JP2009528987A5 - - Google Patents
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- Publication number
- JP2009528987A5 JP2009528987A5 JP2008553534A JP2008553534A JP2009528987A5 JP 2009528987 A5 JP2009528987 A5 JP 2009528987A5 JP 2008553534 A JP2008553534 A JP 2008553534A JP 2008553534 A JP2008553534 A JP 2008553534A JP 2009528987 A5 JP2009528987 A5 JP 2009528987A5
- Authority
- JP
- Japan
- Prior art keywords
- protein
- yeast
- influenza
- antigen
- composition
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 240000004808 Saccharomyces cerevisiae Species 0.000 claims 41
- 239000000203 mixture Substances 0.000 claims 36
- 108090000623 proteins and genes Proteins 0.000 claims 36
- 102000004169 proteins and genes Human genes 0.000 claims 36
- 239000000427 antigen Substances 0.000 claims 31
- 102000036639 antigens Human genes 0.000 claims 31
- 108091007433 antigens Proteins 0.000 claims 31
- 206010022000 influenza Diseases 0.000 claims 25
- 241000712461 unidentified influenza virus Species 0.000 claims 25
- 108010059722 Viral Fusion Proteins Proteins 0.000 claims 21
- 230000003834 intracellular effect Effects 0.000 claims 14
- 108090001074 Nucleocapsid Proteins Proteins 0.000 claims 12
- 230000002163 immunogen Effects 0.000 claims 11
- 101710154606 Hemagglutinin Proteins 0.000 claims 10
- 102000005348 Neuraminidase Human genes 0.000 claims 10
- 108010006232 Neuraminidase Proteins 0.000 claims 10
- 101710093908 Outer capsid protein VP4 Proteins 0.000 claims 10
- 101710135467 Outer capsid protein sigma-1 Proteins 0.000 claims 10
- 101710176177 Protein A56 Proteins 0.000 claims 10
- 108020001507 fusion proteins Proteins 0.000 claims 8
- 102000037865 fusion proteins Human genes 0.000 claims 8
- 239000000185 hemagglutinin Substances 0.000 claims 8
- 210000004027 cell Anatomy 0.000 claims 6
- 244000052769 pathogen Species 0.000 claims 6
- 108090000862 Ion Channels Proteins 0.000 claims 5
- 102000004310 Ion Channels Human genes 0.000 claims 5
- 238000002360 preparation method Methods 0.000 claims 4
- 101800001707 Spacer peptide Proteins 0.000 claims 3
- 125000003275 alpha amino acid group Chemical group 0.000 claims 3
- 230000001717 pathogenic effect Effects 0.000 claims 3
- 241000235648 Pichia Species 0.000 claims 2
- 241000235070 Saccharomyces Species 0.000 claims 2
- 101001039853 Sonchus yellow net virus Matrix protein Proteins 0.000 claims 2
- 201000010099 disease Diseases 0.000 claims 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 2
- 108700010900 influenza virus proteins Proteins 0.000 claims 2
- 238000000034 method Methods 0.000 claims 2
- 108090000765 processed proteins & peptides Proteins 0.000 claims 2
- 101800001415 Bri23 peptide Proteins 0.000 claims 1
- 101800000655 C-terminal peptide Proteins 0.000 claims 1
- 102400000107 C-terminal peptide Human genes 0.000 claims 1
- 241000222120 Candida <Saccharomycetales> Species 0.000 claims 1
- 108010041986 DNA Vaccines Proteins 0.000 claims 1
- 229940021995 DNA vaccine Drugs 0.000 claims 1
- 102000002067 Protein Subunits Human genes 0.000 claims 1
- 108010001267 Protein Subunits Proteins 0.000 claims 1
- 241000235346 Schizosaccharomyces Species 0.000 claims 1
- 239000000284 extract Substances 0.000 claims 1
- 230000028993 immune response Effects 0.000 claims 1
- 230000036039 immunity Effects 0.000 claims 1
- 230000003053 immunization Effects 0.000 claims 1
- 230000001939 inductive effect Effects 0.000 claims 1
- 230000002401 inhibitory effect Effects 0.000 claims 1
- 239000012528 membrane Substances 0.000 claims 1
- 229920001184 polypeptide Polymers 0.000 claims 1
- 230000004481 post-translational protein modification Effects 0.000 claims 1
- 102000004196 processed proteins & peptides Human genes 0.000 claims 1
- 229940031626 subunit vaccine Drugs 0.000 claims 1
- 210000005253 yeast cell Anatomy 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US76502506P | 2006-02-02 | 2006-02-02 | |
| US60/765,025 | 2006-02-02 | ||
| PCT/US2007/061572 WO2007092792A2 (en) | 2006-02-02 | 2007-02-02 | Yeast-based vaccine for inducing an immune response |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012260860A Division JP2013075899A (ja) | 2006-02-02 | 2012-11-29 | 治療用組成物 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2009528987A JP2009528987A (ja) | 2009-08-13 |
| JP2009528987A5 true JP2009528987A5 (enExample) | 2010-04-02 |
| JP5198290B2 JP5198290B2 (ja) | 2013-05-15 |
Family
ID=38345897
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008553534A Expired - Fee Related JP5198290B2 (ja) | 2006-02-02 | 2007-02-02 | 免疫反応を誘発する酵母ベースワクチン |
| JP2012260860A Pending JP2013075899A (ja) | 2006-02-02 | 2012-11-29 | 治療用組成物 |
| JP2014230982A Withdrawn JP2015038147A (ja) | 2006-02-02 | 2014-11-13 | 免疫反応を誘発する酵母ベースワクチン |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012260860A Pending JP2013075899A (ja) | 2006-02-02 | 2012-11-29 | 治療用組成物 |
| JP2014230982A Withdrawn JP2015038147A (ja) | 2006-02-02 | 2014-11-13 | 免疫反応を誘発する酵母ベースワクチン |
Country Status (14)
| Country | Link |
|---|---|
| US (2) | US7736642B2 (enExample) |
| EP (2) | EP1988919A4 (enExample) |
| JP (3) | JP5198290B2 (enExample) |
| KR (2) | KR20140029551A (enExample) |
| CN (2) | CN104826102A (enExample) |
| AU (1) | AU2007212076B2 (enExample) |
| BR (1) | BRPI0706913A2 (enExample) |
| CA (1) | CA2638815A1 (enExample) |
| IL (2) | IL193196A (enExample) |
| IN (1) | IN2014DN08830A (enExample) |
| MX (1) | MX2008009929A (enExample) |
| SG (2) | SG10201402236VA (enExample) |
| TW (2) | TW200806316A (enExample) |
| WO (1) | WO2007092792A2 (enExample) |
Families Citing this family (63)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2002039951A2 (en) * | 2000-11-15 | 2002-05-23 | Globe Immune, Inc. | Yeast-dentritic cell vaccines and uses thereof |
| US8343502B2 (en) * | 2002-12-16 | 2013-01-01 | Globeimmune, Inc. | Yeast-based vaccines as immunotherapy |
| KR101241272B1 (ko) * | 2002-12-16 | 2013-03-15 | 더 리젠츠 오브 더 유니버시티 오브 콜로라도, 어 바디 코포레이트 | 면역 요법으로서의 효모계 백신 |
| SG163572A1 (en) * | 2005-07-11 | 2010-08-30 | Globeimmune Inc | Compositions and methods for eliciting an immune response to escape mutants of targeted therapies |
| US20070172503A1 (en) | 2005-12-13 | 2007-07-26 | Mycologics,Inc. | Compositions and Methods to Elicit Immune Responses Against Pathogenic Organisms Using Yeast Based Vaccines |
| CA2638815A1 (en) * | 2006-02-02 | 2007-08-16 | Globeimmune, Inc. | Yeast-based vaccine for inducing an immune response |
| GB0613977D0 (en) | 2006-02-07 | 2006-08-23 | Peptcell Ltd | Peptide sequences and compositions |
| WO2007130330A2 (en) * | 2006-05-01 | 2007-11-15 | Technovax, Inc. | Polyvalent influenza virus-like particle (vlp) compositions |
| US20100143393A1 (en) * | 2006-05-11 | 2010-06-10 | Gale Smith | Novel influenza m2 vaccines |
| WO2008054540A2 (en) * | 2006-05-18 | 2008-05-08 | Pharmexa Inc. | Inducing immune responses to influenza virus using polypeptide and nucleic acid compositions |
| CA2676783C (en) * | 2007-02-02 | 2016-04-05 | Globeimmune, Inc. | Improved methods for producing yeast-based vaccines |
| BRPI0809247A2 (pt) * | 2007-03-19 | 2014-09-09 | Globeimmune Inc | Composições e métodos para a ablação do escape mutacional de terapias marcadas para câncer. |
| US20100285050A1 (en) | 2007-10-05 | 2010-11-11 | Isis Innovation Limited | Compositions and Methods |
| GB0719526D0 (en) * | 2007-10-05 | 2007-11-14 | Isis Innovation | Compositions and methods |
| WO2010036948A2 (en) * | 2008-09-26 | 2010-04-01 | The United States Of America, As Represented By The Secretary, Department Of Health & Human Services | Dna prime/inactivated vaccine boost immunization to influenza virus |
| EP3320915A1 (en) * | 2009-04-17 | 2018-05-16 | Globeimmune, Inc. | Combination immunotherapy compositions against cancer and methods |
| US20120141525A1 (en) * | 2009-05-18 | 2012-06-07 | Panacea Biotec Limited | Universal influenza vaccine based on recombinant modified vaccine ankara virus (mva) |
| WO2011032119A1 (en) | 2009-09-14 | 2011-03-17 | The Regents Of The University Of Colorado | Modulation of yeast-based immunotherapy products and responses |
| US20120015346A1 (en) * | 2010-07-08 | 2012-01-19 | New York Medical College | Influenza virus detection and diagnosis |
| SG10201709806VA (en) * | 2010-10-04 | 2017-12-28 | Massachusetts Inst Technology | Hemagglutinin polypeptides, and reagents and methods relating thereto |
| AU2011316164B2 (en) * | 2010-10-15 | 2016-01-14 | Bavarian Nordic A/S | Recombinant modified vaccinia virus Ankara (MVA) influenza vaccine |
| EP2651439B1 (en) * | 2010-12-17 | 2018-09-19 | Globeimmune, Inc. | Compositions and methods for the treatment or prevention of human adenovirus-36 infection |
| AU2012212463B2 (en) * | 2011-01-31 | 2016-07-07 | Nanotherapeutics, Inc. | Recombinant viral vectors and methods for inducing a heterosubtypic immune response to influenza A viruses |
| EP3266464A3 (en) | 2011-02-12 | 2018-03-14 | Globeimmune, Inc. | Yeast-based therapeutic for chronic hepatitis b infection |
| KR102046449B1 (ko) * | 2011-03-17 | 2019-11-19 | 글로브이뮨 | 효모-브라큐리 면역요법 조성물 |
| WO2012162342A2 (en) * | 2011-05-23 | 2012-11-29 | The Wistar Institute Of Anatomy And Biology | Influenza vaccines containing modified adenovirus vectors |
| EA030381B1 (ru) | 2011-06-14 | 2018-07-31 | Глоубиммьюн, Инк. | Иммунотерапевтическая композиция, ее применения и способы лечения или профилактики инфекции, вызванной вирусом гепатита дельта |
| JP6113155B2 (ja) * | 2011-06-20 | 2017-04-12 | ユニバーシティ オブ ピッツバーグ − オブ ザ コモンウェルス システム オブ ハイヤー エデュケイション | 計算で最適化した広い反応性を示すｈ１ｎ１インフルエンザの抗原 |
| CA2844500C (en) | 2011-08-17 | 2022-05-10 | Globeimmune, Inc. | Yeast-muc1 immunotherapeutic compositions and uses thereof |
| PL2591798T3 (pl) | 2011-11-09 | 2015-04-30 | Werner Lubitz | Szczepionka do zastosowania w immunoterapii nowotworów |
| DE102011121069A1 (de) * | 2011-12-13 | 2013-06-13 | Martin-Luther-Universität Halle-Wittenberg | Vakzinierung mittels rekombinanter Hefe durch Erzeugung einer protektiven humoralen Immunantwort gegen definierte Antigene |
| US9653272B2 (en) | 2012-06-26 | 2017-05-16 | Biodesix, Inc. | Mass-spectral method for selection, and de-selection, of cancer patients for treatment with immune response generating therapies |
| US20140065173A1 (en) | 2012-09-06 | 2014-03-06 | Orbis Health Solutions Llc | Tumor lysate loaded particles |
| JP5954079B2 (ja) | 2012-09-25 | 2016-07-20 | ソニー株式会社 | 培養観察装置及び培養観察方法 |
| US11105802B2 (en) * | 2012-12-10 | 2021-08-31 | Seattle Children's Hospital | Cell-free biofragment compositions and related systems, devices, and methods |
| WO2014151279A1 (en) * | 2013-03-15 | 2014-09-25 | The Trustees Of The University Of Pennsylvania | Vaccines having an antigen and interleukin-23 as an adjuvant |
| MX374829B (es) | 2013-03-19 | 2025-03-06 | Globeimmune Inc | Composición a base de levadura para usarse para tratar cordoma. |
| US9782473B2 (en) | 2013-03-26 | 2017-10-10 | Globeimmune, Inc. | Compositions and methods for the treatment or prevention of human immunodeficiency virus infection |
| JP2014210747A (ja) * | 2013-04-19 | 2014-11-13 | アンジェスＭｇ株式会社 | 細胞性免疫誘導能が改善された経口ワクチン |
| WO2015031778A2 (en) | 2013-08-30 | 2015-03-05 | Globeimmune, Inc. | Compositions and methods for the treatment or prevention of tuberculosis |
| KR20220062143A (ko) | 2014-01-06 | 2022-05-13 | 더 트러스티스 오브 더 유니버시티 오브 펜실바니아 | Pd1 및 pdl1 항체 및 백신 조합 및 면역요법을 위한 이들의 사용 |
| EP3932392A1 (en) | 2014-03-05 | 2022-01-05 | Orbis Health Solutions LLC | Vaccine delivery systems using yeast cell wall particles |
| CN113419058B (zh) | 2014-04-11 | 2025-04-01 | 全球免疫股份有限公司 | 基于酵母的免疫疗法和i型干扰素敏感性 |
| CN105233302B (zh) * | 2014-07-10 | 2018-10-19 | 中国人民解放军军事医学科学院生物工程研究所 | 一种流感血凝素糖蛋白多聚物纳米颗粒的制备方法 |
| EP3256140B1 (en) | 2015-01-09 | 2020-04-01 | Etubics Corporation | Compositions for ebola virus vaccination |
| US11020470B2 (en) * | 2015-04-13 | 2021-06-01 | The Regents Of The University Of Michigan | Virus-like particles |
| WO2017023840A1 (en) | 2015-08-03 | 2017-02-09 | Globeimmune, Inc. | Modified yeast-brachyury immunotherapeutic compositions |
| AU2016304853C1 (en) * | 2015-08-11 | 2023-03-16 | Orbis Health Solutions Llc | Bacterial and viral vaccine strategy |
| GB2552441A (en) * | 2015-10-22 | 2018-01-31 | Royal Veterinary College | Methods |
| EP3195878A1 (en) | 2016-01-22 | 2017-07-26 | Werner Lubitz | Bacterial ghosts for the treatment of cancer |
| SG11201807770RA (en) | 2016-03-24 | 2018-10-30 | Nantcell Inc | Sequence arrangements and sequences for neoepitope presentation |
| JP7051898B2 (ja) | 2017-04-24 | 2022-04-11 | ナントセル，インコーポレイテッド | 標的型ネオエピトープベクター及びそのための方法 |
| EP3730620A4 (en) * | 2017-12-21 | 2022-01-05 | Green Biomed, Inc. | CROSS-IMMUNIZING ANTIGEN VACCINE AND METHOD OF ITS MANUFACTURING |
| DE102017012109A1 (de) * | 2017-12-27 | 2019-06-27 | Martin-Luther-Universität Halle-Wittenberg | Optimiertes Wirts-/Vektorsystem zur Erzeugung protektiver mono- und multivalenter subunit-Vakzine auf Basis der Hefe Kluyveromyces lactis |
| EP3793576A4 (en) * | 2018-05-15 | 2022-04-06 | Globeimmune, Inc. | Lysates of recombinant yeast for inducing cellular immune responses |
| CN111315407B (zh) | 2018-09-11 | 2023-05-02 | 上海市公共卫生临床中心 | 一种广谱抗流感疫苗免疫原及其应用 |
| WO2020061203A1 (en) | 2018-09-21 | 2020-03-26 | Nantcell, Inc. | Methods and compositions for modulating myeloid-derived suppressor cells |
| CA3138174A1 (en) * | 2019-05-21 | 2020-11-26 | David James O'hagan | Yeast-based oral vaccination |
| AU2021220188A1 (en) * | 2020-02-11 | 2022-09-08 | Cytonus Therapeutics, Inc. | Rapid vaccine platform |
| US12285480B2 (en) | 2020-03-11 | 2025-04-29 | Nantcell, Inc. | Method of inducing immunity against SARS-CoV-2 using spike and nucleocapsid-ETSD immunogens delivered by RNA and replication-defective adenoviruses |
| US11857620B2 (en) | 2020-03-11 | 2024-01-02 | Immunitybio, Inc. | Method of inducing immunity against SARS-CoV-2 using spike (s) and nucleocapsid (N)-ETSD immunogens delivered by a replication-defective adenovirus |
| US20210284716A1 (en) | 2020-03-11 | 2021-09-16 | Immunitybio, Inc. | ACE2-Fc Trap |
| CA3170359A1 (en) | 2020-04-14 | 2021-10-21 | Nantcell, Inc. | Yeast lysate covid-19 vaccine |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5830463A (en) * | 1993-07-07 | 1998-11-03 | University Technology Corporation | Yeast-based delivery vehicles |
| US5413914A (en) | 1993-07-07 | 1995-05-09 | The Regents Of The University Of Colorado | Yeast assay to identify inhibitors of dibasic amino acid processing endoproteases |
| CA2180965C (en) * | 1994-01-11 | 2010-05-11 | Tom Maria Deroo | Influenza vaccine |
| US5691189A (en) * | 1994-01-19 | 1997-11-25 | Bristol-Myers Squibb Company | Saccharomyces cerevisiae expressing M2 protein of influenza A virus |
| US6696251B1 (en) * | 1996-05-31 | 2004-02-24 | Board Of Trustees Of The University Of Illinois | Yeast cell surface display of proteins and uses thereof |
| US20020044948A1 (en) * | 2000-03-15 | 2002-04-18 | Samir Khleif | Methods and compositions for co-stimulation of immunological responses to peptide antigens |
| BRPI0111830B8 (pt) * | 2000-06-23 | 2021-05-25 | American Cyanamid Co | método de produção de partículas semelhantes ao vírus da influenza (vlps), vlps da influenza, vlps quiméricas, composições imunogênica e farmacêutica, e, usos de vlps da influenza e de vlps quiméricas |
| WO2002039951A2 (en) * | 2000-11-15 | 2002-05-23 | Globe Immune, Inc. | Yeast-dentritic cell vaccines and uses thereof |
| US20030008000A1 (en) * | 2001-03-08 | 2003-01-09 | Wong Jonathan P. | DNA vaccine using liposome-encapsulated plasmid DNA encoding for hemagglutinin protein of influenza virus |
| US20030202982A1 (en) * | 2001-08-15 | 2003-10-30 | Birkett Ashley J. | Influenza immunogen and vaccine |
| US7439042B2 (en) * | 2002-12-16 | 2008-10-21 | Globeimmune, Inc. | Yeast-based therapeutic for chronic hepatitis C infection |
| KR101241272B1 (ko) | 2002-12-16 | 2013-03-15 | 더 리젠츠 오브 더 유니버시티 오브 콜로라도, 어 바디 코포레이트 | 면역 요법으로서의 효모계 백신 |
| US8592197B2 (en) * | 2003-07-11 | 2013-11-26 | Novavax, Inc. | Functional influenza virus-like particles (VLPs) |
| JP5331340B2 (ja) * | 2004-05-18 | 2013-10-30 | バイカル インコーポレイテッド | インフルエンザウィルスワクチン組成物、及びその使用方法 |
| ES2375995T3 (es) * | 2004-09-17 | 2012-03-08 | University Of Massachusetts | Composiciones y sus usos para deficiencias de enzima lisosomal. |
| CA2638815A1 (en) * | 2006-02-02 | 2007-08-16 | Globeimmune, Inc. | Yeast-based vaccine for inducing an immune response |
-
2007
- 2007-02-02 CA CA002638815A patent/CA2638815A1/en not_active Withdrawn
- 2007-02-02 WO PCT/US2007/061572 patent/WO2007092792A2/en not_active Ceased
- 2007-02-02 SG SG10201402236VA patent/SG10201402236VA/en unknown
- 2007-02-02 EP EP07717549A patent/EP1988919A4/en not_active Withdrawn
- 2007-02-02 KR KR1020147004408A patent/KR20140029551A/ko not_active Withdrawn
- 2007-02-02 KR KR20087020923A patent/KR101492524B1/ko not_active Ceased
- 2007-02-02 MX MX2008009929A patent/MX2008009929A/es active IP Right Grant
- 2007-02-02 AU AU2007212076A patent/AU2007212076B2/en not_active Ceased
- 2007-02-02 IN IN8830DEN2014 patent/IN2014DN08830A/en unknown
- 2007-02-02 BR BRPI0706913-8A patent/BRPI0706913A2/pt not_active Application Discontinuation
- 2007-02-02 EP EP11180828.3A patent/EP2468296A3/en not_active Withdrawn
- 2007-02-02 US US11/670,902 patent/US7736642B2/en not_active Expired - Fee Related
- 2007-02-02 CN CN201510122553.9A patent/CN104826102A/zh not_active Withdrawn
- 2007-02-02 JP JP2008553534A patent/JP5198290B2/ja not_active Expired - Fee Related
- 2007-02-02 SG SG201100779-6A patent/SG169375A1/en unknown
- 2007-02-02 TW TW096103976A patent/TW200806316A/zh unknown
- 2007-02-02 CN CN200780009861.4A patent/CN101405026B/zh not_active Expired - Fee Related
- 2007-02-02 TW TW102144486A patent/TW201412329A/zh unknown
-
2008
- 2008-07-31 IL IL193196A patent/IL193196A/en active IP Right Review Request
-
2010
- 2010-04-16 US US12/762,221 patent/US20100196411A1/en not_active Abandoned
-
2012
- 2012-11-29 JP JP2012260860A patent/JP2013075899A/ja active Pending
-
2014
- 2014-05-08 IL IL232518A patent/IL232518A0/en unknown
- 2014-11-13 JP JP2014230982A patent/JP2015038147A/ja not_active Withdrawn
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