JP2009538823A5 - - Google Patents
Info
- Publication number
- JP2009538823A5 JP2009538823A5 JP2008556382A JP2008556382A JP2009538823A5 JP 2009538823 A5 JP2009538823 A5 JP 2009538823A5 JP 2008556382 A JP2008556382 A JP 2008556382A JP 2008556382 A JP2008556382 A JP 2008556382A JP 2009538823 A5 JP2009538823 A5 JP 2009538823A5
- Authority
- JP
- Japan
- Prior art keywords
- chroman
- tetramethyl
- succinate
- hydroxy
- methylpentyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 150000001875 compounds Chemical class 0.000 claims 10
- 239000000203 mixture Substances 0.000 claims 9
- 239000008194 pharmaceutical composition Substances 0.000 claims 8
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical group N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims 6
- 125000000217 alkyl group Chemical group 0.000 claims 6
- 150000001735 carboxylic acids Chemical class 0.000 claims 6
- 150000003839 salts Chemical class 0.000 claims 6
- 150000003857 carboxamides Chemical class 0.000 claims 4
- 150000007942 carboxylates Chemical class 0.000 claims 4
- VZWXIQHBIQLMPN-UHFFFAOYSA-N chromane Chemical compound C1=CC=C2CCCOC2=C1 VZWXIQHBIQLMPN-UHFFFAOYSA-N 0.000 claims 4
- 239000001257 hydrogen Substances 0.000 claims 4
- 229910052739 hydrogen Inorganic materials 0.000 claims 4
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical group [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 claims 3
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical group [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims 3
- 239000003085 diluting agent Substances 0.000 claims 3
- 150000002148 esters Chemical class 0.000 claims 3
- 229910052757 nitrogen Inorganic materials 0.000 claims 3
- 229910052760 oxygen Inorganic materials 0.000 claims 3
- 239000001301 oxygen Substances 0.000 claims 3
- 125000000547 substituted alkyl group Chemical group 0.000 claims 3
- 229910052717 sulfur Chemical group 0.000 claims 3
- 239000011593 sulfur Chemical group 0.000 claims 3
- -1 10-aminosulfonamidodecyl Chemical group 0.000 claims 2
- FAIYPDNLZRNKNX-UHFFFAOYSA-N 3-(3,4-dihydro-2h-chromen-6-yl)propanoic acid Chemical compound O1CCCC2=CC(CCC(=O)O)=CC=C21 FAIYPDNLZRNKNX-UHFFFAOYSA-N 0.000 claims 2
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 2
- 239000002671 adjuvant Substances 0.000 claims 2
- 150000002431 hydrogen Chemical class 0.000 claims 2
- FLHAPQNZMHAERM-UHFFFAOYSA-N 4-(3,4-dihydro-2h-chromen-6-yl)butanoic acid Chemical compound O1CCCC2=CC(CCCC(=O)O)=CC=C21 FLHAPQNZMHAERM-UHFFFAOYSA-N 0.000 claims 1
- 230000006820 DNA synthesis Effects 0.000 claims 1
- XBDQKXXYIPTUBI-UHFFFAOYSA-N Propionic acid Substances CCC(O)=O XBDQKXXYIPTUBI-UHFFFAOYSA-N 0.000 claims 1
- 230000001028 anti-proliverative effect Effects 0.000 claims 1
- 230000006907 apoptotic process Effects 0.000 claims 1
- 230000025084 cell cycle arrest Effects 0.000 claims 1
- 230000024245 cell differentiation Effects 0.000 claims 1
- 201000010099 disease Diseases 0.000 claims 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 1
- 229940079593 drug Drugs 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 1
- 125000004491 isohexyl group Chemical group C(CCC(C)C)* 0.000 claims 1
- 125000001147 pentyl group Chemical group C(CCCC)* 0.000 claims 1
- 230000002062 proliferating effect Effects 0.000 claims 1
- 229940124530 sulfonamide Drugs 0.000 claims 1
- 150000003456 sulfonamides Chemical class 0.000 claims 1
- 125000000472 sulfonyl group Chemical group *S(*)(=O)=O 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US77510706P | 2006-02-21 | 2006-02-21 | |
| US60/775,107 | 2006-02-21 | ||
| PCT/US2007/004337 WO2007098139A2 (en) | 2006-02-21 | 2007-02-21 | Anticancer agents |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2009538823A JP2009538823A (ja) | 2009-11-12 |
| JP2009538823A5 true JP2009538823A5 (https=) | 2011-03-03 |
| JP5256049B2 JP5256049B2 (ja) | 2013-08-07 |
Family
ID=38437941
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008556382A Expired - Fee Related JP5256049B2 (ja) | 2006-02-21 | 2007-02-21 | 抗癌剤 |
Country Status (6)
| Country | Link |
|---|---|
| US (2) | US20080009545A1 (https=) |
| EP (1) | EP1986635A4 (https=) |
| JP (1) | JP5256049B2 (https=) |
| AU (1) | AU2007217810B2 (https=) |
| CA (1) | CA2643546A1 (https=) |
| WO (1) | WO2007098139A2 (https=) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2414205T3 (es) | 2006-06-02 | 2013-07-18 | The Ohio State University Research Foundation | Agentes terapéuticos para el tratamiento de linfoma de células del manto |
| CA2726175A1 (en) * | 2008-05-27 | 2009-12-23 | Memorial Sloan-Kettering Cancer Center | Models for combinatorial perturbations of living biological systems |
| JP2012523458A (ja) * | 2009-04-13 | 2012-10-04 | ザ オハイオ ステート ユニバーシティー リサーチ ファウンデーション | タンパク質ホスファターゼ２ａ活性化剤 |
| CA2759011A1 (en) * | 2009-04-17 | 2010-10-21 | The Ohio State University Research Foundation | Antiadhesion agents |
| US8309768B2 (en) | 2010-11-29 | 2012-11-13 | The Ohio State University Research Foundation | FTY720-derived anticancer agents |
| US20140197449A1 (en) * | 2013-01-14 | 2014-07-17 | Electronics And Telecommunications Research Institute | Semiconductor rectifier device |
Family Cites Families (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2680749A (en) * | 1951-12-01 | 1954-06-08 | Eastman Kodak Co | Water-soluble tocopherol derivatives |
| US3459774A (en) * | 1967-02-06 | 1969-08-05 | Eisai Co Ltd | Method of producing alpha-tocopheryl acid succinate |
| DE2822324C3 (de) * | 1978-05-22 | 1981-02-26 | Basf Ag, 6700 Ludwigshafen | Herstellung von Vitamin-E-Trockenpulver |
| JPS59222415A (ja) * | 1983-05-31 | 1984-12-14 | Kuraray Co Ltd | 免疫調節剤 |
| US4751224A (en) * | 1983-07-21 | 1988-06-14 | Brown University Research Foundation | Treatment of metastasis |
| US4938949A (en) * | 1988-09-12 | 1990-07-03 | University Of New York | Treatment of damaged bone marrow and dosage units therefor |
| US6335358B1 (en) * | 1995-04-12 | 2002-01-01 | President And Fellows Of Harvard College | Lactacystin analogs |
| ES2230571T3 (es) * | 1995-12-28 | 2005-05-01 | Mitsubishi Pharma Corporation | `composicion farmaceutica destinada para la administracion topica que comprende el 2-amino-2-(2-(4-octilfenil)etil) propan-1,3-diol para el tratamiento de las enfermedades causadas por una alteracion inmunitaria. |
| US6476004B1 (en) * | 1996-07-18 | 2002-11-05 | Mitsubishi Pharma Corporation | Pharmaceutical composition |
| US6004656A (en) * | 1997-11-14 | 1999-12-21 | 3M Innovative Properties Company | Color changeable device |
| US6703384B2 (en) * | 1998-09-23 | 2004-03-09 | Research Development Foundation | Tocopherols, tocotrienols, other chroman and side chain derivatives and uses thereof |
| JP2002526446A (ja) * | 1998-09-23 | 2002-08-20 | リサーチ ディベロップメント ファンデーション | トロフェロール、トコトリエノール、その他のクロマン及び側鎖誘導体、並びにそれらの利用 |
| US6770672B1 (en) * | 1998-09-23 | 2004-08-03 | Research Development Foundation | Tocopherols, tocotrienols, other chroman and side chain derivatives and uses thereof |
| KR100847678B1 (ko) * | 2000-02-11 | 2008-07-23 | 리서치 디벨럽먼트 파운데이션 | 토코페롤, 토코트리에놀, 다른 크로만 및 측쇄 유도체, 및이들의 용도 |
| US20040248971A1 (en) * | 2001-07-27 | 2004-12-09 | Shuyuan Yeh | Use of vitamin e succinate and antiandrogen combination |
| US6858227B1 (en) * | 2001-11-21 | 2005-02-22 | Sonus Pharmaceuticals, Inc. | Vitamin E conjugates |
| US20050215531A1 (en) * | 2002-05-16 | 2005-09-29 | Thomas Baumruker | Use of edg receptor binding agents in cancer |
| WO2005025553A2 (en) * | 2003-09-12 | 2005-03-24 | Neuronova Ab | Treatment of disorders of nervous systemsystem with fty720 |
| WO2005033092A1 (en) * | 2003-09-19 | 2005-04-14 | Galileo Pharmaceuticals, Inc. | Chroman derivatives |
| KR101346527B1 (ko) * | 2005-12-15 | 2013-12-31 | 미쓰비시 타나베 파마 코퍼레이션 | 아민 화합물 및 그 의약 용도 |
| TWI439263B (zh) * | 2007-06-14 | 2014-06-01 | Mitsubishi Tanabe Pharma Corp | 胺化合物及其醫藥用途 |
-
2007
- 2007-02-21 AU AU2007217810A patent/AU2007217810B2/en not_active Ceased
- 2007-02-21 EP EP07751119A patent/EP1986635A4/en not_active Withdrawn
- 2007-02-21 WO PCT/US2007/004337 patent/WO2007098139A2/en not_active Ceased
- 2007-02-21 CA CA002643546A patent/CA2643546A1/en not_active Abandoned
- 2007-02-21 US US11/708,792 patent/US20080009545A1/en not_active Abandoned
- 2007-02-21 JP JP2008556382A patent/JP5256049B2/ja not_active Expired - Fee Related
-
2010
- 2010-04-27 US US12/768,392 patent/US20100273871A1/en not_active Abandoned
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