JP2009536828A5 - - Google Patents
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- Publication number
- JP2009536828A5 JP2009536828A5 JP2009510183A JP2009510183A JP2009536828A5 JP 2009536828 A5 JP2009536828 A5 JP 2009536828A5 JP 2009510183 A JP2009510183 A JP 2009510183A JP 2009510183 A JP2009510183 A JP 2009510183A JP 2009536828 A5 JP2009536828 A5 JP 2009536828A5
- Authority
- JP
- Japan
- Prior art keywords
- hla
- patient
- drug
- specimen
- drug side
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 208000030453 Drug-Related Side Effects and Adverse reaction Diseases 0.000 claims description 9
- 206010042033 Stevens-Johnson syndrome Diseases 0.000 claims description 5
- 231100000168 Stevens-Johnson syndrome Toxicity 0.000 claims description 5
- 206010044223 Toxic epidermal necrolysis Diseases 0.000 claims description 3
- 208000032509 Stevens-Johnson syndrome/toxic epidermal necrolysis spectrum Diseases 0.000 claims description 2
- 238000000034 method Methods 0.000 claims 12
- 102000006390 HLA-B Antigens Human genes 0.000 claims 6
- 108010058607 HLA-B Antigens Proteins 0.000 claims 6
- 229940079593 drug Drugs 0.000 claims 4
- 239000003814 drug Substances 0.000 claims 4
- 239000000523 sample Substances 0.000 claims 4
- 239000003795 chemical substances by application Substances 0.000 claims 3
- YFGHCGITMMYXAQ-UHFFFAOYSA-N 2-[(diphenylmethyl)sulfinyl]acetamide Chemical compound C=1C=CC=CC=1C(S(=O)CC(=O)N)C1=CC=CC=C1 YFGHCGITMMYXAQ-UHFFFAOYSA-N 0.000 claims 2
- 206010061623 Adverse drug reaction Diseases 0.000 claims 2
- 108700028369 Alleles Proteins 0.000 claims 2
- 150000001875 compounds Chemical class 0.000 claims 2
- 210000002615 epidermis Anatomy 0.000 claims 2
- 239000002207 metabolite Substances 0.000 claims 2
- 229960001165 modafinil Drugs 0.000 claims 2
- 231100000331 toxic Toxicity 0.000 claims 2
- 230000002588 toxic effect Effects 0.000 claims 2
- AETHRPHBGJAIBT-UHFFFAOYSA-N 1-[3-cyano-4-(2,2-dimethylpropoxy)phenyl]pyrazole-4-carboxylic acid Chemical compound C1=C(C#N)C(OCC(C)(C)C)=CC=C1N1N=CC(C(O)=O)=C1 AETHRPHBGJAIBT-UHFFFAOYSA-N 0.000 claims 1
- 108091034117 Oligonucleotide Proteins 0.000 claims 1
- 239000013614 RNA sample Substances 0.000 claims 1
- 229960003459 allopurinol Drugs 0.000 claims 1
- OFCNXPDARWKPPY-UHFFFAOYSA-N allopurinol Chemical compound OC1=NC=NC2=C1C=NN2 OFCNXPDARWKPPY-UHFFFAOYSA-N 0.000 claims 1
- 229960000623 carbamazepine Drugs 0.000 claims 1
- FFGPTBGBLSHEPO-UHFFFAOYSA-N carbamazepine Chemical compound C1=CC2=CC=CC=C2N(C(=O)N)C2=CC=CC=C21 FFGPTBGBLSHEPO-UHFFFAOYSA-N 0.000 claims 1
- 229960005101 febuxostat Drugs 0.000 claims 1
- BQSJTQLCZDPROO-UHFFFAOYSA-N febuxostat Chemical compound C1=C(C#N)C(OCC(C)C)=CC=C1C1=NC(C)=C(C(O)=O)S1 BQSJTQLCZDPROO-UHFFFAOYSA-N 0.000 claims 1
- 210000004209 hair Anatomy 0.000 claims 1
- 238000009396 hybridization Methods 0.000 claims 1
- 229960001816 oxcarbazepine Drugs 0.000 claims 1
- CTRLABGOLIVAIY-UHFFFAOYSA-N oxcarbazepine Chemical group C1C(=O)C2=CC=CC=C2N(C(=O)N)C2=CC=CC=C21 CTRLABGOLIVAIY-UHFFFAOYSA-N 0.000 claims 1
- HXNFUBHNUDHIGC-UHFFFAOYSA-N oxypurinol Chemical group O=C1NC(=O)N=C2NNC=C21 HXNFUBHNUDHIGC-UHFFFAOYSA-N 0.000 claims 1
- 210000005259 peripheral blood Anatomy 0.000 claims 1
- 239000011886 peripheral blood Substances 0.000 claims 1
- 102000004169 proteins and genes Human genes 0.000 claims 1
- 108090000623 proteins and genes Proteins 0.000 claims 1
- 210000003296 saliva Anatomy 0.000 claims 1
- 210000002966 serum Anatomy 0.000 claims 1
- 210000002700 urine Anatomy 0.000 claims 1
- 206010073508 Drug reaction with eosinophilia and systemic symptoms Diseases 0.000 description 2
- 206010033733 Papule Diseases 0.000 description 1
- 238000003745 diagnosis Methods 0.000 description 1
- 230000000857 drug effect Effects 0.000 description 1
- 238000010197 meta-analysis Methods 0.000 description 1
- 230000002265 prevention Effects 0.000 description 1
- 208000011580 syndromic disease Diseases 0.000 description 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US80012106P | 2006-05-11 | 2006-05-11 | |
| PCT/US2007/068782 WO2007134235A2 (en) | 2006-05-11 | 2007-05-11 | Hla alleles associated with adverse drug reactions and methods for detecting such |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2009536828A JP2009536828A (ja) | 2009-10-22 |
| JP2009536828A5 true JP2009536828A5 (cg-RX-API-DMAC7.html) | 2010-06-24 |
Family
ID=38694734
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009510183A Pending JP2009536828A (ja) | 2006-05-11 | 2007-05-11 | 薬剤副作用に関連したｈｌａアレルおよびその検出方法 |
Country Status (17)
| Country | Link |
|---|---|
| US (2) | US7943309B2 (cg-RX-API-DMAC7.html) |
| EP (1) | EP2016198B1 (cg-RX-API-DMAC7.html) |
| JP (1) | JP2009536828A (cg-RX-API-DMAC7.html) |
| KR (1) | KR101450348B1 (cg-RX-API-DMAC7.html) |
| CN (1) | CN101454462A (cg-RX-API-DMAC7.html) |
| AU (1) | AU2007249225B2 (cg-RX-API-DMAC7.html) |
| BR (1) | BRPI0710436A8 (cg-RX-API-DMAC7.html) |
| CA (1) | CA2651954C (cg-RX-API-DMAC7.html) |
| DK (1) | DK2016198T3 (cg-RX-API-DMAC7.html) |
| ES (1) | ES2422735T3 (cg-RX-API-DMAC7.html) |
| IL (1) | IL194900A (cg-RX-API-DMAC7.html) |
| MY (1) | MY150648A (cg-RX-API-DMAC7.html) |
| NZ (2) | NZ597628A (cg-RX-API-DMAC7.html) |
| PL (1) | PL2016198T3 (cg-RX-API-DMAC7.html) |
| PT (1) | PT2016198E (cg-RX-API-DMAC7.html) |
| TW (1) | TWI335937B (cg-RX-API-DMAC7.html) |
| WO (1) | WO2007134235A2 (cg-RX-API-DMAC7.html) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1536021A1 (en) * | 2003-11-27 | 2005-06-01 | Consortium National de Recherche en Genomique (CNRG) | Method for HLA typing |
| JP5996524B2 (ja) * | 2010-04-12 | 2016-09-21 | アカデミア シニカＡｃａｄｅｍｉａ Ｓｉｎｉｃａ | 薬物有害反応に関連するｈｌａ複合体を同定する方法 |
| EP2723888B1 (en) * | 2011-06-23 | 2017-01-11 | Chang Gung Medical Foundation Chang Gung Memorial Hospital at Keelung | Risk assessment for phenytoin-induced adverse drug reactions |
| CN102296109A (zh) * | 2011-06-30 | 2011-12-28 | 北京思尔成生物技术有限公司 | HLA-B*1502基因的SYBR Green I检测方法及其专用引物与试剂盒 |
| US20150225788A1 (en) | 2011-12-12 | 2015-08-13 | Wen-Hung Chung | Risk assessment for phenytoin-induced adverse drug reactions |
| CN102660635B (zh) * | 2012-01-14 | 2014-03-12 | 长沙三济生物科技有限公司 | 一种定性检测hla-b*1502基因亚型的荧光pcr试剂盒 |
| CN103114138B (zh) * | 2013-01-27 | 2014-12-03 | 复旦大学 | Pcr-ssp法定性检测hla-b*1502基因的方法及临床试剂盒 |
| US10041121B2 (en) * | 2013-09-17 | 2018-08-07 | Agency For Science, Technology And Research | Method for detection of a genetic variant |
| CN104017898B (zh) * | 2014-06-25 | 2016-04-27 | 上海荻硕贝肯生物科技有限公司 | 快速检测hla-b*5801等位基因的引物、试剂盒及方法 |
| CN104232781B (zh) * | 2014-09-26 | 2017-04-19 | 陕西佰美基因股份有限公司 | 一种检测HLA‑B*5801等位基因的TaqMan探针实时荧光PCR方法 |
| CN106119362B (zh) * | 2016-06-30 | 2019-09-10 | 江苏伟禾生物科技有限公司 | 一种用于检测hla-b*1502等位基因的引物组及试剂盒 |
| CN108929902B (zh) * | 2018-07-28 | 2022-03-25 | 北京博奥晶典生物技术有限公司 | 用于检测等位基因hla-b*5801的肽核酸引物组合物、试剂盒及方法 |
| CN109355358A (zh) * | 2018-10-22 | 2019-02-19 | 江苏美因康生物科技有限公司 | 一种快速高效检测药源性皮肤不良反应相关基因多态性的试剂盒及方法 |
| CN109554460B (zh) * | 2018-12-17 | 2022-03-22 | 上海市疾病预防控制中心 | 一种基于hla基因多态性位点预测h7n9易感人群的检测方法及其用途 |
| TWI804620B (zh) * | 2019-05-06 | 2023-06-11 | 長庚醫療財團法人林口長庚紀念醫院 | 評估疾病調節抗風濕藥物引發嚴重皮膚藥物不良反應風險的方法、其檢測套組及其用途 |
| SG11202111473UA (en) * | 2019-05-06 | 2021-11-29 | Chang Gung Memorial Hospital Linkou | Methods for assessing the risk of developing severe cutaneous adverse drug reactions induced by disease-modifying antirheumatic drugs, detection kit thereof and uses thereof |
| CN111620924A (zh) * | 2020-06-04 | 2020-09-04 | 华中农业大学 | 基于天然产物的药物设计方法、五环三萜类化合物、其制备方法及应用 |
| CN113308532A (zh) * | 2021-05-28 | 2021-08-27 | 上海康黎诊断技术有限公司 | 一种用于检测人hla-b*1502基因突变的特异性引物探针组合及其试剂盒，以及方法 |
| WO2023080478A1 (ko) * | 2021-11-02 | 2023-05-11 | 주식회사 랩 지노믹스 | Ｈｌａ－ｂ＊5801 대립유전자 검출용 핵산 분자 및 이를 이용한 방법 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5583238A (en) * | 1990-11-19 | 1996-12-10 | G. D. Searle & Co. | Method for making intermediates useful in synthesis of retroviral protease inhibitors |
| WO1994021818A1 (en) | 1993-03-18 | 1994-09-29 | N.V. Innogenetics S.A. | Process for typing hla-b using specific primers and probes sets |
| US5550039A (en) | 1995-03-07 | 1996-08-27 | Hoffmann-La Roche Inc. | Oligonucleotide primers for HLA class I B locus DNA typing |
| US6583139B1 (en) | 1997-07-31 | 2003-06-24 | Eugene D. Thorsett | Compounds which inhibit leukocyte adhesion mediated by VLA-4 |
| WO2004071152A2 (en) * | 2003-02-17 | 2004-08-26 | Novartis Ag | Use of s-10 hydroxy-10, 11-dihydro-carbamazepine for the treatment of anxiety and bipolar disorders |
| US7470513B2 (en) * | 2003-11-10 | 2008-12-30 | Academia Sinica | Risk assessment for adverse drug reactions |
-
2007
- 2007-05-11 NZ NZ597628A patent/NZ597628A/xx not_active IP Right Cessation
- 2007-05-11 BR BRPI0710436A patent/BRPI0710436A8/pt not_active Application Discontinuation
- 2007-05-11 PT PT77974327T patent/PT2016198E/pt unknown
- 2007-05-11 JP JP2009510183A patent/JP2009536828A/ja active Pending
- 2007-05-11 MY MYPI20084331 patent/MY150648A/en unknown
- 2007-05-11 EP EP07797432.7A patent/EP2016198B1/en not_active Revoked
- 2007-05-11 TW TW096116910A patent/TWI335937B/zh active
- 2007-05-11 PL PL07797432T patent/PL2016198T3/pl unknown
- 2007-05-11 NZ NZ572259A patent/NZ572259A/en not_active IP Right Cessation
- 2007-05-11 AU AU2007249225A patent/AU2007249225B2/en not_active Ceased
- 2007-05-11 CN CNA2007800170212A patent/CN101454462A/zh active Pending
- 2007-05-11 US US11/747,674 patent/US7943309B2/en active Active
- 2007-05-11 KR KR1020087027562A patent/KR101450348B1/ko active Active
- 2007-05-11 DK DK07797432.7T patent/DK2016198T3/da active
- 2007-05-11 CA CA2651954A patent/CA2651954C/en active Active
- 2007-05-11 WO PCT/US2007/068782 patent/WO2007134235A2/en not_active Ceased
- 2007-05-11 ES ES07797432T patent/ES2422735T3/es active Active
-
2008
- 2008-10-23 IL IL194900A patent/IL194900A/en active IP Right Grant
-
2011
- 2011-05-04 US US13/100,665 patent/US8142999B2/en active Active
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