JP2009529917A5 - - Google Patents
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- JP2009529917A5 JP2009529917A5 JP2009501596A JP2009501596A JP2009529917A5 JP 2009529917 A5 JP2009529917 A5 JP 2009529917A5 JP 2009501596 A JP2009501596 A JP 2009501596A JP 2009501596 A JP2009501596 A JP 2009501596A JP 2009529917 A5 JP2009529917 A5 JP 2009529917A5
- Authority
- JP
- Japan
- Prior art keywords
- polypeptide
- tag
- viral
- cellular
- cell
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 108090000765 processed proteins & peptides Proteins 0.000 claims 81
- 102000004196 processed proteins & peptides Human genes 0.000 claims 77
- 229920001184 polypeptide Polymers 0.000 claims 76
- 238000000034 method Methods 0.000 claims 32
- 230000003612 virological effect Effects 0.000 claims 30
- 230000001413 cellular effect Effects 0.000 claims 20
- 210000004027 cell Anatomy 0.000 claims 19
- 108020001507 fusion proteins Proteins 0.000 claims 12
- 102000037865 fusion proteins Human genes 0.000 claims 12
- 239000003795 chemical substances by application Substances 0.000 claims 10
- 241000700605 Viruses Species 0.000 claims 9
- 125000003275 alpha amino acid group Chemical group 0.000 claims 9
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 7
- 208000026278 immune system disease Diseases 0.000 claims 6
- 239000012634 fragment Substances 0.000 claims 5
- 101800004937 Protein C Proteins 0.000 claims 4
- 101800001700 Saposin-D Proteins 0.000 claims 4
- 102400000827 Saposin-D Human genes 0.000 claims 4
- 150000001413 amino acids Chemical class 0.000 claims 4
- 208000035475 disorder Diseases 0.000 claims 4
- 229960000856 protein c Drugs 0.000 claims 4
- 230000001018 virulence Effects 0.000 claims 4
- 108060003951 Immunoglobulin Proteins 0.000 claims 3
- 108091005804 Peptidases Proteins 0.000 claims 3
- 239000004365 Protease Substances 0.000 claims 3
- 102100037486 Reverse transcriptase/ribonuclease H Human genes 0.000 claims 3
- 239000000427 antigen Substances 0.000 claims 3
- 102000036639 antigens Human genes 0.000 claims 3
- 108091007433 antigens Proteins 0.000 claims 3
- 201000010099 disease Diseases 0.000 claims 3
- 102000018358 immunoglobulin Human genes 0.000 claims 3
- 108091033319 polynucleotide Proteins 0.000 claims 3
- 102000040430 polynucleotide Human genes 0.000 claims 3
- 239000002157 polynucleotide Substances 0.000 claims 3
- YBJHBAHKTGYVGT-ZKWXMUAHSA-N (+)-Biotin Chemical compound N1C(=O)N[C@@H]2[C@H](CCCCC(=O)O)SC[C@@H]21 YBJHBAHKTGYVGT-ZKWXMUAHSA-N 0.000 claims 2
- 108091032973 (ribonucleotides)n+m Proteins 0.000 claims 2
- 208000024172 Cardiovascular disease Diseases 0.000 claims 2
- HVLSXIKZNLPZJJ-TXZCQADKSA-N HA peptide Chemical compound C([C@@H](C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](C(C)C)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(=O)N[C@@H](C)C(O)=O)NC(=O)[C@H]1N(CCC1)C(=O)[C@@H](N)CC=1C=CC(O)=CC=1)C1=CC=C(O)C=C1 HVLSXIKZNLPZJJ-TXZCQADKSA-N 0.000 claims 2
- 101710154606 Hemagglutinin Proteins 0.000 claims 2
- 101710093908 Outer capsid protein VP4 Proteins 0.000 claims 2
- 101710135467 Outer capsid protein sigma-1 Proteins 0.000 claims 2
- 101710176177 Protein A56 Proteins 0.000 claims 2
- 108010076504 Protein Sorting Signals Proteins 0.000 claims 2
- 239000000185 hemagglutinin Substances 0.000 claims 2
- 210000002865 immune cell Anatomy 0.000 claims 2
- 150000003384 small molecules Chemical class 0.000 claims 2
- 108010018381 streptavidin-binding peptide Proteins 0.000 claims 2
- 239000006228 supernatant Substances 0.000 claims 2
- 102000040650 (ribonucleotides)n+m Human genes 0.000 claims 1
- 108091023037 Aptamer Proteins 0.000 claims 1
- 102000000584 Calmodulin Human genes 0.000 claims 1
- 108010041952 Calmodulin Proteins 0.000 claims 1
- 102000019034 Chemokines Human genes 0.000 claims 1
- 108010012236 Chemokines Proteins 0.000 claims 1
- 108010062580 Concanavalin A Proteins 0.000 claims 1
- 102000004127 Cytokines Human genes 0.000 claims 1
- 108090000695 Cytokines Proteins 0.000 claims 1
- 102000004190 Enzymes Human genes 0.000 claims 1
- 108090000790 Enzymes Proteins 0.000 claims 1
- 206010061192 Haemorrhagic fever Diseases 0.000 claims 1
- 241000711549 Hepacivirus C Species 0.000 claims 1
- 241000700721 Hepatitis B virus Species 0.000 claims 1
- 108010033276 Peptide Fragments Proteins 0.000 claims 1
- 102000007079 Peptide Fragments Human genes 0.000 claims 1
- 241000709664 Picornaviridae Species 0.000 claims 1
- 108020004459 Small interfering RNA Proteins 0.000 claims 1
- 108010090804 Streptavidin Proteins 0.000 claims 1
- 230000000692 anti-sense effect Effects 0.000 claims 1
- 102000023732 binding proteins Human genes 0.000 claims 1
- 108091008324 binding proteins Proteins 0.000 claims 1
- 239000012472 biological sample Substances 0.000 claims 1
- 229960002685 biotin Drugs 0.000 claims 1
- 235000020958 biotin Nutrition 0.000 claims 1
- 239000011616 biotin Substances 0.000 claims 1
- 239000013592 cell lysate Substances 0.000 claims 1
- 210000000170 cell membrane Anatomy 0.000 claims 1
- 208000016097 disease of metabolism Diseases 0.000 claims 1
- 229940079593 drug Drugs 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 229940088598 enzyme Drugs 0.000 claims 1
- 239000000284 extract Substances 0.000 claims 1
- 230000028993 immune response Effects 0.000 claims 1
- 208000015181 infectious disease Diseases 0.000 claims 1
- 230000003993 interaction Effects 0.000 claims 1
- PGHMRUGBZOYCAA-ADZNBVRBSA-N ionomycin Chemical compound O1[C@H](C[C@H](O)[C@H](C)[C@H](O)[C@H](C)/C=C/C[C@@H](C)C[C@@H](C)C(/O)=C/C(=O)[C@@H](C)C[C@@H](C)C[C@@H](CCC(O)=O)C)CC[C@@]1(C)[C@@H]1O[C@](C)([C@@H](C)O)CC1 PGHMRUGBZOYCAA-ADZNBVRBSA-N 0.000 claims 1
- PGHMRUGBZOYCAA-UHFFFAOYSA-N ionomycin Natural products O1C(CC(O)C(C)C(O)C(C)C=CCC(C)CC(C)C(O)=CC(=O)C(C)CC(C)CC(CCC(O)=O)C)CCC1(C)C1OC(C)(C(C)O)CC1 PGHMRUGBZOYCAA-UHFFFAOYSA-N 0.000 claims 1
- 238000004811 liquid chromatography Methods 0.000 claims 1
- 238000004949 mass spectrometry Methods 0.000 claims 1
- 208000030159 metabolic disease Diseases 0.000 claims 1
- 210000003463 organelle Anatomy 0.000 claims 1
- PHEDXBVPIONUQT-RGYGYFBISA-N phorbol 13-acetate 12-myristate Chemical compound C([C@]1(O)C(=O)C(C)=C[C@H]1[C@@]1(O)[C@H](C)[C@H]2OC(=O)CCCCCCCCCCCCC)C(CO)=C[C@H]1[C@H]1[C@]2(OC(C)=O)C1(C)C PHEDXBVPIONUQT-RGYGYFBISA-N 0.000 claims 1
- 239000002644 phorbol ester Substances 0.000 claims 1
- 230000002062 proliferating effect Effects 0.000 claims 1
- 102000004169 proteins and genes Human genes 0.000 claims 1
- 108090000623 proteins and genes Proteins 0.000 claims 1
- 238000010381 tandem affinity purification Methods 0.000 claims 1
- 241000701161 unidentified adenovirus Species 0.000 claims 1
- 241001529453 unidentified herpesvirus Species 0.000 claims 1
- 241001430294 unidentified retrovirus Species 0.000 claims 1
- 230000007923 virulence factor Effects 0.000 claims 1
- 239000000304 virulence factor Substances 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US78462006P | 2006-03-22 | 2006-03-22 | |
| PCT/US2007/007340 WO2007109370A2 (en) | 2006-03-22 | 2007-03-22 | Methods for identifying polypeptide targets and uses thereof for treating immunological diseases |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2009529917A JP2009529917A (ja) | 2009-08-27 |
| JP2009529917A5 true JP2009529917A5 (enExample) | 2010-05-06 |
Family
ID=38229867
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009501596A Pending JP2009529917A (ja) | 2006-03-22 | 2007-03-22 | 標的ポリペプチドの同定方法および免疫学的疾患の治療のためのその使用 |
Country Status (12)
| Country | Link |
|---|---|
| US (2) | US8293500B2 (enExample) |
| EP (3) | EP2275816A3 (enExample) |
| JP (1) | JP2009529917A (enExample) |
| AT (1) | ATE485517T1 (enExample) |
| AU (1) | AU2007227218A1 (enExample) |
| CA (1) | CA2646391A1 (enExample) |
| DE (1) | DE602007009954D1 (enExample) |
| DK (1) | DK2005185T3 (enExample) |
| ES (1) | ES2354954T3 (enExample) |
| PL (1) | PL2005185T3 (enExample) |
| PT (1) | PT2005185E (enExample) |
| WO (1) | WO2007109370A2 (enExample) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8293500B2 (en) | 2006-03-22 | 2012-10-23 | Viral Logic Systems Technology Corp. | Methods for identifying polypeptide targets and uses thereof for treating immunological diseases |
| WO2007133811A2 (en) * | 2006-05-15 | 2007-11-22 | Viral Logic Systems Technology Corp. | Cd47 related compositions and methods for treating immunological diseases and disorders |
| US8377448B2 (en) * | 2006-05-15 | 2013-02-19 | The Board Of Trustees Of The Leland Standford Junior University | CD47 related compositions and methods for treating immunological diseases and disorders |
| US20090068635A1 (en) * | 2007-09-06 | 2009-03-12 | Muerhoff Anthony S | Indirectly labelled assay conjugates and methods of preparing and using same |
| EP2232258A4 (en) * | 2007-12-05 | 2011-01-05 | Govt Of The U S A As Represented By The Secretary Of The Dept Of Health & Human Services | IMPROVED VIRAL PROTEIN QUANTIFICATION AND VACCINE QUALITY CONTROL THEREWITH |
| US20100204121A1 (en) | 2009-02-10 | 2010-08-12 | Romero Augustin T | Dietary supplements containing terpenoid acids of maslinic acid or oleanolic acid and process for enhancing muscle mass in mammals |
| WO2010151664A2 (en) | 2009-06-26 | 2010-12-29 | Massachusetts Institute Of Technology | Compositions and methods for treating cancer and modulating stress granule formation |
| US8268550B2 (en) * | 2009-06-26 | 2012-09-18 | Massachusetts Institute Of Technology | Compositions and methods for identification of PARP function, inhibitors, and activators |
| US8435961B2 (en) * | 2009-06-26 | 2013-05-07 | Massachusetts Institute Of Technology | Methods and compositions for increasing the activity of inhibitory RNA |
| MY172472A (en) | 2009-12-10 | 2019-11-26 | Regeneron Pharma | Mice that make heavy chain antibodies |
| EP2531859A4 (en) * | 2010-02-02 | 2013-07-31 | Jolla Inst Allergy Immunolog | Compositions and methods of modulating receptor protein tyrosine phosphatases |
| BR112016021572A2 (pt) | 2014-03-21 | 2017-10-03 | Regeneron Pharma | Métodos para preparar um animal não humano geneticamente modificado e para produzir proteínas de ligação, hibridoma, ácido nucleico, célula, e, proteína de ligação |
| WO2016012623A1 (en) * | 2014-07-25 | 2016-01-28 | Theravectys | Lentiviral vectors for regulated expression of a chimeric antigen receptor molecule |
| AU2016341402B2 (en) * | 2015-10-23 | 2020-08-27 | Apogenix Ag | Single-chain GITR-receptor agonist proteins |
| EP3672613A4 (en) * | 2017-08-25 | 2021-08-11 | Icahn School of Medicine at Mount Sinai | FUSION PROTEINS INCLUDING DETECTABLE MARKERS, NUCLEIC ACID MOLECULES AND CELL TRACKING METHOD |
| US11974552B2 (en) * | 2018-08-02 | 2024-05-07 | The University Of Toledo | Transgenic C57BL6-BTBR mouse with a humanized MHC II gene that expresses GAD65 |
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-
2007
- 2007-03-22 US US11/728,329 patent/US8293500B2/en not_active Expired - Fee Related
- 2007-03-22 EP EP10186919A patent/EP2275816A3/en not_active Withdrawn
- 2007-03-22 AT AT07753924T patent/ATE485517T1/de active
- 2007-03-22 DE DE602007009954T patent/DE602007009954D1/de active Active
- 2007-03-22 AU AU2007227218A patent/AU2007227218A1/en not_active Abandoned
- 2007-03-22 EP EP11155067A patent/EP2322931A3/en not_active Withdrawn
- 2007-03-22 WO PCT/US2007/007340 patent/WO2007109370A2/en not_active Ceased
- 2007-03-22 CA CA002646391A patent/CA2646391A1/en not_active Abandoned
- 2007-03-22 DK DK07753924.5T patent/DK2005185T3/da active
- 2007-03-22 JP JP2009501596A patent/JP2009529917A/ja active Pending
- 2007-03-22 PL PL07753924T patent/PL2005185T3/pl unknown
- 2007-03-22 EP EP07753924A patent/EP2005185B1/en not_active Not-in-force
- 2007-03-22 ES ES07753924T patent/ES2354954T3/es active Active
- 2007-03-22 PT PT07753924T patent/PT2005185E/pt unknown
-
2012
- 2012-09-14 US US13/616,694 patent/US20130129748A1/en not_active Abandoned
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