MX2008013978A - Metodos y aparatos para identificar el estado de enfermedades utilizando biomarcadores. - Google Patents
Metodos y aparatos para identificar el estado de enfermedades utilizando biomarcadores.Info
- Publication number
- MX2008013978A MX2008013978A MX2008013978A MX2008013978A MX2008013978A MX 2008013978 A MX2008013978 A MX 2008013978A MX 2008013978 A MX2008013978 A MX 2008013978A MX 2008013978 A MX2008013978 A MX 2008013978A MX 2008013978 A MX2008013978 A MX 2008013978A
- Authority
- MX
- Mexico
- Prior art keywords
- data
- biomarker
- condition
- biomarkers
- biomarker data
- Prior art date
Links
- 239000000090 biomarker Substances 0.000 title claims abstract description 445
- 201000010099 disease Diseases 0.000 title claims abstract description 168
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 title claims abstract description 168
- 238000000034 method Methods 0.000 title claims abstract description 73
- 238000013179 statistical model Methods 0.000 claims abstract description 20
- 238000004458 analytical method Methods 0.000 claims description 126
- 238000009826 distribution Methods 0.000 claims description 37
- 230000001186 cumulative effect Effects 0.000 claims description 16
- 230000002829 reductive effect Effects 0.000 claims description 12
- 230000001419 dependent effect Effects 0.000 claims description 8
- 238000004590 computer program Methods 0.000 claims description 6
- 238000011156 evaluation Methods 0.000 claims description 5
- 238000004364 calculation method Methods 0.000 claims description 2
- 239000002131 composite material Substances 0.000 abstract description 18
- 230000008569 process Effects 0.000 description 23
- 206010006187 Breast cancer Diseases 0.000 description 15
- 208000026310 Breast neoplasm Diseases 0.000 description 15
- 102000004890 Interleukin-8 Human genes 0.000 description 13
- 108090001007 Interleukin-8 Proteins 0.000 description 13
- 238000003745 diagnosis Methods 0.000 description 13
- 229940096397 interleukin-8 Drugs 0.000 description 13
- XKTZWUACRZHVAN-VADRZIEHSA-N interleukin-8 Chemical compound C([C@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC=1C2=CC=CC=C2NC=1)NC(=O)[C@@H](NC(C)=O)CCSC)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H]([C@@H](C)O)C(=O)NCC(=O)N[C@@H](CCSC)C(=O)N1[C@H](CCC1)C(=O)N1[C@H](CCC1)C(=O)N[C@@H](C)C(=O)N[C@H](CC(O)=O)C(=O)N[C@H](CCC(O)=O)C(=O)N[C@H](CC(O)=O)C(=O)N[C@H](CC=1C=CC(O)=CC=1)C(=O)N[C@H](CO)C(=O)N1[C@H](CCC1)C(N)=O)C1=CC=CC=C1 XKTZWUACRZHVAN-VADRZIEHSA-N 0.000 description 13
- 108060008682 Tumor Necrosis Factor Proteins 0.000 description 12
- 102000005789 Vascular Endothelial Growth Factors Human genes 0.000 description 12
- 108010019530 Vascular Endothelial Growth Factors Proteins 0.000 description 12
- 230000006870 function Effects 0.000 description 12
- 102100021315 Rab11 family-interacting protein 1 Human genes 0.000 description 10
- 101800000836 Red carotenoid-binding protein Proteins 0.000 description 10
- 102100040247 Tumor necrosis factor Human genes 0.000 description 10
- 102000004889 Interleukin-6 Human genes 0.000 description 9
- 108090001005 Interleukin-6 Proteins 0.000 description 9
- 229940100601 interleukin-6 Drugs 0.000 description 9
- 238000012360 testing method Methods 0.000 description 9
- 239000000523 sample Substances 0.000 description 8
- 238000002965 ELISA Methods 0.000 description 7
- 239000012472 biological sample Substances 0.000 description 7
- 238000012545 processing Methods 0.000 description 7
- 239000003550 marker Substances 0.000 description 6
- 230000035945 sensitivity Effects 0.000 description 5
- 239000003814 drug Substances 0.000 description 4
- 230000000694 effects Effects 0.000 description 4
- 238000005259 measurement Methods 0.000 description 4
- 238000000611 regression analysis Methods 0.000 description 4
- 230000001105 regulatory effect Effects 0.000 description 4
- 208000024827 Alzheimer disease Diseases 0.000 description 3
- 210000004369 blood Anatomy 0.000 description 3
- 239000008280 blood Substances 0.000 description 3
- 210000000481 breast Anatomy 0.000 description 3
- 229940079593 drug Drugs 0.000 description 3
- 230000003993 interaction Effects 0.000 description 3
- 238000012417 linear regression Methods 0.000 description 3
- 238000012986 modification Methods 0.000 description 3
- 230000004048 modification Effects 0.000 description 3
- 230000008520 organization Effects 0.000 description 3
- 238000007619 statistical method Methods 0.000 description 3
- 210000001519 tissue Anatomy 0.000 description 3
- AUNGANRZJHBGPY-SCRDCRAPSA-N Riboflavin Chemical compound OC[C@@H](O)[C@@H](O)[C@@H](O)CN1C=2C=C(C)C(C)=CC=2N=C2C1=NC(=O)NC2=O AUNGANRZJHBGPY-SCRDCRAPSA-N 0.000 description 2
- NKANXQFJJICGDU-QPLCGJKRSA-N Tamoxifen Chemical compound C=1C=CC=CC=1C(/CC)=C(C=1C=CC(OCCN(C)C)=CC=1)/C1=CC=CC=C1 NKANXQFJJICGDU-QPLCGJKRSA-N 0.000 description 2
- 102000000852 Tumor Necrosis Factor-alpha Human genes 0.000 description 2
- 238000013459 approach Methods 0.000 description 2
- 238000003556 assay Methods 0.000 description 2
- 238000007796 conventional method Methods 0.000 description 2
- 238000011161 development Methods 0.000 description 2
- 230000018109 developmental process Effects 0.000 description 2
- 238000007477 logistic regression Methods 0.000 description 2
- 230000000873 masking effect Effects 0.000 description 2
- 230000009245 menopause Effects 0.000 description 2
- 238000003127 radioimmunoassay Methods 0.000 description 2
- 230000000717 retained effect Effects 0.000 description 2
- 210000002966 serum Anatomy 0.000 description 2
- LDQKDRLEMKIYMC-XMMPIXPASA-N (3R)-1'-(9-anthrylcarbonyl)-3-(morpholin-4-ylcarbonyl)-1,4'-bipiperidine Chemical compound O=C([C@H]1CN(CCC1)C1CCN(CC1)C(=O)C=1C2=CC=CC=C2C=C2C=CC=CC2=1)N1CCOCC1 LDQKDRLEMKIYMC-XMMPIXPASA-N 0.000 description 1
- MZOFCQQQCNRIBI-VMXHOPILSA-N (3s)-4-[[(2s)-1-[[(2s)-1-[[(1s)-1-carboxy-2-hydroxyethyl]amino]-4-methyl-1-oxopentan-2-yl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-3-[[2-[[(2s)-2,6-diaminohexanoyl]amino]acetyl]amino]-4-oxobutanoic acid Chemical compound OC[C@@H](C(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(O)=O)NC(=O)CNC(=O)[C@@H](N)CCCCN MZOFCQQQCNRIBI-VMXHOPILSA-N 0.000 description 1
- 238000012935 Averaging Methods 0.000 description 1
- 108090000201 Carboxypeptidase B2 Proteins 0.000 description 1
- AUNGANRZJHBGPY-UHFFFAOYSA-N D-Lyxoflavin Natural products OCC(O)C(O)C(O)CN1C=2C=C(C)C(C)=CC=2N=C2C1=NC(=O)NC2=O AUNGANRZJHBGPY-UHFFFAOYSA-N 0.000 description 1
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 1
- 102100023897 NADPH-cytochrome P450 reductase Human genes 0.000 description 1
- 206010028980 Neoplasm Diseases 0.000 description 1
- 241000208125 Nicotiana Species 0.000 description 1
- 235000002637 Nicotiana tabacum Nutrition 0.000 description 1
- 230000002159 abnormal effect Effects 0.000 description 1
- 238000007792 addition Methods 0.000 description 1
- 230000002411 adverse Effects 0.000 description 1
- 239000000427 antigen Substances 0.000 description 1
- 102000036639 antigens Human genes 0.000 description 1
- 108091007433 antigens Proteins 0.000 description 1
- 238000003149 assay kit Methods 0.000 description 1
- 230000006399 behavior Effects 0.000 description 1
- 230000003542 behavioural effect Effects 0.000 description 1
- 239000012620 biological material Substances 0.000 description 1
- 230000031018 biological processes and functions Effects 0.000 description 1
- 239000000091 biomarker candidate Substances 0.000 description 1
- 238000001574 biopsy Methods 0.000 description 1
- 239000000872 buffer Substances 0.000 description 1
- 238000004422 calculation algorithm Methods 0.000 description 1
- 201000011510 cancer Diseases 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 238000003759 clinical diagnosis Methods 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 230000001276 controlling effect Effects 0.000 description 1
- 230000008878 coupling Effects 0.000 description 1
- 238000010168 coupling process Methods 0.000 description 1
- 238000005859 coupling reaction Methods 0.000 description 1
- 230000006378 damage Effects 0.000 description 1
- 238000007405 data analysis Methods 0.000 description 1
- 238000013479 data entry Methods 0.000 description 1
- 238000001514 detection method Methods 0.000 description 1
- 238000010586 diagram Methods 0.000 description 1
- -1 elements Substances 0.000 description 1
- 230000003511 endothelial effect Effects 0.000 description 1
- 238000009164 estrogen replacement therapy Methods 0.000 description 1
- 238000000605 extraction Methods 0.000 description 1
- 230000035558 fertility Effects 0.000 description 1
- 238000000684 flow cytometry Methods 0.000 description 1
- 230000036541 health Effects 0.000 description 1
- 229940088597 hormone Drugs 0.000 description 1
- 239000005556 hormone Substances 0.000 description 1
- 238000009802 hysterectomy Methods 0.000 description 1
- 230000002055 immunohistochemical effect Effects 0.000 description 1
- 230000000670 limiting effect Effects 0.000 description 1
- 238000013332 literature search Methods 0.000 description 1
- 238000004949 mass spectrometry Methods 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 239000011159 matrix material Substances 0.000 description 1
- 230000007246 mechanism Effects 0.000 description 1
- 230000001404 mediated effect Effects 0.000 description 1
- 238000002483 medication Methods 0.000 description 1
- 230000009247 menarche Effects 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 210000003097 mucus Anatomy 0.000 description 1
- 210000002445 nipple Anatomy 0.000 description 1
- 239000000041 non-steroidal anti-inflammatory agent Substances 0.000 description 1
- 229940021182 non-steroidal anti-inflammatory drug Drugs 0.000 description 1
- 238000010606 normalization Methods 0.000 description 1
- 238000005457 optimization Methods 0.000 description 1
- 239000002245 particle Substances 0.000 description 1
- 230000037081 physical activity Effects 0.000 description 1
- 210000002381 plasma Anatomy 0.000 description 1
- 230000036515 potency Effects 0.000 description 1
- 210000002307 prostate Anatomy 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 229960004622 raloxifene Drugs 0.000 description 1
- GZUITABIAKMVPG-UHFFFAOYSA-N raloxifene Chemical compound C1=CC(O)=CC=C1C1=C(C(=O)C=2C=CC(OCCN3CCCCC3)=CC=2)C2=CC=C(O)C=C2S1 GZUITABIAKMVPG-UHFFFAOYSA-N 0.000 description 1
- 230000009467 reduction Effects 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 229960002477 riboflavin Drugs 0.000 description 1
- 235000019192 riboflavin Nutrition 0.000 description 1
- 239000002151 riboflavin Substances 0.000 description 1
- 210000003296 saliva Anatomy 0.000 description 1
- 230000000391 smoking effect Effects 0.000 description 1
- 230000000153 supplemental effect Effects 0.000 description 1
- 238000001356 surgical procedure Methods 0.000 description 1
- 229960001603 tamoxifen Drugs 0.000 description 1
- 230000009466 transformation Effects 0.000 description 1
- 210000002700 urine Anatomy 0.000 description 1
- 230000002792 vascular Effects 0.000 description 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
-
- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16H—HEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA
- G16H50/00—ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics
- G16H50/20—ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for computer-aided diagnosis, e.g. based on medical expert systems
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
- G01N33/57407—Specifically defined cancers
- G01N33/57411—Specifically defined cancers of cervix
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
- G01N33/57407—Specifically defined cancers
- G01N33/57415—Specifically defined cancers of breast
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
- G01N33/57407—Specifically defined cancers
- G01N33/57438—Specifically defined cancers of liver, pancreas or kidney
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
- G01N33/57407—Specifically defined cancers
- G01N33/57442—Specifically defined cancers of the uterus and endometrial
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
- G01N33/57407—Specifically defined cancers
- G01N33/57449—Specifically defined cancers of ovaries
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
- G01N33/57484—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumor, cancer, neoplasia, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides, metabolites
-
- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
- G16B25/00—ICT specially adapted for hybridisation; ICT specially adapted for gene or protein expression
- G16B25/10—Gene or protein expression profiling; Expression-ratio estimation or normalisation
-
- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
- G16B40/00—ICT specially adapted for biostatistics; ICT specially adapted for bioinformatics-related machine learning or data mining, e.g. knowledge discovery or pattern finding
-
- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16H—HEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA
- G16H10/00—ICT specially adapted for the handling or processing of patient-related medical or healthcare data
- G16H10/40—ICT specially adapted for the handling or processing of patient-related medical or healthcare data for data related to laboratory analysis, e.g. patient specimen analysis
-
- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16H—HEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA
- G16H70/00—ICT specially adapted for the handling or processing of medical references
- G16H70/60—ICT specially adapted for the handling or processing of medical references relating to pathologies
-
- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
- G16B25/00—ICT specially adapted for hybridisation; ICT specially adapted for gene or protein expression
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- Urology & Nephrology (AREA)
- Chemical & Material Sciences (AREA)
- Hematology (AREA)
- Physics & Mathematics (AREA)
- General Health & Medical Sciences (AREA)
- Biotechnology (AREA)
- Pathology (AREA)
- Medical Informatics (AREA)
- Cell Biology (AREA)
- Microbiology (AREA)
- Food Science & Technology (AREA)
- Medicinal Chemistry (AREA)
- Analytical Chemistry (AREA)
- Oncology (AREA)
- Hospice & Palliative Care (AREA)
- Biochemistry (AREA)
- General Physics & Mathematics (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Databases & Information Systems (AREA)
- Data Mining & Analysis (AREA)
- Biophysics (AREA)
- Theoretical Computer Science (AREA)
- Evolutionary Biology (AREA)
- Bioinformatics & Computational Biology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Spectroscopy & Molecular Physics (AREA)
- Genetics & Genomics (AREA)
- Primary Health Care (AREA)
- Evolutionary Computation (AREA)
- Software Systems (AREA)
- Computer Vision & Pattern Recognition (AREA)
- Bioethics (AREA)
- Artificial Intelligence (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US11/381,104 US20070255113A1 (en) | 2006-05-01 | 2006-05-01 | Methods and apparatus for identifying disease status using biomarkers |
| PCT/US2007/067418 WO2007130831A2 (en) | 2006-05-01 | 2007-04-25 | Methods and apparatus for identifying disease status using biomarkers |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MX2008013978A true MX2008013978A (es) | 2009-02-19 |
Family
ID=38648787
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2008013978A MX2008013978A (es) | 2006-05-01 | 2007-04-25 | Metodos y aparatos para identificar el estado de enfermedades utilizando biomarcadores. |
Country Status (13)
| Country | Link |
|---|---|
| US (5) | US20070255113A1 (enExample) |
| EP (2) | EP2016405B1 (enExample) |
| JP (1) | JP2009535644A (enExample) |
| KR (1) | KR20090024686A (enExample) |
| CN (1) | CN101479599A (enExample) |
| AU (1) | AU2007248299A1 (enExample) |
| BR (1) | BRPI0711148A2 (enExample) |
| CA (1) | CA2650872C (enExample) |
| IL (1) | IL195054A0 (enExample) |
| MX (1) | MX2008013978A (enExample) |
| RU (1) | RU2008147223A (enExample) |
| WO (1) | WO2007130831A2 (enExample) |
| ZA (1) | ZA200809968B (enExample) |
Families Citing this family (45)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8158374B1 (en) | 2006-09-05 | 2012-04-17 | Ridge Diagnostics, Inc. | Quantitative diagnostic methods using multiple parameters |
| US20090047694A1 (en) * | 2007-08-17 | 2009-02-19 | Shuber Anthony P | Clinical Intervention Directed Diagnostic Methods |
| US8431367B2 (en) | 2007-09-14 | 2013-04-30 | Predictive Biosciences Corporation | Detection of nucleic acids and proteins |
| US20090075266A1 (en) * | 2007-09-14 | 2009-03-19 | Predictive Biosciences Corporation | Multiple analyte diagnostic readout |
| US20100267041A1 (en) * | 2007-09-14 | 2010-10-21 | Predictive Biosciences, Inc. | Serial analysis of biomarkers for disease diagnosis |
| US7955822B2 (en) * | 2007-09-14 | 2011-06-07 | Predictive Biosciences Corp. | Detection of nucleic acids and proteins |
| EP2329260A4 (en) * | 2008-03-04 | 2011-08-03 | Ridge Diagnostics Inc | DIAGNOSIS AND MONITORING OF DEPRESSIVE DISORDERS BASED ON A PLURALITY OF BIOMARKER PANELS |
| JP5658571B2 (ja) * | 2008-03-12 | 2015-01-28 | リッジ ダイアグノスティックス，インコーポレイテッド | うつ障害をモニタリングするための炎症バイオマーカー |
| US20140342381A1 (en) * | 2008-08-11 | 2014-11-20 | Banyan Biomarkers, Inc. | Devices and methods for biomarker detection process and assay of neurological condition |
| JP5781436B2 (ja) | 2008-08-11 | 2015-09-24 | バンヤン・バイオマーカーズ・インコーポレーテッド | 神経学的状態のバイオマーカー検出方法およびアッセイ |
| WO2010059709A2 (en) | 2008-11-18 | 2010-05-27 | Ridge Diagnostics, Inc. | Metabolic syndrome and hpa axis biomarkers for major depressive disorder |
| WO2011025953A1 (en) * | 2009-08-28 | 2011-03-03 | Lexicor Medical Technology, Llc | Systems and methods to identify a subgroup of adhd at higher risk for complicating conditions |
| US8679474B2 (en) | 2010-08-04 | 2014-03-25 | StemBios Technologies, Inc. | Somatic stem cells |
| US20150127378A1 (en) * | 2012-02-11 | 2015-05-07 | Yougene Corp. | Systems for storing, processing and utilizing proprietary genetic information |
| JP6075973B2 (ja) * | 2012-06-04 | 2017-02-08 | 富士通株式会社 | 健康状態判定装置およびその作動方法 |
| EP2684513A1 (en) * | 2012-07-13 | 2014-01-15 | Universite D'angers | Method for providing reliable non-invasive diagnostic tests |
| CN104822827B (zh) | 2012-12-06 | 2020-01-21 | 干细胞生物科技公司 | Lgr5+体干细胞 |
| EP2746770A1 (en) * | 2012-12-21 | 2014-06-25 | Stembios Technologies, Inc. | Method for evaluating effect of action on subject based on stem celldynamics |
| US11699527B2 (en) * | 2013-03-14 | 2023-07-11 | Otraces, Inc. | Method for improving disease diagnosis using measured analytes |
| US20140275294A1 (en) * | 2013-03-15 | 2014-09-18 | Banyan Biomarkers, Inc. | Devices and methods for biomarker detection process and assay of liver injury |
| CN103279655A (zh) * | 2013-05-20 | 2013-09-04 | 浙江大学 | 一种恶性肿瘤放化疗规范符合度的评估方法 |
| AU2014268417A1 (en) | 2013-05-23 | 2015-11-26 | Iphenotype Llc | Methods and systems for assisting persons, product providers and/or service providers |
| WO2014201516A2 (en) | 2013-06-20 | 2014-12-24 | Immunexpress Pty Ltd | Biomarker identification |
| JP6703479B2 (ja) | 2013-12-16 | 2020-06-03 | フィリップ モリス プロダクツ エス アー | 個人の喫煙ステータスを予測するためのシステムおよび方法 |
| EP3103046B1 (en) | 2014-02-06 | 2020-03-25 | Immunexpress Pty Ltd | Biomarker signature method, and apparatus and kits therefor |
| AU2015243857A1 (en) * | 2014-04-08 | 2016-10-20 | Metabolon, Inc. | Small molecule biochemical profiling of individual subjects for disease diagnosis and health assessment |
| US9176113B1 (en) | 2014-04-11 | 2015-11-03 | Synapdx Corporation | Methods and systems for determining autism spectrum disorder risk |
| US20150294081A1 (en) | 2014-04-11 | 2015-10-15 | Synapdx Corporation | Methods and systems for determining autism spectrum disorder risk |
| US10525020B2 (en) | 2015-02-11 | 2020-01-07 | Laboratory Corporation Of America Holdings | Metabolic markers of attention deficit hyperactivity disorder |
| AU2016267392B2 (en) * | 2015-05-28 | 2021-12-09 | Immunexpress Pty Ltd | Validating biomarker measurement |
| JP6952056B2 (ja) * | 2016-01-22 | 2021-10-20 | オートレイシーズ, インク.Otraces, Inc. | 疾患診断を改善するシステム及び方法 |
| US11594311B1 (en) | 2016-03-31 | 2023-02-28 | OM1, Inc. | Health care information system providing standardized outcome scores across patients |
| US11957897B2 (en) | 2016-04-22 | 2024-04-16 | Newton Howard | Biological co-processor (BCP) |
| CN110366558A (zh) | 2016-10-28 | 2019-10-22 | 班扬生物标记公司 | 针对泛素c末端水解酶l1(uch-l1)和胶质纤维酸性蛋白(gfap)的抗体及相关方法 |
| WO2019183052A1 (en) * | 2018-03-19 | 2019-09-26 | Sri International | Methods and systems for biomarker analysis |
| US20190302119A1 (en) * | 2018-03-27 | 2019-10-03 | Lawrence Abraham | Cancer Diagnostic Metastasis Panel |
| US11967428B1 (en) * | 2018-04-17 | 2024-04-23 | OM1, Inc. | Applying predictive models to data representing a history of events |
| CA3003032A1 (en) * | 2018-04-27 | 2019-10-27 | Nanostics Inc. | Methods of diagnosing disease using microflow cytometry |
| LU100835B1 (en) * | 2018-06-13 | 2019-12-13 | Univ Muenster Westfaelische Wilhelms | Novel biomarkers for recurrent tonsillitis |
| US11862346B1 (en) | 2018-12-22 | 2024-01-02 | OM1, Inc. | Identification of patient sub-cohorts and corresponding quantitative definitions of subtypes as a classification system for medical conditions |
| EP3935581A4 (en) | 2019-03-04 | 2022-11-30 | Iocurrents, Inc. | DATA COMPRESSION AND COMMUNICATION USING MACHINE LEARNING |
| US20200395097A1 (en) * | 2019-05-30 | 2020-12-17 | Tempus Labs, Inc. | Pan-cancer model to predict the pd-l1 status of a cancer cell sample using rna expression data and other patient data |
| TWI740647B (zh) * | 2020-09-15 | 2021-09-21 | 宏碁股份有限公司 | 疾病分類方法及疾病分類裝置 |
| US20220223231A1 (en) * | 2021-01-14 | 2022-07-14 | The Board Of Trustees Of The Leland Stanford Junior University | Systems and Methods for Improved Prognostics in Medical Imaging |
| KR102671925B1 (ko) * | 2022-03-03 | 2024-06-03 | 인제대학교 산학협력단 | 파킨슨병 진단 방법 및 그 시스템 |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6197532B1 (en) * | 1998-01-22 | 2001-03-06 | Board Of Supervisors Of Louisiana State University And Agricultural And Mechanical College | Diagnosis and detection of breast cancer and other cancers |
| US6882990B1 (en) * | 1999-05-01 | 2005-04-19 | Biowulf Technologies, Llc | Methods of identifying biological patterns using multiple data sets |
| US20020115070A1 (en) * | 1999-03-15 | 2002-08-22 | Pablo Tamayo | Methods and apparatus for analyzing gene expression data |
| US6647341B1 (en) * | 1999-04-09 | 2003-11-11 | Whitehead Institute For Biomedical Research | Methods for classifying samples and ascertaining previously unknown classes |
| US6750013B2 (en) * | 1999-12-02 | 2004-06-15 | Protein Design Labs, Inc. | Methods for detection and diagnosing of breast cancer |
| AU2002339841A1 (en) * | 2001-07-13 | 2003-01-29 | Dana-Farber Cancer Institute, Inc. | Leukemogenic transcription factors |
| WO2003041562A2 (en) * | 2001-11-14 | 2003-05-22 | Whitehead Institute For Biomedical Research | Molecular cancer diagnosis using tumor gene expression signature |
| US6949342B2 (en) * | 2001-12-21 | 2005-09-27 | Whitehead Institute For Biomedical Research | Prostate cancer diagnosis and outcome prediction by expression analysis |
| CA2499636A1 (en) * | 2002-04-01 | 2003-10-16 | Phase-1 Molecular Toxicology, Inc. | Liver necrosis predictive genes |
| US20050176057A1 (en) * | 2003-09-26 | 2005-08-11 | Troy Bremer | Diagnostic markers of mood disorders and methods of use thereof |
-
2006
- 2006-05-01 US US11/381,104 patent/US20070255113A1/en not_active Abandoned
-
2007
- 2007-02-28 US US11/679,960 patent/US20070254369A1/en not_active Abandoned
- 2007-04-25 CA CA2650872A patent/CA2650872C/en active Active
- 2007-04-25 EP EP07761281.0A patent/EP2016405B1/en not_active Not-in-force
- 2007-04-25 CN CNA2007800237208A patent/CN101479599A/zh active Pending
- 2007-04-25 RU RU2008147223/14A patent/RU2008147223A/ru not_active Application Discontinuation
- 2007-04-25 EP EP17192958.1A patent/EP3318995A1/en not_active Withdrawn
- 2007-04-25 MX MX2008013978A patent/MX2008013978A/es not_active Application Discontinuation
- 2007-04-25 BR BRPI0711148-7A patent/BRPI0711148A2/pt not_active IP Right Cessation
- 2007-04-25 JP JP2009509959A patent/JP2009535644A/ja not_active Withdrawn
- 2007-04-25 KR KR1020087029423A patent/KR20090024686A/ko not_active Withdrawn
- 2007-04-25 AU AU2007248299A patent/AU2007248299A1/en not_active Abandoned
- 2007-04-25 WO PCT/US2007/067418 patent/WO2007130831A2/en not_active Ceased
-
2008
- 2008-11-02 IL IL195054A patent/IL195054A0/en unknown
- 2008-11-24 ZA ZA200809968A patent/ZA200809968B/xx unknown
-
2010
- 2010-12-07 US US12/962,162 patent/US20110077931A1/en not_active Abandoned
-
2012
- 2012-11-02 US US13/667,842 patent/US20130060549A1/en not_active Abandoned
-
2020
- 2020-01-28 US US16/775,233 patent/US20210041440A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| IL195054A0 (en) | 2009-08-03 |
| AU2007248299A1 (en) | 2007-11-15 |
| US20210041440A1 (en) | 2021-02-11 |
| KR20090024686A (ko) | 2009-03-09 |
| EP2016405B1 (en) | 2017-09-27 |
| US20070254369A1 (en) | 2007-11-01 |
| EP2016405A4 (en) | 2012-10-03 |
| CA2650872C (en) | 2018-04-24 |
| EP2016405A2 (en) | 2009-01-21 |
| CN101479599A (zh) | 2009-07-08 |
| WO2007130831A3 (en) | 2008-10-30 |
| US20110077931A1 (en) | 2011-03-31 |
| JP2009535644A (ja) | 2009-10-01 |
| CA2650872A1 (en) | 2007-11-15 |
| EP3318995A1 (en) | 2018-05-09 |
| ZA200809968B (en) | 2009-08-26 |
| RU2008147223A (ru) | 2010-06-10 |
| US20130060549A1 (en) | 2013-03-07 |
| WO2007130831A2 (en) | 2007-11-15 |
| BRPI0711148A2 (pt) | 2011-08-23 |
| US20070255113A1 (en) | 2007-11-01 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| US20210041440A1 (en) | Methods and apparatus for identifying disease status using biomarkers | |
| Zack et al. | Leveraging machine learning techniques to forecast patient prognosis after percutaneous coronary intervention | |
| Maas et al. | Predicting outcome after traumatic brain injury | |
| Whiting et al. | Development and validation of methods for assessing the quality and reporting of diagnostic studies | |
| US20190324036A1 (en) | Panels for testing for sepsis | |
| CN105229471B (zh) | 用于基于生物化学标记分析确定先兆子痫风险的系统和方法 | |
| US11885733B2 (en) | White blood cell population dynamics | |
| CN107153774A (zh) | 慢性病风险评估双曲线模型的构建及应用该模型的疾病预测系统 | |
| Whitlatch et al. | Validation of the high-dose heparin confirmatory step for the diagnosis of heparin-induced thrombocytopenia | |
| Janes et al. | Matching in studies of classification accuracy: implications for analysis, efficiency, and assessment of incremental value | |
| Wynants et al. | Screening for data clustering in multicenter studies: the residual intraclass correlation | |
| Oosterhuis et al. | The science of systematic reviewing studies of diagnostic tests | |
| CN116779077A (zh) | 基于体检标志物构建生物学年龄及衰老评价的方法及系统 | |
| Knight et al. | Epidemiologic monitoring of prenatal screening for neural tube defects and Down syndrome | |
| Varadhan et al. | Review of guidance documents for selected methods in patient centered outcomes research: standards in addressing heterogeneity of treatment effectiveness in observational and experimental patient centered outcomes research | |
| Murphy | Longitudinal studies 1: Determinants of risk | |
| Mussavi Rizi et al. | Modeling trajectories of routine blood tests as dynamic biomarkers for outcome in spinal cord injury | |
| Ma et al. | Value of SLE-DAS in assessing disease activity in patients with systemic lupus erythematosus: a single-centre retrospective study | |
| Goldman et al. | Facility characteristics do not explain higher false-positive rates in diagnostic mammography at facilities serving vulnerable women | |
| Daya | Characteristics of good causation studies | |
| Comino et al. | Article Not peer-reviewed version | |
| Deng et al. | Introduction to the development and validation of predictive biomarker models from high-throughput data sets | |
| Murphy | Longitudinal studies 1: determination of risk | |
| WO2009108196A1 (en) | Methods and apparatus for identifying disease status using biomarkers | |
| Mayer et al. | Enhancing Phenotype Discovery in Electronic Health Records through Prior Knowledge-Guided Unsupervised Learning |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FA | Abandonment or withdrawal |