CA2648931C - Method and apparatus for the non-invasive measurement of tissue function and metabolism by determination of steady-state fluorescence anisotropy - Google Patents

Method and apparatus for the non-invasive measurement of tissue function and metabolism by determination of steady-state fluorescence anisotropy Download PDF

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Publication number
CA2648931C
CA2648931C CA2648931A CA2648931A CA2648931C CA 2648931 C CA2648931 C CA 2648931C CA 2648931 A CA2648931 A CA 2648931A CA 2648931 A CA2648931 A CA 2648931A CA 2648931 C CA2648931 C CA 2648931C
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tissue
fluorescence anisotropy
steady
stimulated
resting
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French (fr)
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CA2648931A1 (en
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Ralph Zuckerman
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Cellview Imaging Inc
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Cellview Imaging Inc
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/0059—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
    • A61B5/0071—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence by measuring fluorescence emission
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue
    • A61B5/14546—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue for measuring analytes not otherwise provided for, e.g. ions, cytochromes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue
    • A61B5/1455—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue using optical sensors, e.g. spectral photometrical oximeters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue
    • A61B5/1455—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue using optical sensors, e.g. spectral photometrical oximeters
    • A61B5/14551—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue using optical sensors, e.g. spectral photometrical oximeters for measuring blood gases
    • A61B5/14555—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue using optical sensors, e.g. spectral photometrical oximeters for measuring blood gases specially adapted for the eye fundus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue
    • A61B5/1455—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue using optical sensors, e.g. spectral photometrical oximeters
    • A61B5/14551—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue using optical sensors, e.g. spectral photometrical oximeters for measuring blood gases
    • A61B5/14556—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue using optical sensors, e.g. spectral photometrical oximeters for measuring blood gases by fluorescence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/48—Other medical applications
    • A61B5/4842—Monitoring progression or stage of a disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/72—Signal processing specially adapted for physiological signals or for diagnostic purposes
    • A61B5/7235—Details of waveform analysis
    • A61B5/7246—Details of waveform analysis using correlation, e.g. template matching or determination of similarity
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/72—Signal processing specially adapted for physiological signals or for diagnostic purposes
    • A61B5/7271—Specific aspects of physiological measurement analysis
    • A61B5/7278—Artificial waveform generation or derivation, e.g. synthesizing signals from measured signals
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/645—Specially adapted constructive features of fluorimeters
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/645—Specially adapted constructive features of fluorimeters
    • G01N2021/6484—Optical fibres
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/6445—Measuring fluorescence polarisation
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2201/00—Features of devices classified in G01N21/00
    • G01N2201/06—Illumination; Optics
    • G01N2201/068—Optics, miscellaneous
    • G01N2201/0683—Brewster plate; polarisation controlling elements
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2201/00—Features of devices classified in G01N21/00
    • G01N2201/12—Circuits of general importance; Signal processing

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Pathology (AREA)
  • Molecular Biology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Biophysics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Medical Informatics (AREA)
  • Surgery (AREA)
  • Optics & Photonics (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Physiology (AREA)
  • Artificial Intelligence (AREA)
  • Psychiatry (AREA)
  • Signal Processing (AREA)
  • Computer Vision & Pattern Recognition (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Ophthalmology & Optometry (AREA)
  • Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
  • Eye Examination Apparatus (AREA)
CA2648931A 2006-04-13 2007-03-12 Method and apparatus for the non-invasive measurement of tissue function and metabolism by determination of steady-state fluorescence anisotropy Active CA2648931C (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US74483106P 2006-04-13 2006-04-13
US60/744,831 2006-04-13
US11/624,820 US8129105B2 (en) 2006-04-13 2007-01-19 Method and apparatus for the non-invasive measurement of tissue function and metabolism by determination of steady-state fluorescence anisotropy
US11/624,820 2007-01-19
PCT/US2007/063768 WO2007121009A2 (en) 2006-04-13 2007-03-12 Method and apparatus for the non-invasive measurement of tissue function and metabolism by determination of steady-state fluorescence anisotropy

Publications (2)

Publication Number Publication Date
CA2648931A1 CA2648931A1 (en) 2007-10-25
CA2648931C true CA2648931C (en) 2017-06-13

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CA2648931A Active CA2648931C (en) 2006-04-13 2007-03-12 Method and apparatus for the non-invasive measurement of tissue function and metabolism by determination of steady-state fluorescence anisotropy

Country Status (6)

Country Link
US (9) US8129105B2 (https=)
EP (1) EP2004040A4 (https=)
JP (3) JP2009533160A (https=)
AU (1) AU2007238412B2 (https=)
CA (1) CA2648931C (https=)
WO (1) WO2007121009A2 (https=)

Families Citing this family (40)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2904927B1 (fr) * 2006-08-17 2018-05-18 Mauna Kea Technologies Utilisation d'un systeme d'imagerie par fluorescence confocale fibre in vivo in situ, systeme et procede d'imagerie par fluorescence confocale fibres in vivo in situ
US8270689B2 (en) 2006-09-12 2012-09-18 Carestream Health, Inc. Apparatus for caries detection
US20080214940A1 (en) * 2007-03-02 2008-09-04 Benaron David A Medical imaging lens system, and method with high-efficiency light collection and collinear illumination
JP5968590B2 (ja) 2007-11-05 2016-08-10 ケーシーアイ ライセンシング インコーポレイテッド 創面切除のための組織の同定
US8403862B2 (en) * 2007-12-20 2013-03-26 Yeda Research And Development Co. Ltd. Time-based imaging
DK2291640T3 (en) 2008-05-20 2019-03-11 Univ Health Network Device and method for fluorescence-based imaging and monitoring
JP5543126B2 (ja) * 2009-04-16 2014-07-09 キヤノン株式会社 医用画像処理装置及びその制御方法
WO2012061836A2 (en) * 2010-11-05 2012-05-10 Freedom Meditech, Inc. Improved algorithm for detection of diabetes
JP5816486B2 (ja) * 2011-08-18 2015-11-18 オリンパス株式会社 蛍光観察装置および蛍光観察システム並びに蛍光観察装置の蛍光画像処理方法
ES2727868T3 (es) 2011-09-22 2019-10-21 Univ George Washington Sistemas para visualizar el tejido ablacionado
WO2013044182A1 (en) 2011-09-22 2013-03-28 The George Washington University Systems and methods for visualizing ablated tissue
US9677869B2 (en) 2012-12-05 2017-06-13 Perimeter Medical Imaging, Inc. System and method for generating a wide-field OCT image of a portion of a sample
JP6737705B2 (ja) * 2013-11-14 2020-08-12 ザ・ジョージ・ワシントン・ユニバーシティＴｈｅ Ｇｅｏｒｇｅ Ｗａｓｈｉｎｇｔｏｎｕｎｉｖｅｒｓｉｔｙ 損傷部位の深さを決定するシステムの動作方法及び心臓組織の画像を生成するシステム
CN112674861B (zh) * 2013-11-14 2024-11-15 乔治华盛顿大学 用于使用荧光成像来确定损伤灶深度的系统和方法
WO2015077474A1 (en) 2013-11-20 2015-05-28 The George Washington University Systems and methods for hyperspectral analysis of cardiac tissue
EP3957232B1 (en) 2014-07-24 2025-12-31 University Health Network DATA COLLECTION AND ANALYSIS FOR DIAGNOSTIC PURPOSES
CN113143440B (zh) 2014-11-03 2024-07-30 乔治华盛顿大学 用于损伤评估的系统和方法
JP6771731B2 (ja) 2014-11-03 2020-10-21 ４６０メディカル・インコーポレイテッド４６０Ｍｅｄｉｃａｌ， Ｉｎｃ． 接触性評価システム及び方法
US10337983B2 (en) 2015-04-12 2019-07-02 Taiwan Biophotonic Corporation Module, device and method for optical measurement
JP2018516112A (ja) * 2015-04-17 2018-06-21 コーニンクレッカ フィリップス エヌ ヴェＫｏｎｉｎｋｌｉｊｋｅ Ｐｈｉｌｉｐｓ Ｎ．Ｖ． 異方性をもつ生物学的組織の検出
US10779904B2 (en) 2015-07-19 2020-09-22 460Medical, Inc. Systems and methods for lesion formation and assessment
HK1248774A1 (zh) * 2015-08-26 2018-10-19 仓敷纺绩株式会社 细胞测定方法
WO2018016409A1 (ja) * 2016-07-19 2018-01-25 株式会社アサヒビジョン 眼球分析装置および眼球分析方法
JP6438603B2 (ja) * 2016-07-19 2018-12-19 株式会社アサヒビジョン 眼球分析装置
US10201306B2 (en) * 2016-08-30 2019-02-12 Konica Minolta Laboratory U.S.A., Inc. Method and system for capturing images for wound assessment with self color compensation
US10337995B2 (en) 2017-06-12 2019-07-02 Boston Medical Center Corporation Systems and methods for oblique laser scanning
EP3655748B1 (en) 2017-07-18 2023-08-09 Perimeter Medical Imaging, Inc. Sample container for stabilizing and aligning excised biological tissue samples for ex vivo analysis
CN109100325B (zh) * 2018-06-14 2020-12-25 东南大学 一种基于光谱吸收率二次谐波特征提取的气体浓度测量方法
EP3807623B1 (en) * 2018-06-18 2023-03-01 Calico Life Sciences LLC System and method for inferring protein binding
AU2019333082B2 (en) 2018-08-29 2024-06-13 Wisconsin Alumni Research Foundation Systems and methods for sorting T cells by activation state
DE102019006971A1 (de) * 2019-10-07 2021-04-08 aquila biolabs GmbH Verfahren und Vorrichtung zur Bestimmung des Zustands von Zellen in Reaktoren
KR102116232B1 (ko) * 2019-11-12 2020-05-28 (주)로고스바이오시스템스 시료 검출 장치 및 이를 이용한 시료 검출 방법
US12076081B2 (en) 2020-01-08 2024-09-03 460Medical, Inc. Systems and methods for optical interrogation of ablation lesions
WO2021174160A1 (en) 2020-02-28 2021-09-02 Preformed Line Products Co. Cable spacer comprising a ratchet spacer clamp
US12539043B2 (en) 2020-05-27 2026-02-03 The George Washington University Lesion visualization using dual wavelength approach
US12016656B2 (en) * 2020-10-09 2024-06-25 QuantuMed Pty Ltd Cellular ionic activity visualisation
KR102553788B1 (ko) * 2021-01-20 2023-07-12 연세대학교 산학협력단 시료의 광학적 이방성을 정량화하는 현미경 시스템
AU2022234898A1 (en) 2021-03-12 2023-09-28 Stryker European Operations Limited Neurosurgical methods and systems for detecting and removing tumorous tissue
US20230085578A1 (en) * 2021-09-02 2023-03-16 The George Washington University Systems and methods for triple-parametric optical mapping
US11467151B1 (en) 2021-12-23 2022-10-11 United Arab Emirates University Phosphorescence oxygen analyzer and uses thereof

Family Cites Families (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4115699A (en) 1977-06-16 1978-09-19 Kabushiki Kaisha Nihon Kotai Kenkyujo Apparatus for sensitive detection and quantitative analysis of biological and biochemical substances
US4476870A (en) 1982-03-30 1984-10-16 The United States Of America As Represented By The Department Of Health And Human Services Fiber optic PO.sbsb.2 probe
DE3245939C2 (de) 1982-12-11 1985-12-19 Fa. Carl Zeiss, 7920 Heidenheim Vorrichtung zur Erzeugung eines Bildes des Augenhintergrundes
US4810655A (en) 1985-07-03 1989-03-07 Abbott Laboratories Method for measuring oxygen concentration
US5120510A (en) 1986-10-10 1992-06-09 Minnesota Mining And Manufacturing Company Sensor and method for sensing the concentration of a component in a medium
US4947850A (en) 1988-03-11 1990-08-14 Trustees Of The University Of Pennsylvania Method and apparatus for imaging an internal body portion of a host animal
US5039219A (en) 1989-05-26 1991-08-13 Photon Technology Luminescence system and method for determining the nature of substances by measuring fluorescence and phosphorescence properties
EP0471861B1 (en) 1990-08-13 1995-11-08 Hewlett-Packard GmbH Optical probe
US5186173A (en) 1990-08-14 1993-02-16 Drexel University Method for in vivo measurement of oxygen concentration levels
US5318023A (en) 1991-04-03 1994-06-07 Cedars-Sinai Medical Center Apparatus and method of use for a photosensitizer enhanced fluorescence based biopsy needle
EP0515211A3 (en) 1991-05-23 1993-04-07 Becton Dickinson And Company Apparatus and method for phase resolved fluorescence lifetimes of independent and varying amplitude pulses
US5281825A (en) 1991-09-05 1994-01-25 The University Of Maryland School Of Medicine Phase fluorometry using a modulated electroluminescent lamp as a light source
US5341805A (en) 1993-04-06 1994-08-30 Cedars-Sinai Medical Center Glucose fluorescence monitor and method
US5383452A (en) 1993-07-01 1995-01-24 Buchert; Janusz Method, apparatus and procedure for non-invasive monitoring blood glucose by measuring the polarization ratio of blood luminescence
US5515864A (en) 1994-04-21 1996-05-14 Zuckerman; Ralph Method and apparatus for the in vivo measurement of oxygen concentration levels by the indirect determination of fluoescence lifetime
US5701902A (en) 1994-09-14 1997-12-30 Cedars-Sinai Medical Center Spectroscopic burn injury evaluation apparatus and method
US6007994A (en) * 1995-12-22 1999-12-28 Yale University Multiparametric fluorescence in situ hybridization
WO1998038490A1 (en) * 1997-02-27 1998-09-03 Cellomics, Inc. A system for cell-based screening
WO1999060377A1 (en) 1998-05-19 1999-11-25 Spectrx, Inc. Apparatus and method for determining tissue characteristics
IL125614A (en) * 1998-07-31 2003-01-12 Amiram Grinvald System and method for non-invasive imaging of retinal function
EP1475037B1 (en) 2002-02-14 2012-09-12 Toshinori Kato Apparatus for evaluating biological function
CA2541297C (en) 2003-10-03 2013-12-10 Academisch Medisch Centrum System and method for imaging the reflectance of a substrate

Also Published As

Publication number Publication date
US11717166B2 (en) 2023-08-08
CA2648931A1 (en) 2007-10-25
AU2007238412B2 (en) 2013-07-04
WO2007121009A2 (en) 2007-10-25
US20180360318A1 (en) 2018-12-20
US8129105B2 (en) 2012-03-06
US20160174845A1 (en) 2016-06-23
US8309346B2 (en) 2012-11-13
JP2016000215A (ja) 2016-01-07
EP2004040A2 (en) 2008-12-24
WO2007121009A3 (en) 2008-03-06
US20170150887A1 (en) 2017-06-01
AU2007238412A1 (en) 2007-10-25
US9215982B2 (en) 2015-12-22
JP6240833B2 (ja) 2017-12-06
US20220039655A1 (en) 2022-02-10
US9462951B2 (en) 2016-10-11
US10194804B2 (en) 2019-02-05
EP2004040A4 (en) 2010-05-26
US20200329971A1 (en) 2020-10-22
US20080254531A1 (en) 2008-10-16
US20070243521A1 (en) 2007-10-18
US20190254526A1 (en) 2019-08-22
JP2009533160A (ja) 2009-09-17
US10004401B2 (en) 2018-06-26
US20130072769A1 (en) 2013-03-21
JP2013078592A (ja) 2013-05-02
US11064890B2 (en) 2021-07-20
WO2007121009B1 (en) 2008-04-17
US10542891B2 (en) 2020-01-28

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