JP2009535644A - バイオマーカーを使用して疾患状況を同定するための方法および装置 - Google Patents
バイオマーカーを使用して疾患状況を同定するための方法および装置 Download PDFInfo
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- JP2009535644A JP2009535644A JP2009509959A JP2009509959A JP2009535644A JP 2009535644 A JP2009535644 A JP 2009535644A JP 2009509959 A JP2009509959 A JP 2009509959A JP 2009509959 A JP2009509959 A JP 2009509959A JP 2009535644 A JP2009535644 A JP 2009535644A
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| PCT/US2007/067418 WO2007130831A2 (en) | 2006-05-01 | 2007-04-25 | Methods and apparatus for identifying disease status using biomarkers |
Publications (2)
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| JP2009535644A true JP2009535644A (ja) | 2009-10-01 |
| JP2009535644A5 JP2009535644A5 (enExample) | 2011-06-30 |
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| US (5) | US20070255113A1 (enExample) |
| EP (2) | EP2016405B1 (enExample) |
| JP (1) | JP2009535644A (enExample) |
| KR (1) | KR20090024686A (enExample) |
| CN (1) | CN101479599A (enExample) |
| AU (1) | AU2007248299A1 (enExample) |
| BR (1) | BRPI0711148A2 (enExample) |
| CA (1) | CA2650872C (enExample) |
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| WO (1) | WO2007130831A2 (enExample) |
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Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2014121323A (ja) * | 2012-12-21 | 2014-07-03 | Stembios Technologies Inc | 幹細胞による行為効果を評価する方法 |
| JP2017516085A (ja) * | 2014-04-08 | 2017-06-15 | メタボルン インコーポレーティッド | 疾患診断および健康評価のための個々の対象の低分子生化学プロファイリングの方法 |
| US10143710B2 (en) | 2010-08-04 | 2018-12-04 | StemBios Technologies, Inc. | Somatic stem cells |
| US11492592B2 (en) | 2012-12-06 | 2022-11-08 | StemBios Technologies, Inc. | Lgr5+ somatic stem cells |
| JP2023086821A (ja) * | 2016-01-22 | 2023-06-22 | オートレイシーズ,インク. | 疾患診断を改善するシステム及び方法 |
| JP2023156388A (ja) * | 2013-03-14 | 2023-10-24 | オートレイシーズ・インコーポレイテッド | 測定分析物を使用する、疾患診断を改善するための方法 |
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| US8158374B1 (en) | 2006-09-05 | 2012-04-17 | Ridge Diagnostics, Inc. | Quantitative diagnostic methods using multiple parameters |
| US20090047694A1 (en) * | 2007-08-17 | 2009-02-19 | Shuber Anthony P | Clinical Intervention Directed Diagnostic Methods |
| US8431367B2 (en) | 2007-09-14 | 2013-04-30 | Predictive Biosciences Corporation | Detection of nucleic acids and proteins |
| US20090075266A1 (en) * | 2007-09-14 | 2009-03-19 | Predictive Biosciences Corporation | Multiple analyte diagnostic readout |
| US20100267041A1 (en) * | 2007-09-14 | 2010-10-21 | Predictive Biosciences, Inc. | Serial analysis of biomarkers for disease diagnosis |
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| EP2329260A4 (en) * | 2008-03-04 | 2011-08-03 | Ridge Diagnostics Inc | DIAGNOSIS AND MONITORING OF DEPRESSIVE DISORDERS BASED ON A PLURALITY OF BIOMARKER PANELS |
| JP5658571B2 (ja) * | 2008-03-12 | 2015-01-28 | リッジ ダイアグノスティックス,インコーポレイテッド | うつ障害をモニタリングするための炎症バイオマーカー |
| US20140342381A1 (en) * | 2008-08-11 | 2014-11-20 | Banyan Biomarkers, Inc. | Devices and methods for biomarker detection process and assay of neurological condition |
| JP5781436B2 (ja) | 2008-08-11 | 2015-09-24 | バンヤン・バイオマーカーズ・インコーポレーテッド | 神経学的状態のバイオマーカー検出方法およびアッセイ |
| WO2010059709A2 (en) | 2008-11-18 | 2010-05-27 | Ridge Diagnostics, Inc. | Metabolic syndrome and hpa axis biomarkers for major depressive disorder |
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| JP6075973B2 (ja) * | 2012-06-04 | 2017-02-08 | 富士通株式会社 | 健康状態判定装置およびその作動方法 |
| EP2684513A1 (en) * | 2012-07-13 | 2014-01-15 | Universite D'angers | Method for providing reliable non-invasive diagnostic tests |
| US20140275294A1 (en) * | 2013-03-15 | 2014-09-18 | Banyan Biomarkers, Inc. | Devices and methods for biomarker detection process and assay of liver injury |
| CN103279655A (zh) * | 2013-05-20 | 2013-09-04 | 浙江大学 | 一种恶性肿瘤放化疗规范符合度的评估方法 |
| AU2014268417A1 (en) | 2013-05-23 | 2015-11-26 | Iphenotype Llc | Methods and systems for assisting persons, product providers and/or service providers |
| WO2014201516A2 (en) | 2013-06-20 | 2014-12-24 | Immunexpress Pty Ltd | Biomarker identification |
| JP6703479B2 (ja) | 2013-12-16 | 2020-06-03 | フィリップ モリス プロダクツ エス アー | 個人の喫煙ステータスを予測するためのシステムおよび方法 |
| EP3103046B1 (en) | 2014-02-06 | 2020-03-25 | Immunexpress Pty Ltd | Biomarker signature method, and apparatus and kits therefor |
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| US10525020B2 (en) | 2015-02-11 | 2020-01-07 | Laboratory Corporation Of America Holdings | Metabolic markers of attention deficit hyperactivity disorder |
| AU2016267392B2 (en) * | 2015-05-28 | 2021-12-09 | Immunexpress Pty Ltd | Validating biomarker measurement |
| US11594311B1 (en) | 2016-03-31 | 2023-02-28 | OM1, Inc. | Health care information system providing standardized outcome scores across patients |
| US11957897B2 (en) | 2016-04-22 | 2024-04-16 | Newton Howard | Biological co-processor (BCP) |
| CN110366558A (zh) | 2016-10-28 | 2019-10-22 | 班扬生物标记公司 | 针对泛素c末端水解酶l1(uch-l1)和胶质纤维酸性蛋白(gfap)的抗体及相关方法 |
| WO2019183052A1 (en) * | 2018-03-19 | 2019-09-26 | Sri International | Methods and systems for biomarker analysis |
| US20190302119A1 (en) * | 2018-03-27 | 2019-10-03 | Lawrence Abraham | Cancer Diagnostic Metastasis Panel |
| US11967428B1 (en) * | 2018-04-17 | 2024-04-23 | OM1, Inc. | Applying predictive models to data representing a history of events |
| CA3003032A1 (en) * | 2018-04-27 | 2019-10-27 | Nanostics Inc. | Methods of diagnosing disease using microflow cytometry |
| LU100835B1 (en) * | 2018-06-13 | 2019-12-13 | Univ Muenster Westfaelische Wilhelms | Novel biomarkers for recurrent tonsillitis |
| US11862346B1 (en) | 2018-12-22 | 2024-01-02 | OM1, Inc. | Identification of patient sub-cohorts and corresponding quantitative definitions of subtypes as a classification system for medical conditions |
| EP3935581A4 (en) | 2019-03-04 | 2022-11-30 | Iocurrents, Inc. | DATA COMPRESSION AND COMMUNICATION USING MACHINE LEARNING |
| US20200395097A1 (en) * | 2019-05-30 | 2020-12-17 | Tempus Labs, Inc. | Pan-cancer model to predict the pd-l1 status of a cancer cell sample using rna expression data and other patient data |
| TWI740647B (zh) * | 2020-09-15 | 2021-09-21 | 宏碁股份有限公司 | 疾病分類方法及疾病分類裝置 |
| US20220223231A1 (en) * | 2021-01-14 | 2022-07-14 | The Board Of Trustees Of The Leland Stanford Junior University | Systems and Methods for Improved Prognostics in Medical Imaging |
| KR102671925B1 (ko) * | 2022-03-03 | 2024-06-03 | 인제대학교 산학협력단 | 파킨슨병 진단 방법 및 그 시스템 |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6197532B1 (en) * | 1998-01-22 | 2001-03-06 | Board Of Supervisors Of Louisiana State University And Agricultural And Mechanical College | Diagnosis and detection of breast cancer and other cancers |
| US6882990B1 (en) * | 1999-05-01 | 2005-04-19 | Biowulf Technologies, Llc | Methods of identifying biological patterns using multiple data sets |
| US20020115070A1 (en) * | 1999-03-15 | 2002-08-22 | Pablo Tamayo | Methods and apparatus for analyzing gene expression data |
| US6647341B1 (en) * | 1999-04-09 | 2003-11-11 | Whitehead Institute For Biomedical Research | Methods for classifying samples and ascertaining previously unknown classes |
| US6750013B2 (en) * | 1999-12-02 | 2004-06-15 | Protein Design Labs, Inc. | Methods for detection and diagnosing of breast cancer |
| AU2002339841A1 (en) * | 2001-07-13 | 2003-01-29 | Dana-Farber Cancer Institute, Inc. | Leukemogenic transcription factors |
| WO2003041562A2 (en) * | 2001-11-14 | 2003-05-22 | Whitehead Institute For Biomedical Research | Molecular cancer diagnosis using tumor gene expression signature |
| US6949342B2 (en) * | 2001-12-21 | 2005-09-27 | Whitehead Institute For Biomedical Research | Prostate cancer diagnosis and outcome prediction by expression analysis |
| CA2499636A1 (en) * | 2002-04-01 | 2003-10-16 | Phase-1 Molecular Toxicology, Inc. | Liver necrosis predictive genes |
| US20050176057A1 (en) * | 2003-09-26 | 2005-08-11 | Troy Bremer | Diagnostic markers of mood disorders and methods of use thereof |
-
2006
- 2006-05-01 US US11/381,104 patent/US20070255113A1/en not_active Abandoned
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- 2007-02-28 US US11/679,960 patent/US20070254369A1/en not_active Abandoned
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| US10143710B2 (en) | 2010-08-04 | 2018-12-04 | StemBios Technologies, Inc. | Somatic stem cells |
| US11492592B2 (en) | 2012-12-06 | 2022-11-08 | StemBios Technologies, Inc. | Lgr5+ somatic stem cells |
| JP2014121323A (ja) * | 2012-12-21 | 2014-07-03 | Stembios Technologies Inc | 幹細胞による行為効果を評価する方法 |
| JP2023156388A (ja) * | 2013-03-14 | 2023-10-24 | オートレイシーズ・インコーポレイテッド | 測定分析物を使用する、疾患診断を改善するための方法 |
| JP7603115B2 (ja) | 2013-03-14 | 2024-12-19 | オートレイシーズ・インコーポレイテッド | 測定分析物を使用する、疾患診断を改善するための方法 |
| JP2017516085A (ja) * | 2014-04-08 | 2017-06-15 | メタボルン インコーポレーティッド | 疾患診断および健康評価のための個々の対象の低分子生化学プロファイリングの方法 |
| JP2023086821A (ja) * | 2016-01-22 | 2023-06-22 | オートレイシーズ,インク. | 疾患診断を改善するシステム及び方法 |
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| AU2007248299A1 (en) | 2007-11-15 |
| US20210041440A1 (en) | 2021-02-11 |
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| EP2016405B1 (en) | 2017-09-27 |
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| EP2016405A4 (en) | 2012-10-03 |
| CA2650872C (en) | 2018-04-24 |
| EP2016405A2 (en) | 2009-01-21 |
| CN101479599A (zh) | 2009-07-08 |
| WO2007130831A3 (en) | 2008-10-30 |
| MX2008013978A (es) | 2009-02-19 |
| US20110077931A1 (en) | 2011-03-31 |
| CA2650872A1 (en) | 2007-11-15 |
| EP3318995A1 (en) | 2018-05-09 |
| ZA200809968B (en) | 2009-08-26 |
| RU2008147223A (ru) | 2010-06-10 |
| US20130060549A1 (en) | 2013-03-07 |
| WO2007130831A2 (en) | 2007-11-15 |
| BRPI0711148A2 (pt) | 2011-08-23 |
| US20070255113A1 (en) | 2007-11-01 |
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