JP2009520018A5 - - Google Patents
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- Publication number
- JP2009520018A5 JP2009520018A5 JP2008546664A JP2008546664A JP2009520018A5 JP 2009520018 A5 JP2009520018 A5 JP 2009520018A5 JP 2008546664 A JP2008546664 A JP 2008546664A JP 2008546664 A JP2008546664 A JP 2008546664A JP 2009520018 A5 JP2009520018 A5 JP 2009520018A5
- Authority
- JP
- Japan
- Prior art keywords
- phenyl
- pharmaceutically acceptable
- group
- acceptable salt
- ylmethoxy
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- 150000003839 salts Chemical class 0.000 claims 12
- 150000001875 compounds Chemical class 0.000 claims 11
- 125000000217 alkyl group Chemical group 0.000 claims 9
- 125000003545 alkoxy group Chemical group 0.000 claims 8
- 125000005843 halogen group Chemical group 0.000 claims 7
- -1 Thieno [3,2-b] pyridin-7-yl Chemical group 0.000 claims 5
- 125000001072 heteroaryl group Chemical group 0.000 claims 5
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 4
- 125000003386 piperidinyl group Chemical group 0.000 claims 3
- 125000006163 5-membered heteroaryl group Chemical group 0.000 claims 2
- 239000008194 pharmaceutical composition Substances 0.000 claims 2
- 125000001424 substituent group Chemical group 0.000 claims 2
- XMDNOCKUPOOZAJ-ROUUACIJSA-N (3s,4r)-3-[(2-ethoxyphenoxy)methyl]-4-phenylpiperidine Chemical compound CCOC1=CC=CC=C1OC[C@H]1[C@H](C=2C=CC=CC=2)CCNC1 XMDNOCKUPOOZAJ-ROUUACIJSA-N 0.000 claims 1
- DRWNAPKSPOSKPW-HOTGVXAUSA-N (3s,4r)-3-[(2-fluoro-6-methoxyphenoxy)methyl]-4-phenylpiperidine Chemical compound COC1=CC=CC(F)=C1OC[C@H]1[C@H](C=2C=CC=CC=2)CCNC1 DRWNAPKSPOSKPW-HOTGVXAUSA-N 0.000 claims 1
- YWOJKSUKPYWJEY-ROUUACIJSA-N 2-(2-methoxyethoxy)-3-[[(3s,4r)-4-phenylpiperidin-3-yl]methoxy]pyridine Chemical compound COCCOC1=NC=CC=C1OC[C@H]1[C@H](C=2C=CC=CC=2)CCNC1 YWOJKSUKPYWJEY-ROUUACIJSA-N 0.000 claims 1
- JJQVDFJTHMUDDZ-OALUTQOASA-N 2-(2-methylpropoxy)-3-[[(3s,4r)-4-phenylpiperidin-3-yl]methoxy]pyridine Chemical compound CC(C)COC1=NC=CC=C1OC[C@H]1[C@H](C=2C=CC=CC=2)CCNC1 JJQVDFJTHMUDDZ-OALUTQOASA-N 0.000 claims 1
- QIUXLMMTHYOEDZ-OALUTQOASA-N 2-(3-methoxypropoxy)-3-[[(3s,4r)-4-phenylpiperidin-3-yl]methoxy]pyridine Chemical compound COCCCOC1=NC=CC=C1OC[C@H]1[C@H](C=2C=CC=CC=2)CCNC1 QIUXLMMTHYOEDZ-OALUTQOASA-N 0.000 claims 1
- AEYFXFJOVJFLQV-ROUUACIJSA-N 2-[[(3s,4r)-4-phenylpiperidin-3-yl]methoxy]benzonitrile Chemical compound N#CC1=CC=CC=C1OC[C@H]1[C@H](C=2C=CC=CC=2)CCNC1 AEYFXFJOVJFLQV-ROUUACIJSA-N 0.000 claims 1
- LGRIMIMTDDSXQB-IRXDYDNUSA-N 2-ethoxy-3-[[(3s,4r)-4-phenylpiperidin-3-yl]methoxy]pyridine Chemical compound CCOC1=NC=CC=C1OC[C@H]1[C@H](C=2C=CC=CC=2)CCNC1 LGRIMIMTDDSXQB-IRXDYDNUSA-N 0.000 claims 1
- MRKFZMRKZNXLLQ-HOTGVXAUSA-N 2-methoxy-3-[[(3s,4r)-4-phenylpiperidin-3-yl]methoxy]pyridine Chemical compound COC1=NC=CC=C1OC[C@H]1[C@H](C=2C=CC=CC=2)CCNC1 MRKFZMRKZNXLLQ-HOTGVXAUSA-N 0.000 claims 1
- IXJZRDAIOAFSIM-ROUUACIJSA-N 3-[[(3s,4r)-4-phenylpiperidin-3-yl]methoxy]-2-propan-2-yloxypyridine Chemical compound CC(C)OC1=NC=CC=C1OC[C@H]1[C@H](C=2C=CC=CC=2)CCNC1 IXJZRDAIOAFSIM-ROUUACIJSA-N 0.000 claims 1
- LUGSFHKXNHDBCP-ROUUACIJSA-N 3-[[(3s,4r)-4-phenylpiperidin-3-yl]methoxy]-2-propoxypyridine Chemical compound CCCOC1=NC=CC=C1OC[C@H]1[C@H](C=2C=CC=CC=2)CCNC1 LUGSFHKXNHDBCP-ROUUACIJSA-N 0.000 claims 1
- QSBVUUDMEPRSCF-HOTGVXAUSA-N 7-[[(3s,4r)-4-phenylpiperidin-3-yl]methoxy]thieno[3,2-b]pyridine Chemical compound C1([C@@H]2CCNC[C@H]2COC=2C=3SC=CC=3N=CC=2)=CC=CC=C1 QSBVUUDMEPRSCF-HOTGVXAUSA-N 0.000 claims 1
- 208000006096 Attention Deficit Disorder with Hyperactivity Diseases 0.000 claims 1
- 208000036864 Attention deficit/hyperactivity disease Diseases 0.000 claims 1
- 208000020401 Depressive disease Diseases 0.000 claims 1
- 208000001640 Fibromyalgia Diseases 0.000 claims 1
- 208000011688 Generalised anxiety disease Diseases 0.000 claims 1
- 241000124008 Mammalia Species 0.000 claims 1
- 125000002947 alkylene group Chemical group 0.000 claims 1
- 208000015802 attention deficit-hyperactivity disease Diseases 0.000 claims 1
- 125000000753 cycloalkyl group Chemical group 0.000 claims 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 1
- 208000035475 disorder Diseases 0.000 claims 1
- 208000029364 generalized anxiety disease Diseases 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- JUJWROOIHBZHMG-UHFFFAOYSA-N pyridine Substances C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 claims 1
- 201000000980 schizophrenia Diseases 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US75184505P | 2005-12-20 | 2005-12-20 | |
| PCT/IB2006/003639 WO2007072150A2 (en) | 2005-12-20 | 2006-12-16 | Piperidine derivatives |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2009520018A JP2009520018A (ja) | 2009-05-21 |
| JP2009520018A5 true JP2009520018A5 (enExample) | 2009-12-03 |
Family
ID=38015373
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008546664A Withdrawn JP2009520018A (ja) | 2005-12-20 | 2006-12-16 | ピペリジン誘導体 |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US20070142389A1 (enExample) |
| EP (1) | EP1966137A2 (enExample) |
| JP (1) | JP2009520018A (enExample) |
| AR (1) | AR058110A1 (enExample) |
| CA (1) | CA2634172A1 (enExample) |
| DO (1) | DOP2006000287A (enExample) |
| GT (1) | GT200600516A (enExample) |
| NL (2) | NL2000376C2 (enExample) |
| PE (1) | PE20071005A1 (enExample) |
| TW (1) | TW200732304A (enExample) |
| UY (1) | UY30029A1 (enExample) |
| WO (1) | WO2007072150A2 (enExample) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2010059390A1 (en) | 2008-10-30 | 2010-05-27 | Janssen Pharmaceutica Nv | Modulators of serotonin receptor |
| US8642583B2 (en) | 2008-10-30 | 2014-02-04 | Janssen Pharmaceutica Nv | Serotonin receptor modulators |
| DK2358676T3 (da) | 2008-11-14 | 2013-01-14 | Theravance Inc | Krystallinsk form af en 4-[2-(2-fluorphenoxymethyl)phenyl]-piperidinforbindelse |
| JP5705239B2 (ja) | 2010-01-11 | 2015-04-22 | セラヴァンス バイオファーマ アール＆ディー アイピー， エルエルシー | セロトニンおよびノルエピネフリン再取込みインヒビターとしての１−（２−フェノキシメチルフェニル）ピペラジン化合物 |
| TW201334783A (zh) * | 2012-01-31 | 2013-09-01 | Eisai R&D Man Co Ltd | 帕羅西汀（Ｐａｒｏｘｅｔｉｎｅ）衍生物 |
| EP3344248B1 (en) * | 2015-09-02 | 2022-03-23 | Trevena, Inc. | 6-membered aza-heterocyclic containing delta-opioid receptor modulating compounds, methods of using and making the same |
| CA3052480A1 (en) | 2017-02-17 | 2018-08-23 | Trevena, Inc. | 5-membered aza-heterocyclic containing delta-opioid receptor modulating compounds, methods of using and making the same |
| CN110446495B (zh) | 2017-02-17 | 2023-09-05 | 特维娜有限公司 | 含有7元氮杂杂环的δ阿片受体调节化合物及其使用和制备方法 |
| CN111533682B (zh) * | 2020-05-29 | 2022-03-01 | 清华大学 | 帕罗西汀及其类似物的制备方法 |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1422263A (en) * | 1973-01-30 | 1976-01-21 | Ferrosan As | 4-phenyl-piperidine compounds |
| IE45511B1 (en) * | 1976-09-01 | 1982-09-08 | Ciba Geigy Ag | New derivatives of perhydro-aza-heterocycles and processesfor the production thereof |
| US4585777A (en) * | 1984-02-07 | 1986-04-29 | A/S Ferrosan | (-)-Trans-4-(4-fluorophenyl)-3-(4-methoxyphenoxy)methylpiperidine for potentiating 5-HT |
| EP0190496A3 (en) * | 1984-12-13 | 1987-05-27 | Beecham Group Plc | Piperidine derivatives having a gastro-intestinal activity |
| US5227379A (en) * | 1986-11-03 | 1993-07-13 | Novo Nordisk A/S | Piperidine compounds and their preparation and use |
| US5017585A (en) * | 1986-11-03 | 1991-05-21 | Novo Nordisk A/S | Method of treating calcium overload |
| IE66332B1 (en) * | 1986-11-03 | 1995-12-27 | Novo Nordisk As | Piperidine compounds and their preparation and use |
| DK231088D0 (da) * | 1988-04-28 | 1988-04-28 | Ferrosan As | Piperidinforbindelser, deres fremstilling og anvendelse |
| IL98757A (en) * | 1990-07-18 | 1997-01-10 | Novo Nordisk As | Piperidine derivatives their preparation and pharmaceutical compositions containing them |
| US5808139A (en) * | 1992-04-21 | 1998-09-15 | Ligand Pharmaceuticals Incorporated | Non-steroid progesterone receptor agonist and antagonist and compounds and methods |
| US5914328A (en) * | 1992-10-09 | 1999-06-22 | Abbott Laboratories | Heterocyclic ether compounds useful in controlling neurotransmitter release |
| IL123293A (en) * | 1995-09-07 | 2003-06-24 | Hoffmann La Roche | Piperidine derivatives, their preparation and pharmaceutical compositions containing them |
| US20020151712A1 (en) * | 1999-09-14 | 2002-10-17 | Nan-Horng Lin | 3-pyrrolidinyloxy-3'-pyridyl ether compounds useful for controlling chemical synaptic transmission |
| AU1018801A (en) * | 1999-10-29 | 2001-05-14 | Novo Nordisk A/S | Use of 3,4-substituted piperidines |
| US20040087795A1 (en) * | 2000-07-17 | 2004-05-06 | Borrett Gary Thomas | Novel processes for the preparation of 4-phenylpiperidine derivatives |
| US20040235906A1 (en) * | 2001-08-08 | 2004-11-25 | Gouliaev Alex Haahr | Substituted amine derivatives and their use as monoamine neurotransmitter re-up-take inhibitors |
-
2006
- 2006-12-14 US US11/610,696 patent/US20070142389A1/en not_active Abandoned
- 2006-12-15 NL NL2000376A patent/NL2000376C2/nl not_active IP Right Cessation
- 2006-12-16 CA CA002634172A patent/CA2634172A1/en not_active Abandoned
- 2006-12-16 JP JP2008546664A patent/JP2009520018A/ja not_active Withdrawn
- 2006-12-16 EP EP06831727A patent/EP1966137A2/en not_active Withdrawn
- 2006-12-16 WO PCT/IB2006/003639 patent/WO2007072150A2/en not_active Ceased
- 2006-12-18 PE PE2006001623A patent/PE20071005A1/es not_active Application Discontinuation
- 2006-12-18 AR ARP060105599A patent/AR058110A1/es unknown
- 2006-12-18 DO DO2006000287A patent/DOP2006000287A/es unknown
- 2006-12-19 GT GT200600516A patent/GT200600516A/es unknown
- 2006-12-19 TW TW095147655A patent/TW200732304A/zh unknown
- 2006-12-19 UY UY30029A patent/UY30029A1/es not_active Application Discontinuation
-
2007
- 2007-10-15 NL NL2000937A patent/NL2000937C2/nl not_active IP Right Cessation