JP2009531406A5 - - Google Patents
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- Publication number
- JP2009531406A5 JP2009531406A5 JP2009502210A JP2009502210A JP2009531406A5 JP 2009531406 A5 JP2009531406 A5 JP 2009531406A5 JP 2009502210 A JP2009502210 A JP 2009502210A JP 2009502210 A JP2009502210 A JP 2009502210A JP 2009531406 A5 JP2009531406 A5 JP 2009531406A5
- Authority
- JP
- Japan
- Prior art keywords
- integer
- substituents
- cooch
- salt
- straight
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 229910052760 oxygen Inorganic materials 0.000 claims 2
- 229910052717 sulfur Inorganic materials 0.000 claims 2
- 125000000217 alkyl group Chemical group 0.000 claims 1
- 125000002947 alkylene group Chemical group 0.000 claims 1
- 229910052799 carbon Inorganic materials 0.000 claims 1
- 150000001875 compounds Chemical class 0.000 claims 1
- 229910052739 hydrogen Inorganic materials 0.000 claims 1
- 229910052757 nitrogen Inorganic materials 0.000 claims 1
- 150000003839 salts Chemical class 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB0606124.6A GB0606124D0 (en) | 2006-03-28 | 2006-03-28 | Buprenorphine derivatives and uses thereof |
| GB0606124.6 | 2006-03-28 | ||
| PCT/GB2007/001120 WO2007110636A1 (en) | 2006-03-28 | 2007-03-27 | Buprenorphine derivatives and uses thereof |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2009531406A JP2009531406A (ja) | 2009-09-03 |
| JP2009531406A5 true JP2009531406A5 (cg-RX-API-DMAC7.html) | 2010-05-13 |
| JP5167446B2 JP5167446B2 (ja) | 2013-03-21 |
Family
ID=36384277
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009502210A Expired - Fee Related JP5167446B2 (ja) | 2006-03-28 | 2007-03-27 | ブプレノルフィン誘導体及びその使用 |
Country Status (21)
| Country | Link |
|---|---|
| US (1) | US7964610B2 (cg-RX-API-DMAC7.html) |
| EP (1) | EP2001891B1 (cg-RX-API-DMAC7.html) |
| JP (1) | JP5167446B2 (cg-RX-API-DMAC7.html) |
| KR (1) | KR101430626B1 (cg-RX-API-DMAC7.html) |
| CN (2) | CN104151320A (cg-RX-API-DMAC7.html) |
| AU (1) | AU2007231133B2 (cg-RX-API-DMAC7.html) |
| BR (1) | BRPI0709157A8 (cg-RX-API-DMAC7.html) |
| CA (1) | CA2647417C (cg-RX-API-DMAC7.html) |
| DK (1) | DK2001891T3 (cg-RX-API-DMAC7.html) |
| ES (1) | ES2432169T3 (cg-RX-API-DMAC7.html) |
| GB (1) | GB0606124D0 (cg-RX-API-DMAC7.html) |
| IL (1) | IL193917A (cg-RX-API-DMAC7.html) |
| MX (1) | MX2008011984A (cg-RX-API-DMAC7.html) |
| MY (1) | MY151025A (cg-RX-API-DMAC7.html) |
| NZ (1) | NZ570997A (cg-RX-API-DMAC7.html) |
| PL (1) | PL2001891T3 (cg-RX-API-DMAC7.html) |
| PT (1) | PT2001891E (cg-RX-API-DMAC7.html) |
| RU (1) | RU2435773C2 (cg-RX-API-DMAC7.html) |
| TW (1) | TWI501969B (cg-RX-API-DMAC7.html) |
| WO (1) | WO2007110636A1 (cg-RX-API-DMAC7.html) |
| ZA (1) | ZA200807614B (cg-RX-API-DMAC7.html) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2663515C (en) | 2006-09-22 | 2015-09-01 | Alltranz Inc. | Transdermally deliverable buprenorphine prodrugs and abuse-resistant compositions thereof |
| CN102036993B (zh) * | 2008-04-24 | 2014-06-25 | 詹森药业有限公司 | 纳美芬二酯前药 |
| FR2975912B1 (fr) | 2011-05-30 | 2013-06-14 | Flamel Tech Sa | Composition a liberation controlee de buprenorphine |
| KR20180080248A (ko) * | 2015-10-26 | 2018-07-11 | 오르포메드, 인코포레이티드 | 부프레노르핀의 에틸렌 글리콜 에테르 |
| JP2019507783A (ja) | 2016-03-09 | 2019-03-22 | エムダブリュ エンキャップ リミテッド | 乱用防止医薬製剤 |
| CA3033046C (en) | 2016-09-13 | 2021-09-07 | Alar Pharmaceuticals Inc. | Sustained-release buprenorphine formulations |
| WO2019064026A1 (en) | 2017-09-29 | 2019-04-04 | Orexo Ab | NEW PHARMACEUTICAL COMPOSITIONS |
| BR112020016576A2 (pt) | 2018-05-11 | 2020-12-15 | Alar Pharmaceuticals Inc. | Formulações injetáveis de ação prolongada e formas cristalinas de derivados de buprenorfina |
| GB201904767D0 (en) | 2019-04-04 | 2019-05-22 | Orexo Ab | New pharmaceutical compositions |
| WO2023102489A1 (en) * | 2021-12-03 | 2023-06-08 | Board Of Regents Of The University Of Nebraska | Compounds, nanoparticles, and pharmaceutical compositions for the treatment of drug addiction |
| CN116283893B (zh) * | 2023-03-22 | 2024-04-26 | 阜阳欣奕华制药科技有限公司 | 硫代羟基乙酸酐的制备方法 |
Family Cites Families (30)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4668685A (en) | 1984-07-05 | 1987-05-26 | E.I. Du Pont De Nemours And Company | Substituted benzoate ester prodrug derivatives of 3-hydroxymorphinans, which are analgesics or narcotic antagonists |
| GB8728294D0 (en) | 1987-12-03 | 1988-01-06 | Reckitt & Colmann Prod Ltd | Treatment compositions |
| US5985880A (en) | 1996-06-05 | 1999-11-16 | Delta Pharmaceuticals | Compositions and methods for reducing respiratory depression and attendant side effects of mu opioid compounds |
| US5512593A (en) | 1993-03-02 | 1996-04-30 | John S. Nagle | Composition and method of treating depression using natoxone or naltrexone in combination with a serotonin reuptake inhibitor |
| US5750534A (en) | 1994-03-16 | 1998-05-12 | National Science Council | Nalbuphine esters having long acting analgesic action and method of use |
| US6004969A (en) | 1996-04-15 | 1999-12-21 | National Science Council | Transdermal delivery of buprenorphine preparations |
| KR100204659B1 (ko) | 1996-05-28 | 1999-06-15 | 강재헌 | 신규한 부프레노핀계 진통제용 화합물 |
| US6225321B1 (en) | 1997-06-05 | 2001-05-01 | Oliver Yoa-Pu Hu | Long analgesic acting nalbuphine polyester derivative and method of use |
| ATE382386T1 (de) | 1998-11-13 | 2008-01-15 | Jagotec Ag | Multidosis-trockenpulverinhalator mit pulverreservoir |
| CN101703777B (zh) | 2000-02-08 | 2012-11-28 | 欧罗赛铁克股份有限公司 | 抗破坏口服阿片样激动剂 |
| US6716449B2 (en) | 2000-02-08 | 2004-04-06 | Euro-Celtique S.A. | Controlled-release compositions containing opioid agonist and antagonist |
| US20030091635A1 (en) | 2001-09-26 | 2003-05-15 | Baichwal Anand R. | Opioid formulations having reduced potential for abuse |
| US20040033253A1 (en) | 2002-02-19 | 2004-02-19 | Ihor Shevchuk | Acyl opioid antagonists |
| US7666876B2 (en) | 2002-03-19 | 2010-02-23 | Vernalis (R&D) Limited | Buprenorphine formulations for intranasal delivery |
| US7776314B2 (en) | 2002-06-17 | 2010-08-17 | Grunenthal Gmbh | Abuse-proofed dosage system |
| US20050191244A1 (en) | 2002-10-25 | 2005-09-01 | Gruenenthal Gmbh | Abuse-resistant pharmaceutical dosage form |
| US20050186139A1 (en) | 2002-10-25 | 2005-08-25 | Gruenenthal Gmbh | Abuse-proofed dosage form |
| DE10250087A1 (de) | 2002-10-25 | 2004-05-06 | Grünenthal GmbH | Gegen Missbrauch gesicherte Darreichungsform |
| DE10250084A1 (de) | 2002-10-25 | 2004-05-06 | Grünenthal GmbH | Gegen Missbrauch gesicherte Darreichungsform |
| AU2003285934A1 (en) * | 2002-10-25 | 2004-05-25 | Euro-Celtique S.A. | Analogs and prodrugs of buprenorphine |
| RU2215741C1 (ru) * | 2002-11-05 | 2003-11-10 | Открытое Акционерное Общество "Международная Научно-Технологическая Корпорация" | Сложные эфиры n-замещенных 14-гидроксиморфинанов и способ их получения |
| CN1263760C (zh) * | 2002-11-12 | 2006-07-12 | 财团法人奇美医院 | 新颖的丁丙诺啡酯衍生物及其制备方法，以及长效作用镇痛药学组合物 |
| ATE382050T1 (de) | 2002-11-25 | 2008-01-15 | Chi Mei Foundation Medical Ct | Buprenorphinesterderivate, verfahren zu ihrer herstellung, und langwirksame analgetische arzneimittel |
| JP2004175706A (ja) * | 2002-11-26 | 2004-06-24 | Chi Mei Foundation Medical Center | 新規なブプレノルフィンのエステル誘導体及びそれらの調製方法、及び長時間効力持続性鎮痛薬剤組成物 |
| TW200500067A (en) * | 2003-01-21 | 2005-01-01 | Control Delivery Sys Inc | Salts of codrugs and uses related thereto |
| JP2006516963A (ja) | 2003-02-04 | 2006-07-13 | クリサリス テクノロジーズ インコーポレイテッド | エアロゾル製剤及びブスピロン、ブプレノルフィン、トリアゾラム、シクロベンザプリン及びゾルピデムのエアロゾル送出 |
| US7195882B2 (en) | 2003-06-03 | 2007-03-27 | Roche Diagnostics Operations, Inc. | Monoclonal antibodies specific for buprenorphine and metabolites thereof |
| US7759358B2 (en) | 2003-07-23 | 2010-07-20 | Crooks Peter A | Oral bioavailable prodrugs |
| US7589233B2 (en) | 2003-07-29 | 2009-09-15 | Signature R&D Holdings, Llc | L-Threonine derivatives of high therapeutic index |
| US7220842B2 (en) | 2004-04-05 | 2007-05-22 | Dade Behring Inc. | Immunoassays for buprenorphine and norbuprenorphine |
-
2006
- 2006-03-28 GB GBGB0606124.6A patent/GB0606124D0/en not_active Ceased
-
2007
- 2007-03-27 DK DK07732177.6T patent/DK2001891T3/da active
- 2007-03-27 BR BRPI0709157A patent/BRPI0709157A8/pt not_active IP Right Cessation
- 2007-03-27 CN CN201410318622.9A patent/CN104151320A/zh active Pending
- 2007-03-27 EP EP07732177.6A patent/EP2001891B1/en active Active
- 2007-03-27 TW TW096110534A patent/TWI501969B/zh not_active IP Right Cessation
- 2007-03-27 PT PT77321776T patent/PT2001891E/pt unknown
- 2007-03-27 PL PL07732177T patent/PL2001891T3/pl unknown
- 2007-03-27 CN CNA2007800108118A patent/CN101410402A/zh active Pending
- 2007-03-27 RU RU2008142527/04A patent/RU2435773C2/ru not_active IP Right Cessation
- 2007-03-27 US US12/294,462 patent/US7964610B2/en not_active Expired - Fee Related
- 2007-03-27 CA CA2647417A patent/CA2647417C/en not_active Expired - Fee Related
- 2007-03-27 AU AU2007231133A patent/AU2007231133B2/en not_active Ceased
- 2007-03-27 NZ NZ570997A patent/NZ570997A/en not_active IP Right Cessation
- 2007-03-27 KR KR1020087023692A patent/KR101430626B1/ko not_active Expired - Fee Related
- 2007-03-27 JP JP2009502210A patent/JP5167446B2/ja not_active Expired - Fee Related
- 2007-03-27 ES ES07732177T patent/ES2432169T3/es active Active
- 2007-03-27 WO PCT/GB2007/001120 patent/WO2007110636A1/en not_active Ceased
- 2007-03-27 MX MX2008011984A patent/MX2008011984A/es active IP Right Grant
- 2007-03-27 MY MYPI20083500 patent/MY151025A/en unknown
-
2008
- 2008-09-04 IL IL193917A patent/IL193917A/en not_active IP Right Cessation
- 2008-09-04 ZA ZA200807614A patent/ZA200807614B/xx unknown