JP2009517015A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2009517015A5 JP2009517015A5 JP2008541846A JP2008541846A JP2009517015A5 JP 2009517015 A5 JP2009517015 A5 JP 2009517015A5 JP 2008541846 A JP2008541846 A JP 2008541846A JP 2008541846 A JP2008541846 A JP 2008541846A JP 2009517015 A5 JP2009517015 A5 JP 2009517015A5
- Authority
- JP
- Japan
- Prior art keywords
- tsh receptor
- prokaryotic host
- host cell
- fusion protein
- fragment
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- 102000003911 Thyrotropin Receptors Human genes 0.000 claims 65
- 108090000253 Thyrotropin Receptors Proteins 0.000 claims 65
- 210000004027 cell Anatomy 0.000 claims 33
- 108020001507 fusion proteins Proteins 0.000 claims 29
- 102000037865 fusion proteins Human genes 0.000 claims 29
- 229920001184 polypeptide Polymers 0.000 claims 27
- 108090000765 processed proteins & peptides Proteins 0.000 claims 27
- 102000004196 processed proteins & peptides Human genes 0.000 claims 27
- 208000023275 Autoimmune disease Diseases 0.000 claims 19
- 239000012634 fragment Substances 0.000 claims 19
- 230000028993 immune response Effects 0.000 claims 18
- 230000004044 response Effects 0.000 claims 17
- 238000000034 method Methods 0.000 claims 16
- 239000006166 lysate Substances 0.000 claims 12
- 230000015572 biosynthetic process Effects 0.000 claims 9
- 210000000805 cytoplasm Anatomy 0.000 claims 9
- 230000035772 mutation Effects 0.000 claims 9
- 102000005720 Glutathione transferase Human genes 0.000 claims 8
- 108010070675 Glutathione transferase Proteins 0.000 claims 8
- 239000013060 biological fluid Substances 0.000 claims 7
- 108091028043 Nucleic acid sequence Proteins 0.000 claims 6
- 238000012258 culturing Methods 0.000 claims 6
- 230000002934 lysing effect Effects 0.000 claims 6
- 150000007523 nucleic acids Chemical group 0.000 claims 6
- 239000004094 surface-active agent Substances 0.000 claims 6
- 230000001131 transforming effect Effects 0.000 claims 6
- 238000002965 ELISA Methods 0.000 claims 4
- 150000001413 amino acids Chemical class 0.000 claims 4
- 238000003556 assay Methods 0.000 claims 4
- 239000003153 chemical reaction reagent Substances 0.000 claims 4
- 239000007787 solid Substances 0.000 claims 4
- 238000000684 flow cytometry Methods 0.000 claims 2
- RWSXRVCMGQZWBV-WDSKDSINSA-N glutathione Chemical compound OC(=O)[C@@H](N)CCC(=O)N[C@@H](CS)C(=O)NCC(O)=O RWSXRVCMGQZWBV-WDSKDSINSA-N 0.000 claims 2
- 238000001114 immunoprecipitation Methods 0.000 claims 2
- 238000001699 lithographically induced self-assembly Methods 0.000 claims 2
- 238000003127 radioimmunoassay Methods 0.000 claims 2
- 238000001262 western blot Methods 0.000 claims 2
- 108010024636 Glutathione Proteins 0.000 claims 1
- 238000001514 detection method Methods 0.000 claims 1
- 238000003745 diagnosis Methods 0.000 claims 1
- 229960003180 glutathione Drugs 0.000 claims 1
- 230000008105 immune reaction Effects 0.000 claims 1
- 238000000338 in vitro Methods 0.000 claims 1
- 238000012123 point-of-care testing Methods 0.000 claims 1
- 230000002265 prevention Effects 0.000 claims 1
- 238000011002 quantification Methods 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US73802105P | 2005-11-21 | 2005-11-21 | |
| PCT/IB2006/003394 WO2007057778A2 (en) | 2005-11-21 | 2006-11-21 | Recombinant polypeptides and methods for detecting and/or quantifying autoantibodies against tsh receptor |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2009517015A JP2009517015A (ja) | 2009-04-30 |
| JP2009517015A5 true JP2009517015A5 (OSRAM) | 2010-01-14 |
Family
ID=37998447
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008541846A Withdrawn JP2009517015A (ja) | 2005-11-21 | 2006-11-21 | 組換えポリペプチドならびにｔｓｈレセプターに対する自己抗体を検出及び／又は定量化する方法 |
Country Status (4)
| Country | Link |
|---|---|
| US (1) | US20080305098A1 (OSRAM) |
| EP (2) | EP2080772A3 (OSRAM) |
| JP (1) | JP2009517015A (OSRAM) |
| WO (1) | WO2007057778A2 (OSRAM) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8470554B2 (en) * | 2008-12-22 | 2013-06-25 | St. Jude Children's Research Hospital | Prokaryotic expression of soluble, active Dkk |
| EP2367850B1 (en) * | 2008-12-24 | 2015-04-22 | Rsr Limited | Human anti tshr antibodies |
| JP2011136911A (ja) * | 2009-12-25 | 2011-07-14 | Tosoh Corp | 甲状腺刺激ホルモンレセプターの安定化方法 |
| US20130189707A1 (en) * | 2010-01-26 | 2013-07-25 | Svetlana Alexandrovna Sergeeva | Method of determination of autoantibody level by means of enzyme immunoassay |
| CN103975239B (zh) | 2011-09-09 | 2016-08-24 | 魁戴尔公司 | 用于检测自身抗体的组合物和方法 |
| EP2997039B1 (en) | 2013-05-14 | 2019-06-26 | Siemens Healthcare Diagnostics Inc. | Stabilized liquid formulations containing receptors |
| GB201314052D0 (en) * | 2013-08-06 | 2013-09-18 | Apitope Int Nv | Peptides |
| WO2016103213A1 (en) * | 2014-12-24 | 2016-06-30 | Apitope International Nv | Composition |
| CN114601913B (zh) * | 2022-03-09 | 2025-03-04 | 陕西慧普德泰生物科技有限责任公司 | 人TSHR A亚基在预防Graves病中的应用 |
| CN119192331A (zh) * | 2024-11-11 | 2024-12-27 | 郑州伊美诺生物技术有限公司 | 促甲状腺激素受体的突变体及其制备方法和应用 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20030022826A1 (en) * | 1987-09-08 | 2003-01-30 | Duke University | Use of synthetic peptides to induce tolerance to pathogenic T and B cell epitopes of autoantigens or infectious agents |
| JPH0789991A (ja) * | 1993-09-28 | 1995-04-04 | Mitsubishi Chem Corp | 新規なポリペプチドおよびそれを用いるｔｓｈ受容体抗体の測定法 |
| EP1078986B1 (en) | 1999-08-24 | 2007-02-28 | Tosoh Corporation | Secretory thyroid stimulating hormone receptor (TSHR), and method for assaying anti-TSHR antibody using the same |
| EP2383290B1 (en) | 2001-08-23 | 2019-05-08 | Rsr Limited | Epitope regions of a thyrotropin (tsh) receptor, uses thereof and antibodies thereto |
| WO2004050708A2 (en) * | 2002-11-29 | 2004-06-17 | Rsr Limited | Antibody for the thyrotropin receptor and uses thereof |
-
2006
- 2006-11-21 US US12/094,533 patent/US20080305098A1/en not_active Abandoned
- 2006-11-21 JP JP2008541846A patent/JP2009517015A/ja not_active Withdrawn
- 2006-11-21 WO PCT/IB2006/003394 patent/WO2007057778A2/en not_active Ceased
- 2006-11-21 EP EP09005494A patent/EP2080772A3/en not_active Withdrawn
- 2006-11-21 EP EP06820995A patent/EP1951753A2/en not_active Withdrawn
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN113557431A (zh) | 诊断SARS-CoV-2感染的方法和试剂 | |
| US8148084B2 (en) | Diagnosis of autoimmune disease | |
| CN102203609B (zh) | 用于输血相关急性肺损伤(trali)的筛选方法 | |
| JP2010515668A (ja) | アディポネクチン抗体およびアディポネクチンを測定するための方法 | |
| JP2004035534A (ja) | Ｈｃｖ抗コア・モノクローナル抗体 | |
| JP7592412B2 (ja) | 魚介類アレルギーの診断の方法及び製品 | |
| HRP20200585T1 (hr) | Poboljšani test za dijagnozu alergije na kikiriki | |
| JP2009517015A5 (OSRAM) | ||
| AU2018296527B2 (en) | Improved Rep protein for use in a diagnostic assay | |
| CN110832326A (zh) | 变态反应的抗原及其表位 | |
| JP2011528559A5 (OSRAM) | ||
| EP1987057A2 (en) | Peptide aptamer for neutralizing the binding of platelet antigene specific antibodies and diagnostic and therapeutic applications containing the same | |
| WO2008001944A1 (en) | Reagent for detection of autoantibody and kit for diagnosis of autoimmune disease | |
| JP5252339B2 (ja) | Ｐａｄ４及び抗ｐａｄ４抗体の測定方法並びに関節リウマチの検出方法 | |
| JP5712513B2 (ja) | ヒトサイトメガロウイルス感染の検出方法 | |
| CN108948153B (zh) | 一种瓜氨酸修饰肽抗原组合及其应用 | |
| JP2008255046A (ja) | 融合タンパク質、これを用いた抗体捕捉担体および抗原検出法 | |
| EP2140273A2 (en) | Diagnostic assay | |
| WO2007057778A3 (en) | Recombinant polypeptides and methods for detecting and/or quantifying autoantibodies against tsh receptor | |
| CN108948173B (zh) | 一种瓜氨酸修饰肽及其应用 | |
| AU2017209240A1 (en) | Method and kit for diagnosis of active tuberculosis | |
| EP2923205B1 (en) | Analysis for adult-onset still's disease | |
| CN108948174B (zh) | 一种瓜氨酸修饰肽及其应用 | |
| JP2014162772A (ja) | 抗シトルリン化タンパクヒトＩｇＧ抗体およびその用途 | |
| WO2011039350A1 (en) | New markers for the diagnosis of celiac disease |