JP2009532438A - 白血病の処置のためのピリミジルアミノベンズアミド化合物との組合せでのｃ−Ｓｒｃ阻害剤の使用 - Google Patents
白血病の処置のためのピリミジルアミノベンズアミド化合物との組合せでのｃ−Ｓｒｃ阻害剤の使用 Download PDFInfo
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Classifications
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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4709—Non-condensed quinolines and containing further heterocyclic rings
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A—HUMAN NECESSITIES
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Oncology (AREA)
- Hematology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US79043706P | 2006-04-07 | 2006-04-07 | |
| PCT/EP2007/053399 WO2007116025A2 (en) | 2006-04-07 | 2007-04-05 | Use of c-src inhibitors in combination with a pyrimidylaminobenzamide compound for the treatment of leukemia |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013016980A Division JP2013136596A (ja) | 2006-04-07 | 2013-01-31 | 白血病の処置のためのピリミジルアミノベンズアミド化合物との組合せでのｃ−Ｓｒｃ阻害剤の使用 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2009532438A true JP2009532438A (ja) | 2009-09-10 |
| JP2009532438A5 JP2009532438A5 (enExample) | 2010-05-20 |
Family
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Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009503591A Pending JP2009532438A (ja) | 2006-04-07 | 2007-04-05 | 白血病の処置のためのピリミジルアミノベンズアミド化合物との組合せでのｃ−Ｓｒｃ阻害剤の使用 |
| JP2013016980A Pending JP2013136596A (ja) | 2006-04-07 | 2013-01-31 | 白血病の処置のためのピリミジルアミノベンズアミド化合物との組合せでのｃ−Ｓｒｃ阻害剤の使用 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013016980A Pending JP2013136596A (ja) | 2006-04-07 | 2013-01-31 | 白血病の処置のためのピリミジルアミノベンズアミド化合物との組合せでのｃ−Ｓｒｃ阻害剤の使用 |
Country Status (11)
| Country | Link |
|---|---|
| US (2) | US20100152198A1 (enExample) |
| EP (1) | EP2010182A2 (enExample) |
| JP (2) | JP2009532438A (enExample) |
| KR (2) | KR20090031855A (enExample) |
| CN (1) | CN101415426A (enExample) |
| AU (1) | AU2007235976A1 (enExample) |
| BR (1) | BRPI0710675A2 (enExample) |
| CA (1) | CA2644841C (enExample) |
| MX (1) | MX2008012903A (enExample) |
| RU (2) | RU2008143703A (enExample) |
| WO (1) | WO2007116025A2 (enExample) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK1848414T3 (da) | 2005-02-03 | 2011-07-25 | Gen Hospital Corp | Fremgangsmåde til behandling af gefitinib-resistent cancer |
| AU2006311877A1 (en) | 2005-11-04 | 2007-05-18 | Wyeth Llc | Antineoplastic combinations with mTOR inhibitor, herceptin, and/orHKI-272 |
| US8022216B2 (en) | 2007-10-17 | 2011-09-20 | Wyeth Llc | Maleate salts of (E)-N-{4-[3-chloro-4-(2-pyridinylmethoxy)anilino]-3-cyano-7-ethoxy-6-quinolinyl}-4-(dimethylamino)-2-butenamide and crystalline forms thereof |
| SI2310011T1 (sl) | 2008-06-17 | 2013-10-30 | Wyeth Llc | Antineoplastične kombinacije, ki vsebujejo HKI-272 in vinorelbin |
| BRPI0916694B1 (pt) * | 2008-08-04 | 2021-06-08 | Wyeth Llc | uso de neratinibe em combinação com capecitabina para tratar câncer de mama metastático de erbb-2 positivo, kit e produto compreendendo os mesmos |
| EA201890869A3 (ru) | 2010-06-03 | 2019-03-29 | Фармасайкликс, Инк. | Применение ингибиторов тирозинкиназы брутона (btk) |
| WO2014018567A1 (en) | 2012-07-24 | 2014-01-30 | Pharmacyclics, Inc. | Mutations associated with resistance to inhibitors of bruton's tyrosine kinase (btk) |
| CN103113355B (zh) * | 2013-02-27 | 2014-08-13 | 无锡爱内特生物科技有限公司 | 一种Bcr/Abl酪氨酸激酶抑制剂及其制备方法和在治疗慢性粒细胞白血病中的应用 |
| US20170114323A1 (en) | 2014-06-19 | 2017-04-27 | Whitehead Institute For Biomedical Research | Uses of kinase inhibitors for inducing and maintaining pluripotency |
| US12371667B2 (en) | 2021-05-13 | 2025-07-29 | Washington University | Enhanced methods for inducing and maintaining naive human pluripotent stem cells |
| CN116178358B (zh) * | 2022-11-04 | 2024-04-19 | 济南大学 | 一种靶向c-Src激酶SH3结构域的化合物及其应用 |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2005502643A (ja) * | 2001-08-10 | 2005-01-27 | ノバルティス アクチエンゲゼルシャフト | 白血病処置のための単独またはｓｔｉ５７１と組み合せたｃ−ｓｒｃインヒビターの使用 |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CH690773A5 (de) * | 1996-02-01 | 2001-01-15 | Novartis Ag | Pyrrolo(2,3-d)pyrimide und ihre Verwendung. |
| WO2002000024A1 (en) * | 2000-06-30 | 2002-01-03 | The Regents Of The University Of California | New strategy for leukemia therapy |
| WO2002062334A2 (en) * | 2001-02-05 | 2002-08-15 | Pezzuto John M | Cancer chemopreventative compounds and compositions and methods of treating cancers |
| AU2002345670A1 (en) * | 2001-06-14 | 2003-01-02 | The Regents Of The University Of California | Mutations in the bcr-abl tyrosine kinase associated with resistance to sti-571 |
| EP1473043A1 (en) * | 2003-04-29 | 2004-11-03 | Boehringer Ingelheim Pharma GmbH & Co.KG | Pharmaceutical combination for the treatment of diseases involving cell proliferation, migration or apotosis of myeloma cells, or angiogenesis |
| AU2003291245A1 (en) * | 2003-11-06 | 2004-06-06 | Wyeth | 4-anilino-3-quinolinecarbonitriles for the treatment of chronic myelogenous leukemia (cml) |
| US20060069101A1 (en) * | 2004-09-27 | 2006-03-30 | Kim Kyoung S | Prodrugs of protein tyrosine kinase inhibitors |
| US20060235006A1 (en) * | 2005-04-13 | 2006-10-19 | Lee Francis Y | Combinations, methods and compositions for treating cancer |
| GT200600315A (es) * | 2005-07-20 | 2007-03-19 | Formas cristalinas de 4-metilo-n-[3-(4-metilo-imidazol-1-ilo)-5-trifluorometilo-fenilo]-3-(4-pyridina-3-ilo-pirimidina-2-iloamino)-benzamida | |
| GT200600316A (es) * | 2005-07-20 | 2007-04-02 | Sales de 4-metilo-n-(3-(4-metilo-imidazol-1-ilo)-5-trifluorometilo-fenilo)-3-(4-piridina-3-ilo-pirimidina-2-iloamino)- benzamida. |
-
2007
- 2007-04-05 MX MX2008012903A patent/MX2008012903A/es active IP Right Grant
- 2007-04-05 JP JP2009503591A patent/JP2009532438A/ja active Pending
- 2007-04-05 BR BRPI0710675-0A patent/BRPI0710675A2/pt not_active IP Right Cessation
- 2007-04-05 US US12/295,832 patent/US20100152198A1/en not_active Abandoned
- 2007-04-05 WO PCT/EP2007/053399 patent/WO2007116025A2/en not_active Ceased
- 2007-04-05 KR KR1020087027245A patent/KR20090031855A/ko not_active Ceased
- 2007-04-05 AU AU2007235976A patent/AU2007235976A1/en not_active Abandoned
- 2007-04-05 CN CNA2007800120868A patent/CN101415426A/zh active Pending
- 2007-04-05 KR KR1020117016784A patent/KR101292508B1/ko not_active Expired - Fee Related
- 2007-04-05 EP EP07727867A patent/EP2010182A2/en not_active Withdrawn
- 2007-04-05 RU RU2008143703/15A patent/RU2008143703A/ru unknown
- 2007-04-05 CA CA2644841A patent/CA2644841C/en not_active Expired - Fee Related
-
2012
- 2012-09-24 US US13/625,299 patent/US20130040972A1/en not_active Abandoned
- 2012-11-08 RU RU2012147511/15A patent/RU2012147511A/ru not_active Application Discontinuation
-
2013
- 2013-01-31 JP JP2013016980A patent/JP2013136596A/ja active Pending
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2005502643A (ja) * | 2001-08-10 | 2005-01-27 | ノバルティス アクチエンゲゼルシャフト | 白血病処置のための単独またはｓｔｉ５７１と組み合せたｃ−ｓｒｃインヒビターの使用 |
Non-Patent Citations (3)
| Title |
|---|
| JPN5009003534; Ｏ'ＨＡＲＥ Ｔ ｅｔ ａｌ．: ＣＡＮＣＥＲ ＲＥＳＥＡＲＣＨ Ｖｏｌ．６５ Ｎｏ．１１, 20050601, ｐｐ．４５００-４５０５, ＡＭＥＲＩＣＡＮ ＡＳＳＯＣＩＡＴＩＯＮ ＦＯＲ ＣＡＮＣＥＲ ＲＥＳＥＡＲＣＨ * |
| JPN5009003536; ＭＡＮＬＥＹ ＰＷ ｅｔ ａｌ．: ＢＩＯＣＨＩＭＩＣＡ ＥＴ ＢＩＯＰＨＹＳＩＣＡ ＡＣＴＡ Ｖｏｌ．１７５４ Ｎｏ．１-２, 20051230, ｐｐ．３-１３, ＥＬＳＥＶＩＥＲ * |
| JPN6012028011; Ｇｒａｆｏｎｅ Ｔ ｅｔ ａｌ．: 'Ａ Ｎｏｖｅｌ ４-ａｎｉｌｉｎｏ-３-ｑｕｉｎｏｌｉｎｅｃａｒｂｏｎｉｔｒｉｌｅ Ｄｕａｌ Ｓｒｃ ａｎｄ Ａｂｌ Ｋｉｎａｓｅ Ｉｎｈｉｂｉｔｏｒ （ＳＫＩ-６０６） Ｈａｓ Ｉｎ Ｖｉｔｒｏ Ａ' Ｂｌｏｏｄ ２００４ Ｖｏｌ．１０４, 2004 * |
Also Published As
| Publication number | Publication date |
|---|---|
| BRPI0710675A2 (pt) | 2011-08-23 |
| KR20110097966A (ko) | 2011-08-31 |
| CA2644841A1 (en) | 2007-10-18 |
| MX2008012903A (es) | 2008-10-13 |
| KR20090031855A (ko) | 2009-03-30 |
| KR101292508B1 (ko) | 2013-08-01 |
| RU2008143703A (ru) | 2010-05-20 |
| RU2012147511A (ru) | 2014-05-20 |
| WO2007116025A3 (en) | 2007-12-13 |
| WO2007116025A2 (en) | 2007-10-18 |
| AU2007235976A1 (en) | 2007-10-18 |
| US20100152198A1 (en) | 2010-06-17 |
| US20130040972A1 (en) | 2013-02-14 |
| CN101415426A (zh) | 2009-04-22 |
| JP2013136596A (ja) | 2013-07-11 |
| EP2010182A2 (en) | 2009-01-07 |
| CA2644841C (en) | 2013-07-16 |
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