JP2009535421A5 - - Google Patents
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- Publication number
- JP2009535421A5 JP2009535421A5 JP2009509993A JP2009509993A JP2009535421A5 JP 2009535421 A5 JP2009535421 A5 JP 2009535421A5 JP 2009509993 A JP2009509993 A JP 2009509993A JP 2009509993 A JP2009509993 A JP 2009509993A JP 2009535421 A5 JP2009535421 A5 JP 2009535421A5
- Authority
- JP
- Japan
- Prior art keywords
- compound according
- phenyl
- hexyl
- hept
- dichloro
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 150000001875 compounds Chemical class 0.000 claims 14
- -1 (3-methylphenoxy) methyl Chemical group 0.000 claims 8
- 239000000203 mixture Substances 0.000 claims 5
- 229910052739 hydrogen Inorganic materials 0.000 claims 4
- 229910052760 oxygen Inorganic materials 0.000 claims 4
- 239000000651 prodrug Substances 0.000 claims 4
- 229940002612 prodrug Drugs 0.000 claims 4
- 150000003839 salts Chemical class 0.000 claims 4
- 229910052717 sulfur Inorganic materials 0.000 claims 4
- 208000010412 Glaucoma Diseases 0.000 claims 3
- 206010030043 Ocular hypertension Diseases 0.000 claims 3
- 125000004432 carbon atom Chemical group C* 0.000 claims 3
- 125000001183 hydrocarbyl group Chemical group 0.000 claims 3
- 239000001257 hydrogen Substances 0.000 claims 3
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims 3
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical group CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 claims 2
- 241000124008 Mammalia Species 0.000 claims 2
- ZUOUZKKEUPVFJK-UHFFFAOYSA-N diphenyl Chemical class C1=CC=CC=C1C1=CC=CC=C1 ZUOUZKKEUPVFJK-UHFFFAOYSA-N 0.000 claims 2
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 2
- ZZPVJHFTTJXWMD-IUMCTMNXSA-N (z)-7-[(1r,2s,3r,5r)-3,5-dichloro-2-[4-(1-hydroxyhexyl)phenyl]cyclopentyl]hept-5-enoic acid Chemical compound C1=CC(C(O)CCCCC)=CC=C1[C@@H]1[C@@H](C\C=C/CCCC(O)=O)[C@H](Cl)C[C@H]1Cl ZZPVJHFTTJXWMD-IUMCTMNXSA-N 0.000 claims 1
- ZZPVJHFTTJXWMD-LQUPIGEUSA-N (z)-7-[(1r,2s,3s,5r)-3,5-dichloro-2-[4-(1-hydroxyhexyl)phenyl]cyclopentyl]hept-5-enoic acid Chemical compound C1=CC(C(O)CCCCC)=CC=C1[C@@H]1[C@@H](C\C=C/CCCC(O)=O)[C@H](Cl)C[C@@H]1Cl ZZPVJHFTTJXWMD-LQUPIGEUSA-N 0.000 claims 1
- 125000000217 alkyl group Chemical group 0.000 claims 1
- 150000001408 amides Chemical class 0.000 claims 1
- 235000010290 biphenyl Nutrition 0.000 claims 1
- 239000004305 biphenyl Substances 0.000 claims 1
- 229910052799 carbon Inorganic materials 0.000 claims 1
- 125000006297 carbonyl amino group Chemical group [H]N([*:2])C([*:1])=O 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 150000002148 esters Chemical class 0.000 claims 1
- 125000000524 functional group Chemical group 0.000 claims 1
- 125000001072 heteroaryl group Chemical group 0.000 claims 1
- 125000004029 hydroxymethyl group Chemical group [H]OC([H])([H])* 0.000 claims 1
- 239000007788 liquid Substances 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- AKTZNVYKRQZIMN-BKCYZJPNSA-N methyl (z)-7-[(1r,2s,3r,5r)-3,5-dichloro-2-[4-(1-hydroxyhexyl)phenyl]cyclopentyl]hept-5-enoate Chemical compound C1=CC(C(O)CCCCC)=CC=C1[C@@H]1[C@@H](C\C=C/CCCC(=O)OC)[C@H](Cl)C[C@H]1Cl AKTZNVYKRQZIMN-BKCYZJPNSA-N 0.000 claims 1
- AKTZNVYKRQZIMN-CIZPOVBOSA-N methyl (z)-7-[(1r,2s,3s,5r)-3,5-dichloro-2-[4-(1-hydroxyhexyl)phenyl]cyclopentyl]hept-5-enoate Chemical compound C1=CC(C(O)CCCCC)=CC=C1[C@@H]1[C@@H](C\C=C/CCCC(=O)OC)[C@H](Cl)C[C@@H]1Cl AKTZNVYKRQZIMN-CIZPOVBOSA-N 0.000 claims 1
- 150000007524 organic acids Chemical group 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- NXZMSAVZNLOSHL-ZAKVNNCQSA-N propan-2-yl (z)-7-[(1r,2s,3r,5r)-3,5-dichloro-2-[4-(1-hydroxyhexyl)phenyl]cyclopentyl]hept-5-enoate Chemical compound C1=CC(C(O)CCCCC)=CC=C1[C@@H]1[C@@H](C\C=C/CCCC(=O)OC(C)C)[C@H](Cl)C[C@H]1Cl NXZMSAVZNLOSHL-ZAKVNNCQSA-N 0.000 claims 1
- NXZMSAVZNLOSHL-ZURXIWKOSA-N propan-2-yl (z)-7-[(1r,2s,3s,5r)-3,5-dichloro-2-[4-(1-hydroxyhexyl)phenyl]cyclopentyl]hept-5-enoate Chemical compound C1=CC(C(O)CCCCC)=CC=C1[C@@H]1[C@@H](C\C=C/CCCC(=O)OC(C)C)[C@H](Cl)C[C@@H]1Cl NXZMSAVZNLOSHL-ZURXIWKOSA-N 0.000 claims 1
- 125000003107 substituted aryl group Chemical group 0.000 claims 1
- 125000003831 tetrazolyl group Chemical group 0.000 claims 1
- 0 Cc1nnn[n]1* Chemical compound Cc1nnn[n]1* 0.000 description 2
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US74639106P | 2006-05-04 | 2006-05-04 | |
| US60/746,391 | 2006-05-04 | ||
| PCT/US2007/067762 WO2007130902A2 (en) | 2006-05-04 | 2007-04-30 | Therapeutic cyclopentane derivatives |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2009535421A JP2009535421A (ja) | 2009-10-01 |
| JP2009535421A5 true JP2009535421A5 (https=) | 2010-06-24 |
| JP5570212B2 JP5570212B2 (ja) | 2014-08-13 |
Family
ID=38353933
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009509993A Expired - Fee Related JP5570212B2 (ja) | 2006-05-04 | 2007-04-30 | 治療用シクロペンタン誘導体 |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US7491844B2 (https=) |
| EP (1) | EP2021322A2 (https=) |
| JP (1) | JP5570212B2 (https=) |
| AU (1) | AU2007248192B2 (https=) |
| BR (1) | BRPI0711309A2 (https=) |
| CA (1) | CA2651045A1 (https=) |
| WO (1) | WO2007130902A2 (https=) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7799336B2 (en) | 2004-04-30 | 2010-09-21 | Allergan, Inc. | Hypotensive lipid-containing biodegradable intraocular implants and related methods |
| WO2008008700A2 (en) | 2006-07-10 | 2008-01-17 | Allergan, Inc. | Substituted cyclopentane derivatives as therapeutic agents |
| US20090233921A1 (en) * | 2008-03-11 | 2009-09-17 | Allergan, Inc. | Therapeutic cyclopentane derivatives |
| CN105682645B (zh) | 2013-10-31 | 2019-09-06 | 阿勒根公司 | 含前列腺酰胺的眼内植入物及其使用方法 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4140863A (en) * | 1977-06-17 | 1979-02-20 | The Upjohn Company | 9,11-Dihalo-PG2 compounds |
| US5462968A (en) | 1994-01-19 | 1995-10-31 | Allergan, Inc. | EP2 -receptor agonists as agents for lowering intraocular pressure |
| JP3625946B2 (ja) * | 1995-03-10 | 2005-03-02 | 株式会社アールテック・ウエノ | 視神経障害改善剤 |
| JP2001527063A (ja) * | 1998-12-24 | 2001-12-25 | 小野薬品工業株式会社 | ω−シクロアルキル−プロスタグランジンＥ２誘導体 |
| EP2255829A3 (en) * | 2001-07-23 | 2012-03-28 | Ono Pharmaceutical Co., Ltd. | Pharmaceutical composition for treatment of diseases associated with decrease in bone mass comprising EP4 agonist as active ingredient |
| GB0329620D0 (en) | 2003-12-22 | 2004-01-28 | Pharmagene Lab Ltd | EP2 receptor agonists |
| US7091231B2 (en) * | 2004-12-10 | 2006-08-15 | Allergan, Inc. | 12-Aryl prostaglandin analogs |
-
2007
- 2007-04-20 US US11/738,307 patent/US7491844B2/en active Active
- 2007-04-30 WO PCT/US2007/067762 patent/WO2007130902A2/en not_active Ceased
- 2007-04-30 AU AU2007248192A patent/AU2007248192B2/en not_active Ceased
- 2007-04-30 CA CA002651045A patent/CA2651045A1/en not_active Abandoned
- 2007-04-30 EP EP07761569A patent/EP2021322A2/en not_active Withdrawn
- 2007-04-30 BR BRPI0711309-9A patent/BRPI0711309A2/pt not_active IP Right Cessation
- 2007-04-30 JP JP2009509993A patent/JP5570212B2/ja not_active Expired - Fee Related
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