JP2009523010A5 - - Google Patents
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- Publication number
- JP2009523010A5 JP2009523010A5 JP2008538188A JP2008538188A JP2009523010A5 JP 2009523010 A5 JP2009523010 A5 JP 2009523010A5 JP 2008538188 A JP2008538188 A JP 2008538188A JP 2008538188 A JP2008538188 A JP 2008538188A JP 2009523010 A5 JP2009523010 A5 JP 2009523010A5
- Authority
- JP
- Japan
- Prior art keywords
- formulation
- antibody
- motomeko
- seq
- administered
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 238000009472 formulation Methods 0.000 claims 28
- 239000000203 mixture Substances 0.000 claims 28
- 239000004480 active ingredient Substances 0.000 claims 12
- 108010060818 Toll-Like Receptor 9 Proteins 0.000 claims 10
- 102100033117 Toll-like receptor 9 Human genes 0.000 claims 10
- 125000003275 alpha amino acid group Chemical group 0.000 claims 10
- 239000008194 pharmaceutical composition Substances 0.000 claims 10
- 229940044616 toll-like receptor 7 agonist Drugs 0.000 claims 10
- 208000036142 Viral infection Diseases 0.000 claims 8
- 230000003308 immunostimulating effect Effects 0.000 claims 8
- 230000009385 viral infection Effects 0.000 claims 8
- 102000040430 polynucleotide Human genes 0.000 claims 7
- 108091033319 polynucleotide Proteins 0.000 claims 7
- 239000002157 polynucleotide Substances 0.000 claims 7
- 108010047041 Complementarity Determining Regions Proteins 0.000 claims 6
- 101000831496 Homo sapiens Toll-like receptor 3 Proteins 0.000 claims 6
- 102000014150 Interferons Human genes 0.000 claims 6
- 102000045716 human TLR3 Human genes 0.000 claims 6
- 229960002751 imiquimod Drugs 0.000 claims 6
- DOUYETYNHWVLEO-UHFFFAOYSA-N imiquimod Chemical group C1=CC=CC2=C3N(CC(C)C)C=NC3=C(N)N=C21 DOUYETYNHWVLEO-UHFFFAOYSA-N 0.000 claims 6
- 229960001438 immunostimulant agent Drugs 0.000 claims 6
- 239000003022 immunostimulating agent Substances 0.000 claims 6
- 229940079322 interferon Drugs 0.000 claims 6
- 229950010550 resiquimod Drugs 0.000 claims 6
- BXNMTOQRYBFHNZ-UHFFFAOYSA-N resiquimod Chemical compound C1=CC=CC2=C(N(C(COCC)=N3)CC(C)(C)O)C3=C(N)N=C21 BXNMTOQRYBFHNZ-UHFFFAOYSA-N 0.000 claims 6
- 238000011282 treatment Methods 0.000 claims 6
- 108010050904 Interferons Proteins 0.000 claims 5
- 239000000556 agonist Substances 0.000 claims 5
- 208000023275 Autoimmune disease Diseases 0.000 claims 4
- 208000019693 Lung disease Diseases 0.000 claims 4
- 108010060825 Toll-Like Receptor 7 Proteins 0.000 claims 4
- 102100039390 Toll-like receptor 7 Human genes 0.000 claims 4
- 230000005713 exacerbation Effects 0.000 claims 4
- 230000003053 immunization Effects 0.000 claims 4
- 238000002649 immunization Methods 0.000 claims 4
- 230000001404 mediated effect Effects 0.000 claims 4
- 244000052769 pathogen Species 0.000 claims 4
- 230000001717 pathogenic effect Effects 0.000 claims 4
- 208000024891 symptom Diseases 0.000 claims 4
- 208000009329 Graft vs Host Disease Diseases 0.000 claims 3
- 210000004027 cell Anatomy 0.000 claims 3
- 208000024908 graft versus host disease Diseases 0.000 claims 3
- 206010059313 Anogenital warts Diseases 0.000 claims 2
- 208000006545 Chronic Obstructive Pulmonary Disease Diseases 0.000 claims 2
- 208000000907 Condylomata Acuminata Diseases 0.000 claims 2
- 241000725303 Human immunodeficiency virus Species 0.000 claims 2
- 241000701806 Human papillomavirus Species 0.000 claims 2
- 208000022559 Inflammatory bowel disease Diseases 0.000 claims 2
- 206010028980 Neoplasm Diseases 0.000 claims 2
- 206010035737 Pneumonia viral Diseases 0.000 claims 2
- 241000700584 Simplexvirus Species 0.000 claims 2
- 241000700605 Viruses Species 0.000 claims 2
- 208000025009 anogenital human papillomavirus infection Diseases 0.000 claims 2
- 201000004201 anogenital venereal wart Diseases 0.000 claims 2
- 208000006673 asthma Diseases 0.000 claims 2
- 230000001580 bacterial effect Effects 0.000 claims 2
- 206010006451 bronchitis Diseases 0.000 claims 2
- 201000011510 cancer Diseases 0.000 claims 2
- 239000003795 chemical substances by application Substances 0.000 claims 2
- 230000002538 fungal effect Effects 0.000 claims 2
- 208000006454 hepatitis Diseases 0.000 claims 2
- 231100000283 hepatitis Toxicity 0.000 claims 2
- 208000015181 infectious disease Diseases 0.000 claims 2
- 206010025135 lupus erythematosus Diseases 0.000 claims 2
- 238000004519 manufacturing process Methods 0.000 claims 2
- 210000004877 mucosa Anatomy 0.000 claims 2
- 201000006417 multiple sclerosis Diseases 0.000 claims 2
- 239000000825 pharmaceutical preparation Substances 0.000 claims 2
- 238000011321 prophylaxis Methods 0.000 claims 2
- 208000009421 viral pneumonia Diseases 0.000 claims 2
- MZOFCQQQCNRIBI-VMXHOPILSA-N (3s)-4-[[(2s)-1-[[(2s)-1-[[(1s)-1-carboxy-2-hydroxyethyl]amino]-4-methyl-1-oxopentan-2-yl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-3-[[2-[[(2s)-2,6-diaminohexanoyl]amino]acetyl]amino]-4-oxobutanoic acid Chemical compound OC[C@@H](C(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(O)=O)NC(=O)CNC(=O)[C@@H](N)CCCCN MZOFCQQQCNRIBI-VMXHOPILSA-N 0.000 claims 1
- 208000032791 BCR-ABL1 positive chronic myelogenous leukemia Diseases 0.000 claims 1
- 102100021943 C-C motif chemokine 2 Human genes 0.000 claims 1
- 101710155857 C-C motif chemokine 2 Proteins 0.000 claims 1
- 102100032367 C-C motif chemokine 5 Human genes 0.000 claims 1
- 108010055166 Chemokine CCL5 Proteins 0.000 claims 1
- 208000010833 Chronic myeloid leukaemia Diseases 0.000 claims 1
- 206010009900 Colitis ulcerative Diseases 0.000 claims 1
- 208000011231 Crohn disease Diseases 0.000 claims 1
- 102000004127 Cytokines Human genes 0.000 claims 1
- 108090000695 Cytokines Proteins 0.000 claims 1
- 108010054267 Interferon Receptors Proteins 0.000 claims 1
- 108090001007 Interleukin-8 Proteins 0.000 claims 1
- -1 MIP1-α Proteins 0.000 claims 1
- 208000034578 Multiple myelomas Diseases 0.000 claims 1
- 208000033761 Myelogenous Chronic BCR-ABL Positive Leukemia Diseases 0.000 claims 1
- 206010035226 Plasma cell myeloma Diseases 0.000 claims 1
- 206010039491 Sarcoma Diseases 0.000 claims 1
- 102000002689 Toll-like receptor Human genes 0.000 claims 1
- 108020000411 Toll-like receptor Proteins 0.000 claims 1
- 108060008682 Tumor Necrosis Factor Proteins 0.000 claims 1
- 102000000852 Tumor Necrosis Factor-alpha Human genes 0.000 claims 1
- 201000006704 Ulcerative Colitis Diseases 0.000 claims 1
- 239000000427 antigen Substances 0.000 claims 1
- 102000036639 antigens Human genes 0.000 claims 1
- 108091007433 antigens Proteins 0.000 claims 1
- 230000001413 cellular effect Effects 0.000 claims 1
- 238000012258 culturing Methods 0.000 claims 1
- 208000035250 cutaneous malignant susceptibility to 1 melanoma Diseases 0.000 claims 1
- 230000006806 disease prevention Effects 0.000 claims 1
- 201000009277 hairy cell leukemia Diseases 0.000 claims 1
- 210000004408 hybridoma Anatomy 0.000 claims 1
- 230000028993 immune response Effects 0.000 claims 1
- 239000003446 ligand Substances 0.000 claims 1
- 201000001441 melanoma Diseases 0.000 claims 1
- 230000002265 prevention Effects 0.000 claims 1
- 229940044655 toll-like receptor 9 agonist Drugs 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US73079305P | 2005-10-27 | 2005-10-27 | |
| US60/730,793 | 2005-10-27 | ||
| PCT/US2006/060305 WO2007051164A2 (en) | 2005-10-27 | 2006-10-26 | Toll like receptor 3 modulators, methods and uses |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2009523010A JP2009523010A (ja) | 2009-06-18 |
| JP2009523010A5 true JP2009523010A5 (cg-RX-API-DMAC7.html) | 2009-09-17 |
| JP5199878B2 JP5199878B2 (ja) | 2013-05-15 |
Family
ID=37968676
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008538188A Expired - Fee Related JP5199878B2 (ja) | 2005-10-27 | 2006-10-26 | Ｔｏｌｌ様受容体３モジュレーター、方法および用途 |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US7718778B2 (cg-RX-API-DMAC7.html) |
| EP (1) | EP1945820B1 (cg-RX-API-DMAC7.html) |
| JP (1) | JP5199878B2 (cg-RX-API-DMAC7.html) |
| DK (1) | DK1945820T3 (cg-RX-API-DMAC7.html) |
| ES (1) | ES2435775T3 (cg-RX-API-DMAC7.html) |
| WO (1) | WO2007051164A2 (cg-RX-API-DMAC7.html) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20080299138A1 (en) * | 2007-05-25 | 2008-12-04 | Duffy Karen E | Toll-Like Receptor 3 Modulators and Uses Thereof |
| WO2009086352A2 (en) * | 2007-12-26 | 2009-07-09 | Centocor, Inc. | Cynomolgus toll-like receptor 3 |
| EP2138513B1 (en) * | 2008-06-27 | 2011-02-09 | Theranor SPRL | Pharmaceutical compositions of antibodies for diseases caused by viruses |
| WO2010039615A2 (en) * | 2008-10-03 | 2010-04-08 | Centocor Ortho Biotech Inc. | Papio cynocephalus toll-like receptor 3 |
| US20130090457A1 (en) * | 2008-10-31 | 2013-04-11 | Janssen Biotech, Inc. | Toll-Like Receptor 3 Antagonists for the Treatment of Metabolic and Cardiovascular Diseases |
| US8460659B2 (en) | 2008-10-31 | 2013-06-11 | Janssen Biotech, Inc. | Toll-like receptor 3 antagonists for the treatment of metabolic and cardiovascular diseases |
| EA201500316A1 (ru) | 2008-10-31 | 2016-01-29 | Сентокор Орто Байотек Инк. | Антагонисты толл-подобного рецептора 3 |
| US20100137246A1 (en) * | 2008-12-02 | 2010-06-03 | Searete Llc, A Limited Liability Corporation Of The State Of Delaware | Anti-inflammatory compositions and methods |
| US20100136095A1 (en) * | 2008-12-02 | 2010-06-03 | Searete Llc, A Limited Liability Corporation Of The State Of Delaware | Systems for modulating inflammation |
| US20100135983A1 (en) * | 2008-12-02 | 2010-06-03 | Searete Llc, A Limited Liability Corporation Of The State Of Delaware | Anti-inflammatory compositions and methods |
| US20100136094A1 (en) * | 2008-12-02 | 2010-06-03 | Searete Llc, A Limited Liability Corporation Of The State Of Delaware | Systems for modulating inflammation |
| US20100136097A1 (en) * | 2008-12-02 | 2010-06-03 | Searete Llc, A Limited Liability Corporation Of The State Of Delaware | Systems for modulating inflammation |
| US20100137843A1 (en) * | 2008-12-02 | 2010-06-03 | Searete Llc, A Limited Liability Corporation Of The State Of Delaware | Delivery devices for modulating inflammation |
| US20100136096A1 (en) * | 2008-12-02 | 2010-06-03 | Searete Llc, A Limited Liability Corporation Of The State Of Delaware | Systems for modulating inflammation |
| SG175396A1 (en) * | 2009-04-29 | 2011-12-29 | Centocor Ortho Biotech Inc | Toll-like receptor 3 antagonists |
| RU2562865C2 (ru) * | 2009-07-10 | 2015-09-10 | Иннэйт Фарма | Tlr3 связывающие агенты |
| BR112012007137A2 (pt) | 2009-09-30 | 2015-09-15 | Harvard College | metodos para modulacao da autofagia por meio da modulacao de produtos genicos inibidores da autofagia |
| WO2012095432A2 (en) | 2011-01-12 | 2012-07-19 | Innate Pharma | Tlr3 binding agents |
| WO2013178736A1 (en) | 2012-05-31 | 2013-12-05 | Innate Pharma | Tlr3 binding agents |
| JP6366195B2 (ja) * | 2013-04-22 | 2018-08-01 | 国立大学法人 東京大学 | 炎症性疾患の予防又は治療剤 |
| CA3084667A1 (en) * | 2017-12-15 | 2019-06-20 | Silverback Therapeutics, Inc. | Antibody construct-drug conjugate for the treatment of hepatitis |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4816567A (en) | 1983-04-08 | 1989-03-28 | Genentech, Inc. | Recombinant immunoglobin preparations |
| US5225539A (en) * | 1986-03-27 | 1993-07-06 | Medical Research Council | Recombinant altered antibodies and methods of making altered antibodies |
| PT1798288E (pt) | 1997-05-07 | 2009-12-23 | Schering Corp | Proteínas receptoras humanas semelhantes a toll, reagentes e métodos relacionados |
| US20030032090A1 (en) * | 1997-05-07 | 2003-02-13 | Schering Corporation, A New Jersey Corporation | Human receptor proteins; related reagents and methods |
| PT1650219E (pt) * | 1997-10-17 | 2008-03-31 | Genentech Inc | Homólogos de toll humana |
| PT1158989E (pt) | 1999-03-09 | 2007-10-01 | Hans-Dieter Volk | Terapia e utilização de agentes na terapia da caquexia e sintomas debilitantes devido a doenças para além da falha cardíaca congestiva |
| GB9930616D0 (en) | 1999-12-24 | 2000-02-16 | Mathilda & Terence Kennedy Ins | Activation and inhibition of the immune system |
| EA200400407A1 (ru) * | 2001-09-07 | 2004-08-26 | Дзе Трастиз Оф Бостон Юниверсити | Способ и композиция для лечения расстройств, связанных с иммунными комплексами |
| CN1633598A (zh) | 2001-10-05 | 2005-06-29 | 科勒制药股份公司 | Toll样受体3信号传导的激动剂和拮抗剂 |
| WO2003084527A1 (en) | 2002-04-08 | 2003-10-16 | Takeda Chemical Industries, Ltd. | Severe sepsis preventive therapeutic agent |
| CN1671412B (zh) * | 2002-08-15 | 2010-05-26 | 3M创新有限公司 | 免疫刺激组合物及刺激免疫反应的方法 |
| US20050158799A1 (en) * | 2003-10-17 | 2005-07-21 | Fitzgerald Katherine A. | TRIF-related adaptor molecule (TRAM) and uses thereof |
| TWI487535B (zh) * | 2004-11-30 | 2015-06-11 | Centocor Inc | 類鐸受體３（ｔｏｌｌ ｌｉｋｅ ｒｅｃｅｐｔｏｒ３）拮抗劑，方法及用途 |
-
2006
- 2006-10-26 EP EP06846174.8A patent/EP1945820B1/en not_active Not-in-force
- 2006-10-26 JP JP2008538188A patent/JP5199878B2/ja not_active Expired - Fee Related
- 2006-10-26 ES ES06846174T patent/ES2435775T3/es active Active
- 2006-10-26 WO PCT/US2006/060305 patent/WO2007051164A2/en not_active Ceased
- 2006-10-26 DK DK06846174.8T patent/DK1945820T3/da active
- 2006-10-27 US US11/553,633 patent/US7718778B2/en not_active Expired - Fee Related
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