JP2009538318A - 併用療法において免疫調節化合物を用いる方法及び組成物 - Google Patents

併用療法において免疫調節化合物を用いる方法及び組成物 Download PDF

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JP2009538318A
JP2009538318A JP2009512164A JP2009512164A JP2009538318A JP 2009538318 A JP2009538318 A JP 2009538318A JP 2009512164 A JP2009512164 A JP 2009512164A JP 2009512164 A JP2009512164 A JP 2009512164A JP 2009538318 A JP2009538318 A JP 2009538318A
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amino
dione
pharmaceutically acceptable
acceptable salt
effective amount
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JP2009538318A5 (https=
Inventor
ベルヘルレ ドミニクエ
チャン クイレ
クオルラル ラウラ
モウトウフ デ パルセバル ラウレ
ブラドイ ヘレン
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Celgene Corp
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/17—Amides, e.g. hydroxamic acids having the group >N—C(O)—N< or >N—C(S)—N<, e.g. urea, thiourea, carmustine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/06—Antianaemics

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  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
JP2009512164A 2006-05-26 2007-05-24 併用療法において免疫調節化合物を用いる方法及び組成物 Pending JP2009538318A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US80860206P 2006-05-26 2006-05-26
PCT/US2007/012495 WO2007139939A2 (en) 2006-05-26 2007-05-24 Methods and compositions using immunomodulatory compounds in combination therapy

Publications (2)

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JP2009538318A true JP2009538318A (ja) 2009-11-05
JP2009538318A5 JP2009538318A5 (https=) 2010-07-29

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JP2009512164A Pending JP2009538318A (ja) 2006-05-26 2007-05-24 併用療法において免疫調節化合物を用いる方法及び組成物

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Country Link
EP (1) EP2023912A2 (https=)
JP (1) JP2009538318A (https=)
KR (1) KR20090014393A (https=)
CN (1) CN101495111A (https=)
AU (1) AU2007267928A1 (https=)
CA (1) CA2652888A1 (https=)
IL (1) IL195412A0 (https=)
MX (1) MX2008014912A (https=)
RU (1) RU2426542C2 (https=)
WO (1) WO2007139939A2 (https=)
ZA (1) ZA200809956B (https=)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2017511132A (ja) * 2014-03-26 2017-04-20 ザ ブリガム アンド ウィメンズ ホスピタル インコーポレイテッドＴｈｅ Ｂｒｉｇｈａｍ ａｎｄ Ｗｏｍｅｎ’ｓ Ｈｏｓｐｉｔａｌ， Ｉｎｃ． ヒト造血幹／前駆細胞のエクスビボ拡大のための組成物および方法

Families Citing this family (7)

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JP2011510983A (ja) * 2008-01-29 2011-04-07 セルジーン コーポレイション Ｃｄ５９のレベルを調節するための、免疫調節化合物を使用する方法
CA2868302A1 (en) * 2012-03-23 2013-09-26 Dennis M. Brown Compositions and methods to improve the therapeutic benefit of indirubin and analogs thereof, including meisoindigo
KR20210021602A (ko) * 2013-08-22 2021-02-26 반다 파마슈티칼즈, 인코퍼레이티드. 다발성 골수종 치료
EP3616754A1 (en) 2013-08-22 2020-03-04 Vanda Pharmaceuticals Inc. Cancer treatment
WO2015175916A1 (en) * 2014-05-16 2015-11-19 Celgene Corporation Methods and compositions using 4-amino-2-(2,6 dioxo-piperidine-3-yl)-isoindoline-1,3-dione for treatment of cancers
US20240360411A1 (en) * 2021-09-01 2024-10-31 Flagship Pioneering Innovations Vi, Llc Methods and compositions for inducing fetal hemoglobin, modulating erythroid cell lineages, and perturbing megakaryocyte lineages
EP4612128A4 (en) 2022-11-04 2025-09-10 Bristol Myers Squibb Co COMPOUNDS AND THEIR USE FOR THE TREATMENT OF HEMOGLOBINOPATHIES

Citations (6)

* Cited by examiner, † Cited by third party
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JPH08507767A (ja) * 1993-03-01 1996-08-20 ザ・チルドレンズ・メデイカル・センター・コーポレーシヨン 管脈形成を抑制する方法および組成物
JP2005530784A (ja) * 2002-05-17 2005-10-13 セルジーン・コーポレーション 癌および他の疾患を治療および管理するための免疫調節性化合物を用いた方法および組成物
JP2006500911A (ja) * 2002-04-12 2006-01-12 セルジーン・コーポレーション 幹細胞及び前駆細胞の分化のモジュレーション、アッセイ、並びにそれらの使用
JP2006507284A (ja) * 2002-10-24 2006-03-02 セルジーン・コーポレーション 疼痛を治療、改変および管理するための免疫調節化合物の使用方法および組成物
JP2006507325A (ja) * 2002-11-06 2006-03-02 セルジーン・コーポレーション 骨髄増殖性疾患の治療および管理のための免疫調節化合物を含む使用方法および組成物
JP2007513164A (ja) * 2003-12-02 2007-05-24 セルジーン・コーポレーション 異常ヘモグロビン症及び貧血症の治療及び管理のための方法及び組成物

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US20050043233A1 (en) * 2003-04-29 2005-02-24 Boehringer Ingelheim International Gmbh Combinations for the treatment of diseases involving cell proliferation, migration or apoptosis of myeloma cells or angiogenesis
US20060058311A1 (en) * 2004-08-14 2006-03-16 Boehringer Ingelheim International Gmbh Combinations for the treatment of diseases involving cell proliferation

Patent Citations (6)

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JPH08507767A (ja) * 1993-03-01 1996-08-20 ザ・チルドレンズ・メデイカル・センター・コーポレーシヨン 管脈形成を抑制する方法および組成物
JP2006500911A (ja) * 2002-04-12 2006-01-12 セルジーン・コーポレーション 幹細胞及び前駆細胞の分化のモジュレーション、アッセイ、並びにそれらの使用
JP2005530784A (ja) * 2002-05-17 2005-10-13 セルジーン・コーポレーション 癌および他の疾患を治療および管理するための免疫調節性化合物を用いた方法および組成物
JP2006507284A (ja) * 2002-10-24 2006-03-02 セルジーン・コーポレーション 疼痛を治療、改変および管理するための免疫調節化合物の使用方法および組成物
JP2006507325A (ja) * 2002-11-06 2006-03-02 セルジーン・コーポレーション 骨髄増殖性疾患の治療および管理のための免疫調節化合物を含む使用方法および組成物
JP2007513164A (ja) * 2003-12-02 2007-05-24 セルジーン・コーポレーション 異常ヘモグロビン症及び貧血症の治療及び管理のための方法及び組成物

Non-Patent Citations (4)

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JPN6012054646; ＧＯＲＥ，Ｓ．Ｄ．: 'Ｃｏｍｂｉｎａｔｉｏｎ　ｔｈｅｒａｐｙ　ｗｉｔｈ　ＤＮＡ　ｍｅｔｈｙｌｔｒａｎｓｆｅｒａｓｅ　ｉｎｈｉｂｉｔｏｒｓ　ｉｎ　ｈｅｍａｔｏｌｏｇｉｃ　ｍａｌｉｇｎａｎｃｉｅｓ' Ｎａｔ　Ｃｌｉｎ　Ｐｒａｃｔ　Ｏｎｃｏｌ Ｖｏｌ．２　Ｓｕｐｐｌ　１, 2005, ｐ．Ｓ３０-５ *
JPN6012054647; ＭＡＲＩＡＮＮＡ，Ｐ．　ｅｔ　ａｌ: 'Ｖａｌｐｒｏｉｃ　ａｃｉｄ，　ｔｒｉｃｈｏｓｔａｔｉｎ　ａｎｄ　ｔｈｅｉｒ　ｃｏｍｂｉｎａｔｉｏｎ　ｗｉｔｈ　ｈｅｍｉｎ　ｐｒｅｆｅｒｅｎｔｉａｌｌｙ　ｅｎｈａｎｃｅ　ｇａｍｍａ-ｇｌｏｂｉｎ　ｇｅｎ' Ｈａｅｍａｔｏｌｏｇｉｃａ Ｖｏｌ．８６，　Ｎｏ．７, 2001, ｐ．７００-５ *
JPN6012054650; ＤＥ，Ｆ．Ｅ．　ｅｔ　ａｌ: 'Ｈｉｓｔｏｎｅ　ｄｅａｃｅｔｙｌａｓｅ　ｉｎｈｉｂｉｔｏｒ　ｖａｌｐｒｏｉｃ　ａｃｉｄ　ｅｎｈａｎｃｅｓ　ｔｈｅ　ｃｙｔｏｋｉｎｅ-ｉｎｄｕｃｅｄ　ｅｘｐａｎｓｉｏｎ　ｏｆ　ｈｕｍａｎ　ｈｅｍａｔｏｐ' Ｃａｎｃｅｒ　Ｒｅｓ Ｖｏｌ．６５，　Ｎｏ．４, 2005, ｐ．１５０５-１３ *
JPN6012054651; ＢＵＧ，Ｇ．　ｅｔ　ａｌ: 'Ｖａｌｐｒｏｉｃ　ａｃｉｄ　ｓｔｉｍｕｌａｔｅｓ　ｐｒｏｌｉｆｅｒａｔｉｏｎ　ａｎｄ　ｓｅｌｆ-ｒｅｎｅｗａｌ　ｏｆ　ｈｅｍａｔｏｐｏｉｅｔｉｃ　ｓｔｅｍ　ｃｅｌｌｓ' Ｃａｎｃｅｒ　Ｒｅｓ Ｖｏｌ．６５，　Ｎｏ．７, 2005, ｐ．２５３７-４１ *

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2017511132A (ja) * 2014-03-26 2017-04-20 ザ ブリガム アンド ウィメンズ ホスピタル インコーポレイテッドＴｈｅ Ｂｒｉｇｈａｍ ａｎｄ Ｗｏｍｅｎ’ｓ Ｈｏｓｐｉｔａｌ， Ｉｎｃ． ヒト造血幹／前駆細胞のエクスビボ拡大のための組成物および方法
JP2020124212A (ja) * 2014-03-26 2020-08-20 ザ ブリガム アンド ウィメンズ ホスピタル インコーポレイテッドＴｈｅ Ｂｒｉｇｈａｍ ａｎｄ Ｗｏｍｅｎ’ｓ Ｈｏｓｐｉｔａｌ， Ｉｎｃ． ヒト造血幹／前駆細胞のエクスビボ拡大のための組成物および方法

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Publication number Publication date
ZA200809956B (en) 2010-07-28
AU2007267928A1 (en) 2007-12-06
CA2652888A1 (en) 2007-12-06
MX2008014912A (es) 2008-12-10
KR20090014393A (ko) 2009-02-10
IL195412A0 (en) 2009-08-03
EP2023912A2 (en) 2009-02-18
RU2426542C2 (ru) 2011-08-20
WO2007139939A3 (en) 2008-07-03
WO2007139939A2 (en) 2007-12-06
CN101495111A (zh) 2009-07-29
RU2008151713A (ru) 2010-07-10

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