JP2009539822A - 副腎のβ−１１−ヒドロキシラーゼの定量用トレーサーとしての１８Ｆ標識アルキル−１−［（１Ｒ）−１−フェニルエチル］−１Ｈ−イミダゾール−５−カルボキシレートの合成と評価 - Google Patents

副腎のβ−１１−ヒドロキシラーゼの定量用トレーサーとしての１８Ｆ標識アルキル−１−［（１Ｒ）−１−フェニルエチル］−１Ｈ−イミダゾール−５−カルボキシレートの合成と評価 Download PDF

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Publication number
JP2009539822A
JP2009539822A JP2009513791A JP2009513791A JP2009539822A JP 2009539822 A JP2009539822 A JP 2009539822A JP 2009513791 A JP2009513791 A JP 2009513791A JP 2009513791 A JP2009513791 A JP 2009513791A JP 2009539822 A JP2009539822 A JP 2009539822A
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Japan
Prior art keywords
formula
compound
pharmaceutically acceptable
pet
acid
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Pending
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JP2009513791A
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English (en)
Japanese (ja)
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JP2009539822A5 (enExample
Inventor
ラングストロム，ベングト
カリミ，ファーハッド
ブロム，エリザベス
エアランドソン，マリア
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GE Healthcare Ltd
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GE Healthcare Ltd
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Publication date
Application filed by GE Healthcare Ltd filed Critical GE Healthcare Ltd
Publication of JP2009539822A publication Critical patent/JP2009539822A/ja
Publication of JP2009539822A5 publication Critical patent/JP2009539822A5/ja
Pending legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/05—Isotopically modified compounds, e.g. labelled

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicinal Preparation (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
JP2009513791A 2006-06-09 2007-06-07 副腎のβ−１１−ヒドロキシラーゼの定量用トレーサーとしての１８Ｆ標識アルキル−１−［（１Ｒ）−１−フェニルエチル］−１Ｈ−イミダゾール−５−カルボキシレートの合成と評価 Pending JP2009539822A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US81215906P 2006-06-09 2006-06-09
PCT/IB2007/001528 WO2007144725A2 (en) 2006-06-09 2007-06-07 SYNTHESIS AND EVALUATION OF 18F-LABELLED ALKYL-1-[(R)-1-PHENYLETHYL]-1H-IMIDAZOLE-5-CARBOXYLATE AS A TRACER FOR THE QUANTIFICATION OF β-11-HYDROXYLASE ENZYME IN THE ADRENAL GLANDS

Publications (2)

Publication Number Publication Date
JP2009539822A true JP2009539822A (ja) 2009-11-19
JP2009539822A5 JP2009539822A5 (enExample) 2011-06-16

Family

ID=38658301

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2009513791A Pending JP2009539822A (ja) 2006-06-09 2007-06-07 副腎のβ−１１−ヒドロキシラーゼの定量用トレーサーとしての１８Ｆ標識アルキル−１−［（１Ｒ）−１−フェニルエチル］−１Ｈ−イミダゾール−５−カルボキシレートの合成と評価

Country Status (4)

Country Link
US (1) US8071785B2 (enExample)
EP (1) EP2035393A2 (enExample)
JP (1) JP2009539822A (enExample)
WO (1) WO2007144725A2 (enExample)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2015110563A (ja) * 2013-11-08 2015-06-18 日本メジフィジックス株式会社 アルドステロン合成酵素阻害剤
WO2015199205A1 (ja) * 2014-06-26 2015-12-30 日本メジフィジックス株式会社 ２－（３－ピリジニル）－１ｈ－ベンゾイミダゾール誘導体化合物、及び、これを含む医薬

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101918042A (zh) * 2007-11-07 2010-12-15 通用电气医疗集团公司 放射性药物的稳定化
WO2009146024A1 (en) * 2008-03-31 2009-12-03 The General Hospital Corporation Etomidate analogues with improved pharmacokinetic and pharmacodynamic properties
BR112014017230A2 (pt) * 2012-01-13 2020-11-24 The General Hospital Corporation compostos anestésicos e métodos de uso relacionados
GB201202420D0 (en) * 2012-02-13 2012-03-28 Ge Healthcare Ltd Radiotracer compositions
JP6048958B2 (ja) 2012-12-27 2016-12-21 日本メジフィジックス株式会社 副腎疾患の画像診断剤
CN111527079B (zh) 2017-12-28 2023-08-11 日本医事物理股份有限公司 2-[5-（咪唑-1-基甲基）吡啶-3-基]苯并咪唑衍生物化合物及包含其的药物

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050033060A1 (en) * 2003-08-06 2005-02-10 Ilse Zolle Radiolabelled phenylethyl imidazole caboxylic acid ester derivatives

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050033060A1 (en) * 2003-08-06 2005-02-10 Ilse Zolle Radiolabelled phenylethyl imidazole caboxylic acid ester derivatives

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
JPN5009007567; ＷＯＬＦＧＡＮＧ　ＷＡＤＳＡＫ: ＥＵＲＯＰＥＡＮ　ＪＯＵＲＮＡＬ　ＯＦ　ＮＵＣＬＥＡＲ　ＭＥＤＩＣＩＮＥ　ＡＮＤ　ＭＯＬＥＣＵＬＡＲ　ＩＭＡＧＩＮＧ Ｖ３３　Ｎ６, 20060328, Ｐ６６９-６７２, ＳＰＲＩＮＧＥＲ-ＶＥＲＬＡＧ *
JPN6012050267; Ｊｏｕｒｎａｌ　ｏｆ　Ｌａｂｅｌｌｅｄ　Ｃｏｍｐｏｕｎｄｓ　ａｎｄ　Ｒａｄｉｏｐｈａｒｍａｃｅｕｔｉｃａｌｓ ４６（４）, 2003, ｐｐ．３７９-３８８ *

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2015110563A (ja) * 2013-11-08 2015-06-18 日本メジフィジックス株式会社 アルドステロン合成酵素阻害剤
WO2015199205A1 (ja) * 2014-06-26 2015-12-30 日本メジフィジックス株式会社 ２－（３－ピリジニル）－１ｈ－ベンゾイミダゾール誘導体化合物、及び、これを含む医薬
JPWO2015199205A1 (ja) * 2014-06-26 2017-04-20 日本メジフィジックス株式会社 ２−（３−ピリジニル）−１ｈ−ベンゾイミダゾール誘導体化合物、及び、これを含む医薬
US10189815B2 (en) 2014-06-26 2019-01-29 Nihon Medi-Physics Co., Ltd. 2-(3-pyridinyl)-1H-benzimidazole derivative compound and medicine containing same
US10358434B2 (en) 2014-06-26 2019-07-23 Nihon Medi-Physics Co., Ltd. 2-(3-pyridinyl)-1H-benzimidazole derivative compound and medicament containing same

Also Published As

Publication number Publication date
EP2035393A2 (en) 2009-03-18
US20090297447A1 (en) 2009-12-03
WO2007144725A2 (en) 2007-12-21
US8071785B2 (en) 2011-12-06
WO2007144725A3 (en) 2008-02-21

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