000 claims 1
- 206010044652 trigeminal neuralgia Diseases 0.000 claims 1
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US80639106P | 2006-06-30 | 2006-06-30 | |
| US84246506P | 2006-09-05 | 2006-09-05 | |
| US91429307P | 2007-04-26 | 2007-04-26 | |
| PCT/US2007/015396 WO2008005456A2 (en) | 2006-06-30 | 2007-07-02 | Fused heterocyclic inhibitors of d-amino acid oxidase |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2009542683A JP2009542683A (ja) | 2009-12-03 |
| JP2009542683A5 true JP2009542683A5 (https=) | 2010-08-05 |
Family
ID=38877507
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009518342A Pending JP2009542683A (ja) | 2006-06-30 | 2007-07-02 | Ｄ−アミノ酸オキシダーゼの縮合ヘテロ環式阻害剤 |
Country Status (9)
| Country | Link |
|---|---|
| EP (1) | EP2057162A2 (https=) |
| JP (1) | JP2009542683A (https=) |
| KR (1) | KR20090024823A (https=) |
| AU (1) | AU2007269646A1 (https=) |
| BR (1) | BRPI0713216A2 (https=) |
| CA (1) | CA2659060A1 (https=) |
| IL (1) | IL195921A0 (https=) |
| MX (1) | MX2008016525A (https=) |
| WO (1) | WO2008005456A2 (https=) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2004312530A1 (en) | 2003-12-29 | 2005-07-21 | Sepracor Inc. | Pyrrole and pyrazole DAAO inhibitors |
| BRPI0706365A2 (pt) | 2006-01-06 | 2011-03-22 | Sepracor Inc | Cicloalquilaminas como inibidores da recaptação de monoamina |
| NZ569608A (en) | 2006-01-06 | 2011-09-30 | Sepracor Inc | Tetralone-based monoamine reuptake inhibitors |
| DK2816024T3 (en) | 2006-03-31 | 2017-10-30 | Sunovion Pharmaceuticals Inc | CHIRALE AMINER |
| US7579370B2 (en) * | 2006-06-30 | 2009-08-25 | Sepracor Inc. | Fused heterocycles |
| US7884124B2 (en) | 2006-06-30 | 2011-02-08 | Sepracor Inc. | Fluoro-substituted inhibitors of D-amino acid oxidase |
| US8492405B2 (en) | 2006-10-18 | 2013-07-23 | Takeda Pharmaceutical Company Limited | Glucokinase-activating fused heterocyclic compounds and methods of treating diabetes and obesity |
| US7902252B2 (en) * | 2007-01-18 | 2011-03-08 | Sepracor, Inc. | Inhibitors of D-amino acid oxidase |
| AU2008259841B2 (en) | 2007-05-31 | 2015-02-05 | Sunovion Pharmaceuticals Inc. | Phenyl substituted cycloalkylamines as monoamine reuptake inhibitors |
| AR076766A1 (es) | 2009-05-14 | 2011-07-06 | Japan Tobacco Inc | Compuestos de azetidina, composiciones farmaceuticas y su uso en el tratamiento de enfermedades autoinmunes. |
| GB201111705D0 (en) * | 2011-07-07 | 2011-08-24 | Takeda Pharmaceutical | Compounds and their use |
| JO3115B1 (ar) * | 2011-08-22 | 2017-09-20 | Takeda Pharmaceuticals Co | مركبات بيريدازينون واستخدامها كمثبطات daao |
| GB201222711D0 (en) * | 2012-12-17 | 2013-01-30 | Takeda Pharmaceutical | Novel compounds |
| PT3137658T (pt) * | 2014-04-30 | 2022-05-05 | Univ Nat Taiwan | Uso de compostos conhecidos como inibidores do d-aminoácido oxidase |
| MX388871B (es) | 2014-06-27 | 2025-03-20 | Nogra Pharma Ltd | Moduladores del receptor arilo y metodos para elaborar y usar los mismos. |
| TW202115086A (zh) * | 2019-06-28 | 2021-04-16 | 美商輝瑞大藥廠 | Bckdk抑制劑 |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9803228D0 (en) * | 1998-02-17 | 1998-04-08 | Zeneca Ltd | Chemical compounds |
| ATE257480T1 (de) * | 1999-09-30 | 2004-01-15 | Pfizer Prod Inc | Bicyclische pyrrolylamide als glycogenphosphorylase-inhibitoren |
| EP1391460A1 (en) * | 1999-09-30 | 2004-02-25 | Pfizer Products Inc. | Tricyclic pyrrolyl amides as glycogen phosphorylase inhibitors |
| US20030162825A1 (en) * | 2001-11-09 | 2003-08-28 | Sepracor Inc. | D-amino acid oxidase inhibitors for learning and memory |
| EP1543011B1 (en) * | 2002-09-06 | 2006-05-03 | Janssen Pharmaceutica N.V. | Thienopyrrolyl and furanopyrrolyl compounds and their use as histamine h4 receptor ligands |
| AU2004312530A1 (en) * | 2003-12-29 | 2005-07-21 | Sepracor Inc. | Pyrrole and pyrazole DAAO inhibitors |
| WO2006004040A1 (ja) * | 2004-07-01 | 2006-01-12 | Daiichi Asubio Pharma Co., Ltd. | Ｐｄｅ７阻害作用を有するチエノピラゾール誘導体 |
| CA2594665A1 (en) * | 2005-01-19 | 2006-07-27 | Biolipox Ab | Thienopyrroles useful in the treatment of inflammation |
| US20090306169A1 (en) * | 2005-10-06 | 2009-12-10 | Brandish Philip E | Use of Fused Pyrrole Carboxylic Acids for the Treatment of Neurodegenerative and Psychiatric Diseases and D-Amino Acid Oxidase Inhibitors |
| UA95788C2 (en) * | 2005-12-15 | 2011-09-12 | Ф. Хоффманн-Ля Рош Аг | Fused pyrrole derivatives |
-
2007
- 2007-07-02 EP EP07796659A patent/EP2057162A2/en not_active Withdrawn
- 2007-07-02 BR BRPI0713216-6A patent/BRPI0713216A2/pt not_active IP Right Cessation
- 2007-07-02 JP JP2009518342A patent/JP2009542683A/ja active Pending
- 2007-07-02 AU AU2007269646A patent/AU2007269646A1/en not_active Abandoned
- 2007-07-02 KR KR1020097001738A patent/KR20090024823A/ko not_active Withdrawn
- 2007-07-02 WO PCT/US2007/015396 patent/WO2008005456A2/en not_active Ceased
- 2007-07-02 MX MX2008016525A patent/MX2008016525A/es not_active Application Discontinuation
- 2007-07-02 CA CA002659060A patent/CA2659060A1/en not_active Abandoned
-
2008
- 2008-12-14 IL IL195921A patent/IL195921A0/en unknown
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