JP2009533452A5 - - Google Patents
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- JP2009533452A5 JP2009533452A5 JP2009505475A JP2009505475A JP2009533452A5 JP 2009533452 A5 JP2009533452 A5 JP 2009533452A5 JP 2009505475 A JP2009505475 A JP 2009505475A JP 2009505475 A JP2009505475 A JP 2009505475A JP 2009533452 A5 JP2009533452 A5 JP 2009533452A5
- Authority
- JP
- Japan
- Prior art keywords
- cancer
- plk1
- disease
- compound
- carcinoma
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
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- NLDMNSXOCDLTTB-UHFFFAOYSA-N Heterophylliin A Natural products O1C2COC(=O)C3=CC(O)=C(O)C(O)=C3C3=C(O)C(O)=C(O)C=C3C(=O)OC2C(OC(=O)C=2C=C(O)C(O)=C(O)C=2)C(O)C1OC(=O)C1=CC(O)=C(O)C(O)=C1 NLDMNSXOCDLTTB-UHFFFAOYSA-N 0.000 description 1
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- 101000924577 Homo sapiens Adenomatous polyposis coli protein Proteins 0.000 description 1
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- 208000003849 large cell carcinoma Diseases 0.000 description 1
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- 201000006721 lip cancer Diseases 0.000 description 1
- 239000002502 liposome Substances 0.000 description 1
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- 201000002250 liver carcinoma Diseases 0.000 description 1
- 201000005249 lung adenocarcinoma Diseases 0.000 description 1
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- 239000000463 material Substances 0.000 description 1
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- 239000004530 micro-emulsion Substances 0.000 description 1
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- 239000008194 pharmaceutical composition Substances 0.000 description 1
- 230000002062 proliferating effect Effects 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 206010038038 rectal cancer Diseases 0.000 description 1
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- 230000000699 topical effect Effects 0.000 description 1
- 239000012049 topical pharmaceutical composition Substances 0.000 description 1
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- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US79180706P | 2006-04-13 | 2006-04-13 | |
| PCT/US2007/009018 WO2007120760A2 (en) | 2006-04-13 | 2007-04-12 | Thiophene-carboxamides useful as inhibitors of protein kinases |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2009533452A JP2009533452A (ja) | 2009-09-17 |
| JP2009533452A5 true JP2009533452A5 (enExample) | 2010-06-03 |
Family
ID=38476868
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009505475A Pending JP2009533452A (ja) | 2006-04-13 | 2007-04-12 | タンパク質キナーゼの阻害剤として有用なチオフェン−カルボキサミド |
Country Status (7)
| Country | Link |
|---|---|
| US (2) | US7829590B2 (enExample) |
| EP (2) | EP2007757B1 (enExample) |
| JP (1) | JP2009533452A (enExample) |
| CN (1) | CN101466708A (enExample) |
| AU (1) | AU2007238698A1 (enExample) |
| CA (1) | CA2648207A1 (enExample) |
| WO (1) | WO2007120760A2 (enExample) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2474546A1 (en) | 2006-01-23 | 2012-07-11 | Vertex Pharmaceuticals Inc. | Thiophene-carboxamides useful as inhibitors of protein kinases |
| EP2007757B1 (en) | 2006-04-13 | 2012-10-03 | Vertex Pharmceuticals Incorporated | Thiophene-carboxamides useful as inhibitors of protein kinases |
| JP2009538305A (ja) * | 2006-05-23 | 2009-11-05 | バーテックス ファーマシューティカルズ インコーポレイテッド | プロテインキナーゼのインヒビターとして有用なチオフェンカルボキサミド |
| CA2652816A1 (en) * | 2006-05-23 | 2007-12-06 | Vertex Pharmaceuticals Incorporated | Thiophene-carboxamides useful as inhibitors of protein kinases |
| BRPI0906473A8 (pt) | 2008-01-04 | 2016-02-10 | Intellikine Inc | Certas entidades químicas, composições e métodos |
| US8193182B2 (en) | 2008-01-04 | 2012-06-05 | Intellikine, Inc. | Substituted isoquinolin-1(2H)-ones, and methods of use thereof |
| CA2803446C (en) | 2010-07-02 | 2019-06-04 | University Health Network | Use of plk4 antagonists for treating pten mutant diseases |
| EP3238722B1 (en) | 2011-01-10 | 2019-03-13 | Infinity Pharmaceuticals, Inc. | Solid forms of isoquinolinones |
| US8828998B2 (en) | 2012-06-25 | 2014-09-09 | Infinity Pharmaceuticals, Inc. | Treatment of lupus, fibrotic conditions, and inflammatory myopathies and other disorders using PI3 kinase inhibitors |
| RU2702908C2 (ru) | 2012-11-01 | 2019-10-14 | Инфинити Фармасьютикалз, Инк. | Лечение злокачественных опухолей с использованием модуляторов изоформ pi3-киназы |
| JP6426694B2 (ja) | 2013-03-15 | 2018-11-21 | グローバル ブラッド セラピューティクス インコーポレイテッド | ヘモグロビンの修飾のための化合物及びその使用 |
| CN103408540B (zh) * | 2013-08-22 | 2016-05-18 | 中国药科大学 | 2-唑环取代噻吩类plk1抑制剂及其用途及其用途 |
| EA201992707A1 (ru) | 2013-11-18 | 2020-06-30 | Глобал Блад Терапьютикс, Инк. | Соединения и их применения для модуляции гемоглобина |
| WO2015160975A2 (en) | 2014-04-16 | 2015-10-22 | Infinity Pharmaceuticals, Inc. | Combination therapies |
| EP3474856B1 (en) | 2016-06-24 | 2022-09-14 | Infinity Pharmaceuticals, Inc. | Combination therapies |
| CN116057045B (zh) | 2020-06-05 | 2026-06-09 | 金耐特生物制药公司 | 成纤维细胞生长因子受体激酶抑制剂 |
| CN116785296B (zh) * | 2023-06-06 | 2025-09-05 | 河北渤腾医药技术有限公司 | 一种plk1的抑制剂及其应用 |
Family Cites Families (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IT1255802B (it) | 1992-08-07 | 1995-11-16 | Luso Farmaco Inst | Derivati imidazolici ad attivita' a ii antagonista |
| AU726058B2 (en) | 1995-09-01 | 2000-10-26 | Signal Pharmaceuticals, Inc. | Pyrimidine carboxylates and related compounds and methods for treating inflammatory conditions |
| EP0922043B1 (en) * | 1997-04-24 | 2002-01-30 | Dow AgroSciences LLC | Pesticidal 3-(substituted phenyl)-5-(thienyl or furyl)-1,2,4-triazoles |
| DE19744026A1 (de) * | 1997-10-06 | 1999-04-08 | Hoechst Marion Roussel De Gmbh | Pyrazol-Derivate, ihre Herstellung und ihre Verwendung in Arzneimitteln |
| PT957099E (pt) | 1998-04-15 | 2003-02-28 | Pfizer Prod Inc | Carboxamidas heterociclicas |
| CN1136218C (zh) | 1998-10-23 | 2004-01-28 | 道农业科学公司 | 制备3-(取代的苯基)-5-(噻吩基或呋喃基)-1,2,4-三唑的方法以及在其中使用的新中间体 |
| AU2001245401A1 (en) | 2000-03-01 | 2001-09-12 | Sumitomo Pharmaceuticals Company, Limited | Hydrazones and analogs as cholesterol lowering agents |
| US7273868B2 (en) * | 2000-04-28 | 2007-09-25 | Tanabe Seiyaku Co., Ltd. | Pyrazine derivatives |
| US7041685B2 (en) | 2001-06-08 | 2006-05-09 | Cytovia, Inc. | Substituted 3-aryl-5-aryl-[1,2,4]-oxadiazoles and analogs as activators of caspases and inducers of apoptosis and the use thereof |
| AU2002356871A1 (en) * | 2001-10-30 | 2003-05-12 | Pharmacia Corporation | Heteroaromatic carboxamide derivatives for the treatment of inflammation |
| MXPA04000908A (es) | 2002-05-30 | 2004-03-26 | King Pharmaceuticals Res & Dev | Compuestos farmaceuticamente activos que tienen estructura de anillo de pirazolotriazolopirimidina triciclica y metodos de uso. |
| MXPA05001544A (es) * | 2002-08-08 | 2005-04-19 | Smithkline Beecham Corp | Compuestos de tiofeno. |
| JP2006516250A (ja) | 2002-12-18 | 2006-06-29 | サイトビア インコーポレイティッド | カスパーゼ活性化剤およびアポトーシス誘導物質としての３，５−二置換−［１，２，４］−オキサジアゾールおよびそれらの誘導体ならびにそれらの使用 |
| US7462614B2 (en) | 2003-04-01 | 2008-12-09 | Smithkline Beecham Corporation | Imidazotriazine compounds |
| US20050090529A1 (en) * | 2003-07-31 | 2005-04-28 | Pfizer Inc | 3,5 Disubstituted indazole compounds with nitrogen-bearing 5-membered heterocycles, pharmaceutical compositions, and methods for mediating or inhibiting cell proliferation |
| EP1685128A1 (en) | 2003-10-16 | 2006-08-02 | Smithkline Beecham Corporation | Process for preparing benzimidazole thiophenes |
| US20080293716A1 (en) | 2004-01-30 | 2008-11-27 | Smithkline Beecham Corporation | Chemical Compounds |
| GB0402809D0 (en) | 2004-02-09 | 2004-03-10 | Glaxo Group Ltd | Chemical compounds |
| WO2005095386A1 (en) * | 2004-03-30 | 2005-10-13 | Chiron Corporation | Substituted thiophene derivatives as anti-cancer agents |
| US7514448B2 (en) | 2004-04-02 | 2009-04-07 | Vertex Pharmaceuticals Incorporated | Azaindoles useful as inhibitors of rock and other protein kinases |
| WO2006049339A1 (ja) | 2004-11-08 | 2006-05-11 | Banyu Pharmaceutical Co., Ltd. | 新規縮環イミダゾール誘導体 |
| AU2005316312B2 (en) | 2004-12-17 | 2009-10-22 | Amgen, Inc. | Aminopyrimidine compounds and methods of use |
| EP1924572B1 (en) | 2005-09-06 | 2009-12-30 | SmithKline Beecham Corporation | Regioselective process for preparing benzimidazole thiophenes |
| EP2474546A1 (en) * | 2006-01-23 | 2012-07-11 | Vertex Pharmaceuticals Inc. | Thiophene-carboxamides useful as inhibitors of protein kinases |
| EP2007757B1 (en) | 2006-04-13 | 2012-10-03 | Vertex Pharmceuticals Incorporated | Thiophene-carboxamides useful as inhibitors of protein kinases |
| JP2009538305A (ja) * | 2006-05-23 | 2009-11-05 | バーテックス ファーマシューティカルズ インコーポレイテッド | プロテインキナーゼのインヒビターとして有用なチオフェンカルボキサミド |
| CA2652816A1 (en) | 2006-05-23 | 2007-12-06 | Vertex Pharmaceuticals Incorporated | Thiophene-carboxamides useful as inhibitors of protein kinases |
-
2007
- 2007-04-12 EP EP07775260A patent/EP2007757B1/en not_active Not-in-force
- 2007-04-12 EP EP11188838A patent/EP2418210A1/en not_active Withdrawn
- 2007-04-12 JP JP2009505475A patent/JP2009533452A/ja active Pending
- 2007-04-12 AU AU2007238698A patent/AU2007238698A1/en not_active Abandoned
- 2007-04-12 CN CNA200780021663XA patent/CN101466708A/zh active Pending
- 2007-04-12 CA CA002648207A patent/CA2648207A1/en not_active Abandoned
- 2007-04-12 US US11/786,579 patent/US7829590B2/en not_active Expired - Fee Related
- 2007-04-12 WO PCT/US2007/009018 patent/WO2007120760A2/en not_active Ceased
-
2010
- 2010-09-28 US US12/891,973 patent/US8188134B2/en not_active Expired - Fee Related
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