CA2636879A1 - Novel amino alcohol-substituted arylthienopyrimidinones, process for their preparation and their use as medicaments - Google Patents
Novel amino alcohol-substituted arylthienopyrimidinones, process for their preparation and their use as medicaments Download PDFInfo
- Publication number
- CA2636879A1 CA2636879A1 CA002636879A CA2636879A CA2636879A1 CA 2636879 A1 CA2636879 A1 CA 2636879A1 CA 002636879 A CA002636879 A CA 002636879A CA 2636879 A CA2636879 A CA 2636879A CA 2636879 A1 CA2636879 A1 CA 2636879A1
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- CA
- Canada
- Prior art keywords
- alkyl
- alkoxy
- independently
- group
- hydroxy
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
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- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 title abstract description 9
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- 229910000029 sodium carbonate Inorganic materials 0.000 description 1
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- ITFVMMSNUZDOAR-UHFFFAOYSA-N tert-butyl 3-(4-nitrophenoxy)-8-azabicyclo[3.2.1]octane-8-carboxylate 3-(4-nitrophenoxy)-8-azabicyclo[3.2.1]octane Chemical compound C(C)(C)(C)OC(=O)N1C2CC(CC1CC2)OC2=CC=C(C=C2)[N+](=O)[O-].[N+](=O)([O-])C2=CC=C(OC1CC3CCC(C1)N3)C=C2 ITFVMMSNUZDOAR-UHFFFAOYSA-N 0.000 description 1
- SEGZJJSZYOEABC-UHFFFAOYSA-N tert-butyl 3-hydroxy-8-azabicyclo[3.2.1]octane-8-carboxylate Chemical compound C1C(O)CC2CCC1N2C(=O)OC(C)(C)C SEGZJJSZYOEABC-UHFFFAOYSA-N 0.000 description 1
- VMKWPQAOHLHQOH-UHFFFAOYSA-N tert-butyl 3-hydroxy-8-azabicyclo[3.2.1]octane-8-carboxylate;tert-butyl 3-(4-nitrophenoxy)-8-azabicyclo[3.2.1]octane-8-carboxylate Chemical compound C1C(O)CC2CCC1N2C(=O)OC(C)(C)C.CC(C)(C)OC(=O)N1C(C2)CCC1CC2OC1=CC=C([N+]([O-])=O)C=C1 VMKWPQAOHLHQOH-UHFFFAOYSA-N 0.000 description 1
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- REDWTYHGGQXALI-UHFFFAOYSA-N tert-butyl-chloro-diphenylsilane;methyl 5-[[tert-butyl(diphenyl)silyl]oxymethyl]-3-[(2-methylpropan-2-yl)oxycarbonylamino]thiophene-2-carboxylate Chemical compound C=1C=CC=CC=1[Si](Cl)(C(C)(C)C)C1=CC=CC=C1.CC(C)(C)OC(=O)NC1=C(C(=O)OC)SC(CO[Si](C=2C=CC=CC=2)(C=2C=CC=CC=2)C(C)(C)C)=C1 REDWTYHGGQXALI-UHFFFAOYSA-N 0.000 description 1
- CXGTZJYQWSUFET-IBGZPJMESA-N tesaglitazar Chemical compound C1=CC(C[C@H](OCC)C(O)=O)=CC=C1OCCC1=CC=C(OS(C)(=O)=O)C=C1 CXGTZJYQWSUFET-IBGZPJMESA-N 0.000 description 1
- 229950004704 tesaglitazar Drugs 0.000 description 1
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- 230000001225 therapeutic effect Effects 0.000 description 1
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- 150000001467 thiazolidinediones Chemical class 0.000 description 1
- 201000005665 thrombophilia Diseases 0.000 description 1
- GZNAASVAJNXPPW-UHFFFAOYSA-M tin(4+) chloride dihydrate Chemical compound O.O.[Cl-].[Sn+4] GZNAASVAJNXPPW-UHFFFAOYSA-M 0.000 description 1
- FWPIDFUJEMBDLS-UHFFFAOYSA-L tin(II) chloride dihydrate Substances O.O.Cl[Sn]Cl FWPIDFUJEMBDLS-UHFFFAOYSA-L 0.000 description 1
- 229950004437 tiqueside Drugs 0.000 description 1
- 235000010384 tocopherol Nutrition 0.000 description 1
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- 229930003799 tocopherol Natural products 0.000 description 1
- 239000011732 tocopherol Substances 0.000 description 1
- CMSGWTNRGKRWGS-NQIIRXRSSA-N torcetrapib Chemical compound COC(=O)N([C@H]1C[C@@H](CC)N(C2=CC=C(C=C21)C(F)(F)F)C(=O)OCC)CC1=CC(C(F)(F)F)=CC(C(F)(F)F)=C1 CMSGWTNRGKRWGS-NQIIRXRSSA-N 0.000 description 1
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- AHZJKOKFZJYCLG-UHFFFAOYSA-K trifluoromethanesulfonate;ytterbium(3+) Chemical compound [Yb+3].[O-]S(=O)(=O)C(F)(F)F.[O-]S(=O)(=O)C(F)(F)F.[O-]S(=O)(=O)C(F)(F)F AHZJKOKFZJYCLG-UHFFFAOYSA-K 0.000 description 1
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 description 1
- CWMFRHBXRUITQE-UHFFFAOYSA-N trimethylsilylacetylene Chemical group C[Si](C)(C)C#C CWMFRHBXRUITQE-UHFFFAOYSA-N 0.000 description 1
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- SYOKIDBDQMKNDQ-XWTIBIIYSA-N vildagliptin Chemical compound C1C(O)(C2)CC(C3)CC1CC32NCC(=O)N1CCC[C@H]1C#N SYOKIDBDQMKNDQ-XWTIBIIYSA-N 0.000 description 1
- 125000000391 vinyl group Chemical group [H]C([*])=C([H])[H] 0.000 description 1
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- GVJHHUAWPYXKBD-IEOSBIPESA-N α-tocopherol Chemical compound OC1=C(C)C(C)=C2O[C@@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-IEOSBIPESA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Diabetes (AREA)
- Obesity (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Hematology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Emergency Medicine (AREA)
- Endocrinology (AREA)
- Child & Adolescent Psychology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE102006007049.6 | 2006-02-15 | ||
| DE102006007049 | 2006-02-15 | ||
| PCT/EP2007/001213 WO2007093365A2 (en) | 2006-02-15 | 2007-02-13 | Novel amino alcohol-substituted arylthienopyrimidinones, process for their preparation and their use as medicaments |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2636879A1 true CA2636879A1 (en) | 2007-08-23 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002636879A Abandoned CA2636879A1 (en) | 2006-02-15 | 2007-02-13 | Novel amino alcohol-substituted arylthienopyrimidinones, process for their preparation and their use as medicaments |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US8853208B2 (enExample) |
| EP (1) | EP1987042B1 (enExample) |
| JP (1) | JP2009526794A (enExample) |
| KR (1) | KR20080096670A (enExample) |
| CN (1) | CN101384605A (enExample) |
| AR (1) | AR059520A1 (enExample) |
| AU (1) | AU2007214710A1 (enExample) |
| BR (1) | BRPI0707870A2 (enExample) |
| CA (1) | CA2636879A1 (enExample) |
| IL (1) | IL193342A0 (enExample) |
| TW (1) | TW200801022A (enExample) |
| UY (1) | UY30164A1 (enExample) |
| WO (1) | WO2007093365A2 (enExample) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| HRP20110917T1 (hr) * | 2006-05-19 | 2012-03-31 | Abbott Laboratories | Derivati azabicikličkih alkana supstituirani fuzioniranim bicikloheterociklima aktivni u središnjem živčanom sustavu |
| US8470841B2 (en) | 2008-07-09 | 2013-06-25 | Sanofi | Heterocyclic compounds, processes for their preparation, medicaments comprising these compounds, and the use thereof |
| UY32793A (es) | 2009-07-21 | 2011-01-31 | Gilead Sciences Inc | Compuestos inhibidores de los virus flaviviridae, composición farmacéutica que los contiene y sus usos |
| EP2507249B1 (en) | 2009-09-09 | 2015-11-11 | Gilead Sciences, Inc. | Inhibitors of flaviviridae viruses |
| KR101727776B1 (ko) | 2010-01-15 | 2017-04-17 | 길리애드 사이언시즈, 인코포레이티드 | 플라비비리다에 바이러스의 억제제 |
| EA201290575A1 (ru) | 2010-01-15 | 2013-01-30 | Джилид Сайэнс, Инк. | Ингибиторы вирусов flaviviridae |
| HUP1100241A3 (en) | 2011-05-06 | 2013-12-30 | Richter Gedeon Nyrt | Oxetane substituted pyrimidones |
| JP5987056B2 (ja) | 2011-07-13 | 2016-09-06 | ギリアード サイエンシーズ， インコーポレイテッド | Ｆｌａｖｉｖｉｒｉｄａｅウイルスのインヒビターとして有用なチオフェン−２−カルボン酸誘導体 |
| US8759544B2 (en) | 2012-08-17 | 2014-06-24 | Gilead Sciences, Inc. | Synthesis of an antiviral compound |
| US8841340B2 (en) | 2012-08-17 | 2014-09-23 | Gilead Sciences, Inc. | Solid forms of an antiviral compound |
| US8927741B2 (en) | 2012-08-17 | 2015-01-06 | Gilead Sciences, Inc. | Synthesis of an antiviral compound |
| US10221191B2 (en) | 2015-12-22 | 2019-03-05 | SHY Therapeutics LLC | Compounds for the treatment of cancer and inflammatory disease |
| JP7514005B2 (ja) | 2017-06-21 | 2024-07-10 | シャイ・セラピューティクス・エルエルシー | がん、炎症性疾患、ラソパシー、及び線維性疾患の治療のためのｒａｓスーパーファミリーと相互作用する化合物 |
| EP3898609A1 (en) | 2018-12-19 | 2021-10-27 | Shy Therapeutics LLC | Compounds that interact with the ras superfamily for the treatment of cancers, inflammatory diseases, rasopathies, and fibrotic disease |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| GB0124627D0 (en) * | 2001-10-15 | 2001-12-05 | Smithkline Beecham Plc | Novel compounds |
| ES2431630T3 (es) * | 2001-11-13 | 2013-11-27 | Emisphere Technologies, Inc. | Compuestos de fenoxiamina y composiciones para administrar principios activos |
| DE10233817A1 (de) * | 2002-07-25 | 2004-02-12 | Aventis Pharma Deutschland Gmbh | Substituierte Diarylheterocyclen, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel |
| DE10238865A1 (de) * | 2002-08-24 | 2004-03-11 | Boehringer Ingelheim International Gmbh | Neue Carbonsäureamid-Verbindungen mit MCH-antagonistischer Wirkung, diese Verbindungen enthaltende Arzneimittel und Verfahren zu ihrer Herstellung |
| AU2003287880A1 (en) * | 2002-12-11 | 2004-06-30 | 7Tm Pharma A/S | Cyclic quinoline compounds for use in mch receptor related disorders |
| DE10306250A1 (de) * | 2003-02-14 | 2004-09-09 | Aventis Pharma Deutschland Gmbh | Substituierte N-Arylheterozyklen, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel |
| KR20060100412A (ko) * | 2003-10-23 | 2006-09-20 | 글락소 그룹 리미티드 | 비만, 당뇨, 우울증 및 불안증을 치료하기 위한 ｍｃｈｒ１ 길항제로서의 3-(4-아미노페닐)티에노피리미드-4-온유도체 |
| WO2005085200A1 (ja) * | 2004-03-05 | 2005-09-15 | Banyu Pharmaceutical Co., Ltd. | ピリドン誘導体 |
| US20050256124A1 (en) * | 2004-04-15 | 2005-11-17 | Neurocrine Biosciences, Inc. | Melanin-concentrating hormone receptor antagonists and compositions and methods related thereto |
-
2007
- 2007-02-13 JP JP2008554654A patent/JP2009526794A/ja active Pending
- 2007-02-13 WO PCT/EP2007/001213 patent/WO2007093365A2/en not_active Ceased
- 2007-02-13 EP EP07711519.4A patent/EP1987042B1/en not_active Not-in-force
- 2007-02-13 AU AU2007214710A patent/AU2007214710A1/en not_active Abandoned
- 2007-02-13 CA CA002636879A patent/CA2636879A1/en not_active Abandoned
- 2007-02-13 TW TW096105357A patent/TW200801022A/zh unknown
- 2007-02-13 CN CNA2007800056310A patent/CN101384605A/zh active Pending
- 2007-02-13 KR KR1020087020095A patent/KR20080096670A/ko not_active Withdrawn
- 2007-02-13 BR BRPI0707870-6A patent/BRPI0707870A2/pt not_active IP Right Cessation
- 2007-02-15 UY UY30164A patent/UY30164A1/es unknown
- 2007-02-15 AR ARP070100659A patent/AR059520A1/es not_active Application Discontinuation
-
2008
- 2008-08-10 IL IL193342A patent/IL193342A0/en unknown
- 2008-08-14 US US12/191,678 patent/US8853208B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| JP2009526794A (ja) | 2009-07-23 |
| UY30164A1 (es) | 2007-09-28 |
| US20090076002A1 (en) | 2009-03-19 |
| CN101384605A (zh) | 2009-03-11 |
| EP1987042A2 (en) | 2008-11-05 |
| KR20080096670A (ko) | 2008-10-31 |
| IL193342A0 (en) | 2009-05-04 |
| AR059520A1 (es) | 2008-04-09 |
| TW200801022A (en) | 2008-01-01 |
| WO2007093365A3 (en) | 2007-10-04 |
| US8853208B2 (en) | 2014-10-07 |
| WO2007093365A2 (en) | 2007-08-23 |
| BRPI0707870A2 (pt) | 2011-05-10 |
| AU2007214710A1 (en) | 2007-08-23 |
| EP1987042B1 (en) | 2015-01-21 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FZDE | Discontinued |