JP2009532437A5 - - Google Patents
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- Publication number
- JP2009532437A5 JP2009532437A5 JP2009503590A JP2009503590A JP2009532437A5 JP 2009532437 A5 JP2009532437 A5 JP 2009532437A5 JP 2009503590 A JP2009503590 A JP 2009503590A JP 2009503590 A JP2009503590 A JP 2009503590A JP 2009532437 A5 JP2009532437 A5 JP 2009532437A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- different
- same
- halogen atoms
- hydrogen atom
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
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- 125000005843 halogen group Chemical group 0.000 claims description 122
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims description 61
- 125000000623 heterocyclic group Chemical group 0.000 claims description 49
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 19
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims description 10
- 125000004093 cyano group Chemical group *C#N 0.000 claims description 8
- 150000001875 compounds Chemical class 0.000 claims 27
- -1 2-bromo-4-methyl-1,3-thiazol-5-yl Chemical group 0.000 claims 19
- 229910052739 hydrogen Inorganic materials 0.000 claims 6
- 239000001257 hydrogen Substances 0.000 claims 6
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims 6
- 125000006715 (C1-C5) alkylthio group Chemical group 0.000 claims 5
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 5
- 125000006730 (C2-C5) alkynyl group Chemical group 0.000 claims 4
- 125000000217 alkyl group Chemical group 0.000 claims 4
- 125000001181 organosilyl group Chemical group [SiH3]* 0.000 claims 4
- 125000003854 p-chlorophenyl group Chemical group [H]C1=C([H])C(*)=C([H])C([H])=C1Cl 0.000 claims 4
- 125000000951 phenoxy group Chemical group [H]C1=C([H])C([H])=C(O*)C([H])=C1[H] 0.000 claims 4
- 125000003118 aryl group Chemical group 0.000 claims 3
- 125000000051 benzyloxy group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])O* 0.000 claims 3
- 125000001559 cyclopropyl group Chemical group [H]C1([H])C([H])([H])C1([H])* 0.000 claims 3
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 3
- 125000003356 phenylsulfanyl group Chemical group [*]SC1=C([H])C([H])=C([H])C([H])=C1[H] 0.000 claims 3
- 125000004844 (C1-C6) alkoxyimino group Chemical group 0.000 claims 2
- 125000006729 (C2-C5) alkenyl group Chemical group 0.000 claims 2
- KXDHJXZQYSOELW-UHFFFAOYSA-M Carbamate Chemical compound NC([O-])=O KXDHJXZQYSOELW-UHFFFAOYSA-M 0.000 claims 2
- 125000004453 alkoxycarbonyl group Chemical group 0.000 claims 2
- 125000004644 alkyl sulfinyl group Chemical group 0.000 claims 2
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 claims 2
- 125000000440 benzylamino group Chemical group [H]N(*)C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H] 0.000 claims 2
- 125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 claims 2
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims 2
- 125000000753 cycloalkyl group Chemical group 0.000 claims 2
- 229910052731 fluorine Inorganic materials 0.000 claims 2
- 125000001153 fluoro group Chemical group F* 0.000 claims 2
- 125000002485 formyl group Chemical group [H]C(*)=O 0.000 claims 2
- 125000005842 heteroatom Chemical group 0.000 claims 2
- 125000001624 naphthyl group Chemical group 0.000 claims 2
- 125000004076 pyridyl group Chemical group 0.000 claims 2
- 229910052717 sulfur Inorganic materials 0.000 claims 2
- 125000004434 sulfur atom Chemical group 0.000 claims 2
- 125000003396 thiol group Chemical group [H]S* 0.000 claims 2
- 241000233866 Fungi Species 0.000 claims 1
- 125000005103 alkyl silyl group Chemical group 0.000 claims 1
- 125000002490 anilino group Chemical group [H]N(*)C1=C([H])C([H])=C([H])C([H])=C1[H] 0.000 claims 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims 1
- 235000013399 edible fruits Nutrition 0.000 claims 1
- 125000001188 haloalkyl group Chemical group 0.000 claims 1
- 150000002431 hydrogen Chemical class 0.000 claims 1
- 229910052760 oxygen Inorganic materials 0.000 claims 1
- 239000001301 oxygen Substances 0.000 claims 1
- 125000001639 phenylmethylene group Chemical group [H]C(=*)C1=C([H])C([H])=C([H])C([H])=C1[H] 0.000 claims 1
- 230000003032 phytopathogenic effect Effects 0.000 claims 1
- 239000002689 soil Substances 0.000 claims 1
- 125000000383 tetramethylene group Chemical group [H]C([H])([*:1])C([H])([H])C([H])([H])C([H])([H])[*:2] 0.000 claims 1
- 0 Cc1n[o]c(C)c1* Chemical compound Cc1n[o]c(C)c1* 0.000 description 55
- HSQGRXTXMXMKPQ-UHFFFAOYSA-N Cc1c(C)[s]nn1 Chemical compound Cc1c(C)[s]nn1 HSQGRXTXMXMKPQ-UHFFFAOYSA-N 0.000 description 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP06356039 | 2006-04-05 | ||
| PCT/EP2007/053387 WO2007113327A2 (en) | 2006-04-05 | 2007-04-05 | Fungicide n-cyclopropyl-sulfonylamide derivatives |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2009532437A JP2009532437A (ja) | 2009-09-10 |
| JP2009532437A5 true JP2009532437A5 (enExample) | 2010-02-04 |
Family
ID=37027680
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009503590A Withdrawn JP2009532437A (ja) | 2006-04-05 | 2007-04-05 | 殺菌剤ｎ−シクロプロピル−スルホニルアミド誘導体 |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US7932283B2 (enExample) |
| EP (1) | EP2007745A2 (enExample) |
| JP (1) | JP2009532437A (enExample) |
| CN (1) | CN101415698A (enExample) |
| WO (1) | WO2007113327A2 (enExample) |
Families Citing this family (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MX2012013897A (es) * | 2010-06-03 | 2012-12-17 | Bayer Cropscience Ag | N[(het)ariletil)]pirazol (tio)carboxamidas y sus analogos heterosustituidos. |
| CA2796194A1 (en) * | 2010-06-03 | 2011-12-08 | Bayer Cropscience Ag | N-[(het)arylalkyl)] pyrazole (thio)carboxamides and their heterosubstituted analogues |
| AU2011318398B2 (en) * | 2010-10-18 | 2015-09-10 | E. I. Du Pont De Nemours And Company | Nematocidal sulfonamides |
| WO2012065944A1 (en) | 2010-11-15 | 2012-05-24 | Bayer Cropscience Ag | N-aryl pyrazole(thio)carboxamides |
| EP2540163A1 (en) | 2011-06-30 | 2013-01-02 | Bayer CropScience AG | Nematocide N-cyclopropyl-sulfonylamide derivatives |
| CN105859623B (zh) * | 2013-09-18 | 2018-01-16 | 河北兰升生物科技有限公司 | 吡唑酰基氨磺酰苯甲酰胺制备方法及其中间体 |
| EP3798214B1 (en) | 2014-10-06 | 2022-09-14 | Vertex Pharmaceuticals Incorporated | Modulators of cystic fibrosis transmembrane conductance regulator |
| CN104610204B (zh) * | 2015-02-05 | 2016-08-24 | 西华大学 | 甲酰氨基二苯基酰胺类化合物及其应用 |
| CN104610205B (zh) * | 2015-02-05 | 2016-08-24 | 西华大学 | 亚甲基二苯基酰胺类化合物及其应用 |
| EP3436446B1 (en) | 2016-03-31 | 2023-06-07 | Vertex Pharmaceuticals Incorporated | Modulators of cystic fibrosis transmembrane conductance regulator |
| SG10201913595YA (en) | 2016-09-30 | 2020-02-27 | Vertex Pharma | Modulator of cystic fibrosis transmembrane conductance regulator, pharmaceutical compositions, methods of treatment, and process for making the modulator |
| TW201822637A (zh) * | 2016-11-07 | 2018-07-01 | 德商拜耳廠股份有限公司 | 用於控制動物害蟲的經取代磺醯胺類 |
| MA49235B1 (fr) | 2016-12-09 | 2021-02-26 | Vertex Pharma | Modulateur de régulateur de conductance transmembranaire de fibrose kystique, compositions pharmaceutiques, procédés de traitement et procédé de fabrication du modulateur |
| EP3634402B1 (en) | 2017-06-08 | 2026-01-21 | Vertex Pharmaceuticals Incorporated | Methods of treatment for cystic fibrosis |
| BR112020000941A2 (pt) | 2017-07-17 | 2020-07-21 | Vertex Pharmaceuticals Incorporated | métodos de tratamento para fibrose cística |
| TWI799435B (zh) | 2017-08-02 | 2023-04-21 | 美商維泰克斯製藥公司 | 製備化合物之製程 |
| IL273831B2 (en) | 2017-10-19 | 2024-10-01 | Vertex Pharma | Crystalline forms and compositions of cftr modulators |
| CN111757874B (zh) | 2017-12-08 | 2024-03-08 | 弗特克斯药品有限公司 | 用于制备囊性纤维化跨膜传导调节因子的调节剂的方法 |
| TWI810243B (zh) | 2018-02-05 | 2023-08-01 | 美商維泰克斯製藥公司 | 用於治療囊腫纖化症之醫藥組合物 |
| US11414439B2 (en) | 2018-04-13 | 2022-08-16 | Vertex Pharmaceuticals Incorporated | Modulators of cystic fibrosis transmembrane conductance regulator, pharmaceutical compositions, methods of treatment, and process for making the modulator |
| CN111423379B (zh) * | 2020-05-21 | 2021-08-03 | 湖南科技大学 | 取代3-吲唑类Mcl-1蛋白抑制剂及制备方法和应用 |
| MX2024009226A (es) * | 2022-01-27 | 2024-08-06 | Pi Industries Ltd | Compuestos de 1,2,3-triazol carbonil sulfonilamidas y uso de los mismos. |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH08277277A (ja) | 1995-04-06 | 1996-10-22 | Mitsui Toatsu Chem Inc | イソチアゾールカルボン酸誘導体およびこれらを有効成分とするイネいもち病防除剤 |
| JPH0931069A (ja) | 1995-07-24 | 1997-02-04 | Nissan Chem Ind Ltd | チアゾールカルボン酸誘導体および植物病害防除剤 |
| JP2001294581A (ja) * | 2000-04-12 | 2001-10-23 | Nippon Bayer Agrochem Co Ltd | イソチアゾール誘導体 |
-
2007
- 2007-04-05 WO PCT/EP2007/053387 patent/WO2007113327A2/en not_active Ceased
- 2007-04-05 CN CNA200780012170XA patent/CN101415698A/zh active Pending
- 2007-04-05 US US12/225,968 patent/US7932283B2/en not_active Expired - Fee Related
- 2007-04-05 EP EP07727855A patent/EP2007745A2/en not_active Withdrawn
- 2007-04-05 JP JP2009503590A patent/JP2009532437A/ja not_active Withdrawn
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