JP2009526794A - 新規なアミノアルコール置換アリールチエノピリミジノン、それらの製造方法及び薬剤としてそれらの使用 - Google Patents
新規なアミノアルコール置換アリールチエノピリミジノン、それらの製造方法及び薬剤としてそれらの使用 Download PDFInfo
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- JP2009526794A JP2009526794A JP2008554654A JP2008554654A JP2009526794A JP 2009526794 A JP2009526794 A JP 2009526794A JP 2008554654 A JP2008554654 A JP 2008554654A JP 2008554654 A JP2008554654 A JP 2008554654A JP 2009526794 A JP2009526794 A JP 2009526794A
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- CFWAUCQHISPBGG-UHFFFAOYSA-N methyl 3-amino-5-(cyclopentanecarbonyl)thiophene-2-carboxylate Chemical compound NC1=C(C(=O)OC)SC(C(=O)C2CCCC2)=C1 CFWAUCQHISPBGG-UHFFFAOYSA-N 0.000 description 1
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- AXNGVHNQKNGUNG-UHFFFAOYSA-N tert-butyl (2-methylpropan-2-yl)oxycarbonyl carbonate methyl 3-[(2-methylpropan-2-yl)oxycarbonylamino]thiophene-2-carboxylate Chemical compound C(C)(C)(C)OC(=O)OC(=O)OC(C)(C)C.COC(=O)C=1SC=CC1NC(=O)OC(C)(C)C AXNGVHNQKNGUNG-UHFFFAOYSA-N 0.000 description 1
- ITFVMMSNUZDOAR-UHFFFAOYSA-N tert-butyl 3-(4-nitrophenoxy)-8-azabicyclo[3.2.1]octane-8-carboxylate 3-(4-nitrophenoxy)-8-azabicyclo[3.2.1]octane Chemical compound C(C)(C)(C)OC(=O)N1C2CC(CC1CC2)OC2=CC=C(C=C2)[N+](=O)[O-].[N+](=O)([O-])C2=CC=C(OC1CC3CCC(C1)N3)C=C2 ITFVMMSNUZDOAR-UHFFFAOYSA-N 0.000 description 1
- SEGZJJSZYOEABC-UHFFFAOYSA-N tert-butyl 3-hydroxy-8-azabicyclo[3.2.1]octane-8-carboxylate Chemical compound C1C(O)CC2CCC1N2C(=O)OC(C)(C)C SEGZJJSZYOEABC-UHFFFAOYSA-N 0.000 description 1
- VMKWPQAOHLHQOH-UHFFFAOYSA-N tert-butyl 3-hydroxy-8-azabicyclo[3.2.1]octane-8-carboxylate;tert-butyl 3-(4-nitrophenoxy)-8-azabicyclo[3.2.1]octane-8-carboxylate Chemical compound C1C(O)CC2CCC1N2C(=O)OC(C)(C)C.CC(C)(C)OC(=O)N1C(C2)CCC1CC2OC1=CC=C([N+]([O-])=O)C=C1 VMKWPQAOHLHQOH-UHFFFAOYSA-N 0.000 description 1
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- OEQJOYQHIGIVTN-UHFFFAOYSA-N tert-butyl nonanoate Chemical compound CCCCCCCCC(=O)OC(C)(C)C OEQJOYQHIGIVTN-UHFFFAOYSA-N 0.000 description 1
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- HPGGPRDJHPYFRM-UHFFFAOYSA-J tin(iv) chloride Chemical compound Cl[Sn](Cl)(Cl)Cl HPGGPRDJHPYFRM-UHFFFAOYSA-J 0.000 description 1
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- 229950004514 torcetrapib Drugs 0.000 description 1
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- 238000001890 transfection Methods 0.000 description 1
- DBGVGMSCBYYSLD-UHFFFAOYSA-N tributylstannane Chemical compound CCCC[SnH](CCCC)CCCC DBGVGMSCBYYSLD-UHFFFAOYSA-N 0.000 description 1
- AHZJKOKFZJYCLG-UHFFFAOYSA-K trifluoromethanesulfonate;ytterbium(3+) Chemical compound [Yb+3].[O-]S(=O)(=O)C(F)(F)F.[O-]S(=O)(=O)C(F)(F)F.[O-]S(=O)(=O)C(F)(F)F AHZJKOKFZJYCLG-UHFFFAOYSA-K 0.000 description 1
- CWMFRHBXRUITQE-UHFFFAOYSA-N trimethylsilylacetylene Chemical group C[Si](C)(C)C#C CWMFRHBXRUITQE-UHFFFAOYSA-N 0.000 description 1
- BWHDROKFUHTORW-UHFFFAOYSA-O tritert-butylphosphanium Chemical compound CC(C)(C)[PH+](C(C)(C)C)C(C)(C)C BWHDROKFUHTORW-UHFFFAOYSA-O 0.000 description 1
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- 125000000391 vinyl group Chemical group [H]C([*])=C([H])[H] 0.000 description 1
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- 229940088594 vitamin Drugs 0.000 description 1
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- 235000019163 vitamin B12 Nutrition 0.000 description 1
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- GVJHHUAWPYXKBD-IEOSBIPESA-N α-tocopherol Chemical compound OC1=C(C)C(C)=C2O[C@@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-IEOSBIPESA-N 0.000 description 1
- OENHQHLEOONYIE-JLTXGRSLSA-N β-Carotene Chemical compound CC=1CCCC(C)(C)C=1\C=C\C(\C)=C\C=C\C(\C)=C\C=C\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C OENHQHLEOONYIE-JLTXGRSLSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Diabetes (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Life Sciences & Earth Sciences (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Emergency Medicine (AREA)
- Endocrinology (AREA)
- Child & Adolescent Psychology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE102006007049 | 2006-02-15 | ||
| PCT/EP2007/001213 WO2007093365A2 (en) | 2006-02-15 | 2007-02-13 | Novel amino alcohol-substituted arylthienopyrimidinones, process for their preparation and their use as medicaments |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2009526794A true JP2009526794A (ja) | 2009-07-23 |
| JP2009526794A5 JP2009526794A5 (enExample) | 2010-04-02 |
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| EP (1) | EP1987042B1 (enExample) |
| JP (1) | JP2009526794A (enExample) |
| KR (1) | KR20080096670A (enExample) |
| CN (1) | CN101384605A (enExample) |
| AR (1) | AR059520A1 (enExample) |
| AU (1) | AU2007214710A1 (enExample) |
| BR (1) | BRPI0707870A2 (enExample) |
| CA (1) | CA2636879A1 (enExample) |
| IL (1) | IL193342A0 (enExample) |
| TW (1) | TW200801022A (enExample) |
| UY (1) | UY30164A1 (enExample) |
| WO (1) | WO2007093365A2 (enExample) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2016053056A (ja) * | 2006-05-19 | 2016-04-14 | アボット・ラボラトリーズＡｂｂｏｔｔ Ｌａｂｏｒａｔｏｒｉｅｓ | Ｃｎｓ活性縮合ビシクロ複素環置換アザ二環式アルカン誘導体 |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2010003624A2 (en) | 2008-07-09 | 2010-01-14 | Sanofi-Aventis | Heterocyclic compounds, processes for their preparation, medicaments comprising these compounds, and the use thereof |
| EA020816B1 (ru) * | 2009-07-21 | 2015-01-30 | Джилид Сайэнс, Инк. | Ингибиторы вирусов flaviviridae |
| JP5774008B2 (ja) | 2009-09-09 | 2015-09-02 | ギリアード サイエンシーズ， インコーポレイテッド | Ｆｌａｖｉｖｉｒｉｄａｅウイルスの阻害剤 |
| KR20120123678A (ko) | 2010-01-15 | 2012-11-09 | 길리애드 사이언시즈, 인코포레이티드 | 플라비비리다에 바이러스의 억제제 |
| AU2011205744B2 (en) | 2010-01-15 | 2015-06-25 | Gilead Sciences, Inc. | Inhibitors of Flaviviridae viruses |
| HUP1100241A3 (en) | 2011-05-06 | 2013-12-30 | Richter Gedeon Nyrt | Oxetane substituted pyrimidones |
| AU2012280959B2 (en) | 2011-07-13 | 2015-08-06 | Gilead Sciences, Inc. | Thiophen-2-carboxylic acid derivatives useful as inhibitors of Flaviviridae viruses |
| US8927741B2 (en) | 2012-08-17 | 2015-01-06 | Gilead Sciences, Inc. | Synthesis of an antiviral compound |
| US8759544B2 (en) | 2012-08-17 | 2014-06-24 | Gilead Sciences, Inc. | Synthesis of an antiviral compound |
| US8841340B2 (en) | 2012-08-17 | 2014-09-23 | Gilead Sciences, Inc. | Solid forms of an antiviral compound |
| US10221191B2 (en) | 2015-12-22 | 2019-03-05 | SHY Therapeutics LLC | Compounds for the treatment of cancer and inflammatory disease |
| SG11201911929XA (en) | 2017-06-21 | 2020-01-30 | SHY Therapeutics LLC | Compounds that interact with the ras superfamily for the treatment of cancers, inflammatory diseases, rasopathies, and fibrotic disease |
| WO2020132071A1 (en) | 2018-12-19 | 2020-06-25 | Shy Therapeutics. Llc | Compounds that interact with the ras superfamily for the treatment of cancers, inflammatory diseases, rasopathies, and f1brotic disease |
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| WO2004052371A2 (en) * | 2002-12-11 | 2004-06-24 | 7Tm Pharma A/S | Cyclic quinoline compounds for use in mch receptor related disorders |
| WO2004072025A2 (de) * | 2003-02-14 | 2004-08-26 | Aventis Pharma Deutschland Gmbh | Substituierte n-arylheterozyklen, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel |
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| JP2005519875A (ja) * | 2001-11-13 | 2005-07-07 | エミスフェアー・テクノロジーズ・インク | 活性剤を送達するためのフェノキシアミン化合物および組成物 |
| WO2005085200A1 (ja) * | 2004-03-05 | 2005-09-15 | Banyu Pharmaceutical Co., Ltd. | ピリドン誘導体 |
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| MXPA06003997A (es) * | 2003-10-23 | 2006-07-05 | Glaxo Group Ltd | Derivados de 3-(4-aminofenil) tienopirimid-4-ona como antagonistas mch r1 para el tratamiento de obesidad, diabetes, depresion y ansiedad. |
-
2007
- 2007-02-13 JP JP2008554654A patent/JP2009526794A/ja active Pending
- 2007-02-13 TW TW096105357A patent/TW200801022A/zh unknown
- 2007-02-13 BR BRPI0707870-6A patent/BRPI0707870A2/pt not_active IP Right Cessation
- 2007-02-13 CN CNA2007800056310A patent/CN101384605A/zh active Pending
- 2007-02-13 WO PCT/EP2007/001213 patent/WO2007093365A2/en not_active Ceased
- 2007-02-13 EP EP07711519.4A patent/EP1987042B1/en not_active Not-in-force
- 2007-02-13 CA CA002636879A patent/CA2636879A1/en not_active Abandoned
- 2007-02-13 AU AU2007214710A patent/AU2007214710A1/en not_active Abandoned
- 2007-02-13 KR KR1020087020095A patent/KR20080096670A/ko not_active Withdrawn
- 2007-02-15 AR ARP070100659A patent/AR059520A1/es not_active Application Discontinuation
- 2007-02-15 UY UY30164A patent/UY30164A1/es unknown
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2008
- 2008-08-10 IL IL193342A patent/IL193342A0/en unknown
- 2008-08-14 US US12/191,678 patent/US8853208B2/en not_active Expired - Fee Related
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| WO2004024702A1 (de) * | 2002-08-24 | 2004-03-25 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Neue carbonsäureamid-verbindungen mit mch-antagonistischer wirkung, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung |
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| WO2004072025A2 (de) * | 2003-02-14 | 2004-08-26 | Aventis Pharma Deutschland Gmbh | Substituierte n-arylheterozyklen, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel |
| WO2005085200A1 (ja) * | 2004-03-05 | 2005-09-15 | Banyu Pharmaceutical Co., Ltd. | ピリドン誘導体 |
| WO2005103039A1 (en) * | 2004-04-15 | 2005-11-03 | Neurocrine Biosciences, Inc. | 2- (3-aminopyrrolidin-1-yl) pyridines as melanin-concentrating hormone receptor an tagonists |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2016053056A (ja) * | 2006-05-19 | 2016-04-14 | アボット・ラボラトリーズＡｂｂｏｔｔ Ｌａｂｏｒａｔｏｒｉｅｓ | Ｃｎｓ活性縮合ビシクロ複素環置換アザ二環式アルカン誘導体 |
Also Published As
| Publication number | Publication date |
|---|---|
| CN101384605A (zh) | 2009-03-11 |
| TW200801022A (en) | 2008-01-01 |
| CA2636879A1 (en) | 2007-08-23 |
| US8853208B2 (en) | 2014-10-07 |
| WO2007093365A3 (en) | 2007-10-04 |
| AR059520A1 (es) | 2008-04-09 |
| WO2007093365A2 (en) | 2007-08-23 |
| EP1987042B1 (en) | 2015-01-21 |
| KR20080096670A (ko) | 2008-10-31 |
| US20090076002A1 (en) | 2009-03-19 |
| EP1987042A2 (en) | 2008-11-05 |
| IL193342A0 (en) | 2009-05-04 |
| BRPI0707870A2 (pt) | 2011-05-10 |
| UY30164A1 (es) | 2007-09-28 |
| AU2007214710A1 (en) | 2007-08-23 |
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