JP2009526087A5 - - Google Patents
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- Publication number
- JP2009526087A5 JP2009526087A5 JP2008555886A JP2008555886A JP2009526087A5 JP 2009526087 A5 JP2009526087 A5 JP 2009526087A5 JP 2008555886 A JP2008555886 A JP 2008555886A JP 2008555886 A JP2008555886 A JP 2008555886A JP 2009526087 A5 JP2009526087 A5 JP 2009526087A5
- Authority
- JP
- Japan
- Prior art keywords
- macrolide
- beta
- agonist
- agent
- composition
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- 239000003120 macrolide antibiotic agent Substances 0.000 claims 12
- 239000003795 chemical substances by application Substances 0.000 claims 11
- 239000000556 agonist Substances 0.000 claims 10
- 239000003814 drug Substances 0.000 claims 10
- 239000000203 mixture Substances 0.000 claims 10
- 229940079593 drug Drugs 0.000 claims 8
- RXZBMPWDPOLZGW-XMRMVWPWSA-N (E)-roxithromycin Chemical compound O([C@@H]1[C@@H](C)C(=O)O[C@@H]([C@@]([C@H](O)[C@@H](C)C(=N/OCOCCOC)/[C@H](C)C[C@@](C)(O)[C@H](O[C@H]2[C@@H]([C@H](C[C@@H](C)O2)N(C)C)O)[C@H]1C)(C)O)CC)[C@H]1C[C@@](C)(OC)[C@@H](O)[C@H](C)O1 RXZBMPWDPOLZGW-XMRMVWPWSA-N 0.000 claims 6
- 239000000041 non-steroidal anti-inflammatory agent Substances 0.000 claims 6
- 229940021182 non-steroidal anti-inflammatory drug Drugs 0.000 claims 6
- 229960005224 roxithromycin Drugs 0.000 claims 6
- 239000008194 pharmaceutical composition Substances 0.000 claims 5
- OBRNDARFFFHCGE-PERKLWIXSA-N (S,S)-formoterol fumarate Chemical group OC(=O)\C=C\C(O)=O.C1=CC(OC)=CC=C1C[C@H](C)NC[C@@H](O)C1=CC=C(O)C(NC=O)=C1.C1=CC(OC)=CC=C1C[C@H](C)NC[C@@H](O)C1=CC=C(O)C(NC=O)=C1 OBRNDARFFFHCGE-PERKLWIXSA-N 0.000 claims 4
- 102000010907 Cyclooxygenase 2 Human genes 0.000 claims 4
- 108010037462 Cyclooxygenase 2 Proteins 0.000 claims 4
- 229960000193 formoterol fumarate Drugs 0.000 claims 4
- 241000124008 Mammalia Species 0.000 claims 3
- MQTOSJVFKKJCRP-BICOPXKESA-N azithromycin Chemical compound O([C@@H]1[C@@H](C)C(=O)O[C@@H]([C@@]([C@H](O)[C@@H](C)N(C)C[C@H](C)C[C@@](C)(O)[C@H](O[C@H]2[C@@H]([C@H](C[C@@H](C)O2)N(C)C)O)[C@H]1C)(C)O)CC)[C@H]1C[C@@](C)(OC)[C@@H](O)[C@H](C)O1 MQTOSJVFKKJCRP-BICOPXKESA-N 0.000 claims 3
- 229960004099 azithromycin Drugs 0.000 claims 3
- NDAUXUAQIAJITI-UHFFFAOYSA-N albuterol Chemical compound CC(C)(C)NCC(O)C1=CC=C(O)C(CO)=C1 NDAUXUAQIAJITI-UHFFFAOYSA-N 0.000 claims 2
- 229960003060 bambuterol Drugs 0.000 claims 2
- ANZXOIAKUNOVQU-UHFFFAOYSA-N bambuterol Chemical group CN(C)C(=O)OC1=CC(OC(=O)N(C)C)=CC(C(O)CNC(C)(C)C)=C1 ANZXOIAKUNOVQU-UHFFFAOYSA-N 0.000 claims 2
- 229960002626 clarithromycin Drugs 0.000 claims 2
- AGOYDEPGAOXOCK-KCBOHYOISA-N clarithromycin Chemical compound O([C@@H]1[C@@H](C)C(=O)O[C@@H]([C@@]([C@H](O)[C@@H](C)C(=O)[C@H](C)C[C@](C)([C@H](O[C@H]2[C@@H]([C@H](C[C@@H](C)O2)N(C)C)O)[C@H]1C)OC)(C)O)CC)[C@H]1C[C@@](C)(OC)[C@@H](O)[C@H](C)O1 AGOYDEPGAOXOCK-KCBOHYOISA-N 0.000 claims 2
- 239000003937 drug carrier Substances 0.000 claims 2
- 239000003112 inhibitor Substances 0.000 claims 2
- 239000002599 prostaglandin synthase inhibitor Substances 0.000 claims 2
- 229960002052 salbutamol Drugs 0.000 claims 2
- VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 claims 1
- 229940122204 Cyclooxygenase inhibitor Drugs 0.000 claims 1
- 230000036528 appetite Effects 0.000 claims 1
- 235000019789 appetite Nutrition 0.000 claims 1
- 229960004296 megestrol acetate Drugs 0.000 claims 1
- RQZAXGRLVPAYTJ-GQFGMJRRSA-N megestrol acetate Chemical compound C1=C(C)C2=CC(=O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@@](C(C)=O)(OC(=O)C)[C@@]1(C)CC2 RQZAXGRLVPAYTJ-GQFGMJRRSA-N 0.000 claims 1
- 150000003431 steroids Chemical class 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US75311805P | 2005-12-22 | 2005-12-22 | |
| US77275206P | 2006-02-13 | 2006-02-13 | |
| PCT/IB2006/004315 WO2008093148A2 (en) | 2005-12-22 | 2006-12-20 | Compositions and methods for prevention and treatment of cachexia |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2009526087A JP2009526087A (ja) | 2009-07-16 |
| JP2009526087A5 true JP2009526087A5 (https=) | 2010-01-07 |
Family
ID=38194678
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008555886A Withdrawn JP2009526087A (ja) | 2005-12-22 | 2006-12-20 | 悪液質の予防および処置のための組成物および方法 |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US8080528B2 (https=) |
| EP (1) | EP1991270A4 (https=) |
| JP (1) | JP2009526087A (https=) |
| MX (1) | MX2008007790A (https=) |
| NO (1) | NO20083240L (https=) |
| WO (1) | WO2008093148A2 (https=) |
Families Citing this family (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ATE457169T1 (de) | 1998-10-15 | 2010-02-15 | Imp Innovations Ltd | Verbindungen für die behandlung von gewichtsverlust |
| GB0624282D0 (en) * | 2006-12-05 | 2007-01-10 | Cavalla David | Treatment of cachexia |
| EP2155180B1 (en) * | 2007-04-24 | 2016-07-13 | Acacia Pharma Limited | Drug combination and its use in the treatment of muscle loss |
| US8404235B2 (en) | 2007-05-21 | 2013-03-26 | Alderbio Holdings Llc | Antagonists of IL-6 to raise albumin and/or lower CRP |
| US8178101B2 (en) | 2007-05-21 | 2012-05-15 | Alderbio Holdings Inc. | Use of anti-IL-6 antibodies having specific binding properties to treat cachexia |
| US7906117B2 (en) | 2007-05-21 | 2011-03-15 | Alderbio Holdings Llc | Antagonists of IL-6 to prevent or treat cachexia, weakness, fatigue, and/or fever |
| US8062864B2 (en) | 2007-05-21 | 2011-11-22 | Alderbio Holdings Llc | Nucleic acids encoding antibodies to IL-6, and recombinant production of anti-IL-6 antibodies |
| US8252286B2 (en) | 2007-05-21 | 2012-08-28 | Alderbio Holdings Llc | Antagonists of IL-6 to prevent or treat thrombosis |
| HUE032563T2 (en) | 2007-05-21 | 2017-09-28 | Alderbio Holdings Llc | Antibodies to IL-6 and their use |
| US9701747B2 (en) | 2007-05-21 | 2017-07-11 | Alderbio Holdings Llc | Method of improving patient survivability and quality of life by anti-IL-6 antibody administration |
| WO2009064532A1 (en) * | 2007-11-18 | 2009-05-22 | Anaborex, Inc. | Compositions and methods for treating serous exudative effusion |
| US8257684B2 (en) * | 2008-03-26 | 2012-09-04 | Neurosigma, Inc. | Methods for identifying and targeting autonomic brain regions |
| US9212223B2 (en) | 2008-11-25 | 2015-12-15 | Alderbio Holdings Llc | Antagonists of IL-6 to prevent or treat thrombosis |
| US8337847B2 (en) | 2008-11-25 | 2012-12-25 | Alderbio Holdings Llc | Methods of treating anemia using anti-IL-6 antibodies |
| US8992920B2 (en) | 2008-11-25 | 2015-03-31 | Alderbio Holdings Llc | Anti-IL-6 antibodies for the treatment of arthritis |
| US9452227B2 (en) | 2008-11-25 | 2016-09-27 | Alderbio Holdings Llc | Methods of treating or diagnosing conditions associated with elevated IL-6 using anti-IL-6 antibodies or fragments |
| US8323649B2 (en) | 2008-11-25 | 2012-12-04 | Alderbio Holdings Llc | Antibodies to IL-6 and use thereof |
| US8420089B2 (en) | 2008-11-25 | 2013-04-16 | Alderbio Holdings Llc | Antagonists of IL-6 to raise albumin and/or lower CRP |
| CA2744400C (en) * | 2008-11-25 | 2019-01-15 | Alder Biopharmaceuticals, Inc. | Antibodies to il-6 and use thereof |
| WO2011066374A2 (en) | 2009-11-24 | 2011-06-03 | Alder Biopharmaceuticals, Inc. | Antagonists of il-6 to prevent or treat cachexia, weakness, fatigue, and/or fever |
| US9775921B2 (en) | 2009-11-24 | 2017-10-03 | Alderbio Holdings Llc | Subcutaneously administrable composition containing anti-IL-6 antibody |
| US8791105B2 (en) | 2010-07-14 | 2014-07-29 | Kansas State University Research Foundation | Methods for alleviating chronic pain and improving performance of cattle undergoing dehorning or castration |
| US9304134B2 (en) | 2010-11-23 | 2016-04-05 | Alderbio Holdings Llc | Anti-IL-6 antibodies for the treatment of anemia |
| US20160009767A9 (en) * | 2012-03-28 | 2016-01-14 | Affibody Ab | Oral administration |
| WO2020018554A1 (en) * | 2018-07-17 | 2020-01-23 | The Regents Of The University Of California | Methods of treating renal disease |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4859782A (en) * | 1986-06-26 | 1989-08-22 | Harbor Branch Oceanographic Institution, Inc. | Misakinolide compositions and their derivatives |
| EP0308157B1 (en) * | 1987-09-15 | 1997-02-26 | The Rowett Research Institute | Therapeutic applications of beta-adrenergic agonists |
| HUT50044A (en) * | 1988-04-12 | 1989-12-28 | Bristol Myers Co | Process for producing pharmaceutical composition comprising megestrol acetate as active ingredient |
| US5252564A (en) * | 1991-03-29 | 1993-10-12 | The United States Of America As Represented By The Secretary Of Agriculture | Method to decrease cortisol secretion by feeding melengesterol acetate |
| EP0771205A2 (de) * | 1994-06-28 | 1997-05-07 | Dr. Zerle Gmbh | Neue klinische anwendungen von polyen-makroliden |
| US5750493A (en) * | 1995-08-30 | 1998-05-12 | Raymond F. Schinazi | Method to improve the biological and antiviral activity of protease inhibitors |
| US6706892B1 (en) * | 1999-09-07 | 2004-03-16 | Conjuchem, Inc. | Pulmonary delivery for bioconjugation |
| US7101576B2 (en) * | 2002-04-12 | 2006-09-05 | Elan Pharma International Limited | Nanoparticulate megestrol formulations |
| US7211568B2 (en) * | 2003-12-18 | 2007-05-01 | Kosan Biosciences Incorporated | 9-Desoxoerythromycin compounds as prokinetic agents |
| WO2008004224A2 (en) | 2006-07-03 | 2008-01-10 | Arie Levine | Synergistic compositions for crohn's disease and inflammatory gastrointestinal disorders |
-
2006
- 2006-12-20 WO PCT/IB2006/004315 patent/WO2008093148A2/en not_active Ceased
- 2006-12-20 JP JP2008555886A patent/JP2009526087A/ja not_active Withdrawn
- 2006-12-20 US US11/614,056 patent/US8080528B2/en not_active Expired - Fee Related
- 2006-12-20 EP EP06852000A patent/EP1991270A4/en not_active Withdrawn
- 2006-12-20 MX MX2008007790A patent/MX2008007790A/es not_active Application Discontinuation
-
2008
- 2008-07-22 NO NO20083240A patent/NO20083240L/no not_active Application Discontinuation
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