JP2009541489A5 - - Google Patents

Download PDF

Info

Publication number
JP2009541489A5
JP2009541489A5 JP2009518489A JP2009518489A JP2009541489A5 JP 2009541489 A5 JP2009541489 A5 JP 2009541489A5 JP 2009518489 A JP2009518489 A JP 2009518489A JP 2009518489 A JP2009518489 A JP 2009518489A JP 2009541489 A5 JP2009541489 A5 JP 2009541489A5
Authority
JP
Japan
Prior art keywords
pharmacological chaperone
glucocerebrosidase
isophagomine
disease
individual
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP2009518489A
Other languages
English (en)
Japanese (ja)
Other versions
JP5303458B2 (ja
JP2009541489A (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/US2007/072016 external-priority patent/WO2007150064A2/en
Publication of JP2009541489A publication Critical patent/JP2009541489A/ja
Publication of JP2009541489A5 publication Critical patent/JP2009541489A5/ja
Application granted granted Critical
Publication of JP5303458B2 publication Critical patent/JP5303458B2/ja
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

Links

JP2009518489A 2006-06-23 2007-06-25 β−グルコセレブロシダーゼの活性増強による神経学的疾患の治療方法 Expired - Fee Related JP5303458B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US81595206P 2006-06-23 2006-06-23
US60/815,952 2006-06-23
PCT/US2007/072016 WO2007150064A2 (en) 2006-06-23 2007-06-25 METHOD FOR THE TREATMENT OF NEUROLOGICAL DISORDERS BY ENHANCING THE ACTIVITY OF β-GLUCOCEREBROSIDASE

Publications (3)

Publication Number Publication Date
JP2009541489A JP2009541489A (ja) 2009-11-26
JP2009541489A5 true JP2009541489A5 (https=) 2010-08-12
JP5303458B2 JP5303458B2 (ja) 2013-10-02

Family

ID=38834440

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2009518489A Expired - Fee Related JP5303458B2 (ja) 2006-06-23 2007-06-25 β−グルコセレブロシダーゼの活性増強による神経学的疾患の治療方法

Country Status (15)

Country Link
US (4) US7829579B2 (https=)
EP (1) EP2040548B1 (https=)
JP (1) JP5303458B2 (https=)
KR (1) KR101402554B1 (https=)
AT (1) ATE555788T1 (https=)
AU (1) AU2007260812B2 (https=)
BR (1) BRPI0713442A2 (https=)
CA (1) CA2656643C (https=)
DK (1) DK2040548T3 (https=)
ES (1) ES2387845T3 (https=)
IL (1) IL196151A (https=)
MX (1) MX2009000032A (https=)
PT (1) PT2040548E (https=)
WO (1) WO2007150064A2 (https=)
ZA (1) ZA200900270B (https=)

Families Citing this family (44)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7138262B1 (en) 2000-08-18 2006-11-21 Shire Human Genetic Therapies, Inc. High mannose proteins and methods of making high mannose proteins
JP5303458B2 (ja) 2006-06-23 2013-10-02 アミークス セラピューティックス インコーポレイテッド β−グルコセレブロシダーゼの活性増強による神経学的疾患の治療方法
GB0622702D0 (en) * 2006-11-15 2006-12-27 Univ Dundee Selective glycosidase inhibitors
EP2154969B1 (en) 2007-05-16 2015-11-18 The Brigham and Women's Hospital, Inc. Treatment of synucleinopathies
AU2009262670B2 (en) * 2008-06-26 2013-06-20 Zevra Denmark A/S Use of Hsp70 as a regulator of enzymatic activity
WO2010056413A2 (en) * 2008-11-14 2010-05-20 Parkinson's Institute COMPOSITIONS AND METHODS FOR THE TREATMENT OF ALTERED α-SYNUCLEIN FUNCTION
GB0906159D0 (en) * 2009-04-09 2009-05-20 Summit Corp Plc Drug combination for the treatment of proteostatic diseases
CA2758187C (en) * 2009-04-09 2017-03-07 Robert Boyd Methods for preventing and/or treating degenerative disorders of the central nervous system
US8940766B2 (en) * 2009-04-09 2015-01-27 Amicus Therapeutics, Inc. Methods for preventing and/or treating lysosomal storage disorders
US9206457B2 (en) * 2009-05-26 2015-12-08 Amicus Therapeutics, Inc. Utilization of pharmacological chaperones to improve manufacturing and purification of biologics
US20110070643A1 (en) * 2009-05-26 2011-03-24 Do Hung V Utilization of Pharmacological Chaperones to Improve Manufacturing and Purification of Biologics
AU2010281403B2 (en) * 2009-07-28 2016-03-10 Takeda Pharmaceutical Company Limited Compositions and methods for treating Gaucher disease
WO2011049737A1 (en) * 2009-10-19 2011-04-28 Amicus Therapeutics, Inc. Novel compositions for preventing and/or treating lysosomal storage disorders
SI2490532T1 (sl) * 2009-10-19 2017-03-31 Amicus Therapeutics, Inc. Novi sestavki za preventivo in/ali zdravljenje degenerativnih motenj centralnega živčnega sistema
WO2011049787A1 (en) * 2009-10-19 2011-04-28 Amicus Therapeutics, Inc. Method for treating alzheimer's disease using pharmacological chaperones to increase the activity of gangliosidases
CA2817773A1 (en) 2010-11-30 2012-06-07 Orphazyme Aps Methods for increasing intracellular activity of hsp70
DK2707101T3 (da) 2011-05-12 2019-05-13 Proteostasis Therapeutics Inc Proteostaseregulatorer
EP2533051A1 (en) 2011-06-06 2012-12-12 Centogene GmbH Method for the diagnosis of Gaucher's disease
WO2012177997A1 (en) * 2011-06-22 2012-12-27 The General Hospital Corporation Treatment of proteinopathies
CA2861464C (en) 2012-01-25 2018-03-06 Proteostasis Therapeutics, Inc. Proteasome activity modulating tricyclic compounds
JP2016503405A (ja) * 2012-11-05 2016-02-04 ジェンザイム・コーポレーション タンパク質症を処置するための組成物および方法
WO2014089449A1 (en) 2012-12-07 2014-06-12 Rush University Nedical Center Composition and method for treating neuronal ceroid lipofuscinosis
WO2015095963A1 (en) 2013-12-23 2015-07-02 Alectos Therapeutics Inc. Glucocerebrosidase modulators and uses thereof
US9675627B2 (en) 2014-04-14 2017-06-13 Amicus Therapeutics, Inc. Dosing regimens for treating and/or preventing cerebral amyloidoses
AU2015317447B2 (en) 2014-09-15 2021-02-25 Zevra Denmark A/S Arimoclomol formulation
HRP20240644T1 (hr) 2014-11-06 2024-08-02 Bial-R&D Investments, S.A. Supstituirani pirazolo(1,5-a)pirimidini i njihova uporaba u liječenju medicinskih poremećaja
EP3292206B8 (en) 2015-05-07 2022-02-09 Takeda Pharmaceutical Company Limited Glucocerebrosidase gene therapy for parkinson's disease
CA3020305A1 (en) 2016-04-06 2017-10-12 Lysosomal Therapeutics Inc. Imidazo [1,5-a]pyrimidinyl carboxamide compounds and their use in the treatment of medical disorders
US11192892B2 (en) 2016-04-06 2021-12-07 Bial—R&D Investments, S.A. Substituted pyrazolo[1,5-a]pyrimidines for the treatment of medical disorders
EP3440081A4 (en) 2016-04-06 2019-09-18 Lysosomal Therapeutics Inc. PYRROLO [1,2-A] PYRIMIDINYL-CARBOXAMIDE COMPOUNDS AND THEIR USE IN THE TREATMENT OF MEDICAL DISORDER
US10898476B2 (en) 2016-04-13 2021-01-26 Orphazyme A/S Heat shock proteins and cholesterol homeostasis
DK3782624T3 (da) 2016-04-29 2025-12-15 Zevra Denmark As Arimoclomol til behandling af glucocerebrosidase-associerede lidelser
SG11201809693SA (en) 2016-05-05 2018-11-29 Lysosomal Therapeutics Inc SUBSTITUTED IMIDAZO[1,2-b]PYRIDAZINES, SUBSTITUTED IMIDAZO[1,5-b]PYRIDAZINES, RELATED COMPOUNDS, AND THEIR USE IN THE TREATMENT OF MEDICAL DISORDERS
EP3264092A1 (en) * 2016-07-01 2018-01-03 Centogene AG Use of lyso-gb1 as druggable target
CN111278439A (zh) * 2017-10-26 2020-06-12 夏尔人类遗传性治疗公司 包含葡萄糖脑苷脂酶和异烟肼的调配物
CN108428452B (zh) 2018-03-14 2019-12-13 百度在线网络技术(北京)有限公司 终端支架和远场语音交互系统
CN112585130A (zh) 2018-06-27 2021-03-30 蛋白质平衡治疗股份有限公司 蛋白酶体活性增强化合物
BR112020026580A2 (pt) 2018-06-27 2021-03-23 Proteostasis Therapeutics, Inc. (Fem) Compostos, composição farmacêutica e métodos para tratar um paciente
US20220184185A1 (en) 2018-07-25 2022-06-16 Modernatx, Inc. Mrna based enzyme replacement therapy combined with a pharmacological chaperone for the treatment of lysosomal storage disorders
CA3121785A1 (en) * 2018-12-05 2020-06-11 Washington University Methods of detecting, preventing, reversing, and treating neurological diseases
JP7642561B2 (ja) * 2019-04-25 2025-03-10 武田薬品工業株式会社 イソファゴミン塩、その使用方法および製剤
CN111450306B (zh) * 2020-03-06 2021-11-19 大连理工大学 外用纳米羟基磷灰石/聚多巴胺湿黏附型止血粉及其制备方法
KR20230128462A (ko) 2020-11-19 2023-09-05 제브라 덴마크 에이/에스 아리모클로몰 시트레이트 및 이의 중간체를 제조하기 위한 공정
EP4329881A4 (en) * 2021-04-30 2025-06-11 Vanqua Bio, Inc. Small molecule modulators of glucocerebrosidase activity and uses thereof

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2001503141A (ja) * 1996-10-15 2001-03-06 インペリアル カレッジ オブ サイエンス,テクノロジー アンド メディシン 海綿状脳症の診断方法
GB2354946B (en) * 1996-10-15 2001-05-16 Imperial College Means for the treatment of prion disease
US6274597B1 (en) 1998-06-01 2001-08-14 Mount Sinai School Of Medicine Of New York University Method of enhancing lysosomal α-Galactosidase A
PT2441467E (pt) * 2003-01-31 2015-10-12 Sinai School Medicine Terapia combinada para o tratamento de transtornos associados a uma deficiência proteica
EP1682504B1 (en) 2003-11-12 2012-12-26 Amicus Therapeutics Inc. Hydroxy piperidine derivatives to treat gaucher disease
CN101541172A (zh) 2005-06-08 2009-09-23 阿米库斯治疗学公司 溶酶体酶编码基因突变相关的cns紊乱的治疗
PT1860101E (pt) * 2006-05-24 2011-07-12 Amicus Therapeutics Inc Sal de tartrato da isofagomina e métodos de uso
JP5303458B2 (ja) 2006-06-23 2013-10-02 アミークス セラピューティックス インコーポレイテッド β−グルコセレブロシダーゼの活性増強による神経学的疾患の治療方法
KR101650726B1 (ko) * 2007-05-22 2016-08-24 아미쿠스 세라퓨틱스, 인코포레이티드 이소파고민과 이의 유도체를 제조하는 새로운 방법

Similar Documents

Publication Publication Date Title
JP2009541489A5 (https=)
RU2015147509A (ru) Новые композиции для предупреждения и/или лечения дегенеративных расстройств центральной нервной системы
JP2015518055A5 (https=)
JP2010509356A5 (https=)
JP2012521429A5 (https=)
JP2005526741A5 (https=)
MX356032B (es) Compuestos indola y métodos para tratar el dolor visceral.
JP2010501479A5 (https=)
MY156747A (en) Isoxazolo-pyridine derivatives
JP2014518546A5 (https=)
AR076412A1 (es) Compuestos diamida que tienen actividad antagonista de receptores muscarinicos y agonista del receptor adrenergico (beta)2
ES2759312T3 (es) Compuestos de aminocarbonilcarbamato
JP2007515429A5 (https=)
JP2006522035A5 (https=)
JP2012508249A5 (https=)
JP2014532730A5 (ja) オピオイド受容体の調節物質およびそれを含む薬学的組成物
JP2010532383A5 (https=)
JP2008503533A5 (https=)
JP2017512211A5 (https=)
JP2017502278A5 (https=)
US20230218562A1 (en) Aminocarbonylcarbamate compounds
JP2015515465A5 (https=)
JP2010538010A5 (https=)
JP2012524070A5 (https=)
PE20080206A1 (es) Derivados de aril y heteroaril-etil-acilguanidina como inhibidores de renina