JP2009534312A5 - - Google Patents
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- Publication number
- JP2009534312A5 JP2009534312A5 JP2009504260A JP2009504260A JP2009534312A5 JP 2009534312 A5 JP2009534312 A5 JP 2009534312A5 JP 2009504260 A JP2009504260 A JP 2009504260A JP 2009504260 A JP2009504260 A JP 2009504260A JP 2009534312 A5 JP2009534312 A5 JP 2009534312A5
- Authority
- JP
- Japan
- Prior art keywords
- propargyl
- pharmaceutically acceptable
- acceptable salt
- aminoindan
- aminoindane
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- RUOKEQAAGRXIBM-UHFFFAOYSA-N n-prop-2-ynyl-2,3-dihydro-1h-inden-1-amine Chemical compound C1=CC=C2C(NCC#C)CCC2=C1 RUOKEQAAGRXIBM-UHFFFAOYSA-N 0.000 claims 17
- 150000003839 salts Chemical class 0.000 claims 16
- 208000005793 Restless legs syndrome Diseases 0.000 claims 5
- UGJMXCAKCUNAIE-UHFFFAOYSA-N Gabapentin Chemical compound OC(=O)CC1(CN)CCCCC1 UGJMXCAKCUNAIE-UHFFFAOYSA-N 0.000 claims 4
- 208000024891 symptom Diseases 0.000 claims 4
- AFVFQIVMOAPDHO-UHFFFAOYSA-N Methanesulfonic acid Chemical compound CS(O)(=O)=O AFVFQIVMOAPDHO-UHFFFAOYSA-N 0.000 claims 3
- GJSURZIOUXUGAL-UHFFFAOYSA-N Clonidine Chemical compound ClC1=CC=CC(Cl)=C1NC1=NCCN1 GJSURZIOUXUGAL-UHFFFAOYSA-N 0.000 claims 2
- BRUQQQPBMZOVGD-XFKAJCMBSA-N Oxycodone Chemical compound O=C([C@@H]1O2)CC[C@@]3(O)[C@H]4CC5=CC=C(OC)C2=C5[C@@]13CCN4C BRUQQQPBMZOVGD-XFKAJCMBSA-N 0.000 claims 2
- 208000002193 Pain Diseases 0.000 claims 2
- FFGPTBGBLSHEPO-UHFFFAOYSA-N carbamazepine Chemical compound C1=CC2=CC=CC=C2N(C(=O)N)C2=CC=CC=C21 FFGPTBGBLSHEPO-UHFFFAOYSA-N 0.000 claims 2
- 229960000623 carbamazepine Drugs 0.000 claims 2
- DGBIGWXXNGSACT-UHFFFAOYSA-N clonazepam Chemical compound C12=CC([N+](=O)[O-])=CC=C2NC(=O)CN=C1C1=CC=CC=C1Cl DGBIGWXXNGSACT-UHFFFAOYSA-N 0.000 claims 2
- 229960003120 clonazepam Drugs 0.000 claims 2
- 229960002896 clonidine Drugs 0.000 claims 2
- 229960002870 gabapentin Drugs 0.000 claims 2
- 229960002085 oxycodone Drugs 0.000 claims 2
- 229960004851 pergolide Drugs 0.000 claims 2
- YEHCICAEULNIGD-MZMPZRCHSA-N pergolide Chemical compound C1=CC([C@H]2C[C@@H](CSC)CN([C@@H]2C2)CCC)=C3C2=CNC3=C1 YEHCICAEULNIGD-MZMPZRCHSA-N 0.000 claims 2
- FASDKYOPVNHBLU-ZETCQYMHSA-N pramipexole Chemical compound C1[C@@H](NCCC)CCC2=C1SC(N)=N2 FASDKYOPVNHBLU-ZETCQYMHSA-N 0.000 claims 2
- 229960003089 pramipexole Drugs 0.000 claims 2
- UHSKFQJFRQCDBE-UHFFFAOYSA-N ropinirole Chemical compound CCCN(CCC)CCC1=CC=CC2=C1CC(=O)N2 UHSKFQJFRQCDBE-UHFFFAOYSA-N 0.000 claims 2
- 229960001879 ropinirole Drugs 0.000 claims 2
- AEQFSUDEHCCHBT-UHFFFAOYSA-M sodium valproate Chemical compound [Na+].CCCC(C([O-])=O)CCC AEQFSUDEHCCHBT-UHFFFAOYSA-M 0.000 claims 2
- 229940102566 valproate Drugs 0.000 claims 2
- VDSNLNUVOLTORK-UHFFFAOYSA-N 2,3-dihydro-1h-inden-1-amine;methanesulfonic acid Chemical compound CS(O)(=O)=O.C1=CC=C2C(N)CCC2=C1 VDSNLNUVOLTORK-UHFFFAOYSA-N 0.000 claims 1
- WTDRDQBEARUVNC-LURJTMIESA-N L-DOPA Chemical compound OC(=O)[C@@H](N)CC1=CC=C(O)C(O)=C1 WTDRDQBEARUVNC-LURJTMIESA-N 0.000 claims 1
- WTDRDQBEARUVNC-UHFFFAOYSA-N L-Dopa Natural products OC(=O)C(N)CC1=CC=C(O)C(O)=C1 WTDRDQBEARUVNC-UHFFFAOYSA-N 0.000 claims 1
- 208000007101 Muscle Cramp Diseases 0.000 claims 1
- 206010033425 Pain in extremity Diseases 0.000 claims 1
- QAOWNCQODCNURD-UHFFFAOYSA-L Sulfate Chemical compound [O-]S([O-])(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 claims 1
- 229960004205 carbidopa Drugs 0.000 claims 1
- TZFNLOMSOLWIDK-JTQLQIEISA-N carbidopa (anhydrous) Chemical compound NN[C@@](C(O)=O)(C)CC1=CC=C(O)C(O)=C1 TZFNLOMSOLWIDK-JTQLQIEISA-N 0.000 claims 1
- 230000003247 decreasing effect Effects 0.000 claims 1
- 239000002552 dosage form Substances 0.000 claims 1
- CCIVGXIOQKPBKL-UHFFFAOYSA-M ethanesulfonate Chemical compound CCS([O-])(=O)=O CCIVGXIOQKPBKL-UHFFFAOYSA-M 0.000 claims 1
- 229960004502 levodopa Drugs 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 230000000284 resting effect Effects 0.000 claims 1
- RPACBEVZENYWOL-XFULWGLBSA-M sodium;(2r)-2-[6-(4-chlorophenoxy)hexyl]oxirane-2-carboxylate Chemical compound [Na+].C=1C=C(Cl)C=CC=1OCCCCCC[C@]1(C(=O)[O-])CO1 RPACBEVZENYWOL-XFULWGLBSA-M 0.000 claims 1
- 150000003892 tartrate salts Chemical class 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US78861706P | 2006-04-03 | 2006-04-03 | |
| US60/788,617 | 2006-04-03 | ||
| PCT/US2007/008261 WO2007117431A2 (en) | 2006-04-03 | 2007-03-30 | Use of rasagiline for the treatment of restless legs syndrome |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013087636A Division JP2013166772A (ja) | 2006-04-03 | 2013-04-18 | レストレスレッグス症候群の治療のためのラサギリンの使用 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2009534312A JP2009534312A (ja) | 2009-09-24 |
| JP2009534312A5 true JP2009534312A5 (cg-RX-API-DMAC10.html) | 2010-05-13 |
| JP5769923B2 JP5769923B2 (ja) | 2015-08-26 |
Family
ID=38581572
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009504260A Expired - Fee Related JP5769923B2 (ja) | 2006-04-03 | 2007-03-30 | レストレスレッグス症候群の治療のためのラサギリンの使用 |
| JP2013087636A Pending JP2013166772A (ja) | 2006-04-03 | 2013-04-18 | レストレスレッグス症候群の治療のためのラサギリンの使用 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013087636A Pending JP2013166772A (ja) | 2006-04-03 | 2013-04-18 | レストレスレッグス症候群の治療のためのラサギリンの使用 |
Country Status (11)
| Country | Link |
|---|---|
| US (16) | US8946300B2 (cg-RX-API-DMAC10.html) |
| EP (1) | EP2007369A4 (cg-RX-API-DMAC10.html) |
| JP (2) | JP5769923B2 (cg-RX-API-DMAC10.html) |
| CN (1) | CN101442997B (cg-RX-API-DMAC10.html) |
| AU (1) | AU2007235517B2 (cg-RX-API-DMAC10.html) |
| CA (1) | CA2646250A1 (cg-RX-API-DMAC10.html) |
| IL (5) | IL194328A (cg-RX-API-DMAC10.html) |
| MX (1) | MX2008012781A (cg-RX-API-DMAC10.html) |
| NZ (1) | NZ571591A (cg-RX-API-DMAC10.html) |
| WO (1) | WO2007117431A2 (cg-RX-API-DMAC10.html) |
| ZA (1) | ZA200808409B (cg-RX-API-DMAC10.html) |
Families Citing this family (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20060018957A1 (en) * | 2004-07-26 | 2006-01-26 | Lerner E I | Pharmaceutical dosage forms including rasagiline |
| RS52867B (sr) * | 2005-02-17 | 2013-12-31 | Teva Pharmaceutical Industries Ltd. | Kombinovana terapija glatiramer acetatom i razagilinom za lečenje multiple skleroze |
| US7815942B2 (en) | 2005-02-23 | 2010-10-19 | Teva Pharmaceutical Industries, Ltd. | Rasagiline formulations of improved content uniformity |
| US7491847B2 (en) * | 2005-11-17 | 2009-02-17 | Teva Pharmaceutical Industries, Ltd. | Methods for isolating propargylated aminoindans |
| US7572834B1 (en) | 2005-12-06 | 2009-08-11 | Teva Pharmaceutical Industries, Ltd. | Rasagiline formulations and processes for their preparation |
| US8809310B2 (en) | 2006-02-21 | 2014-08-19 | Teva Pharmaceutical Industries, Ltd. | Use of rasagiline for the treatment of multiple system atrophy |
| AU2007235517B2 (en) | 2006-04-03 | 2013-01-31 | Teva Pharmaceutical Industries, Ltd. | Use of rasagiline for the treatment of Restless Legs Syndrome |
| EP1892233A1 (de) | 2006-08-18 | 2008-02-27 | Ratiopharm GmbH | Neue Salze des Wirkstoffs Rasagilin |
| AU2007334428B2 (en) | 2006-12-14 | 2014-05-29 | Teva Pharmaceutical Industries, Ltd. | Crystalline solid rasagiline base |
| UA97382C2 (ru) * | 2006-12-14 | 2012-02-10 | Тева Фармасьютікл Індастріз, Лтд. | Таннат разагилина |
| EP1987816A1 (de) * | 2007-04-30 | 2008-11-05 | Ratiopharm GmbH | Adsorbate eines Rasagilinsalzes mit einem wasserlöslichen Hilfsstoff |
| US20090062400A1 (en) * | 2007-09-05 | 2009-03-05 | Laurence Oron | Method of treating glaucoma using rasagiline |
| US8188149B2 (en) * | 2007-09-17 | 2012-05-29 | Teva Pharmaceutical Industries, Ltd. | Use of R(+)-N-propargy1-1-aminoindan to treat or prevent hearing loss |
| RU2540470C9 (ru) | 2008-06-06 | 2015-07-20 | Фарма Ту Б Лтд. | Фармацевтические композиции для лечения болезни паркинсона |
| AU2009258120B2 (en) * | 2008-06-10 | 2014-11-27 | Teva Pharmaceutical Industries, Ltd. | Rasagiline soft gelatin capsules |
| EP2296462A4 (en) * | 2008-06-13 | 2011-06-15 | Teva Pharma | RASAGILINE FOR INFLUENCING MORBUS PARKINSON |
| JP2011525489A (ja) * | 2008-06-19 | 2011-09-22 | テバ ファーマシューティカル インダストリーズ リミティド | ラサリジン塩基の精製方法 |
| NZ589547A (en) | 2008-06-19 | 2013-03-28 | Teva Pharma | Dried rasagiline base having a water content less than 0.5 % by weight |
| US20100189790A1 (en) * | 2009-01-23 | 2010-07-29 | Teva Pharmaceutical Industries, Ltd. | Delayed release rasagiline formulation |
| PT2451771E (pt) | 2009-07-09 | 2014-09-19 | Ratiopharm Gmbh | Sais de rasagilina e suas preparações farmacêuticas |
| RU2587330C2 (ru) | 2010-07-27 | 2016-06-20 | Тева Фармасьютикал Индастриз Лтд. | Применение разагилина для лечения обонятельной дисфункции |
| WO2012015946A1 (en) | 2010-07-27 | 2012-02-02 | Teva Pharmaceutical Industries Ltd. | Dispersion of rasagiline citrate |
| CA2851433A1 (en) | 2011-10-10 | 2013-04-18 | Teva Pharmaceutical Industries Ltd. | R(+)-n-methyl-propargyl-aminoindan |
| BR112014008555A2 (pt) | 2011-10-10 | 2017-04-18 | Teva Pharma | r(+)-n-formil-propargil-aminoindano |
| JP6243351B2 (ja) * | 2012-01-12 | 2017-12-06 | ファーマ ツゥ ビー リミテッド | パーキンソン病の固定投与量薬剤組合せ治療 |
| AR092168A1 (es) * | 2012-08-17 | 2015-03-25 | Teva Pharma | Formulaciones parenterales de rasagilina |
| RS65663B1 (sr) | 2018-02-15 | 2024-07-31 | Intrabio Ltd | Acetil leucin za upotrebu u lečenju sindroma nemirnih nogu |
Family Cites Families (71)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3513249A (en) * | 1968-12-24 | 1970-05-19 | Ideal Ind | Explosion connector with improved insulating means |
| DE3572485D1 (en) | 1984-12-22 | 1989-09-28 | Thomae Gmbh Dr K | Tetrahydro-benzothiazoles, their production and their use as intermediates or drugs |
| GB8914804D0 (en) | 1989-06-28 | 1989-08-16 | Glaxo Group Ltd | Process |
| US5744500A (en) | 1990-01-03 | 1998-04-28 | Teva Pharmaceutical Industries, Ltd. | Use of R-enantiomer of N-propargyl-1-aminoindan, salts, and compositions thereof |
| IL92952A (en) * | 1990-01-03 | 1994-06-24 | Teva Pharma | R-enantiomers of n-propargyl-1-aminoindan compounds, their preparation and pharmaceutical compositions containing them |
| US5844003A (en) * | 1991-04-04 | 1998-12-01 | Innovations Foundation | Use of deprenyl compounds to maintain, prevent loss, or recover nerve cell function |
| US5444095A (en) * | 1991-04-04 | 1995-08-22 | University Of Toronto, Innovations Foundation | Use of deprenyl to rescue damaged nerve cells |
| US5767164A (en) * | 1991-04-04 | 1998-06-16 | Innovations Foundation | Use of deprenyl to rescue damaged nerve cells |
| IL99759A (en) | 1991-10-16 | 1997-06-10 | Teva Pharma | Mono-fluorinated derivatives of n-propargyl-1-aminoindan, their preparation and pharmaceutical compositions containing them |
| IL111240A (en) * | 1993-10-18 | 2001-10-31 | Teva Pharma | Salts of r(+) - enantiomers of n- propargyl-1-aminoindan and pharmaceutical compositions comprising them |
| EP0738149B1 (en) | 1994-01-10 | 2006-11-29 | Teva Pharmaceutical Industries, Ltd. | 1-aminoindan derivatives and compositions thereof |
| IL115357A (en) | 1995-09-20 | 2000-01-31 | Teva Pharma | Stable compositions containing N-propargyl-1-aminoindan and polyhydric alcohols |
| IL118836A (en) | 1996-07-11 | 2001-01-11 | Teva Pharma | Pharmaceutical compositions comprising s-(-)-n-propargyl-1-aminoindan |
| CA2275425C (en) * | 1996-12-18 | 2009-08-04 | Michael Chorev | Aminoindan derivatives |
| DE19701619B4 (de) * | 1997-01-17 | 2007-10-11 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Verwendung von Pramipexol zur Behandlung des restless legs syndroms |
| WO1999037293A2 (en) * | 1998-01-27 | 1999-07-29 | Thomas Thomas N | Use of an mao-a or mao-b inhibitor for the treatment of vascular disorders |
| PL343593A1 (en) * | 1998-03-27 | 2001-08-27 | Upjohn Co | Use of cabergoline in the treatment of restless legs syndrome |
| DE19938823A1 (de) | 1999-08-19 | 2001-02-22 | Boehringer Ingelheim Pharma | Medikamentöse Behandlung des Restless Leg Syndroms |
| US20040052843A1 (en) * | 2001-12-24 | 2004-03-18 | Lerner E. Itzhak | Controlled release dosage forms |
| US20040010038A1 (en) * | 2002-02-27 | 2004-01-15 | Eran Blaugrund | Propargylamino indan derivatives and propargylamino tetralin derivatives as brain-selective MAO inhibitors |
| AU2003219913A1 (en) | 2002-02-27 | 2003-09-09 | Teva Pharmaceutical Industries, Ltd. | Propargylamino indan derivatives and propargylamino tetralin derivatives as brain-selective mao inhibitors |
| SI1567152T1 (sl) | 2002-11-15 | 2013-10-30 | Teva Pharmaceutical Industries Ltd. | Uporaba rasagilina z riluzolom za zdravljenje amiotrofične lateralne skleroze |
| JP2005060370A (ja) * | 2003-07-25 | 2005-03-10 | Kyowa Hakko Kogyo Co Ltd | 医薬組成物 |
| US7735024B2 (en) * | 2003-10-29 | 2010-06-08 | Intel Corporation | Methods and apparatus to provide a handheld pointer-based user interface |
| EP1588704A1 (en) | 2004-04-22 | 2005-10-26 | Newron Pharmaceuticals S.p.A. | Alpha-aminoamide derivatives useful in the treatment of restless legs syndrome and addictive disorders |
| US20060018957A1 (en) * | 2004-07-26 | 2006-01-26 | Lerner E I | Pharmaceutical dosage forms including rasagiline |
| ES2371883T3 (es) | 2004-11-24 | 2012-01-11 | Teva Pharmaceutical Industries Ltd. | Composiciones de rasagilina de disgregación oral. |
| WO2006057912A2 (en) | 2004-11-24 | 2006-06-01 | Teva Pharmaceutical Industries, Ltd. | Rasagiline orally disintegrating compositions |
| US7815942B2 (en) * | 2005-02-23 | 2010-10-19 | Teva Pharmaceutical Industries, Ltd. | Rasagiline formulations of improved content uniformity |
| US7491847B2 (en) * | 2005-11-17 | 2009-02-17 | Teva Pharmaceutical Industries, Ltd. | Methods for isolating propargylated aminoindans |
| US7572834B1 (en) * | 2005-12-06 | 2009-08-11 | Teva Pharmaceutical Industries, Ltd. | Rasagiline formulations and processes for their preparation |
| KR20080078075A (ko) * | 2005-12-20 | 2008-08-26 | 세레우사이언스 아베 | 하지 불안 증후군의 치료 및 진단을 위한 방법 및 조성물 |
| US8809310B2 (en) * | 2006-02-21 | 2014-08-19 | Teva Pharmaceutical Industries, Ltd. | Use of rasagiline for the treatment of multiple system atrophy |
| CN101032474B (zh) * | 2006-03-06 | 2011-02-16 | 重庆医药工业研究院有限责任公司 | 一种治疗或预防神经系统疾病的雷沙吉兰透皮贴片及其制备方法 |
| AU2007235517B2 (en) | 2006-04-03 | 2013-01-31 | Teva Pharmaceutical Industries, Ltd. | Use of rasagiline for the treatment of Restless Legs Syndrome |
| EP1892233A1 (de) * | 2006-08-18 | 2008-02-27 | Ratiopharm GmbH | Neue Salze des Wirkstoffs Rasagilin |
| UA97382C2 (ru) * | 2006-12-14 | 2012-02-10 | Тева Фармасьютікл Індастріз, Лтд. | Таннат разагилина |
| AU2007334428B2 (en) * | 2006-12-14 | 2014-05-29 | Teva Pharmaceutical Industries, Ltd. | Crystalline solid rasagiline base |
| EP1987816A1 (de) * | 2007-04-30 | 2008-11-05 | Ratiopharm GmbH | Adsorbate eines Rasagilinsalzes mit einem wasserlöslichen Hilfsstoff |
| US20090062400A1 (en) * | 2007-09-05 | 2009-03-05 | Laurence Oron | Method of treating glaucoma using rasagiline |
| US8188149B2 (en) * | 2007-09-17 | 2012-05-29 | Teva Pharmaceutical Industries, Ltd. | Use of R(+)-N-propargy1-1-aminoindan to treat or prevent hearing loss |
| WO2009081148A1 (en) | 2007-12-24 | 2009-07-02 | Cipla Limited | Process for the synthesis of propargylated aminoindan derivatives |
| EA201070842A1 (ru) * | 2008-01-11 | 2011-04-29 | Тева Фармасьютикал Индастриз, Лтд. | Препаративные формы разагилина, их получение и применение |
| WO2009122301A2 (en) | 2008-03-31 | 2009-10-08 | Actavis Group Ptc Ehf | Rasagiline mesylate particles and process for the preparation thereof |
| AU2009258120B2 (en) * | 2008-06-10 | 2014-11-27 | Teva Pharmaceutical Industries, Ltd. | Rasagiline soft gelatin capsules |
| EP2296462A4 (en) | 2008-06-13 | 2011-06-15 | Teva Pharma | RASAGILINE FOR INFLUENCING MORBUS PARKINSON |
| JP2011525489A (ja) * | 2008-06-19 | 2011-09-22 | テバ ファーマシューティカル インダストリーズ リミティド | ラサリジン塩基の精製方法 |
| NZ589547A (en) * | 2008-06-19 | 2013-03-28 | Teva Pharma | Dried rasagiline base having a water content less than 0.5 % by weight |
| CN101606923B (zh) | 2008-06-20 | 2013-01-09 | 重庆医药工业研究院有限责任公司 | 一种稳定的控释释放的雷沙吉兰透皮贴片及其制备方法 |
| EA201170181A1 (ru) | 2008-07-11 | 2011-08-30 | Синтон Бв | Полиморфные формы разагилина гидрохлорида |
| US20100041920A1 (en) | 2008-07-18 | 2010-02-18 | Stephen Benedict David Winter | New salt forms of an aminoindan derivative |
| US20100029987A1 (en) | 2008-07-29 | 2010-02-04 | Dipharma Francis S.R.I. | Crystalline Form of Rasagiline and Process for the Preparation Thereof |
| AU2009275665A1 (en) | 2008-07-30 | 2010-02-04 | Generics [Uk] Limited | Polymorphic form of rasagiline mesylate |
| EP2181980A1 (en) | 2008-10-28 | 2010-05-05 | Chemo Ibérica, S.A. | A process for the preparation of (R)-1-aminoindanes |
| DE102008064061A1 (de) * | 2008-12-19 | 2010-06-24 | Ratiopharm Gmbh | Feste Zusammensetzung mit dem Wirkstoff Rasagilin |
| TW201028257A (en) * | 2009-01-16 | 2010-08-01 | Pao-Fang Liu | Three-stage valve switch structure |
| US20100189790A1 (en) * | 2009-01-23 | 2010-07-29 | Teva Pharmaceutical Industries, Ltd. | Delayed release rasagiline formulation |
| PT2451771E (pt) | 2009-07-09 | 2014-09-19 | Ratiopharm Gmbh | Sais de rasagilina e suas preparações farmacêuticas |
| WO2011009873A2 (en) | 2009-07-20 | 2011-01-27 | Medichem, S.A. | New form of an aminoindan mesylate derivative |
| AU2010274589A1 (en) | 2009-07-23 | 2012-02-16 | Alkem Laboratories Ltd. | Oral pharmaceutical composition of rasagiline and process for preparing thereof |
| JP2013507352A (ja) * | 2009-10-09 | 2013-03-04 | テバ ファーマシューティカル インダストリーズ リミティド | 進行性核上性麻痺の治療のためのラサギリンの使用 |
| WO2011087791A1 (en) | 2009-12-22 | 2011-07-21 | Teva Pharmaceutical Industries Ltd. | 3-keto-n-propargyl-1-aminoindan |
| WO2012015946A1 (en) * | 2010-07-27 | 2012-02-02 | Teva Pharmaceutical Industries Ltd. | Dispersion of rasagiline citrate |
| RU2587330C2 (ru) * | 2010-07-27 | 2016-06-20 | Тева Фармасьютикал Индастриз Лтд. | Применение разагилина для лечения обонятельной дисфункции |
| WO2012050971A2 (en) | 2010-09-29 | 2012-04-19 | Teva Pharmaceutical Industries Ltd. | Propargyl-trifluoromethoxy-aminobenzothiazole derivatives, their preparation and use |
| CN103188933A (zh) | 2010-10-26 | 2013-07-03 | 泰华制药工业有限公司 | 富集氘的雷沙吉兰 |
| CA2851433A1 (en) * | 2011-10-10 | 2013-04-18 | Teva Pharmaceutical Industries Ltd. | R(+)-n-methyl-propargyl-aminoindan |
| BR112014008555A2 (pt) * | 2011-10-10 | 2017-04-18 | Teva Pharma | r(+)-n-formil-propargil-aminoindano |
| US20130089611A1 (en) * | 2011-10-10 | 2013-04-11 | Teva Pharmaceutical Industries, Ltd. | Rasagiline citramide |
| JP6243351B2 (ja) | 2012-01-12 | 2017-12-06 | ファーマ ツゥ ビー リミテッド | パーキンソン病の固定投与量薬剤組合せ治療 |
| AR092168A1 (es) | 2012-08-17 | 2015-03-25 | Teva Pharma | Formulaciones parenterales de rasagilina |
-
2007
- 2007-03-30 AU AU2007235517A patent/AU2007235517B2/en not_active Ceased
- 2007-03-30 CA CA002646250A patent/CA2646250A1/en not_active Abandoned
- 2007-03-30 JP JP2009504260A patent/JP5769923B2/ja not_active Expired - Fee Related
- 2007-03-30 CN CN2007800117920A patent/CN101442997B/zh not_active Expired - Fee Related
- 2007-03-30 EP EP07754738A patent/EP2007369A4/en not_active Ceased
- 2007-03-30 WO PCT/US2007/008261 patent/WO2007117431A2/en not_active Ceased
- 2007-03-30 US US11/731,493 patent/US8946300B2/en active Active
- 2007-03-30 NZ NZ571591A patent/NZ571591A/en unknown
- 2007-03-30 MX MX2008012781A patent/MX2008012781A/es active IP Right Grant
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2008
- 2008-09-24 IL IL194328A patent/IL194328A/en active IP Right Grant
- 2008-10-02 ZA ZA2008/08409A patent/ZA200808409B/en unknown
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2013
- 2013-04-18 JP JP2013087636A patent/JP2013166772A/ja active Pending
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2014
- 2014-09-18 IL IL234749A patent/IL234749A0/en unknown
- 2014-10-27 US US14/524,993 patent/US20150080441A1/en not_active Abandoned
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2016
- 2016-04-11 US US15/096,038 patent/US20160317471A1/en not_active Abandoned
- 2016-09-15 IL IL247850A patent/IL247850A0/en unknown
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2017
- 2017-09-07 US US15/697,935 patent/US20170360723A1/en not_active Abandoned
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2018
- 2018-02-13 US US15/895,962 patent/US20180169038A1/en not_active Abandoned
- 2018-08-13 US US16/102,148 patent/US20190000780A1/en not_active Abandoned
- 2018-12-26 US US16/233,046 patent/US20190142766A1/en not_active Abandoned
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2019
- 2019-04-07 IL IL265866A patent/IL265866A/en unknown
- 2019-05-07 US US16/405,468 patent/US20190262284A1/en not_active Abandoned
- 2019-08-16 US US16/543,164 patent/US20190365674A1/en not_active Abandoned
- 2019-11-26 US US16/696,568 patent/US20200093758A1/en not_active Abandoned
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2020
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- 2020-07-06 IL IL275890A patent/IL275890A/en unknown
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2021
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- 2021-05-03 US US17/306,106 patent/US20210251921A1/en not_active Abandoned
- 2021-08-11 US US17/399,753 patent/US12310929B2/en active Active