JP2009524008A5 - - Google Patents
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- JP2009524008A5 JP2009524008A5 JP2008543520A JP2008543520A JP2009524008A5 JP 2009524008 A5 JP2009524008 A5 JP 2009524008A5 JP 2008543520 A JP2008543520 A JP 2008543520A JP 2008543520 A JP2008543520 A JP 2008543520A JP 2009524008 A5 JP2009524008 A5 JP 2009524008A5
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- JP
- Japan
- Prior art keywords
- sample
- ibd
- antibody
- group
- marker
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 238000000034 method Methods 0.000 claims description 24
- 208000022559 Inflammatory bowel disease Diseases 0.000 claims description 10
- 239000003550 marker Substances 0.000 claims 6
- 238000013528 artificial neural network Methods 0.000 claims 3
- 238000003018 immunoassay Methods 0.000 claims 3
- 238000007637 random forest analysis Methods 0.000 claims 3
- 206010009900 Colitis ulcerative Diseases 0.000 claims 2
- 208000011231 Crohn disease Diseases 0.000 claims 2
- 238000012896 Statistical algorithm Methods 0.000 claims 2
- 201000006704 Ulcerative Colitis Diseases 0.000 claims 2
- 230000001086 cytosolic effect Effects 0.000 claims 2
- 230000002055 immunohistochemical effect Effects 0.000 claims 2
- 102000016911 Deoxyribonucleases Human genes 0.000 claims 1
- 108010053770 Deoxyribonucleases Proteins 0.000 claims 1
- 238000002965 ELISA Methods 0.000 claims 1
- 102000004190 Enzymes Human genes 0.000 claims 1
- 108090000790 Enzymes Proteins 0.000 claims 1
- 101800004937 Protein C Proteins 0.000 claims 1
- 102100036546 Salivary acidic proline-rich phosphoprotein 1/2 Human genes 0.000 claims 1
- 101800001700 Saposin-D Proteins 0.000 claims 1
- 230000006978 adaptation Effects 0.000 claims 1
- 230000000844 anti-bacterial effect Effects 0.000 claims 1
- 230000000845 anti-microbial effect Effects 0.000 claims 1
- 239000003795 chemical substances by application Substances 0.000 claims 1
- 238000001514 detection method Methods 0.000 claims 1
- 238000003745 diagnosis Methods 0.000 claims 1
- 229940088598 enzyme Drugs 0.000 claims 1
- 238000010166 immunofluorescence Methods 0.000 claims 1
- 229940099472 immunoglobulin a Drugs 0.000 claims 1
- 229940027941 immunoglobulin g Drugs 0.000 claims 1
- 238000012308 immunohistochemistry method Methods 0.000 claims 1
- 230000003993 interaction Effects 0.000 claims 1
- 230000002452 interceptive effect Effects 0.000 claims 1
- 238000010801 machine learning Methods 0.000 claims 1
- 210000000440 neutrophil Anatomy 0.000 claims 1
- 229960000856 protein c Drugs 0.000 claims 1
- 238000012706 support-vector machine Methods 0.000 claims 1
- 208000024891 symptom Diseases 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US11/293,616 | 2005-12-01 | ||
| US11/293,616 US20060154276A1 (en) | 2004-05-13 | 2005-12-01 | Methods of diagnosing inflammatory bowel disease |
| PCT/US2006/046136 WO2007064964A2 (en) | 2005-12-01 | 2006-11-30 | Methods of diagnosing inflammatory bowel disease |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2009524008A JP2009524008A (ja) | 2009-06-25 |
| JP2009524008A5 true JP2009524008A5 (https=) | 2010-01-07 |
| JP5634023B2 JP5634023B2 (ja) | 2014-12-03 |
Family
ID=38092870
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008543520A Expired - Fee Related JP5634023B2 (ja) | 2005-12-01 | 2006-11-30 | 試料が炎症性腸疾患と関連しているか分類する方法 |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US20060154276A1 (https=) |
| EP (1) | EP1955070B1 (https=) |
| JP (1) | JP5634023B2 (https=) |
| AT (1) | ATE534911T1 (https=) |
| AU (1) | AU2006320384B2 (https=) |
| CA (1) | CA2632972C (https=) |
| IL (1) | IL191679A (https=) |
| WO (1) | WO2007064964A2 (https=) |
Families Citing this family (47)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7759079B2 (en) * | 2004-05-13 | 2010-07-20 | Prometheus Laboratories Inc. | Methods of diagnosing inflammatory bowel disease |
| WO2008109782A2 (en) * | 2007-03-06 | 2008-09-12 | Cedars-Sinai Medical Center | Diagnosis of inflammatory bowel disease in children |
| US12110555B2 (en) | 2004-12-08 | 2024-10-08 | Cedars-Sinai Medical Center | Diagnosis and treatment of inflammatory bowel disease |
| US10544459B2 (en) | 2004-12-08 | 2020-01-28 | Cedars-Sinai Medical Center | Methods of using genetic variants for the diagnosis and treatment of inflammatory bowel disease |
| CA2589746A1 (en) * | 2004-12-08 | 2006-06-15 | Cedars-Sinai Medical Center | Methods for diagnosis and treatment of crohn's disease |
| US11268149B2 (en) | 2004-12-08 | 2022-03-08 | Cedars-Sinai Medical Center | Diagnosis and treatment of inflammatory bowel disease |
| US20080085524A1 (en) * | 2006-08-15 | 2008-04-10 | Prometheus Laboratories Inc. | Methods for diagnosing irritable bowel syndrome |
| US20100021917A1 (en) * | 2007-02-14 | 2010-01-28 | Cedars-Sinai Medical Center | Methods of using genes and genetic variants to predict or diagnose inflammatory bowel disease |
| US20100190162A1 (en) * | 2007-02-26 | 2010-07-29 | Cedars-Sinai Medical Center | Methods of using single nucleotide polymorphisms in the tl1a gene to predict or diagnose inflammatory bowel disease |
| WO2008137762A2 (en) * | 2007-05-04 | 2008-11-13 | Cedars-Sinai Medical Center | Methods of diagnosis and treatment of crohn's disease |
| WO2008106579A2 (en) * | 2007-02-28 | 2008-09-04 | Cedars-Sinai Medical Center | The role of il-12, il-23 and il-17 receptors in inflammatory bowel disease |
| WO2008116150A2 (en) * | 2007-03-21 | 2008-09-25 | Cedars-Sinai Medical Center | Ileal pouch-anal anastomosis (ipaa) factors in the treatment of inflammatory bowel disease |
| WO2008134569A2 (en) * | 2007-04-26 | 2008-11-06 | Cedars-Sinai Medical Center | Diagnosis and treatment of inflammatory bowel disease in the puerto rican population |
| US8153443B2 (en) * | 2007-05-10 | 2012-04-10 | Cedars-Sinai Medical Center | Characterization of the CBir1 antigenic response for diagnosis and treatment of Crohn's disease |
| US9305137B1 (en) | 2007-05-18 | 2016-04-05 | Cedars-Sinai Medical Center | Methods of identifying the genetic basis of a disease by a combinatorial genomics approach, biological pathway approach, and sequential approach |
| US11779571B2 (en) | 2008-02-26 | 2023-10-10 | Salix Pharmaceuticals, Inc. | Methods for treating irritable bowel syndrome (IBS) |
| BRPI0908026B8 (pt) | 2008-02-26 | 2021-05-25 | Salix Pharmaceuticals Ltd | uso de rifaximina no tratamento de doenças do intestino |
| US20110065741A1 (en) | 2009-02-26 | 2011-03-17 | Salix Pharmaceuticals, Ltd. | Methods for treating irritable bowel syndrome (ibs) |
| WO2009143278A2 (en) * | 2008-05-20 | 2009-11-26 | Cedars-Sinai Medical Center | Methods of diagnosing and characterizing cannabinoid signaling in crohn's disease |
| US20110177969A1 (en) * | 2008-10-01 | 2011-07-21 | Cedars-Sinai Medical Center | The role of il17rd and the il23-1l17 pathway in crohn's disease |
| US8170804B2 (en) * | 2008-10-17 | 2012-05-01 | Roche Molecular Systems, Inc. | Determination of melting temperatures of DNA |
| US20110189685A1 (en) * | 2008-10-22 | 2011-08-04 | Cedars-Sinai Medical Center | Methods of using jak3 genetic variants to diagnose and predict crohn's disease |
| WO2010056682A2 (en) | 2008-11-11 | 2010-05-20 | Prometheus Laboratories Inc. | Methods for prediction of inflammatory bowel disease (ibd) using serologic markers |
| US20110229471A1 (en) | 2008-11-26 | 2011-09-22 | Cedars-Sinai Medical Center | Methods of determining responsiveness to anti-tnf alpha therapy in inflammatory bowel disease |
| US9580752B2 (en) | 2008-12-24 | 2017-02-28 | Cedars-Sinai Medical Center | Methods of predicting medically refractive ulcerative colitis (MR-UC) requiring colectomy |
| CN108181457B (zh) | 2009-03-12 | 2021-03-30 | 癌症预防和治疗有限公司 | 鉴定、评估、预防以及治疗肺疾病的方法及试剂盒 |
| WO2010120814A1 (en) * | 2009-04-14 | 2010-10-21 | Prometheus Laboratories Inc. | Inflammatory bowel disease prognostics |
| JP5414422B2 (ja) * | 2009-08-25 | 2014-02-12 | 日本電信電話株式会社 | 病原体検出方法 |
| AU2012249288C1 (en) * | 2011-04-29 | 2017-12-21 | Lung Cancer Proteomics Llc | Methods of identification and diagnosis of lung diseases using classification systems and kits thereof |
| WO2015067913A1 (en) | 2013-11-07 | 2015-05-14 | Diagnodus Limited | Biomarkers |
| JP2015502740A (ja) * | 2011-10-21 | 2015-01-29 | ネステク ソシエテ アノニム | 炎症性腸疾患の診断を改善するための方法 |
| MY193914A (en) | 2012-03-05 | 2022-11-01 | Oy Arctic Partners Ab | Methods and apparatuses for predicting risk of prostate cancer and prostate gland volume |
| MX360479B (es) | 2012-10-05 | 2018-11-05 | Nestec Sa | Anticuerpos contra microbioma, factores de estres y marcadores de mastocitos como marcadores de diagnostico para ibs. |
| KR20230109779A (ko) | 2013-03-27 | 2023-07-20 | 세다르스-신나이 메디칼 센터 | Tl1a 기능 및 관련된 신호전달 경로의 저해에 의한섬유증 및 염증의 완화 및 반전 |
| JP2016521683A (ja) | 2013-05-24 | 2016-07-25 | ネステク ソシエテ アノニム | 過敏性腸症候群の診断を予測するための経路特異的なアッセイ |
| EP3022295A4 (en) | 2013-07-19 | 2017-03-01 | Cedars-Sinai Medical Center | Signature of tl1a (tnfsf15) signaling pathway |
| US12326453B2 (en) | 2014-03-28 | 2025-06-10 | Opko Diagnostics, Llc | Compositions and methods for active surveillance of prostate cancer |
| DK3123381T3 (da) | 2014-03-28 | 2023-11-27 | Opko Diagnostics Llc | Sammensætninger og fremgangsmåder relateret til diagnose af prostatacancer |
| WO2016160545A1 (en) | 2015-03-27 | 2016-10-06 | Opko Diagnostics, Llc | Prostate antigen standards and uses thereof |
| CN106446599A (zh) * | 2015-08-11 | 2017-02-22 | 中国科学院青岛生物能源与过程研究所 | 一种筛选婴幼儿龋病的口腔致病性生物标记物的方法 |
| WO2017079653A2 (en) | 2015-11-06 | 2017-05-11 | Vetica Labs, Inc. | Methods of detecting inflammatory markers and treating inflammatory conditions in companion animals |
| KR20240095481A (ko) | 2016-03-17 | 2024-06-25 | 세다르스-신나이 메디칼 센터 | Rnaset2를 통한 염증성 장 질환의 진단 방법 |
| US10444213B2 (en) | 2016-08-25 | 2019-10-15 | Viavi Solutions Inc. | Spectroscopic classification of conformance with dietary restrictions |
| CN110709936A (zh) | 2017-04-04 | 2020-01-17 | 肺癌蛋白质组学有限责任公司 | 用于早期肺癌预后的基于血浆的蛋白质概况分析 |
| US12431244B2 (en) | 2018-08-07 | 2025-09-30 | Yale University | Interpretable deep machine learning for clinical radiology |
| US12224071B2 (en) * | 2018-10-10 | 2025-02-11 | Lukasz R. Kiljanek | Generation of simulated patient data for training predicted medical outcome analysis engine |
| US20260000713A1 (en) * | 2021-12-01 | 2026-01-01 | Cedars-Sinai Medical Center | Microbial metabolites on intestinal inflammation |
Family Cites Families (28)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4277250A (en) | 1979-12-10 | 1981-07-07 | Baylor College Of Medicine | Methods for detecting and quantifying occult blood |
| JPH0684970B2 (ja) | 1987-03-31 | 1994-10-26 | 株式会社京都医科学研究所 | 糞便中の潜血検出方法 |
| US5081040A (en) | 1987-06-29 | 1992-01-14 | Helena Laboratories Corporation | Composition and kit for testing for occult blood in human and animal excretions, fluids, or tissue matrixes |
| JPH0736013B2 (ja) | 1991-04-27 | 1995-04-19 | 一男 田畑 | 潜血検出用試薬 |
| US6019944A (en) | 1992-05-21 | 2000-02-01 | Biosite Diagnostics, Inc. | Diagnostic devices and apparatus for the controlled movement of reagents without membranes |
| DK0615129T3 (da) * | 1993-03-10 | 2000-08-07 | Cedars Sinai Medical Center | Fremgangsmåder til selektiv påvisning af perinukleært anti-neutrophilt cytoplasmatisk antistof fra ulcerativ colitis eller |
| US5830675A (en) | 1993-03-10 | 1998-11-03 | Cedars-Sinai Medical Center | Methods for selectively detecting perinuclear anti-neutrophil cytoplasmic antibody of ulcerative colitis, primary sclerosing cholangitis, or type 1 autoimmune hepatitis |
| US6074835A (en) | 1996-04-12 | 2000-06-13 | Regents Of The Univ. Of California | Diagnosis, prevention and treatment of ulcerative colitis, and clinical subtypes thereof, using histone H1 |
| US6033864A (en) | 1996-04-12 | 2000-03-07 | The Regents Of The University Of California | Diagnosis, prevention and treatment of ulcerative colitis, and clinical subtypes thereof, using microbial UC pANCA antigens |
| US6218129B1 (en) * | 1998-05-15 | 2001-04-17 | Prometheus Laboratories, Inc. | Inflammatory bowel disease first step assay system |
| US6406862B1 (en) | 1998-10-06 | 2002-06-18 | The United States Of America As Represented By The Secretary Of The Army | Dip-stick assay for C-reactive protein |
| US6309643B1 (en) | 1999-04-30 | 2001-10-30 | The Regents Of The University Of California | IBD-associated microbial antigens and methods of using same |
| FR2802536B1 (fr) | 1999-11-23 | 2003-06-13 | Chru Lille | Oligomannosides de synthese, leur preparation et leur utilisation a la detection d'anticorps et a la prevention d'infections |
| FR2806739B1 (fr) | 2000-03-27 | 2005-02-18 | Fond Jean Dausset Ceph | Genes impliques dans les maladies inflammatoires de l'intestin et leur utilisation |
| US6838250B2 (en) | 2000-03-31 | 2005-01-04 | Ortho-Clinical Diagnostics, Inc. | Immunoassay for C-reactive protein |
| US7138237B1 (en) | 2000-05-19 | 2006-11-21 | Cedars-Sinai Medical Center | Diagnosis, prevention and treatment of Crohn's disease using the OmpC antigen |
| US20050164929A1 (en) * | 2000-11-06 | 2005-07-28 | Lupine Logic, Inc. | Methods of preventing and treating inflammatory bowel disease |
| AU2002902A (en) | 2000-11-14 | 2002-05-27 | Techlab Inc | Method for differentiating irritable bowel syndrome from inflammatory bowel disease (ibd) and for monitoring persons with ibd using total endogenous lactoferrinas a marker |
| DK2224012T3 (da) | 2001-12-17 | 2013-05-13 | Corixa Corp | Sammensætninger og fremgangsmåder til terapi og diagnose af inflammatoriske tarmsygdomme |
| US20030204507A1 (en) * | 2002-04-25 | 2003-10-30 | Li Jonathan Qiang | Classification of rare events with high reliability |
| ES2306902T3 (es) | 2002-10-25 | 2008-11-16 | Techlab, Inc. | Panel de diagnostico ibd-first chek para la enfermedad inflamatoria del intestino y el sindrome del colon irritable. |
| WO2004048600A2 (en) * | 2002-11-22 | 2004-06-10 | Emory University | Diagnostic tests and methods for diagnosing inflammatory bowel disease |
| US7662569B2 (en) * | 2003-04-11 | 2010-02-16 | Cedars-Sinai Medical Center | Methods of assessing Crohn's disease patient phenotype by I2 serologic response |
| US20070208514A1 (en) * | 2003-04-23 | 2007-09-06 | Hiroshi Yatsuhashi | Method of Preparing Disease Prognosis Model, Disease Prognosis Prediction Method using this Model, Prognosis Prediction Device Based on this Model, and Program for Performing the Device and Storage Medium Wherein Said Program is Stored |
| US20040242972A1 (en) * | 2003-05-28 | 2004-12-02 | General Electric Company | Method, system and computer product for prognosis of a medical disorder |
| WO2005041896A2 (en) | 2003-11-03 | 2005-05-12 | Duke University | Methods of identifying individuals at risk of perioperative bleeding, renal dysfunction or stroke |
| CA2554836A1 (en) * | 2004-02-05 | 2005-08-25 | Medtronic, Inc. | Methods and apparatus for identifying patients at risk for life threatening arrhythmias |
| US20060019410A1 (en) | 2004-07-21 | 2006-01-26 | Qualyst, Inc. | Apparatus, kits and methods for evaluating binding interactions, for detecting and quantifying binding molecules, and for sample preparation |
-
2005
- 2005-12-01 US US11/293,616 patent/US20060154276A1/en active Pending
-
2006
- 2006-11-30 WO PCT/US2006/046136 patent/WO2007064964A2/en not_active Ceased
- 2006-11-30 EP EP06838862A patent/EP1955070B1/en not_active Not-in-force
- 2006-11-30 AT AT06838862T patent/ATE534911T1/de active
- 2006-11-30 CA CA2632972A patent/CA2632972C/en active Active
- 2006-11-30 JP JP2008543520A patent/JP5634023B2/ja not_active Expired - Fee Related
- 2006-11-30 AU AU2006320384A patent/AU2006320384B2/en not_active Ceased
-
2008
- 2008-05-25 IL IL191679A patent/IL191679A/en not_active IP Right Cessation
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