JP2009519467A5 - - Google Patents
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- JP2009519467A5 JP2009519467A5 JP2008545656A JP2008545656A JP2009519467A5 JP 2009519467 A5 JP2009519467 A5 JP 2009519467A5 JP 2008545656 A JP2008545656 A JP 2008545656A JP 2008545656 A JP2008545656 A JP 2008545656A JP 2009519467 A5 JP2009519467 A5 JP 2009519467A5
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- Prior art keywords
- patient
- anesthetic
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- 150000001875 compounds Chemical class 0.000 claims 20
- 230000003444 anaesthetic effect Effects 0.000 claims 17
- 238000000034 method Methods 0.000 claims 14
- 239000003814 drug Substances 0.000 claims 13
- 229940124597 therapeutic agent Drugs 0.000 claims 13
- 238000005516 engineering process Methods 0.000 claims 11
- 239000003550 marker Substances 0.000 claims 9
- 206010002091 Anaesthesia Diseases 0.000 claims 5
- 230000037005 anaesthesia Effects 0.000 claims 5
- 239000007789 gas Substances 0.000 claims 5
- 238000001990 intravenous administration Methods 0.000 claims 5
- 238000012544 monitoring process Methods 0.000 claims 5
- 230000029058 respiratory gaseous exchange Effects 0.000 claims 5
- XTWYTFMLZFPYCI-KQYNXXCUSA-N 5'-adenylphosphoric acid Chemical compound C1=NC=2C(N)=NC=NC=2N1[C@@H]1O[C@H](COP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]1O XTWYTFMLZFPYCI-KQYNXXCUSA-N 0.000 claims 4
- ZKHQWZAMYRWXGA-KQYNXXCUSA-J ATP(4-) Chemical compound C1=NC=2C(N)=NC=NC=2N1[C@@H]1O[C@H](COP([O-])(=O)OP([O-])(=O)OP([O-])([O-])=O)[C@@H](O)[C@H]1O ZKHQWZAMYRWXGA-KQYNXXCUSA-J 0.000 claims 4
- XTWYTFMLZFPYCI-UHFFFAOYSA-N Adenosine diphosphate Natural products C1=NC=2C(N)=NC=NC=2N1C1OC(COP(O)(=O)OP(O)(O)=O)C(O)C1O XTWYTFMLZFPYCI-UHFFFAOYSA-N 0.000 claims 4
- ZKHQWZAMYRWXGA-UHFFFAOYSA-N Adenosine triphosphate Natural products C1=NC=2C(N)=NC=NC=2N1C1OC(COP(O)(=O)OP(O)(=O)OP(O)(O)=O)C(O)C1O ZKHQWZAMYRWXGA-UHFFFAOYSA-N 0.000 claims 4
- QGZKDVFQNNGYKY-UHFFFAOYSA-N Ammonia Chemical compound N QGZKDVFQNNGYKY-UHFFFAOYSA-N 0.000 claims 4
- BPYKTIZUTYGOLE-IFADSCNNSA-N Bilirubin Chemical compound N1C(=O)C(C)=C(C=C)\C1=C\C1=C(C)C(CCC(O)=O)=C(CC2=C(C(C)=C(\C=C/3C(=C(C=C)C(=O)N\3)C)N2)CCC(O)=O)N1 BPYKTIZUTYGOLE-IFADSCNNSA-N 0.000 claims 4
- IAZDPXIOMUYVGZ-UHFFFAOYSA-N Dimethylsulphoxide Chemical compound CS(C)=O IAZDPXIOMUYVGZ-UHFFFAOYSA-N 0.000 claims 4
- XSQUKJJJFZCRTK-UHFFFAOYSA-N Urea Chemical compound NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 claims 4
- OIRDTQYFTABQOQ-KQYNXXCUSA-N adenosine Chemical compound C1=NC=2C(N)=NC=NC=2N1[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1O OIRDTQYFTABQOQ-KQYNXXCUSA-N 0.000 claims 4
- HUMNYLRZRPPJDN-UHFFFAOYSA-N benzaldehyde Chemical compound O=CC1=CC=CC=C1 HUMNYLRZRPPJDN-UHFFFAOYSA-N 0.000 claims 4
- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 claims 4
- 239000003983 inhalation anesthetic agent Substances 0.000 claims 4
- JVTAAEKCZFNVCJ-UHFFFAOYSA-N lactic acid Chemical compound CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 claims 4
- 239000000126 substance Substances 0.000 claims 4
- OBHRVMZSZIDDEK-UHFFFAOYSA-N urobilinogen Chemical compound CCC1=C(C)C(=O)NC1CC1=C(C)C(CCC(O)=O)=C(CC2=C(C(C)=C(CC3C(=C(CC)C(=O)N3)C)N2)CCC(O)=O)N1 OBHRVMZSZIDDEK-UHFFFAOYSA-N 0.000 claims 4
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 claims 3
- 239000008103 glucose Substances 0.000 claims 3
- GRWFGVWFFZKLTI-IUCAKERBSA-N (-)-α-pinene Chemical compound CC1=CC[C@@H]2C(C)(C)[C@H]1C2 GRWFGVWFFZKLTI-IUCAKERBSA-N 0.000 claims 2
- XOHUEYCVLUUEJJ-UHFFFAOYSA-N 2,3-Bisphosphoglyceric acid Chemical compound OP(=O)(O)OC(C(=O)O)COP(O)(O)=O XOHUEYCVLUUEJJ-UHFFFAOYSA-N 0.000 claims 2
- QQEILXDLZRLTME-UHFFFAOYSA-N 6-sulfatoxymelatonin Chemical compound C1=C(OS(O)(=O)=O)C(OC)=CC2=C1NC=C2CCNC(C)=O QQEILXDLZRLTME-UHFFFAOYSA-N 0.000 claims 2
- KWOLFJPFCHCOCG-UHFFFAOYSA-N Acetophenone Chemical compound CC(=O)C1=CC=CC=C1 KWOLFJPFCHCOCG-UHFFFAOYSA-N 0.000 claims 2
- 239000002126 C01EB10 - Adenosine Substances 0.000 claims 2
- 102000004127 Cytokines Human genes 0.000 claims 2
- 108090000695 Cytokines Proteins 0.000 claims 2
- NOOLISFMXDJSKH-UHFFFAOYSA-N DL-menthol Natural products CC(C)C1CCC(C)CC1O NOOLISFMXDJSKH-UHFFFAOYSA-N 0.000 claims 2
- 101001046870 Homo sapiens Hypoxia-inducible factor 1-alpha Proteins 0.000 claims 2
- 102100022875 Hypoxia-inducible factor 1-alpha Human genes 0.000 claims 2
- 102000002177 Hypoxia-inducible factor-1 alpha Human genes 0.000 claims 2
- 108050009527 Hypoxia-inducible factor-1 alpha Proteins 0.000 claims 2
- 102000015696 Interleukins Human genes 0.000 claims 2
- 108010063738 Interleukins Proteins 0.000 claims 2
- JVTAAEKCZFNVCJ-UHFFFAOYSA-M Lactate Chemical compound CC(O)C([O-])=O JVTAAEKCZFNVCJ-UHFFFAOYSA-M 0.000 claims 2
- YJPIGAIKUZMOQA-UHFFFAOYSA-N Melatonin Natural products COC1=CC=C2N(C(C)=O)C=C(CCN)C2=C1 YJPIGAIKUZMOQA-UHFFFAOYSA-N 0.000 claims 2
- 108091034117 Oligonucleotide Proteins 0.000 claims 2
- LEHOTFFKMJEONL-UHFFFAOYSA-N Uric Acid Chemical compound N1C(=O)NC(=O)C2=C1NC(=O)N2 LEHOTFFKMJEONL-UHFFFAOYSA-N 0.000 claims 2
- TVWHNULVHGKJHS-UHFFFAOYSA-N Uric acid Natural products N1C(=O)NC(=O)C2NC(=O)NC21 TVWHNULVHGKJHS-UHFFFAOYSA-N 0.000 claims 2
- 229960005305 adenosine Drugs 0.000 claims 2
- UDMBCSSLTHHNCD-KQYNXXCUSA-N adenosine 5'-monophosphate Chemical compound C1=NC=2C(N)=NC=NC=2N1[C@@H]1O[C@H](COP(O)(O)=O)[C@@H](O)[C@H]1O UDMBCSSLTHHNCD-KQYNXXCUSA-N 0.000 claims 2
- 229910021529 ammonia Inorganic materials 0.000 claims 2
- 239000003994 anesthetic gas Substances 0.000 claims 2
- JSLCOZYBKYHZNL-UHFFFAOYSA-N butylisobutyrate Chemical compound CCCCOC(=O)C(C)C JSLCOZYBKYHZNL-UHFFFAOYSA-N 0.000 claims 2
- CRPUJAZIXJMDBK-UHFFFAOYSA-N camphene Chemical compound C1CC2C(=C)C(C)(C)C1C2 CRPUJAZIXJMDBK-UHFFFAOYSA-N 0.000 claims 2
- 239000004202 carbamide Substances 0.000 claims 2
- 235000012000 cholesterol Nutrition 0.000 claims 2
- NEHNMFOYXAPHSD-UHFFFAOYSA-N citronellal Chemical compound O=CCC(C)CCC=C(C)C NEHNMFOYXAPHSD-UHFFFAOYSA-N 0.000 claims 2
- 239000003792 electrolyte Substances 0.000 claims 2
- RRAFCDWBNXTKKO-UHFFFAOYSA-N eugenol Chemical compound COC1=CC(CC=C)=CC=C1O RRAFCDWBNXTKKO-UHFFFAOYSA-N 0.000 claims 2
- 229920001109 fluorescent polymer Polymers 0.000 claims 2
- 229940088597 hormone Drugs 0.000 claims 2
- 239000005556 hormone Substances 0.000 claims 2
- NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 claims 2
- 150000002576 ketones Chemical class 0.000 claims 2
- 239000004310 lactic acid Substances 0.000 claims 2
- 235000014655 lactic acid Nutrition 0.000 claims 2
- 150000002617 leukotrienes Chemical class 0.000 claims 2
- 229960003987 melatonin Drugs 0.000 claims 2
- DRLFMBDRBRZALE-UHFFFAOYSA-N melatonin Chemical compound COC1=CC=C2NC=C(CCNC(C)=O)C2=C1 DRLFMBDRBRZALE-UHFFFAOYSA-N 0.000 claims 2
- 230000001114 myogenic effect Effects 0.000 claims 2
- 102000004169 proteins and genes Human genes 0.000 claims 2
- 108090000623 proteins and genes Proteins 0.000 claims 2
- 229940116269 uric acid Drugs 0.000 claims 2
- NOOLISFMXDJSKH-UTLUCORTSA-N (+)-Neomenthol Chemical compound CC(C)[C@@H]1CC[C@@H](C)C[C@@H]1O NOOLISFMXDJSKH-UTLUCORTSA-N 0.000 claims 1
- DSSYKIVIOFKYAU-XCBNKYQSSA-N (R)-camphor Chemical compound C1C[C@@]2(C)C(=O)C[C@@H]1C2(C)C DSSYKIVIOFKYAU-XCBNKYQSSA-N 0.000 claims 1
- WEEGYLXZBRQIMU-UHFFFAOYSA-N 1,8-cineole Natural products C1CC2CCC1(C)OC2(C)C WEEGYLXZBRQIMU-UHFFFAOYSA-N 0.000 claims 1
- KPPNOMMXCHIJKC-BJILWQEISA-N 1-methoxy-4-prop-1-enylbenzene 1-methoxy-4-[(E)-prop-1-enyl]benzene Chemical compound COC1=CC=C(C=CC)C=C1.COC1=CC=C(\C=C\C)C=C1 KPPNOMMXCHIJKC-BJILWQEISA-N 0.000 claims 1
- XOHUEYCVLUUEJJ-UHFFFAOYSA-I 2,3-Diphosphoglycerate Chemical compound [O-]P(=O)([O-])OC(C(=O)[O-])COP([O-])([O-])=O XOHUEYCVLUUEJJ-UHFFFAOYSA-I 0.000 claims 1
- QTWJRLJHJPIABL-UHFFFAOYSA-N 2-methylphenol;3-methylphenol;4-methylphenol Chemical compound CC1=CC=C(O)C=C1.CC1=CC=CC(O)=C1.CC1=CC=CC=C1O QTWJRLJHJPIABL-UHFFFAOYSA-N 0.000 claims 1
- LSFCNJZMBBDBJT-UHFFFAOYSA-N 3-phenylprop-2-enal Chemical compound O=CC=CC1=CC=CC=C1.O=CC=CC1=CC=CC=C1 LSFCNJZMBBDBJT-UHFFFAOYSA-N 0.000 claims 1
- 240000002234 Allium sativum Species 0.000 claims 1
- 244000099147 Ananas comosus Species 0.000 claims 1
- 235000007119 Ananas comosus Nutrition 0.000 claims 1
- 206010002383 Angina Pectoris Diseases 0.000 claims 1
- 208000019901 Anxiety disease Diseases 0.000 claims 1
- 108091023037 Aptamer Proteins 0.000 claims 1
- NPBVQXIMTZKSBA-UHFFFAOYSA-N Chavibetol Natural products COC1=CC=C(CC=C)C=C1O NPBVQXIMTZKSBA-UHFFFAOYSA-N 0.000 claims 1
- 241000723346 Cinnamomum camphora Species 0.000 claims 1
- WTEVQBCEXWBHNA-UHFFFAOYSA-N Citral Natural products CC(C)=CCCC(C)=CC=O WTEVQBCEXWBHNA-UHFFFAOYSA-N 0.000 claims 1
- UDMBCSSLTHHNCD-UHFFFAOYSA-N Coenzym Q(11) Natural products C1=NC=2C(N)=NC=NC=2N1C1OC(COP(O)(O)=O)C(O)C1O UDMBCSSLTHHNCD-UHFFFAOYSA-N 0.000 claims 1
- 206010009900 Colitis ulcerative Diseases 0.000 claims 1
- 208000011231 Crohn disease Diseases 0.000 claims 1
- XDTMQSROBMDMFD-UHFFFAOYSA-N Cyclohexane Chemical compound C1CCCCC1 XDTMQSROBMDMFD-UHFFFAOYSA-N 0.000 claims 1
- RBNPOMFGQQGHHO-UWTATZPHSA-N D-glyceric acid Chemical compound OC[C@@H](O)C(O)=O RBNPOMFGQQGHHO-UWTATZPHSA-N 0.000 claims 1
- WEEGYLXZBRQIMU-WAAGHKOSSA-N Eucalyptol Chemical compound C1C[C@H]2CC[C@]1(C)OC2(C)C WEEGYLXZBRQIMU-WAAGHKOSSA-N 0.000 claims 1
- 239000005770 Eugenol Substances 0.000 claims 1
- 238000004566 IR spectroscopy Methods 0.000 claims 1
- 206010061218 Inflammation Diseases 0.000 claims 1
- 102000004877 Insulin Human genes 0.000 claims 1
- 108090001061 Insulin Proteins 0.000 claims 1
- 229910002651 NO3 Inorganic materials 0.000 claims 1
- 206010028980 Neoplasm Diseases 0.000 claims 1
- NHNBFGGVMKEFGY-UHFFFAOYSA-N Nitrate Chemical compound [O-][N+]([O-])=O NHNBFGGVMKEFGY-UHFFFAOYSA-N 0.000 claims 1
- ZYEMGPIYFIJGTP-UHFFFAOYSA-N O-methyleugenol Chemical compound COC1=CC=C(CC=C)C=C1OC ZYEMGPIYFIJGTP-UHFFFAOYSA-N 0.000 claims 1
- 208000018262 Peripheral vascular disease Diseases 0.000 claims 1
- 240000004760 Pimpinella anisum Species 0.000 claims 1
- PXRCIOIWVGAZEP-UHFFFAOYSA-N Primaeres Camphenhydrat Natural products C1CC2C(O)(C)C(C)(C)C1C2 PXRCIOIWVGAZEP-UHFFFAOYSA-N 0.000 claims 1
- UVMRYBDEERADNV-UHFFFAOYSA-N Pseudoeugenol Natural products COC1=CC(C(C)=C)=CC=C1O UVMRYBDEERADNV-UHFFFAOYSA-N 0.000 claims 1
- 201000006704 Ulcerative Colitis Diseases 0.000 claims 1
- 206010047115 Vasculitis Diseases 0.000 claims 1
- IKHGUXGNUITLKF-XPULMUKRSA-N acetaldehyde Chemical compound [14CH]([14CH3])=O IKHGUXGNUITLKF-XPULMUKRSA-N 0.000 claims 1
- LNQVTSROQXJCDD-UHFFFAOYSA-N adenosine monophosphate Natural products C1=NC=2C(N)=NC=NC=2N1C1OC(CO)C(OP(O)(O)=O)C1O LNQVTSROQXJCDD-UHFFFAOYSA-N 0.000 claims 1
- XCPQUQHBVVXMRQ-UHFFFAOYSA-N alpha-Fenchene Natural products C1CC2C(=C)CC1C2(C)C XCPQUQHBVVXMRQ-UHFFFAOYSA-N 0.000 claims 1
- MVNCAPSFBDBCGF-UHFFFAOYSA-N alpha-pinene Natural products CC1=CCC23C1CC2C3(C)C MVNCAPSFBDBCGF-UHFFFAOYSA-N 0.000 claims 1
- 230000000202 analgesic effect Effects 0.000 claims 1
- 230000036506 anxiety Effects 0.000 claims 1
- 238000003491 array Methods 0.000 claims 1
- 239000001518 benzyl (E)-3-phenylprop-2-enoate Substances 0.000 claims 1
- NGHOLYJTSCBCGC-QXMHVHEDSA-N benzyl cinnamate Chemical compound C=1C=CC=CC=1\C=C/C(=O)OCC1=CC=CC=C1 NGHOLYJTSCBCGC-QXMHVHEDSA-N 0.000 claims 1
- WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 claims 1
- 229930006739 camphene Natural products 0.000 claims 1
- ZYPYEBYNXWUCEA-UHFFFAOYSA-N camphenilone Natural products C1CC2C(=O)C(C)(C)C1C2 ZYPYEBYNXWUCEA-UHFFFAOYSA-N 0.000 claims 1
- 229930008380 camphor Natural products 0.000 claims 1
- 229960000846 camphor Drugs 0.000 claims 1
- 201000011510 cancer Diseases 0.000 claims 1
- 229960005233 cineole Drugs 0.000 claims 1
- NGHOLYJTSCBCGC-UHFFFAOYSA-N cis-cinnamic acid benzyl ester Natural products C=1C=CC=CC=1C=CC(=O)OCC1=CC=CC=C1 NGHOLYJTSCBCGC-UHFFFAOYSA-N 0.000 claims 1
- 229940043350 citral Drugs 0.000 claims 1
- 229930003633 citronellal Natural products 0.000 claims 1
- 235000000983 citronellal Nutrition 0.000 claims 1
- 229920001940 conductive polymer Polymers 0.000 claims 1
- 208000029078 coronary artery disease Diseases 0.000 claims 1
- 229930003836 cresol Natural products 0.000 claims 1
- 238000001514 detection method Methods 0.000 claims 1
- 238000012377 drug delivery Methods 0.000 claims 1
- 206010015037 epilepsy Diseases 0.000 claims 1
- 229960002217 eugenol Drugs 0.000 claims 1
- 235000004611 garlic Nutrition 0.000 claims 1
- 238000004817 gas chromatography Methods 0.000 claims 1
- 239000003193 general anesthetic agent Substances 0.000 claims 1
- WTEVQBCEXWBHNA-JXMROGBWSA-N geranial Chemical compound CC(C)=CCC\C(C)=C\C=O WTEVQBCEXWBHNA-JXMROGBWSA-N 0.000 claims 1
- 230000004054 inflammatory process Effects 0.000 claims 1
- 229940125396 insulin Drugs 0.000 claims 1
- 229940047122 interleukins Drugs 0.000 claims 1
- 150000002500 ions Chemical class 0.000 claims 1
- KQNPFQTWMSNSAP-UHFFFAOYSA-M isobutyrate Chemical compound CC(C)C([O-])=O KQNPFQTWMSNSAP-UHFFFAOYSA-M 0.000 claims 1
- -1 kadinene Chemical compound 0.000 claims 1
- 229940041616 menthol Drugs 0.000 claims 1
- 239000002207 metabolite Substances 0.000 claims 1
- 239000002184 metal Substances 0.000 claims 1
- 229910044991 metal oxide Inorganic materials 0.000 claims 1
- 150000004706 metal oxides Chemical class 0.000 claims 1
- 125000004108 n-butyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 claims 1
- 150000002823 nitrates Chemical class 0.000 claims 1
- 230000003287 optical effect Effects 0.000 claims 1
- 210000000056 organ Anatomy 0.000 claims 1
- 201000008482 osteoarthritis Diseases 0.000 claims 1
- 229940094443 oxytocics prostaglandins Drugs 0.000 claims 1
- QNGNSVIICDLXHT-UHFFFAOYSA-N para-ethylbenzaldehyde Natural products CCC1=CC=C(C=O)C=C1 QNGNSVIICDLXHT-UHFFFAOYSA-N 0.000 claims 1
- WVDDGKGOMKODPV-ZQBYOMGUSA-N phenyl(114C)methanol Chemical compound O[14CH2]C1=CC=CC=C1 WVDDGKGOMKODPV-ZQBYOMGUSA-N 0.000 claims 1
- 150000003180 prostaglandins Chemical class 0.000 claims 1
- GRWFGVWFFZKLTI-UHFFFAOYSA-N rac-alpha-Pinene Natural products CC1=CCC2C(C)(C)C1C2 GRWFGVWFFZKLTI-UHFFFAOYSA-N 0.000 claims 1
- 230000000241 respiratory effect Effects 0.000 claims 1
- 206010039073 rheumatoid arthritis Diseases 0.000 claims 1
- 238000005070 sampling Methods 0.000 claims 1
- RGFNRWTWDWVHDD-UHFFFAOYSA-N sec-butyl ester of butyric acid Natural products CCCC(=O)OCC(C)C RGFNRWTWDWVHDD-UHFFFAOYSA-N 0.000 claims 1
- 239000004065 semiconductor Substances 0.000 claims 1
- 238000004611 spectroscopical analysis Methods 0.000 claims 1
- 238000004416 surface enhanced Raman spectroscopy Methods 0.000 claims 1
- 201000000596 systemic lupus erythematosus Diseases 0.000 claims 1
- 229940126585 therapeutic drug Drugs 0.000 claims 1
- 150000003626 triacylglycerols Chemical class 0.000 claims 1
- UFTFJSFQGQCHQW-UHFFFAOYSA-N triformin Chemical compound O=COCC(OC=O)COC=O UFTFJSFQGQCHQW-UHFFFAOYSA-N 0.000 claims 1
Claims (16)
- 患者の呼出した息(expired breath)をサンプリングする段階、
患者における少なくとも一つの内因性化合物の対応する濃度に比例する少なくとも一つの内因性化合物マーカーの息中濃度を、センサー技術を使用して分析する段階、
患者の息中の内因性化合物マーカーの濃度を計算する段階、および
患者の息中の内因性化合物マーカーの計算された濃度に基づいて、患者における内因性化合物の対応する濃度を計算する段階
を含む、患者における内因性化合物をモニタリングするための方法。 - 内因性化合物マーカーが内因性化合物であり、グルコース；タンパク質；ウロビリノーゲン；ウロビリルビン；ビリルビン；ホルモン；オリゴヌクレオチド；アデノシン；アデノシン三リン酸（ATP）；アデノシン二リン酸（ADP）；アデノシン一リン酸（AMP）；プロスタグランジン；ロイコトリエン；サイトカイン；インターロイキン；メラトニン；6-スルホキシメラトニン(6-sulfoxymelatonin)；低酸素誘導因子1α（HIF-1α）；筋原性制御因子；2,3-ジホスホグリセレート（2,3-DPG）；ケトン；ナイトレート；電解質；尿素；尿酸；アンモニア；乳酸；コレステロール；トリグリセリド；乳酸デヒドゲナーゼ（LDH）；および癌マーカーからなる群より選択される物質のいずれか一つまたは組み合わせである、請求項1記載の方法。
- 内因性化合物マーカーが、内因性化合物から直接誘導される化合物である、請求項1記載の方法。
- 内因性化合物マーカーが、グルコース；タンパク質；ウロビリノーゲン；ウロビリルビン；ビリルビン；ホルモン；オリゴヌクレオチド；アデノシン；アデノシン三リン酸（ATP）；アデノシン二リン酸（ADP）；アデノシン一リン酸（AMP）；プロスタグランジン；ロイコトリエン；サイトカイン；インターロイキン；メラトニン；6-スルホキシメラトニン；低酸素誘導因子1α（HIF-1α）；筋原性制御因子；2,3-ジホスホグリセレート（2,3-DPG）；ケトン；ナイトレート；電解質；尿素；尿酸；アンモニア；乳酸；コレステロール；トリグリセリド；乳酸デヒドゲナーゼ（LDH）；および癌マーカーからなる群より選択される内因性化合物のいずれか一つから誘導される代謝産物である、請求項3記載の方法。
- センサー技術が、金属-絶縁体-金属アンサンブル（MIME）センサー、交差反応性光学マイクロセンサーアレイ、蛍光ポリマーフィルム、表面増感ラマン分光法（SERS）、ダイオードレーザー、選択イオン流量管(selected ion flow tube)、金属酸化物センサー（MOS）、バルク音響波（BAW）センサー、比色管、赤外分光法、ガスクロマトグラフィー、半導体ガスセンサー技術；質量分光計、蛍光分光光度計、導電性ポリマーガスセンサー技術；アプタマーセンサー技術；増幅蛍光ポリマー（AFP）センサー技術；マイクロカンチレバー技術；分子的ポリマーフィルム技術(molecularly polymeric film technology)；表面共鳴アレイ；マイクロ重量測定(microgravimetric)センサー；厚さ剪断モードセンサー；または表面音響波ガスセンサー技術からなる群より選択される、請求項1記載の方法。
- センサー技術が、少なくとも一つの標的マーカーの検出および濃度を特徴付けるための特有の電子フィンガープリントを生成する、請求項5記載の方法。
- 患者における内因性化合物の計算された濃度に応答して治療薬の投与を自動的に制御する段階をさらに含む、請求項1記載の方法。
- 内因性化合物がグルコースであり、治療薬がインスリンである、請求項7記載の方法。
- 患者の息試料を捕集するための手段、
患者における少なくとも一つの内因性化合物の対応する濃度に比例する少なくとも一つの内因性化合物マーカーの息中濃度を分析し、分析された濃度に関するシグナルを発するためのセンサー技術、および
センサーからのシグナルを受けかつ分析して、患者の息中の内因性化合物マーカーの濃度に基づいて患者における内因性化合物の対応する濃度を計算し、伝達する、センサー技術に接続されたプロセッサ
を含む、内因性化合物モニタリングシステム。 - 供給により提供される麻酔剤の量を制御するための制御装置を有する麻酔供給源、
患者の血流中の麻酔剤濃度を示す少なくとも一つの物質の濃度に関して患者の息を分析し、患者に送達される麻酔剤濃度を示すシグナルを提供するための息分析装置、および
シグナルを受け、シグナルに基づいて麻酔剤の量を制御する、麻酔供給源に接続されたシステム制御装置
を含む、所望の用量の麻酔剤を患者に送達するための麻酔剤送達システム。 - 供給により呼吸回路に提供される揮発性麻酔剤の量を制御するための制御装置を有する麻酔ガス供給源、
患者に静脈投与されるIV麻酔剤の量を制御するための制御装置を有する静脈麻酔剤供給源、
呼吸回路中の麻酔ガスの濃度を分析するための吸気(inspired gas)分析装置、
患者の血流中の麻酔剤濃度を示す少なくとも一つの物質の濃度に関して患者の息を分析し、患者に送達される麻酔剤濃度を示す少なくとも一つのシグナルを提供するための呼気分析装置、および
シグナルを受け、シグナルに基づいて麻酔剤投与量を制御する、各麻酔供給源に接続されたシステム制御装置
を含む、呼吸回路およびIVを介してバランス麻酔を患者に送達するための麻酔剤送達およびモニタリングシステム。 - 少なくとも一つの静脈麻酔剤の少なくとも一つの供給源、
該少なくとも一つの静脈麻酔剤を患者に制御可能に静脈内に送達するための静脈内送達手段、
少なくとも一つの吸入麻酔剤の少なくとも一つの供給源、
該吸入麻酔剤の送達のための呼吸回路、
該吸入麻酔剤に関して該呼吸回路中のガスを分析するための吸気分析装置、
患者の血流中の麻酔剤を示す少なくとも一つの物質の濃度に関して患者の息を分析し、患者に送達される麻酔剤濃度を示すためのシグナルを提供するための呼気分析装置、
シグナルを受け、シグナルに基づいて麻酔剤の量を制御する、静脈内送達手段に接続されたシステム制御装置、および
シグナルを受け、シグナルに基づいて麻酔剤の量を制御する、呼吸回路に接続されたシステム制御装置
を含む、バランス麻酔を患者に投与するための装置。 - 少なくとも一つの治療薬を患者に投与する段階、
少なくとも一つのセンサーを患者からの呼気に暴露する段階、
治療薬からの一つまたは複数の標的マーカーを該センサーで検出する段階
を含む、少なくとも一つの治療薬の投与中に患者をモニタリングする方法。 - 標的マーカーが、ジメチルスルホキシド（DMSO）、アセトアルデヒド、アセトフェノン、トランス-アネトール（1-メトキシ-4-プロペニルベンゼン）（アニス）、ベンズアルデヒド（安息香酸アルデヒド）、ベンジルアルコール、桂皮酸ベンジル、カジネン、カンフェン、ショウノウ、桂皮アルデヒド（3-フェニルプロペナール）、ガーリック、シトロネラール、クレゾール、シクロヘキサン、オイカリプトール、およびオイゲノール、オイゲニルメチルエーテル；イソ酪酸ブチル（n-ブチル2, メチルプロパノエート）（パイナップル）；シトラール（2-トランス-3,7-ジメチル-2,6-アクタジエン-1-アール）；メントール（1-メチル-4-イソプロピルシクロヘキサン-3-オール）；ならびにα-ピネン（2,6,6-トリメチルビシクロ-(3,1,1)-2-ヘプテン）からなる群より選択される、請求項13記載の方法。
- 少なくとも一つの治療薬が、関節リウマチ、全身性エリテマトーデス、アンギナ、冠動脈疾患、末梢血管疾患、潰瘍性大腸炎、クローン病、臓器拒絶反応、てんかん、不安、変性性関節炎、血管炎および炎症からなる群より選択される状態の処置のために選択されるか、またはうつ病治療薬であるか、または鎮痛薬である、請求項13記載の方法。
- 供給により患者に提供される治療薬の量を制御するための制御装置を有する少なくとも一つの治療薬供給源、
患者の血流中の治療薬濃度を示す少なくとも一つの標的マーカーの存在および濃度に関して患者の息を分析し、患者の血流中の治療薬の濃度に関するシグナルを送信するための呼気センサー、および
センサーからのシグナルを受けかつ分析し、シグナルに基づいて患者への治療薬投与量を制御する、治療薬供給源に接続されたシステム制御装置
を含む、適切な投薬量の治療薬を患者に送達するための治療薬送達およびモニタリングシステム。
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US11/301,911 US20070167853A1 (en) | 2002-01-22 | 2005-12-13 | System and method for monitoring health using exhaled breath |
| PCT/US2006/046660 WO2007089328A2 (en) | 2005-12-13 | 2006-12-06 | System and method for monitoring health using exhaled breath |
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| JP2009519467A5 true JP2009519467A5 (ja) | 2011-02-24 |
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-
2006
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- 2006-12-06 JP JP2008545656A patent/JP2009519467A/ja not_active Withdrawn
- 2006-12-06 WO PCT/US2006/046660 patent/WO2007089328A2/en active Application Filing
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- 2006-12-06 CA CA002633826A patent/CA2633826A1/en not_active Abandoned
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2011
- 2011-09-27 US US13/246,436 patent/US20120016252A1/en not_active Abandoned
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