JP2009529884A5 - - Google Patents
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- Publication number
- JP2009529884A5 JP2009529884A5 JP2009500509A JP2009500509A JP2009529884A5 JP 2009529884 A5 JP2009529884 A5 JP 2009529884A5 JP 2009500509 A JP2009500509 A JP 2009500509A JP 2009500509 A JP2009500509 A JP 2009500509A JP 2009529884 A5 JP2009529884 A5 JP 2009529884A5
- Authority
- JP
- Japan
- Prior art keywords
- dpp
- measured
- parameter
- activity
- isoform
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 238000000034 method Methods 0.000 claims 73
- 102000001708 Protein Isoforms Human genes 0.000 claims 32
- 108010029485 Protein Isoforms Proteins 0.000 claims 32
- 108090000194 Dipeptidyl-peptidases and tripeptidyl-peptidases Proteins 0.000 claims 30
- 102000003779 Dipeptidyl-peptidases and tripeptidyl-peptidases Human genes 0.000 claims 30
- 230000000694 effects Effects 0.000 claims 30
- 108010067722 Dipeptidyl Peptidase 4 Proteins 0.000 claims 29
- 102100025012 Dipeptidyl peptidase 4 Human genes 0.000 claims 29
- 230000000875 corresponding effect Effects 0.000 claims 14
- 201000010099 disease Diseases 0.000 claims 10
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 10
- 239000013610 patient sample Substances 0.000 claims 10
- 230000004481 post-translational protein modification Effects 0.000 claims 6
- 239000000758 substrate Substances 0.000 claims 4
- 208000001072 type 2 diabetes mellitus Diseases 0.000 claims 4
- 210000004369 blood Anatomy 0.000 claims 3
- 239000008280 blood Substances 0.000 claims 3
- 230000014509 gene expression Effects 0.000 claims 3
- 210000002381 plasma Anatomy 0.000 claims 3
- 210000002966 serum Anatomy 0.000 claims 3
- 239000004475 Arginine Chemical group 0.000 claims 2
- 208000023275 Autoimmune disease Diseases 0.000 claims 2
- ODKSFYDXXFIFQN-BYPYZUCNSA-P L-argininium(2+) Chemical group NC(=[NH2+])NCCC[C@H]([NH3+])C(O)=O ODKSFYDXXFIFQN-BYPYZUCNSA-P 0.000 claims 2
- 102000004856 Lectins Human genes 0.000 claims 2
- 108090001090 Lectins Proteins 0.000 claims 2
- 206010028980 Neoplasm Diseases 0.000 claims 2
- ONIBWKKTOPOVIA-UHFFFAOYSA-N Proline Natural products OC(=O)C1CCCN1 ONIBWKKTOPOVIA-UHFFFAOYSA-N 0.000 claims 2
- 208000036142 Viral infection Diseases 0.000 claims 2
- 235000004279 alanine Nutrition 0.000 claims 2
- 235000001014 amino acid Nutrition 0.000 claims 2
- 150000001413 amino acids Chemical class 0.000 claims 2
- 210000004381 amniotic fluid Anatomy 0.000 claims 2
- ODKSFYDXXFIFQN-UHFFFAOYSA-N arginine Chemical group OC(=O)C(N)CCCNC(N)=N ODKSFYDXXFIFQN-UHFFFAOYSA-N 0.000 claims 2
- 238000003556 assay Methods 0.000 claims 2
- 201000011510 cancer Diseases 0.000 claims 2
- 210000001175 cerebrospinal fluid Anatomy 0.000 claims 2
- 230000002596 correlated effect Effects 0.000 claims 2
- 206010012601 diabetes mellitus Diseases 0.000 claims 2
- 208000016097 disease of metabolism Diseases 0.000 claims 2
- 239000012530 fluid Substances 0.000 claims 2
- 238000002955 isolation Methods 0.000 claims 2
- 239000002523 lectin Substances 0.000 claims 2
- 208000030159 metabolic disease Diseases 0.000 claims 2
- 210000003097 mucus Anatomy 0.000 claims 2
- 210000003296 saliva Anatomy 0.000 claims 2
- 210000000582 semen Anatomy 0.000 claims 2
- 238000000926 separation method Methods 0.000 claims 2
- 210000001138 tear Anatomy 0.000 claims 2
- 210000001519 tissue Anatomy 0.000 claims 2
- 210000002700 urine Anatomy 0.000 claims 2
- 230000009385 viral infection Effects 0.000 claims 2
- ONIBWKKTOPOVIA-BYPYZUCNSA-N L-Proline Chemical group OC(=O)[C@@H]1CCCN1 ONIBWKKTOPOVIA-BYPYZUCNSA-N 0.000 claims 1
- QNAYBMKLOCPYGJ-REOHCLBHSA-N L-alanine Chemical group C[C@H](N)C(O)=O QNAYBMKLOCPYGJ-REOHCLBHSA-N 0.000 claims 1
- 125000003295 alanine group Chemical group N[C@@H](C)C(=O)* 0.000 claims 1
- 238000010790 dilution Methods 0.000 claims 1
- 239000012895 dilution Substances 0.000 claims 1
- 238000001962 electrophoresis Methods 0.000 claims 1
- 238000001997 free-flow electrophoresis Methods 0.000 claims 1
- 230000008014 freezing Effects 0.000 claims 1
- 238000007710 freezing Methods 0.000 claims 1
- 238000000265 homogenisation Methods 0.000 claims 1
- 239000000463 material Substances 0.000 claims 1
- 239000011159 matrix material Substances 0.000 claims 1
- 238000005259 measurement Methods 0.000 claims 1
- 239000013642 negative control Substances 0.000 claims 1
- 239000013641 positive control Substances 0.000 claims 1
- 125000001500 prolyl group Chemical group [H]N1C([H])(C(=O)[*])C([H])([H])C([H])([H])C1([H])[H] 0.000 claims 1
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US78192406P | 2006-03-13 | 2006-03-13 | |
| US60/781,924 | 2006-03-13 | ||
| US80439706P | 2006-06-09 | 2006-06-09 | |
| US60/804,397 | 2006-06-09 | ||
| US89276707P | 2007-03-02 | 2007-03-02 | |
| US60/892,767 | 2007-03-02 | ||
| PCT/US2007/006653 WO2007106595A1 (en) | 2006-03-13 | 2007-03-13 | Diagnosis and prognosis of dipeptidyl peptidase-associated disease states |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2009529884A JP2009529884A (ja) | 2009-08-27 |
| JP2009529884A5 true JP2009529884A5 (https=) | 2010-05-06 |
| JP5410955B2 JP5410955B2 (ja) | 2014-02-05 |
Family
ID=38265130
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009500509A Active JP5410955B2 (ja) | 2006-03-13 | 2007-03-13 | ジペプチジルペプチダーゼ関連の疾患状態の診断および予後 |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US8652789B2 (https=) |
| EP (1) | EP1994415B9 (https=) |
| JP (1) | JP5410955B2 (https=) |
| KR (1) | KR101376471B1 (https=) |
| CN (1) | CN101460851B (https=) |
| AU (1) | AU2007225054B2 (https=) |
| BR (1) | BRPI0708900A2 (https=) |
| CA (1) | CA2645302C (https=) |
| ES (1) | ES2549860T3 (https=) |
| MX (1) | MX2008011665A (https=) |
| WO (1) | WO2007106595A1 (https=) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2527649T3 (es) * | 2007-12-10 | 2015-01-28 | F. Hoffmann-La Roche Ag | Panel de marcadores para el cáncer colorrectal |
| ES2533428T3 (es) * | 2009-05-04 | 2015-04-10 | F. Hoffmann-La Roche Ag | Uso de DPPIV/Seprasa como un marcador para el cáncer |
| JP6065172B2 (ja) * | 2010-10-22 | 2017-01-25 | 国立大学法人名古屋大学 | 微小血管障害又はその関連疾患のバイオマーカー |
| US20140273008A1 (en) * | 2013-03-15 | 2014-09-18 | Molecular Bioproducts, Inc. | Methods to assess enzyme activity using mass spectrometric immunoassay |
| EP3314004A1 (en) * | 2015-06-26 | 2018-05-02 | DuPont Nutrition Biosciences ApS | Aminopeptidases for protein hydrolyzates |
| AU2017252212B2 (en) * | 2016-04-21 | 2023-09-07 | 4TEEN4 Pharmaceuticals GmbH | Methods for determining DPP3 and therapeutic methods |
| CN110426518A (zh) * | 2019-07-19 | 2019-11-08 | 宁波熙宁检测技术有限公司 | 一种定量检测人类血浆中dpp-4酶活性的方法 |
| EP4308937B1 (en) * | 2021-03-16 | 2026-02-04 | Astrazeneca AB | System and method for online detection of a post-translational modification of a polypeptide |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4900662A (en) | 1987-07-21 | 1990-02-13 | International Immunoassay Laboratories, Inc. | CK-MM myocardial infarction immunoassay |
| US5382515A (en) | 1987-07-21 | 1995-01-17 | International Immunoassay Laboratories, Inc. | Creative kinase-MB immunoassay for myocardial infarction and reagents |
| US5382522A (en) | 1987-07-21 | 1995-01-17 | International Immunoassay Laboratories, Inc. | Immunoassay for creatine kinase-MB and creatine kinase-BB isoforms and reagents |
| EP1631680A2 (en) * | 2003-05-21 | 2006-03-08 | Bayer HealthCare AG | Diagnostics and therapeutics for diseases associated with dipeptidylpeptidase iv (dpp4) |
| US7169926B1 (en) | 2003-08-13 | 2007-01-30 | Takeda Pharmaceutical Company Limited | Dipeptidyl peptidase inhibitors |
-
2007
- 2007-03-13 CN CN200780016051.1A patent/CN101460851B/zh active Active
- 2007-03-13 WO PCT/US2007/006653 patent/WO2007106595A1/en not_active Ceased
- 2007-03-13 AU AU2007225054A patent/AU2007225054B2/en active Active
- 2007-03-13 JP JP2009500509A patent/JP5410955B2/ja active Active
- 2007-03-13 KR KR1020087024813A patent/KR101376471B1/ko active Active
- 2007-03-13 EP EP07753293.5A patent/EP1994415B9/en not_active Not-in-force
- 2007-03-13 ES ES07753293.5T patent/ES2549860T3/es active Active
- 2007-03-13 US US11/724,029 patent/US8652789B2/en active Active
- 2007-03-13 BR BRPI0708900-7A patent/BRPI0708900A2/pt not_active Application Discontinuation
- 2007-03-13 CA CA2645302A patent/CA2645302C/en active Active
- 2007-03-13 MX MX2008011665A patent/MX2008011665A/es active IP Right Grant
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