JP2009533160A5 - - Google Patents
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- Publication number
- JP2009533160A5 JP2009533160A5 JP2009505524A JP2009505524A JP2009533160A5 JP 2009533160 A5 JP2009533160 A5 JP 2009533160A5 JP 2009505524 A JP2009505524 A JP 2009505524A JP 2009505524 A JP2009505524 A JP 2009505524A JP 2009533160 A5 JP2009533160 A5 JP 2009533160A5
- Authority
- JP
- Japan
- Prior art keywords
- tissue
- fluorescence anisotropy
- state
- fluorescence
- steady state
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 238000000198 fluorescence anisotropy Methods 0.000 claims 50
- 238000000034 method Methods 0.000 claims 49
- OAICVXFJPJFONN-UHFFFAOYSA-N Phosphorus Chemical compound [P] OAICVXFJPJFONN-UHFFFAOYSA-N 0.000 claims 18
- 230000004060 metabolic process Effects 0.000 claims 8
- 102000028526 Dihydrolipoamide Dehydrogenase Human genes 0.000 claims 6
- 108010028127 Dihydrolipoamide Dehydrogenase Proteins 0.000 claims 6
- 238000005259 measurement Methods 0.000 claims 6
- 230000001066 destructive effect Effects 0.000 claims 4
- 230000004064 dysfunction Effects 0.000 claims 4
- 230000001678 irradiating effect Effects 0.000 claims 4
- 230000009092 tissue dysfunction Effects 0.000 claims 4
- 230000010287 polarization Effects 0.000 claims 3
- 206010021143 Hypoxia Diseases 0.000 claims 2
- 230000006907 apoptotic process Effects 0.000 claims 2
- 201000010099 disease Diseases 0.000 claims 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 2
- 230000005284 excitation Effects 0.000 claims 2
- 230000007954 hypoxia Effects 0.000 claims 2
- 230000002438 mitochondrial effect Effects 0.000 claims 2
- 230000008520 organization Effects 0.000 claims 2
- 230000007170 pathology Effects 0.000 claims 2
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims 1
- 238000012925 biological evaluation Methods 0.000 claims 1
- 230000003247 decreasing effect Effects 0.000 claims 1
- 238000011156 evaluation Methods 0.000 claims 1
- 230000002503 metabolic effect Effects 0.000 claims 1
- 230000003287 optical effect Effects 0.000 claims 1
- 229910052760 oxygen Inorganic materials 0.000 claims 1
- 239000001301 oxygen Substances 0.000 claims 1
- 230000005855 radiation Effects 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US74483106P | 2006-04-13 | 2006-04-13 | |
| US11/624,820 US8129105B2 (en) | 2006-04-13 | 2007-01-19 | Method and apparatus for the non-invasive measurement of tissue function and metabolism by determination of steady-state fluorescence anisotropy |
| PCT/US2007/063768 WO2007121009A2 (en) | 2006-04-13 | 2007-03-12 | Method and apparatus for the non-invasive measurement of tissue function and metabolism by determination of steady-state fluorescence anisotropy |
Related Child Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012255630A Division JP2013078592A (ja) | 2006-04-13 | 2012-11-21 | 生物組織の機能的能力の変化を非破壊的に測定する方法 |
| JP2015151263A Division JP6240833B2 (ja) | 2006-04-13 | 2015-07-30 | 生体組織を非破壊的に評価する装置および当該装置の作動方法 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2009533160A JP2009533160A (ja) | 2009-09-17 |
| JP2009533160A5 true JP2009533160A5 (https=) | 2010-06-24 |
Family
ID=38605233
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009505524A Pending JP2009533160A (ja) | 2006-04-13 | 2007-03-12 | 定常状態の蛍光異方性を測定することで組織機能と代謝の非侵襲計測をする方法および装置 |
| JP2012255630A Pending JP2013078592A (ja) | 2006-04-13 | 2012-11-21 | 生物組織の機能的能力の変化を非破壊的に測定する方法 |
| JP2015151263A Expired - Fee Related JP6240833B2 (ja) | 2006-04-13 | 2015-07-30 | 生体組織を非破壊的に評価する装置および当該装置の作動方法 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012255630A Pending JP2013078592A (ja) | 2006-04-13 | 2012-11-21 | 生物組織の機能的能力の変化を非破壊的に測定する方法 |
| JP2015151263A Expired - Fee Related JP6240833B2 (ja) | 2006-04-13 | 2015-07-30 | 生体組織を非破壊的に評価する装置および当該装置の作動方法 |
Country Status (6)
| Country | Link |
|---|---|
| US (9) | US8129105B2 (https=) |
| EP (1) | EP2004040A4 (https=) |
| JP (3) | JP2009533160A (https=) |
| AU (1) | AU2007238412B2 (https=) |
| CA (1) | CA2648931C (https=) |
| WO (1) | WO2007121009A2 (https=) |
Families Citing this family (40)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2904927B1 (fr) * | 2006-08-17 | 2018-05-18 | Mauna Kea Technologies | Utilisation d'un systeme d'imagerie par fluorescence confocale fibre in vivo in situ, systeme et procede d'imagerie par fluorescence confocale fibres in vivo in situ |
| US8270689B2 (en) | 2006-09-12 | 2012-09-18 | Carestream Health, Inc. | Apparatus for caries detection |
| US20080214940A1 (en) * | 2007-03-02 | 2008-09-04 | Benaron David A | Medical imaging lens system, and method with high-efficiency light collection and collinear illumination |
| JP5968590B2 (ja) | 2007-11-05 | 2016-08-10 | ケーシーアイ ライセンシング インコーポレイテッド | 創面切除のための組織の同定 |
| US8403862B2 (en) * | 2007-12-20 | 2013-03-26 | Yeda Research And Development Co. Ltd. | Time-based imaging |
| DK2291640T3 (en) | 2008-05-20 | 2019-03-11 | Univ Health Network | Device and method for fluorescence-based imaging and monitoring |
| JP5543126B2 (ja) * | 2009-04-16 | 2014-07-09 | キヤノン株式会社 | 医用画像処理装置及びその制御方法 |
| WO2012061836A2 (en) * | 2010-11-05 | 2012-05-10 | Freedom Meditech, Inc. | Improved algorithm for detection of diabetes |
| JP5816486B2 (ja) * | 2011-08-18 | 2015-11-18 | オリンパス株式会社 | 蛍光観察装置および蛍光観察システム並びに蛍光観察装置の蛍光画像処理方法 |
| ES2727868T3 (es) | 2011-09-22 | 2019-10-21 | Univ George Washington | Sistemas para visualizar el tejido ablacionado |
| WO2013044182A1 (en) | 2011-09-22 | 2013-03-28 | The George Washington University | Systems and methods for visualizing ablated tissue |
| US9677869B2 (en) | 2012-12-05 | 2017-06-13 | Perimeter Medical Imaging, Inc. | System and method for generating a wide-field OCT image of a portion of a sample |
| JP6737705B2 (ja) * | 2013-11-14 | 2020-08-12 | ザ・ジョージ・ワシントン・ユニバーシティＴｈｅ Ｇｅｏｒｇｅ Ｗａｓｈｉｎｇｔｏｎｕｎｉｖｅｒｓｉｔｙ | 損傷部位の深さを決定するシステムの動作方法及び心臓組織の画像を生成するシステム |
| CN112674861B (zh) * | 2013-11-14 | 2024-11-15 | 乔治华盛顿大学 | 用于使用荧光成像来确定损伤灶深度的系统和方法 |
| WO2015077474A1 (en) | 2013-11-20 | 2015-05-28 | The George Washington University | Systems and methods for hyperspectral analysis of cardiac tissue |
| EP3957232B1 (en) | 2014-07-24 | 2025-12-31 | University Health Network | DATA COLLECTION AND ANALYSIS FOR DIAGNOSTIC PURPOSES |
| CN113143440B (zh) | 2014-11-03 | 2024-07-30 | 乔治华盛顿大学 | 用于损伤评估的系统和方法 |
| JP6771731B2 (ja) | 2014-11-03 | 2020-10-21 | ４６０メディカル・インコーポレイテッド４６０Ｍｅｄｉｃａｌ， Ｉｎｃ． | 接触性評価システム及び方法 |
| US10337983B2 (en) | 2015-04-12 | 2019-07-02 | Taiwan Biophotonic Corporation | Module, device and method for optical measurement |
| JP2018516112A (ja) * | 2015-04-17 | 2018-06-21 | コーニンクレッカ フィリップス エヌ ヴェＫｏｎｉｎｋｌｉｊｋｅ Ｐｈｉｌｉｐｓ Ｎ．Ｖ． | 異方性をもつ生物学的組織の検出 |
| US10779904B2 (en) | 2015-07-19 | 2020-09-22 | 460Medical, Inc. | Systems and methods for lesion formation and assessment |
| HK1248774A1 (zh) * | 2015-08-26 | 2018-10-19 | 仓敷纺绩株式会社 | 细胞测定方法 |
| WO2018016409A1 (ja) * | 2016-07-19 | 2018-01-25 | 株式会社アサヒビジョン | 眼球分析装置および眼球分析方法 |
| JP6438603B2 (ja) * | 2016-07-19 | 2018-12-19 | 株式会社アサヒビジョン | 眼球分析装置 |
| US10201306B2 (en) * | 2016-08-30 | 2019-02-12 | Konica Minolta Laboratory U.S.A., Inc. | Method and system for capturing images for wound assessment with self color compensation |
| US10337995B2 (en) | 2017-06-12 | 2019-07-02 | Boston Medical Center Corporation | Systems and methods for oblique laser scanning |
| EP3655748B1 (en) | 2017-07-18 | 2023-08-09 | Perimeter Medical Imaging, Inc. | Sample container for stabilizing and aligning excised biological tissue samples for ex vivo analysis |
| CN109100325B (zh) * | 2018-06-14 | 2020-12-25 | 东南大学 | 一种基于光谱吸收率二次谐波特征提取的气体浓度测量方法 |
| EP3807623B1 (en) * | 2018-06-18 | 2023-03-01 | Calico Life Sciences LLC | System and method for inferring protein binding |
| AU2019333082B2 (en) | 2018-08-29 | 2024-06-13 | Wisconsin Alumni Research Foundation | Systems and methods for sorting T cells by activation state |
| DE102019006971A1 (de) * | 2019-10-07 | 2021-04-08 | aquila biolabs GmbH | Verfahren und Vorrichtung zur Bestimmung des Zustands von Zellen in Reaktoren |
| KR102116232B1 (ko) * | 2019-11-12 | 2020-05-28 | (주)로고스바이오시스템스 | 시료 검출 장치 및 이를 이용한 시료 검출 방법 |
| US12076081B2 (en) | 2020-01-08 | 2024-09-03 | 460Medical, Inc. | Systems and methods for optical interrogation of ablation lesions |
| WO2021174160A1 (en) | 2020-02-28 | 2021-09-02 | Preformed Line Products Co. | Cable spacer comprising a ratchet spacer clamp |
| US12539043B2 (en) | 2020-05-27 | 2026-02-03 | The George Washington University | Lesion visualization using dual wavelength approach |
| US12016656B2 (en) * | 2020-10-09 | 2024-06-25 | QuantuMed Pty Ltd | Cellular ionic activity visualisation |
| KR102553788B1 (ko) * | 2021-01-20 | 2023-07-12 | 연세대학교 산학협력단 | 시료의 광학적 이방성을 정량화하는 현미경 시스템 |
| AU2022234898A1 (en) | 2021-03-12 | 2023-09-28 | Stryker European Operations Limited | Neurosurgical methods and systems for detecting and removing tumorous tissue |
| US20230085578A1 (en) * | 2021-09-02 | 2023-03-16 | The George Washington University | Systems and methods for triple-parametric optical mapping |
| US11467151B1 (en) | 2021-12-23 | 2022-10-11 | United Arab Emirates University | Phosphorescence oxygen analyzer and uses thereof |
Family Cites Families (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4115699A (en) | 1977-06-16 | 1978-09-19 | Kabushiki Kaisha Nihon Kotai Kenkyujo | Apparatus for sensitive detection and quantitative analysis of biological and biochemical substances |
| US4476870A (en) | 1982-03-30 | 1984-10-16 | The United States Of America As Represented By The Department Of Health And Human Services | Fiber optic PO.sbsb.2 probe |
| DE3245939C2 (de) | 1982-12-11 | 1985-12-19 | Fa. Carl Zeiss, 7920 Heidenheim | Vorrichtung zur Erzeugung eines Bildes des Augenhintergrundes |
| US4810655A (en) | 1985-07-03 | 1989-03-07 | Abbott Laboratories | Method for measuring oxygen concentration |
| US5120510A (en) | 1986-10-10 | 1992-06-09 | Minnesota Mining And Manufacturing Company | Sensor and method for sensing the concentration of a component in a medium |
| US4947850A (en) | 1988-03-11 | 1990-08-14 | Trustees Of The University Of Pennsylvania | Method and apparatus for imaging an internal body portion of a host animal |
| US5039219A (en) | 1989-05-26 | 1991-08-13 | Photon Technology | Luminescence system and method for determining the nature of substances by measuring fluorescence and phosphorescence properties |
| EP0471861B1 (en) | 1990-08-13 | 1995-11-08 | Hewlett-Packard GmbH | Optical probe |
| US5186173A (en) | 1990-08-14 | 1993-02-16 | Drexel University | Method for in vivo measurement of oxygen concentration levels |
| US5318023A (en) | 1991-04-03 | 1994-06-07 | Cedars-Sinai Medical Center | Apparatus and method of use for a photosensitizer enhanced fluorescence based biopsy needle |
| EP0515211A3 (en) | 1991-05-23 | 1993-04-07 | Becton Dickinson And Company | Apparatus and method for phase resolved fluorescence lifetimes of independent and varying amplitude pulses |
| US5281825A (en) | 1991-09-05 | 1994-01-25 | The University Of Maryland School Of Medicine | Phase fluorometry using a modulated electroluminescent lamp as a light source |
| US5341805A (en) | 1993-04-06 | 1994-08-30 | Cedars-Sinai Medical Center | Glucose fluorescence monitor and method |
| US5383452A (en) | 1993-07-01 | 1995-01-24 | Buchert; Janusz | Method, apparatus and procedure for non-invasive monitoring blood glucose by measuring the polarization ratio of blood luminescence |
| US5515864A (en) | 1994-04-21 | 1996-05-14 | Zuckerman; Ralph | Method and apparatus for the in vivo measurement of oxygen concentration levels by the indirect determination of fluoescence lifetime |
| US5701902A (en) | 1994-09-14 | 1997-12-30 | Cedars-Sinai Medical Center | Spectroscopic burn injury evaluation apparatus and method |
| US6007994A (en) * | 1995-12-22 | 1999-12-28 | Yale University | Multiparametric fluorescence in situ hybridization |
| WO1998038490A1 (en) * | 1997-02-27 | 1998-09-03 | Cellomics, Inc. | A system for cell-based screening |
| WO1999060377A1 (en) | 1998-05-19 | 1999-11-25 | Spectrx, Inc. | Apparatus and method for determining tissue characteristics |
| IL125614A (en) * | 1998-07-31 | 2003-01-12 | Amiram Grinvald | System and method for non-invasive imaging of retinal function |
| EP1475037B1 (en) | 2002-02-14 | 2012-09-12 | Toshinori Kato | Apparatus for evaluating biological function |
| CA2541297C (en) | 2003-10-03 | 2013-12-10 | Academisch Medisch Centrum | System and method for imaging the reflectance of a substrate |
-
2007
- 2007-01-19 US US11/624,820 patent/US8129105B2/en not_active Expired - Fee Related
- 2007-03-12 CA CA2648931A patent/CA2648931C/en active Active
- 2007-03-12 EP EP07758327A patent/EP2004040A4/en not_active Ceased
- 2007-03-12 JP JP2009505524A patent/JP2009533160A/ja active Pending
- 2007-03-12 WO PCT/US2007/063768 patent/WO2007121009A2/en not_active Ceased
- 2007-03-12 AU AU2007238412A patent/AU2007238412B2/en not_active Ceased
- 2007-10-10 US US11/870,355 patent/US8309346B2/en not_active Expired - Fee Related
-
2012
- 2012-11-09 US US13/673,377 patent/US9215982B2/en active Active
- 2012-11-21 JP JP2012255630A patent/JP2013078592A/ja active Pending
-
2015
- 2015-07-30 JP JP2015151263A patent/JP6240833B2/ja not_active Expired - Fee Related
- 2015-12-18 US US14/974,550 patent/US9462951B2/en not_active Expired - Fee Related
-
2016
- 2016-10-07 US US15/288,840 patent/US10004401B2/en active Active
-
2018
- 2018-06-22 US US16/015,659 patent/US10194804B2/en active Active
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2019
- 2019-01-22 US US16/253,633 patent/US10542891B2/en active Active
-
2020
- 2020-01-24 US US16/751,678 patent/US11064890B2/en not_active Expired - Fee Related
-
2021
- 2021-07-19 US US17/379,227 patent/US11717166B2/en active Active
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