JP2009536159A5 - - Google Patents
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- Publication number
- JP2009536159A5 JP2009536159A5 JP2009506531A JP2009506531A JP2009536159A5 JP 2009536159 A5 JP2009536159 A5 JP 2009536159A5 JP 2009506531 A JP2009506531 A JP 2009506531A JP 2009506531 A JP2009506531 A JP 2009506531A JP 2009536159 A5 JP2009536159 A5 JP 2009536159A5
- Authority
- JP
- Japan
- Prior art keywords
- poly
- diol
- polymer
- amide
- ester amide
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- -1 poly (ester amide Chemical class 0.000 claims 10
- 229920000642 polymer Polymers 0.000 claims 10
- 239000002253 acid Substances 0.000 claims 6
- 239000007795 chemical reaction product Substances 0.000 claims 4
- 239000003814 drug Substances 0.000 claims 4
- 150000001413 amino acids Chemical class 0.000 claims 3
- 150000002009 diols Chemical class 0.000 claims 3
- 239000002904 solvent Substances 0.000 claims 3
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 2
- 239000000470 constituent Substances 0.000 claims 1
- 239000012528 membrane Substances 0.000 claims 1
Claims (3)
- （ｉ）二塩基酸とジオールと第１アミノ酸との反応生成物を含む第１ポリ（エステルアミド）ポリマー及び（ii）アミドジオールと二塩基酸との反応生成物を塩基性構成成分として含む第２ポリ（エステルアミド）ポリマーとから成る群より選択されるポリマーと、 治療薬と、
少なくとも一部が水混和性の溶媒と、
を含むことを特徴とする組成物。 - （ａ）（ｉ）二塩基酸とジオールと第１アミノ酸との反応生成物を含む第１ポリ（エステルアミド）ポリマー、及び（ii）アミドジオールと二塩基酸との反応生成物を含む第２ポリ（エステルアミド）ポリマーから成る群より選択されるポリマーと、
（ｂ）治療薬と、
（ｃ）少なくとも一部が水混和性の溶媒と
を含む組成物を生理学上の環境へデリバリするステップと、
前記ポリ（エステルアミド）ポリマーを含む膜を形成するために前記組成物を相分離させるステップと、
から成り、前記治療薬は前記膜内に含有されていることを特徴とする方法。 - シリンジと、
（ａ）（ｉ）二塩基酸とジオールと第１アミノ酸とを含む第１ポリ（エステルアミド）ポリマー、及び（ii）アミドジオールと二塩基酸とを含む第２ポリ（エステルアミド）ポリマーから成る群より選択されるポリマーと、（ｂ）治療薬と、（ｃ）溶媒とを含む組成物と、
から構成され、前記組成物は前記シリンジ内に収容されていることを特徴とするキット。
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US11/405,976 US8658210B2 (en) | 2006-04-17 | 2006-04-17 | Polyesteramide platform for site specific drug delivery |
| US11/405,976 | 2006-04-17 | ||
| PCT/US2007/009290 WO2007123872A2 (en) | 2006-04-17 | 2007-04-13 | Polyesteramide platform for site specific drug delivery |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2009536159A JP2009536159A (ja) | 2009-10-08 |
| JP2009536159A5 true JP2009536159A5 (ja) | 2010-06-03 |
| JP5443159B2 JP5443159B2 (ja) | 2014-03-19 |
Family
ID=38605110
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009506531A Expired - Fee Related JP5443159B2 (ja) | 2006-04-17 | 2007-04-13 | 部位特異的ドラッグデリバリのためのポリエステルアミドプラットフォーム |
Country Status (4)
| Country | Link |
|---|---|
| US (4) | US8658210B2 (ja) |
| EP (1) | EP2010142A2 (ja) |
| JP (1) | JP5443159B2 (ja) |
| WO (1) | WO2007123872A2 (ja) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7910152B2 (en) | 2006-02-28 | 2011-03-22 | Advanced Cardiovascular Systems, Inc. | Poly(ester amide)-based drug delivery systems with controlled release rate and morphology |
| US8367108B2 (en) * | 2006-09-01 | 2013-02-05 | Bezwada Biomedical, Llc | Functionalized non-phenolic amino acids and absorbable polymers therefrom |
| US20080200377A1 (en) * | 2007-02-16 | 2008-08-21 | Trollsas Mikael O | Polymer particles |
| US8252361B2 (en) | 2007-06-05 | 2012-08-28 | Abbott Cardiovascular Systems Inc. | Implantable medical devices for local and regional treatment |
| WO2009073814A2 (en) * | 2007-12-06 | 2009-06-11 | Medivas, Llc | Oligo-ethylene glycol-based polymer compositions and methods of use |
| CA2833960C (en) | 2008-09-22 | 2015-12-22 | Tyrx, Inc. | Linear polyesteramides from aminophenolic esters |
| EP2334343A1 (en) * | 2008-10-15 | 2011-06-22 | Medivas, LLC | Biodegradable proline-based polymers |
| US9839628B2 (en) | 2009-06-01 | 2017-12-12 | Tyrx, Inc. | Compositions and methods for preventing sternal wound infections |
| CN102094066B (zh) * | 2010-12-13 | 2013-07-31 | 华南农业大学 | 一种筛选ε-聚赖氨酸产生菌的方法 |
| KR101390589B1 (ko) | 2012-05-30 | 2014-04-30 | 가천대학교 산학협력단 | 다이아민을 포함하는 당뇨병의 예방 또는 치료용 조성물 |
| EP2784101A1 (en) * | 2013-03-28 | 2014-10-01 | Nitto Europe N.V | Hydroxyphenyl functionalized poly(ester amide) |
| CN104448300B (zh) * | 2014-12-09 | 2017-01-11 | 西安医学院 | 低分子量l-聚谷氨酸-丝裂霉素c及其合成方法和应用 |
| WO2017106333A1 (en) * | 2015-12-14 | 2017-06-22 | University Of Pittsburgh-Of The Commonwealth System Of Higher Education | Complex coacervate for controlled release and related methods |
| US11298423B2 (en) | 2016-03-04 | 2022-04-12 | University of Pittsburgh—of the Commonwealth System of Higher Education | Protection and delivery of multiple therapeutic proteins |
| CN108743972A (zh) * | 2018-06-21 | 2018-11-06 | 东华大学 | 一种氨基酸基聚酯胺胶束、制备方法及其应用 |
| CN110652502A (zh) * | 2018-06-28 | 2020-01-07 | 复旦大学 | 一种靶向治疗类风湿关节炎的药物组合物 |
| CN113318264A (zh) * | 2021-05-28 | 2021-08-31 | 瑞聚再生(厦门)医学科技有限公司 | 一种可降解聚氨酯生物材料及其制备方法和应用 |
| CN115381851B (zh) * | 2022-07-06 | 2023-12-19 | 重庆市妇幼保健院(重庆市妇产科医院、重庆市遗传与生殖研究所) | 一种自组装纳米抗凝、溶栓药物、其制备方法及应用 |
Family Cites Families (30)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5324519A (en) * | 1989-07-24 | 1994-06-28 | Atrix Laboratories, Inc. | Biodegradable polymer composition |
| WO1995027481A1 (en) | 1994-04-08 | 1995-10-19 | Atrix Laboratories, Inc. | Liquid delivery compositions |
| US5684889A (en) * | 1995-04-28 | 1997-11-04 | Sloan-Kettering Institute For Cancer Research | Parametric image representation of imaging agent kinetics |
| WO1998032398A1 (en) | 1997-01-28 | 1998-07-30 | United States Surgical Corporation | Polyesteramide, its preparation and surgical devices fabricated therefrom |
| US20040009229A1 (en) | 2000-01-05 | 2004-01-15 | Unger Evan Charles | Stabilized nanoparticle formulations of camptotheca derivatives |
| US6703040B2 (en) | 2000-01-11 | 2004-03-09 | Intralytix, Inc. | Polymer blends as biodegradable matrices for preparing biocomposites |
| US6585716B2 (en) | 2000-04-05 | 2003-07-01 | Biocardia, Inc. | Method of treating the heart |
| US6503538B1 (en) | 2000-08-30 | 2003-01-07 | Cornell Research Foundation, Inc. | Elastomeric functional biodegradable copolyester amides and copolyester urethanes |
| US20060177416A1 (en) | 2003-10-14 | 2006-08-10 | Medivas, Llc | Polymer particle delivery compositions and methods of use |
| US6720007B2 (en) * | 2000-10-25 | 2004-04-13 | Tufts University | Polymeric microspheres |
| US20060286063A1 (en) * | 2000-11-06 | 2006-12-21 | Afmedica, Inc. | Combination drug therapy for reducing scar tissue formation |
| US20030049320A1 (en) | 2000-12-18 | 2003-03-13 | Wockhardt Limited | Novel in-situ forming controlled release microcarrier delivery system |
| US6692466B1 (en) | 2000-12-21 | 2004-02-17 | Advanced Cardiovascular Systems, Inc. | Drug delivery catheter with retractable needle |
| AR039729A1 (es) | 2002-06-25 | 2005-03-09 | Alza Corp | Formulaciones de deposito de corta duracion |
| US20040170685A1 (en) | 2003-02-26 | 2004-09-02 | Medivas, Llc | Bioactive stents and methods for use thereof |
| WO2005020933A2 (en) | 2003-09-02 | 2005-03-10 | University Of South Florida | Nanoparticles for drug-delivery |
| US7311901B2 (en) | 2003-10-10 | 2007-12-25 | Samyang Corporation | Amphiphilic block copolymer and polymeric composition comprising the same for drug delivery |
| US7220816B2 (en) | 2003-12-16 | 2007-05-22 | Advanced Cardiovascular Systems, Inc. | Biologically absorbable coatings for implantable devices based on poly(ester amides) and methods for fabricating the same |
| US7273469B1 (en) | 2003-12-31 | 2007-09-25 | Advanced Cardiovascular Systems, Inc. | Modified needle catheter for directional orientation delivery |
| US8685431B2 (en) | 2004-03-16 | 2014-04-01 | Advanced Cardiovascular Systems, Inc. | Biologically absorbable coatings for implantable devices based on copolymers having ester bonds and methods for fabricating the same |
| US20050265960A1 (en) * | 2004-05-26 | 2005-12-01 | Pacetti Stephen D | Polymers containing poly(ester amides) and agents for use with medical articles and methods of fabricating the same |
| GB0412866D0 (en) | 2004-06-09 | 2004-07-14 | Novartis Ag | Organic compounds |
| US20060034889A1 (en) | 2004-08-16 | 2006-02-16 | Macromed, Inc. | Biodegradable diblock copolymers having reverse thermal gelation properties and methods of use thereof |
| US7166680B2 (en) * | 2004-10-06 | 2007-01-23 | Advanced Cardiovascular Systems, Inc. | Blends of poly(ester amide) polymers |
| US8609123B2 (en) | 2004-11-29 | 2013-12-17 | Advanced Cardiovascular Systems, Inc. | Derivatized poly(ester amide) as a biobeneficial coating |
| AU2006214655A1 (en) | 2005-02-17 | 2006-08-24 | Medivas, Llc. | Polymer particle delivery compositions and methods of use |
| JP5305135B2 (ja) | 2008-08-05 | 2013-10-02 | 株式会社リコー | 潤滑剤薄膜化装置、並びに、これを備える画像形成装置及びプロセスカートリッジ |
| US20140105957A1 (en) | 2011-05-02 | 2014-04-17 | Dsm Ip Assets B.V. | Bis-(alpha-amino-diol-diester) containing polyesteramide for ophtamology |
| WO2012150265A1 (en) | 2011-05-02 | 2012-11-08 | Dsm Ip Assets B.V. | Fiber comprising a biodegradable polymer |
| EP3159368A1 (en) | 2011-06-23 | 2017-04-26 | DSM IP Assets B.V. | New biodegradable polyesteramide copolymers for drug delivery |
-
2006
- 2006-04-17 US US11/405,976 patent/US8658210B2/en not_active Expired - Fee Related
-
2007
- 2007-04-13 EP EP07755524A patent/EP2010142A2/en not_active Withdrawn
- 2007-04-13 WO PCT/US2007/009290 patent/WO2007123872A2/en active Application Filing
- 2007-04-13 JP JP2009506531A patent/JP5443159B2/ja not_active Expired - Fee Related
-
2014
- 2014-01-07 US US14/149,533 patent/US8865148B2/en not_active Expired - Fee Related
- 2014-09-22 US US14/493,197 patent/US9095619B2/en not_active Expired - Fee Related
-
2015
- 2015-06-25 US US14/750,732 patent/US9603943B2/en not_active Expired - Fee Related
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