JP2009518021A - 抗原特異的エフェクターt細胞の生成法 - Google Patents

抗原特異的エフェクターt細胞の生成法 Download PDF

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JP2009518021A
JP2009518021A JP2008543852A JP2008543852A JP2009518021A JP 2009518021 A JP2009518021 A JP 2009518021A JP 2008543852 A JP2008543852 A JP 2008543852A JP 2008543852 A JP2008543852 A JP 2008543852A JP 2009518021 A JP2009518021 A JP 2009518021A
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tcr
antigen
rna
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シャフト,ニールズ
シュラー,ゲロルト
ドリエ,ヤン
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アルゴス・セラピューティクス・インコーポレーテッド
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    • A61K40/00Cellular immunotherapy
    • A61K40/10Cellular immunotherapy characterised by the cell type used
    • A61K40/11T-cells, e.g. tumour infiltrating lymphocytes [TIL] or regulatory T [Treg] cells; Lymphokine-activated killer [LAK] cells
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    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00Cellular immunotherapy
    • A61K40/30Cellular immunotherapy characterised by the recombinant expression of specific molecules in the cells of the immune system
    • A61K40/32T-cell receptors [TCR]
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    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00Cellular immunotherapy
    • A61K40/40Cellular immunotherapy characterised by antigens that are targeted or presented by cells of the immune system
    • A61K40/41Vertebrate antigens
    • A61K40/42Cancer antigens
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    • A61K40/41Vertebrate antigens
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    • A61K40/4271Melanoma antigens
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    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
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    • C12N15/87Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
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    • C12N5/00Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06Animal cells or tissues; Human cells or tissues
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    • C12N5/0634Cells from the blood or the immune system
    • C12N5/0636T lymphocytes
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JP2008543852A 2005-12-09 2006-12-11 抗原特異的エフェクターt細胞の生成法 Withdrawn JP2009518021A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP05111928A EP1795599A1 (en) 2005-12-09 2005-12-09 Methods for generating antigen-specific effector T cells
US77958806P 2006-03-06 2006-03-06
PCT/EP2006/069549 WO2007065957A2 (en) 2005-12-09 2006-12-11 Methods for generating antigen-specific effector t cells

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JP2009518021A true JP2009518021A (ja) 2009-05-07
JP2009518021A5 JP2009518021A5 (https=) 2010-01-28

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US (1) US20090226404A1 (https=)
EP (2) EP1795599A1 (https=)
JP (1) JP2009518021A (https=)
KR (1) KR20080077272A (https=)
CN (1) CN101415827A (https=)
AU (1) AU2006323961A1 (https=)
CA (1) CA2631785A1 (https=)
WO (1) WO2007065957A2 (https=)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2012531904A (ja) * 2009-07-03 2012-12-13 イムノコア リミテッド T細胞レセプター
JP2015518816A (ja) * 2012-04-02 2015-07-06 モデルナ セラピューティクス インコーポレイテッドModerna Therapeutics,Inc. 腫瘍学関連タンパク質およびペプチドの産生のための修飾ポリヌクレオチド
JP2017169566A (ja) * 2016-03-18 2017-09-28 北海道公立大学法人 札幌医科大学 T細胞レセプターとその利用
JP2019509753A (ja) * 2016-03-31 2019-04-11 ライオン ティーシーアール ピーティーイー.エルティーディー. 外因性ウイルス特異的t細胞受容体(tcr)を発現する非活性化t細胞

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DE10112851C1 (de) 2001-03-16 2002-10-10 Gsf Forschungszentrum Umwelt Semi-allogene Antitumor-Vakzine mit HLA-haplo-identischen Antigen-präsentierenden Zellen
US7994298B2 (en) 2004-09-24 2011-08-09 Trustees Of Dartmouth College Chimeric NK receptor and methods for treating cancer
WO2006065495A2 (en) 2004-11-24 2006-06-22 Fred Hutchinson Cancer Research Center Methods of using il-21 for adoptive immunotherapy and identification of tumor antigens
ES2341802T3 (es) * 2005-09-05 2010-06-28 Immatics Biotechnologies Gmbh Peptidos asociados a tumores unidos promiscuamente a moleculas del antigeno de leucocito humano (hla) de clase ii.
EP2126054B1 (en) 2007-01-31 2016-07-06 Yeda Research And Development Company Limited Redirected, genetically-engineered t regulatory cells and their use in suppression of autoimmune and inflammatory disease
US9249423B2 (en) 2007-02-02 2016-02-02 Yale University Method of de-differentiating and re-differentiating somatic cells using RNA
US8859229B2 (en) * 2007-02-02 2014-10-14 Yale University Transient transfection with RNA
US10155038B2 (en) 2007-02-02 2018-12-18 Yale University Cells prepared by transient transfection and methods of use thereof
GB0718160D0 (en) 2007-09-18 2007-10-24 Medical Res Council Methods
US9809797B2 (en) 2007-10-03 2017-11-07 National Institutes Of Health (Nih) U.S. Dept. Of Health And Human Services (Dhhs) Division Of Extramural Inventions And Technology Enhanced generation of cytotoxic T-lymphocytes by IL-21 mediated FOXP3 suppression
KR100900837B1 (ko) 2007-12-07 2009-06-04 (주)두비엘 리포펩타이드와 폴리(i:c)를 아쥬반트로 포함하는 강력한백신 조성물
EP2090659A1 (en) * 2008-02-14 2009-08-19 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. Infectious particle, process for its preparation and use thereof
WO2009108341A1 (en) 2008-02-28 2009-09-03 Argos Therapeutics, Inc. Transient expression of immunomodulatory polypeptides for the prevention and treatment of autoimmune disease, allergy and transplant rejection
US8450112B2 (en) 2008-04-09 2013-05-28 Maxcyte, Inc. Engineering and delivery of therapeutic compositions of freshly isolated cells
US20140161782A1 (en) * 2008-06-09 2014-06-12 Targazyme, Inc. Augmentation of cell therapy efficacy including treatment with alpha 1-3 fucoslytransferase
CN102272153B (zh) 2008-11-24 2015-04-15 德国慕尼黑亥姆霍兹研究中心健康和环境有限公司 高亲和力t细胞受体及其应用
WO2010089412A1 (en) 2009-02-09 2010-08-12 Helmholtz Zentrum Muenchen Deutsches Forschungszentrum Fuer Gesundheit Und Umwelt (Gmbh) Repertoire of allo-restricted peptide-specific t cell receptor sequences and use thereof
US12492376B2 (en) 2009-10-29 2025-12-09 The Trustees Of Dartmouth College T-cell receptor-deficient T cell compositions
WO2011059836A2 (en) 2009-10-29 2011-05-19 Trustees Of Dartmouth College T cell receptor-deficient t cell compositions
US9273283B2 (en) 2009-10-29 2016-03-01 The Trustees Of Dartmouth College Method of producing T cell receptor-deficient T cells expressing a chimeric receptor
ES2635335T3 (es) * 2010-09-20 2017-10-03 Biontech Cell & Gene Therapies Gmbh Receptores de células T específicos de antígeno y epítopos de células T
CN110200997A (zh) * 2011-03-23 2019-09-06 弗雷德哈钦森癌症研究中心 用于细胞免疫治疗的方法和组合物
US9833476B2 (en) 2011-08-31 2017-12-05 The Trustees Of Dartmouth College NKP30 receptor targeted therapeutics
US9254311B2 (en) 2012-04-02 2016-02-09 Moderna Therapeutics, Inc. Modified polynucleotides for the production of proteins
US10501513B2 (en) 2012-04-02 2019-12-10 Modernatx, Inc. Modified polynucleotides for the production of oncology-related proteins and peptides
ES2719495T5 (en) 2012-05-07 2025-09-10 Dartmouth College Anti-b7-h6 antibody, fusion proteins, and methods of using the same
PL3736329T3 (pl) * 2012-09-11 2022-07-18 Corning Incorporated Zużywalne krioprezerwowane komórki wykazujące przejściową nadekspresję genu(-ów) kodującego(-ych) białko(-a) transportera leku i/lub enzym(y) metabolizujący(-e) lek
CN102911267B (zh) * 2012-09-19 2014-04-02 南方医科大学 一种结核/hiv抗原肽双特异性tcr、其重组逆转录病毒载体与应用
JP6580579B2 (ja) 2014-01-29 2019-09-25 ユニバーシティー ヘルス ネットワーク T細胞受容体を発現する細胞を生産する方法および組成物
WO2016095934A2 (en) * 2014-12-14 2016-06-23 El Abd Hisham Mohamed Magdy A novel genetic device to engineer cell behavior
ES2857998T3 (es) 2015-02-12 2021-09-29 Univ Health Network Receptores de antígenos quiméricos
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CN107557339A (zh) * 2017-09-19 2018-01-09 深圳市北科生物科技有限公司 特异性识别plac1的t细胞及其与细胞因子的联合的应用
CA3076261A1 (en) 2017-09-19 2019-03-28 Admare Vintageco1 Investments Ltd. Anti-hla-a2 antibodies and methods of using the same
EP3684822A4 (en) 2017-09-20 2021-06-16 The University of British Columbia NEW ANTI-HLA-A2 ANTIBODIES AND USES THEREOF
WO2019196088A1 (en) * 2018-04-13 2019-10-17 Syz Cell Therapy Co. Methods of obtaining tumor-specific t cell receptors
WO2019241549A1 (en) 2018-06-15 2019-12-19 A2 Biotherapeutics, Inc. Foxp3-expressing car-t regulatory cells
CN110627895B (zh) * 2018-06-25 2021-03-23 北京大学 肺癌特异性tcr及其分析技术和应用
US12134637B2 (en) 2018-07-12 2024-11-05 Bgi Shenzhen MART-1(27-35) epitope-specific T cell receptor
US20220370586A1 (en) * 2019-08-08 2022-11-24 Cedars-Sinai Medical Center Method of generating activated t cells for cancer therapy
US12378521B2 (en) 2020-04-15 2025-08-05 Amgen Inc. Method for enhancing production of genetically engineered autologous T cells
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CN112941030B (zh) * 2021-01-25 2023-08-08 吉林大学 一种抗原特异性Treg及其制备方法和应用
CA3218590A1 (en) 2021-06-07 2022-12-15 Providence Health & Services - Oregon Cxcr5, pd-1, and icos expressing tumor reactive cd4 t cells and their use
WO2024008274A1 (en) * 2022-07-04 2024-01-11 Universiteit Antwerpen T regulatory cell modification
CN117797253A (zh) * 2024-02-29 2024-04-02 诺未科技(北京)有限公司 一种能扩展t细胞抗原表位的肿瘤疫苗及其制备方法

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Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2012531904A (ja) * 2009-07-03 2012-12-13 イムノコア リミテッド T細胞レセプター
JP2016039812A (ja) * 2009-07-03 2016-03-24 イムノコア リミテッド T細胞レセプター
JP2015518816A (ja) * 2012-04-02 2015-07-06 モデルナ セラピューティクス インコーポレイテッドModerna Therapeutics,Inc. 腫瘍学関連タンパク質およびペプチドの産生のための修飾ポリヌクレオチド
JP2017169566A (ja) * 2016-03-18 2017-09-28 北海道公立大学法人 札幌医科大学 T細胞レセプターとその利用
JP2021184738A (ja) * 2016-03-18 2021-12-09 北海道公立大学法人 札幌医科大学 T細胞レセプターとその利用
JP7138881B2 (ja) 2016-03-18 2022-09-20 北海道公立大学法人 札幌医科大学 T細胞レセプターとその利用
JP2019509753A (ja) * 2016-03-31 2019-04-11 ライオン ティーシーアール ピーティーイー.エルティーディー. 外因性ウイルス特異的t細胞受容体(tcr)を発現する非活性化t細胞

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WO2007065957A3 (en) 2007-07-26
CA2631785A1 (en) 2007-06-14
US20090226404A1 (en) 2009-09-10
CN101415827A (zh) 2009-04-22
EP1795599A1 (en) 2007-06-13
WO2007065957A2 (en) 2007-06-14
AU2006323961A1 (en) 2007-06-14
KR20080077272A (ko) 2008-08-21
EP1960527A2 (en) 2008-08-27

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