JP2009542622A5 - - Google Patents
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- Publication number
- JP2009542622A5 JP2009542622A5 JP2009517603A JP2009517603A JP2009542622A5 JP 2009542622 A5 JP2009542622 A5 JP 2009542622A5 JP 2009517603 A JP2009517603 A JP 2009517603A JP 2009517603 A JP2009517603 A JP 2009517603A JP 2009542622 A5 JP2009542622 A5 JP 2009542622A5
- Authority
- JP
- Japan
- Prior art keywords
- peptide
- agent
- seq
- copolymer
- group
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 108090000765 processed proteins & peptides Proteins 0.000 claims 34
- 239000003795 chemical substances by application Substances 0.000 claims 28
- 108091005601 modified peptides Proteins 0.000 claims 11
- 125000000539 amino acid group Chemical group 0.000 claims 9
- 102000004388 Interleukin-4 Human genes 0.000 claims 7
- 108090000978 Interleukin-4 Proteins 0.000 claims 7
- 210000001744 T-lymphocyte Anatomy 0.000 claims 7
- 229920001577 copolymer Polymers 0.000 claims 7
- 239000003814 drug Substances 0.000 claims 7
- 241000283690 Bos taurus Species 0.000 claims 6
- 230000004048 modification Effects 0.000 claims 6
- 238000012986 modification Methods 0.000 claims 6
- 210000000066 myeloid cell Anatomy 0.000 claims 6
- 230000001717 pathogenic effect Effects 0.000 claims 5
- 210000001185 bone marrow Anatomy 0.000 claims 4
- 229940079593 drug Drugs 0.000 claims 4
- 102000004196 processed proteins & peptides Human genes 0.000 claims 4
- 229920005604 random copolymer Polymers 0.000 claims 4
- 108091008874 T cell receptors Proteins 0.000 claims 3
- 102000016266 T-Cell Antigen Receptors Human genes 0.000 claims 3
- 108010048996 interstitial retinol-binding protein Proteins 0.000 claims 3
- 239000002773 nucleotide Substances 0.000 claims 3
- 125000003729 nucleotide group Chemical group 0.000 claims 3
- 229920001184 polypeptide Polymers 0.000 claims 3
- 238000006467 substitution reaction Methods 0.000 claims 3
- 208000023275 Autoimmune disease Diseases 0.000 claims 2
- 101000665878 Bos taurus Retinol-binding protein 3 Proteins 0.000 claims 2
- WHUUTDBJXJRKMK-UHFFFAOYSA-N Glutamic acid Natural products OC(=O)C(N)CCC(O)=O WHUUTDBJXJRKMK-UHFFFAOYSA-N 0.000 claims 2
- DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 claims 2
- 102100037850 Interferon gamma Human genes 0.000 claims 2
- 108010074328 Interferon-gamma Proteins 0.000 claims 2
- QNAYBMKLOCPYGJ-REOHCLBHSA-N L-alanine Chemical compound C[C@H](N)C(O)=O QNAYBMKLOCPYGJ-REOHCLBHSA-N 0.000 claims 2
- WHUUTDBJXJRKMK-VKHMYHEASA-N L-glutamic acid Chemical compound OC(=O)[C@@H](N)CCC(O)=O WHUUTDBJXJRKMK-VKHMYHEASA-N 0.000 claims 2
- OUYCCCASQSFEME-QMMMGPOBSA-N L-tyrosine Chemical compound OC(=O)[C@@H](N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-QMMMGPOBSA-N 0.000 claims 2
- KDXKERNSBIXSRK-UHFFFAOYSA-N Lysine Natural products NCCCCC(N)C(O)=O KDXKERNSBIXSRK-UHFFFAOYSA-N 0.000 claims 2
- 239000004472 Lysine Substances 0.000 claims 2
- 235000004279 alanine Nutrition 0.000 claims 2
- 239000000427 antigen Substances 0.000 claims 2
- 102000036639 antigens Human genes 0.000 claims 2
- 108091007433 antigens Proteins 0.000 claims 2
- 210000004443 dendritic cell Anatomy 0.000 claims 2
- 235000013922 glutamic acid Nutrition 0.000 claims 2
- 239000004220 glutamic acid Substances 0.000 claims 2
- 235000018977 lysine Nutrition 0.000 claims 2
- 230000001404 mediated effect Effects 0.000 claims 2
- 210000001616 monocyte Anatomy 0.000 claims 2
- 210000005259 peripheral blood Anatomy 0.000 claims 2
- 239000011886 peripheral blood Substances 0.000 claims 2
- 210000003819 peripheral blood mononuclear cell Anatomy 0.000 claims 2
- 235000002374 tyrosine Nutrition 0.000 claims 2
- OUYCCCASQSFEME-UHFFFAOYSA-N tyrosine Natural products OC(=O)C(N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-UHFFFAOYSA-N 0.000 claims 2
- 239000004475 Arginine Substances 0.000 claims 1
- 239000004471 Glycine Substances 0.000 claims 1
- 101000611338 Homo sapiens Rhodopsin Proteins 0.000 claims 1
- CKLJMWTZIZZHCS-REOHCLBHSA-N L-aspartic acid Chemical compound OC(=O)[C@@H](N)CC(O)=O CKLJMWTZIZZHCS-REOHCLBHSA-N 0.000 claims 1
- KDXKERNSBIXSRK-YFKPBYRVSA-N L-lysine Chemical compound NCCCC[C@H](N)C(O)=O KDXKERNSBIXSRK-YFKPBYRVSA-N 0.000 claims 1
- QIVBCDIJIAJPQS-VIFPVBQESA-N L-tryptophane Chemical compound C1=CC=C2C(C[C@H](N)C(O)=O)=CNC2=C1 QIVBCDIJIAJPQS-VIFPVBQESA-N 0.000 claims 1
- 102100038247 Retinol-binding protein 3 Human genes 0.000 claims 1
- QIVBCDIJIAJPQS-UHFFFAOYSA-N Tryptophan Natural products C1=CC=C2C(CC(N)C(O)=O)=CNC2=C1 QIVBCDIJIAJPQS-UHFFFAOYSA-N 0.000 claims 1
- 206010046851 Uveitis Diseases 0.000 claims 1
- 206010064930 age-related macular degeneration Diseases 0.000 claims 1
- 235000001014 amino acid Nutrition 0.000 claims 1
- 150000001413 amino acids Chemical class 0.000 claims 1
- ODKSFYDXXFIFQN-UHFFFAOYSA-N arginine Natural products OC(=O)C(N)CCCNC(N)=N ODKSFYDXXFIFQN-UHFFFAOYSA-N 0.000 claims 1
- 235000003704 aspartic acid Nutrition 0.000 claims 1
- OQFSQFPPLPISGP-UHFFFAOYSA-N beta-carboxyaspartic acid Natural products OC(=O)C(N)C(C(O)=O)C(O)=O OQFSQFPPLPISGP-UHFFFAOYSA-N 0.000 claims 1
- 210000004027 cell Anatomy 0.000 claims 1
- 208000002780 macular degeneration Diseases 0.000 claims 1
- 229920001897 terpolymer Polymers 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US80604106P | 2006-06-28 | 2006-06-28 | |
| US60/806,041 | 2006-06-28 | ||
| PCT/IL2007/000798 WO2008001380A2 (en) | 2006-06-28 | 2007-06-28 | Method of treatment of age-related macular degeneration |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2009542622A JP2009542622A (ja) | 2009-12-03 |
| JP2009542622A5 true JP2009542622A5 (enExample) | 2010-09-24 |
| JP5412280B2 JP5412280B2 (ja) | 2014-02-12 |
Family
ID=38846104
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009517603A Expired - Fee Related JP5412280B2 (ja) | 2006-06-28 | 2007-06-28 | 加齢性黄斑変性症の治療法 |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US9089509B2 (enExample) |
| EP (1) | EP2046366B1 (enExample) |
| JP (1) | JP5412280B2 (enExample) |
| AU (1) | AU2007264682B2 (enExample) |
| CA (1) | CA2656463C (enExample) |
| ES (1) | ES2605154T3 (enExample) |
| WO (1) | WO2008001380A2 (enExample) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2008075365A1 (en) * | 2006-12-20 | 2008-06-26 | Yissum Research Development Company Of The Hebrew University Of Jerusalem | Compositions and methods for treatment of age related degeneration of the retina |
| JP2012518407A (ja) * | 2009-02-20 | 2012-08-16 | ザ スクリプス リサーチ インスティチュート | 単離された単球集団及び関連した治療応用 |
| USRE49251E1 (en) | 2010-01-04 | 2022-10-18 | Mapi Pharma Ltd. | Depot systems comprising glatiramer or pharmacologically acceptable salt thereof |
| WO2012143924A1 (en) | 2011-04-21 | 2012-10-26 | Mapi Pharma Ltd. | Random pentapolymer for treatment of autoimmune diseases |
| US20130217986A1 (en) * | 2012-02-21 | 2013-08-22 | Ucl Business Plc | Method and system for predicting an amyloidosis status |
| WO2016183585A1 (en) * | 2015-05-14 | 2016-11-17 | Joslin Diabetes Center, Inc. | Retinol-binding protein 3 (rbp3) as a protective factor in non-diabetic retinal degeneration |
| US12097292B2 (en) | 2016-08-28 | 2024-09-24 | Mapi Pharma Ltd. | Process for preparing microparticles containing glatiramer acetate |
| HRP20250396T1 (hr) | 2016-08-31 | 2025-05-23 | Mapi Pharma Ltd. | Depo sustavi koji sadrže glatiramer acetat |
| PL3565823T3 (pl) * | 2017-01-04 | 2024-10-28 | Worg Pharmaceuticals (Zhejiang) Co., Ltd. | Peptydy S-arestyn oraz ich zastosowanie terapeutyczne |
| AU2018242998B2 (en) | 2017-03-26 | 2023-11-02 | Mapi Pharma Ltd. | Glatiramer depot systems for treating progressive forms of multiple sclerosis |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL36670A (en) | 1971-04-21 | 1974-09-10 | Sela M | Therapeutic basic copolymers of amino acids |
| US5800808A (en) | 1994-05-24 | 1998-09-01 | Veda Research And Development Co., Ltd. | Copolymer-1 improvements in compositions of copolymers |
| JP2003521448A (ja) | 1998-07-23 | 2003-07-15 | ザ・プレジデント・アンド・フェローズ・オブ・ハーバード・カレッジ | 合成ペプチドおよび自己免疫疾患治療のための使用方法 |
| WO2000005250A1 (en) | 1998-07-23 | 2000-02-03 | Yeda Research And Development Co., Ltd | Treatment of autoimmune conditions with copolymer 1 and related copolymers and peptides |
| US20030149997A1 (en) * | 1999-02-19 | 2003-08-07 | Hageman Gregory S. | Diagnostics and therapeutics for arterial wall disruptive disorders |
| US6420378B1 (en) * | 1999-10-15 | 2002-07-16 | Supergen, Inc. | Inhibition of abnormal cell proliferation with camptothecin and combinations including the same |
| DK1248643T3 (da) * | 2000-01-20 | 2005-11-07 | Yeda Res & Dev | Anvendelse af copolymer 1 og beslægtede peptider og polypeptider og T-celler behandlet dermed til neurobeskyttende terapi |
| US7399740B2 (en) * | 2001-06-28 | 2008-07-15 | Yeda Research And Development Co. Ltd. | Poly-Glu,Tyr for neuroprotective therapy |
| US6524012B1 (en) * | 2001-09-06 | 2003-02-25 | Gkn Automotive, Inc. | Securing members together by spring rings |
| EP1476583B1 (en) * | 2002-01-25 | 2013-08-28 | Biomedical Design, Inc. | Calcification-resistant fixation |
| WO2003079968A2 (en) | 2002-03-26 | 2003-10-02 | Yeda Research And Development Co. Ltd | Use of an organ-specific self-pathogen for treatment of a non-autoimmune disease of said organ |
| CN1705438A (zh) * | 2002-06-14 | 2005-12-07 | 耶达研究及发展有限公司 | 用于神经保护和神经再生的抗原呈递细胞 |
| US7860975B2 (en) * | 2002-07-31 | 2010-12-28 | Oracle America, Inc. | System and method for secure sticky routing of requests within a server farm |
| US7354574B2 (en) * | 2002-11-07 | 2008-04-08 | Advanced Ocular Systems Limited | Treatment of ocular disease |
| MXPA05007329A (es) * | 2003-01-07 | 2005-09-30 | Yeda Res & Dev | Vacuna de gotas oculares que contiene copolimero 1 para inmunizacion terapeutica. |
-
2007
- 2007-06-28 CA CA2656463A patent/CA2656463C/en not_active Expired - Fee Related
- 2007-06-28 WO PCT/IL2007/000798 patent/WO2008001380A2/en not_active Ceased
- 2007-06-28 JP JP2009517603A patent/JP5412280B2/ja not_active Expired - Fee Related
- 2007-06-28 US US12/308,880 patent/US9089509B2/en not_active Expired - Fee Related
- 2007-06-28 AU AU2007264682A patent/AU2007264682B2/en not_active Ceased
- 2007-06-28 ES ES07766829.1T patent/ES2605154T3/es active Active
- 2007-06-28 EP EP07766829.1A patent/EP2046366B1/en active Active
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