JP2009526023A - ３，９−ジアザビシクロ［３．３．１］ノナン誘導体及びモノアミン神経伝達物質再取り込み阻害薬としてのその使用 - Google Patents
３，９−ジアザビシクロ［３．３．１］ノナン誘導体及びモノアミン神経伝達物質再取り込み阻害薬としてのその使用 Download PDFInfo
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- JP2009526023A JP2009526023A JP2008553776A JP2008553776A JP2009526023A JP 2009526023 A JP2009526023 A JP 2009526023A JP 2008553776 A JP2008553776 A JP 2008553776A JP 2008553776 A JP2008553776 A JP 2008553776A JP 2009526023 A JP2009526023 A JP 2009526023A
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- Prior art keywords
- disorder
- pain
- quinolin
- methyl
- diaza
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
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- VHZTYXMOVMLTLM-UHFFFAOYSA-N 3-(9-methyl-3,9-diazabicyclo[3.3.1]nonan-3-yl)quinolin-7-ol Chemical compound C1=C(O)C=CC2=CC(N3CC4CCCC(C3)N4C)=CN=C21 VHZTYXMOVMLTLM-UHFFFAOYSA-N 0.000 claims description 3
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- IZLGOGRHBJIRNU-UHFFFAOYSA-N tert-butyl 3,9-diazabicyclo[3.3.1]nonane-9-carboxylate Chemical compound C1CCC2CNCC1N2C(=O)OC(C)(C)C IZLGOGRHBJIRNU-UHFFFAOYSA-N 0.000 description 1
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- JOXIMZWYDAKGHI-UHFFFAOYSA-N toluene-4-sulfonic acid Chemical compound CC1=CC=C(S(O)(=O)=O)C=C1 JOXIMZWYDAKGHI-UHFFFAOYSA-N 0.000 description 1
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Classifications
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- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
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Landscapes
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- Chemical & Material Sciences (AREA)
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US77188906P | 2006-02-10 | 2006-02-10 | |
| DKPA200600191 | 2006-02-10 | ||
| PCT/EP2007/051271 WO2007090887A1 (en) | 2006-02-10 | 2007-02-09 | 3, 9-diazabicyclo [3.3. 1]nonane derivatives and their use as monoamine?neurotransmitter re-uptake inhibitors |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2009526023A true JP2009526023A (ja) | 2009-07-16 |
| JP2009526023A5 JP2009526023A5 (enExample) | 2010-03-25 |
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| Application Number | Title | Priority Date | Filing Date |
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| JP2008553776A Abandoned JP2009526023A (ja) | 2006-02-10 | 2007-02-09 | ３，９−ジアザビシクロ［３．３．１］ノナン誘導体及びモノアミン神経伝達物質再取り込み阻害薬としてのその使用 |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US7687517B2 (enExample) |
| EP (1) | EP1984366B1 (enExample) |
| JP (1) | JP2009526023A (enExample) |
| AU (1) | AU2007213670A1 (enExample) |
| CA (1) | CA2641683A1 (enExample) |
| WO (1) | WO2007090887A1 (enExample) |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| WO2007090888A1 (en) | 2006-02-10 | 2007-08-16 | Neurosearch A/S | 3-heteroaryl- 3,9-diazabicyclo[3.3.1]nonane derivatives as nicotinic acetylcholine receptor agonists |
| CN101379063A (zh) | 2006-02-10 | 2009-03-04 | 神经研究公司 | 3,9-二氮杂双环[3.3.1]壬烷衍生物及其作为单胺神经递质再摄取抑制剂的用途 |
| US20110142758A1 (en) * | 2008-06-10 | 2011-06-16 | Neurosearch A/S | Indolyl-pyridazinyl-diazabicyclononane derivatives in labelled and unlabelled form and their use in diagnostic methods |
Family Cites Families (21)
| Publication number | Priority date | Publication date | Assignee | Title |
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| US3196154A (en) * | 1962-05-17 | 1965-07-20 | Sterling Drug Inc | 3-substituted-9-methyl-3, 9-diazabicyclo [3.3.1] nonanes |
| IN166416B (enExample) | 1985-09-18 | 1990-05-05 | Pfizer | |
| US5478939A (en) * | 1994-07-20 | 1995-12-26 | American Cyanamid Company | (R,R) and (S,S) 2,5-diazabicyclo [2,2,1]heptane derivatives |
| AU736798B2 (en) | 1997-05-30 | 2001-08-02 | Neurosearch A/S | 9-Azabicyclo(3.3.1)non-2-ene and nonane derivatives as cholinergic ligands at nicotinic ACh receptors |
| EE04057B1 (et) | 1997-05-30 | 2003-06-16 | Neurosearch A/S | 8-asabitsüklo[3,2,1]okt-2-eeni ja -oktaani derivaadid, nende valmistamismeetod, kasutamine ja farmatseutiline kompositsioon |
| ES2226284T3 (es) | 1998-04-16 | 2005-03-16 | Pfizer Products Inc. | N-acil y n-aroil-aralquilamidas. |
| FR2786770B1 (fr) | 1998-12-04 | 2001-01-19 | Synthelabo | Derives de 1,4-diazabicyclo[3.2.2.]nonane, leur preparation et leur application en therapeutique |
| US7265115B2 (en) * | 1999-01-29 | 2007-09-04 | Abbott Laboratories | Diazabicyclic CNS active agents |
| PT1147112E (pt) | 1999-01-29 | 2004-03-31 | Abbott Lab | Derivados diazabiciclicos como liganos nicotinicos do receptor de acetilcolina |
| ATE261448T1 (de) * | 1999-05-04 | 2004-03-15 | Neurosearch As | Heteroaryl diazabicycloalkene, deren herstellung und verwendung |
| US6852721B2 (en) | 2000-05-25 | 2005-02-08 | Targacept, Inc. | Pharmaceutical compositions and methods for use |
| CA2410945A1 (en) | 2000-07-04 | 2002-01-10 | Neurosearch A/S | Aryl and heteroaryl diazabicycloalkanes, their preparation and use |
| DE60203007T2 (de) | 2001-06-01 | 2005-07-07 | Neurosearch A/S | Heteroaryl-diazabicycloalkanderivaten als cns-modulatoren |
| US7399765B2 (en) * | 2003-09-19 | 2008-07-15 | Abbott Laboratories | Substituted diazabicycloalkane derivatives |
| JP2007510642A (ja) * | 2003-11-03 | 2007-04-26 | ワーナー−ランバート カンパニー リミテッド ライアビリティー カンパニー | 中枢神経系障害の治療のための新規ノルエピネフリン再取込み阻害薬 |
| CA2584838A1 (en) | 2004-10-20 | 2006-05-04 | Neurosearch A/S | Novel diazabicyclic aryl derivatives and their medical use |
| DK1805158T3 (en) | 2004-10-29 | 2018-08-06 | Kalypsys Inc | SULFONYL-SUBSTITUTED BICYCLIC COMPOUNDS AS MODULATORS OF PPAR |
| EP1863819B1 (en) | 2005-02-16 | 2011-01-12 | NeuroSearch A/S | Diazabicyclic aryl derivatives and their use as chinolinergic ligands at the nicotinic acetylcholine receptors |
| CN101305004B (zh) | 2005-12-06 | 2011-11-16 | 神经研究公司 | 新颖的二氮杂双环芳基衍生物和它们的医药用途 |
| CN101379063A (zh) | 2006-02-10 | 2009-03-04 | 神经研究公司 | 3,9-二氮杂双环[3.3.1]壬烷衍生物及其作为单胺神经递质再摄取抑制剂的用途 |
| WO2007090888A1 (en) | 2006-02-10 | 2007-08-16 | Neurosearch A/S | 3-heteroaryl- 3,9-diazabicyclo[3.3.1]nonane derivatives as nicotinic acetylcholine receptor agonists |
-
2007
- 2007-02-09 EP EP07704486A patent/EP1984366B1/en not_active Not-in-force
- 2007-02-09 US US12/159,074 patent/US7687517B2/en not_active Expired - Fee Related
- 2007-02-09 JP JP2008553776A patent/JP2009526023A/ja not_active Abandoned
- 2007-02-09 AU AU2007213670A patent/AU2007213670A1/en not_active Abandoned
- 2007-02-09 CA CA002641683A patent/CA2641683A1/en not_active Abandoned
- 2007-02-09 WO PCT/EP2007/051271 patent/WO2007090887A1/en not_active Ceased
Also Published As
| Publication number | Publication date |
|---|---|
| US7687517B2 (en) | 2010-03-30 |
| WO2007090887A1 (en) | 2007-08-16 |
| EP1984366A1 (en) | 2008-10-29 |
| US20080306078A1 (en) | 2008-12-11 |
| CA2641683A1 (en) | 2007-08-16 |
| AU2007213670A1 (en) | 2007-08-16 |
| EP1984366B1 (en) | 2010-12-15 |
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