JP2009541409A - ヘパラナーゼの抑制の為にデフィブロチドを使用する方法。 - Google Patents

ヘパラナーゼの抑制の為にデフィブロチドを使用する方法。 Download PDF

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Publication number
JP2009541409A
JP2009541409A JP2009517063A JP2009517063A JP2009541409A JP 2009541409 A JP2009541409 A JP 2009541409A JP 2009517063 A JP2009517063 A JP 2009517063A JP 2009517063 A JP2009517063 A JP 2009517063A JP 2009541409 A JP2009541409 A JP 2009541409A
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heparanase
defibrotide
cells
activity
medicament
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English (en)
Japanese (ja)
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JP2009541409A5 (enExample
Inventor
シナラ エカート
イリス フェッロ，ラウラ
イアコベッリ，マッシモ
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ゲンチウム エスピーエー
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Publication of JP2009541409A publication Critical patent/JP2009541409A/ja
Publication of JP2009541409A5 publication Critical patent/JP2009541409A5/ja
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A61K31/711—Natural deoxyribonucleic acids, i.e. containing only 2'-deoxyriboses attached to adenine, guanine, cytosine or thymine and having 3'-5' phosphodiester links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Biochemistry (AREA)
  • Epidemiology (AREA)
  • Molecular Biology (AREA)
  • Hematology (AREA)
  • Endocrinology (AREA)
  • Obesity (AREA)
  • Emergency Medicine (AREA)
  • Immunology (AREA)
  • Urology & Nephrology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
JP2009517063A 2006-06-27 2007-05-14 ヘパラナーゼの抑制の為にデフィブロチドを使用する方法。 Pending JP2009541409A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP06425436A EP1872787A1 (en) 2006-06-27 2006-06-27 Use of defibrotide for the inhibition of heparanase
PCT/EP2007/054633 WO2008000549A1 (en) 2006-06-27 2007-05-14 Use of defibrotide for the inhibition of heparanase

Publications (2)

Publication Number Publication Date
JP2009541409A true JP2009541409A (ja) 2009-11-26
JP2009541409A5 JP2009541409A5 (enExample) 2010-06-17

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ID=37496823

Family Applications (1)

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JP2009517063A Pending JP2009541409A (ja) 2006-06-27 2007-05-14 ヘパラナーゼの抑制の為にデフィブロチドを使用する方法。

Country Status (6)

Country Link
US (2) US20090131362A1 (enExample)
EP (2) EP1872787A1 (enExample)
JP (1) JP2009541409A (enExample)
CA (1) CA2655522A1 (enExample)
IL (1) IL195971A0 (enExample)
WO (1) WO2008000549A1 (enExample)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ITMI20031714A1 (it) 2003-09-05 2005-03-06 Gentium Spa Formazioni ad azione antitumorale.
EP1982722A1 (en) * 2007-04-16 2008-10-22 Gentium S.p.A. Use of oligotide for the treatment of renal diseases
DK2637672T3 (en) 2010-11-12 2018-10-22 Gentium S R L DEFIBROTID FOR USE IN PROPHYLAXY AND / OR TREATMENT OF GRAPHIC VERSUS HOST DISEASE (GVHD)
KR102038357B1 (ko) 2012-06-22 2019-10-31 젠티엄 에스알엘 디파이브로타이드의 생물학적 활성 측정을 위한 유우글로불린에 기초한 방법
EP3026122A1 (en) 2014-11-27 2016-06-01 Gentium S.p.A. Cellular-based method for determining the potency of defibrotide
CN111132663A (zh) 2017-08-03 2020-05-08 爵士制药爱尔兰有限公司 包含高浓度核酸的制剂
AU2019252790A1 (en) 2018-04-12 2020-10-15 Jazz Pharmaceuticals, Inc. Defibrotide for the prevention and treatment of cytokine release syndrome and neurotoxicity associated with immunodepletion
US20220023533A1 (en) 2018-12-07 2022-01-27 Jazz Phrmaceticals Ireland Limited Subcutaneous delivery of high concentration formulations
WO2021174039A1 (en) 2020-02-28 2021-09-02 Jazz Pharmaceuticals Ireland Limited Delivery of low viscosity formulations
TW202308659A (zh) 2021-05-06 2023-03-01 愛爾蘭商爵士製藥愛爾蘭有限責任公司 用於急性呼吸窘迫症候群之治療及預防的去纖維蛋白多核苷酸

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JPN5009009316; ＤＡＶＩ　Ｇ: ＴＨＲＯＭＢＯＳＩＳ　ＲＥＳＥＡＲＣＨ Ｖ６５　Ｎ２, 1992, Ｐ２１１-２２０ *
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Also Published As

Publication number Publication date
EP2035013A1 (en) 2009-03-18
EP1872787A1 (en) 2008-01-02
IL195971A0 (en) 2009-09-01
CA2655522A1 (en) 2008-01-03
WO2008000549A1 (en) 2008-01-03
US20090131362A1 (en) 2009-05-21
US20150196580A1 (en) 2015-07-16

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