JP2009517009A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2009517009A5 JP2009517009A5 JP2008541750A JP2008541750A JP2009517009A5 JP 2009517009 A5 JP2009517009 A5 JP 2009517009A5 JP 2008541750 A JP2008541750 A JP 2008541750A JP 2008541750 A JP2008541750 A JP 2008541750A JP 2009517009 A5 JP2009517009 A5 JP 2009517009A5
- Authority
- JP
- Japan
- Prior art keywords
- polypeptide
- seq
- amino acid
- group
- sequence shown
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 108090000765 processed proteins & peptides Proteins 0.000 claims 154
- 229920001184 polypeptide Polymers 0.000 claims 146
- 102000004196 processed proteins & peptides Human genes 0.000 claims 146
- 235000001014 amino acid Nutrition 0.000 claims 45
- 125000003275 alpha amino acid group Chemical group 0.000 claims 29
- 230000035772 mutation Effects 0.000 claims 28
- 150000001413 amino acids Chemical class 0.000 claims 27
- 230000037430 deletion Effects 0.000 claims 18
- 238000012217 deletion Methods 0.000 claims 18
- 108020004707 nucleic acids Proteins 0.000 claims 11
- 102000039446 nucleic acids Human genes 0.000 claims 11
- 150000007523 nucleic acids Chemical class 0.000 claims 11
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 9
- 230000004988 N-glycosylation Effects 0.000 claims 8
- AYFVYJQAPQTCCC-UHFFFAOYSA-N Threonine Natural products CC(O)C(N)C(O)=O AYFVYJQAPQTCCC-UHFFFAOYSA-N 0.000 claims 8
- 239000004473 Threonine Substances 0.000 claims 8
- 208000007502 anemia Diseases 0.000 claims 8
- 208000035475 disorder Diseases 0.000 claims 7
- 239000012634 fragment Substances 0.000 claims 7
- 206010028980 Neoplasm Diseases 0.000 claims 6
- 239000003814 drug Substances 0.000 claims 6
- 201000011510 cancer Diseases 0.000 claims 5
- 239000008194 pharmaceutical composition Substances 0.000 claims 5
- WHUUTDBJXJRKMK-UHFFFAOYSA-N Glutamic acid Natural products OC(=O)C(N)CCC(O)=O WHUUTDBJXJRKMK-UHFFFAOYSA-N 0.000 claims 4
- 210000004027 cell Anatomy 0.000 claims 4
- 229940079593 drug Drugs 0.000 claims 4
- 235000013922 glutamic acid Nutrition 0.000 claims 4
- 239000004220 glutamic acid Substances 0.000 claims 4
- ZDXPYRJPNDTMRX-UHFFFAOYSA-N glutamine Natural products OC(=O)C(N)CCC(N)=O ZDXPYRJPNDTMRX-UHFFFAOYSA-N 0.000 claims 4
- 238000005534 hematocrit Methods 0.000 claims 4
- 208000024891 symptom Diseases 0.000 claims 4
- 102100031939 Erythropoietin Human genes 0.000 claims 3
- 210000003169 central nervous system Anatomy 0.000 claims 3
- 239000003795 chemical substances by application Substances 0.000 claims 3
- 208000020832 chronic kidney disease Diseases 0.000 claims 3
- 208000022831 chronic renal failure syndrome Diseases 0.000 claims 3
- 230000000295 complement effect Effects 0.000 claims 3
- OXCMYAYHXIHQOA-UHFFFAOYSA-N potassium;[2-butyl-5-chloro-3-[[4-[2-(1,2,4-triaza-3-azanidacyclopenta-1,4-dien-5-yl)phenyl]phenyl]methyl]imidazol-4-yl]methanol Chemical compound [K+].CCCCC1=NC(Cl)=C(CO)N1CC1=CC=C(C=2C(=CC=CC=2)C2=N[N-]N=N2)C=C1 OXCMYAYHXIHQOA-UHFFFAOYSA-N 0.000 claims 3
- 102000011022 Chorionic Gonadotropin Human genes 0.000 claims 2
- 108010062540 Chorionic Gonadotropin Proteins 0.000 claims 2
- 241000124008 Mammalia Species 0.000 claims 2
- 238000002512 chemotherapy Methods 0.000 claims 2
- 201000010099 disease Diseases 0.000 claims 2
- 239000003937 drug carrier Substances 0.000 claims 2
- 230000000694 effects Effects 0.000 claims 2
- 108020001507 fusion proteins Proteins 0.000 claims 2
- 102000037865 fusion proteins Human genes 0.000 claims 2
- 229940084986 human chorionic gonadotropin Drugs 0.000 claims 2
- 238000004519 manufacturing process Methods 0.000 claims 2
- 239000000546 pharmaceutical excipient Substances 0.000 claims 2
- 239000003381 stabilizer Substances 0.000 claims 2
- KISWVXRQTGLFGD-UHFFFAOYSA-N 2-[[2-[[6-amino-2-[[2-[[2-[[5-amino-2-[[2-[[1-[2-[[6-amino-2-[(2,5-diamino-5-oxopentanoyl)amino]hexanoyl]amino]-5-(diaminomethylideneamino)pentanoyl]pyrrolidine-2-carbonyl]amino]-3-hydroxypropanoyl]amino]-5-oxopentanoyl]amino]-5-(diaminomethylideneamino)p Chemical compound C1CCN(C(=O)C(CCCN=C(N)N)NC(=O)C(CCCCN)NC(=O)C(N)CCC(N)=O)C1C(=O)NC(CO)C(=O)NC(CCC(N)=O)C(=O)NC(CCCN=C(N)N)C(=O)NC(CO)C(=O)NC(CCCCN)C(=O)NC(C(=O)NC(CC(C)C)C(O)=O)CC1=CC=C(O)C=C1 KISWVXRQTGLFGD-UHFFFAOYSA-N 0.000 claims 1
- 208000024827 Alzheimer disease Diseases 0.000 claims 1
- 208000030760 Anaemia of chronic disease Diseases 0.000 claims 1
- 208000024172 Cardiovascular disease Diseases 0.000 claims 1
- 102000003951 Erythropoietin Human genes 0.000 claims 1
- 108090000394 Erythropoietin Proteins 0.000 claims 1
- 206010020772 Hypertension Diseases 0.000 claims 1
- 108060003951 Immunoglobulin Proteins 0.000 claims 1
- 208000006136 Leigh Disease Diseases 0.000 claims 1
- 208000017507 Leigh syndrome Diseases 0.000 claims 1
- 206010024291 Leukaemias acute myeloid Diseases 0.000 claims 1
- 206010025323 Lymphomas Diseases 0.000 claims 1
- 208000034578 Multiple myelomas Diseases 0.000 claims 1
- 108020004711 Nucleic Acid Probes Proteins 0.000 claims 1
- 208000018737 Parkinson disease Diseases 0.000 claims 1
- 206010035226 Plasma cell myeloma Diseases 0.000 claims 1
- 206010063837 Reperfusion injury Diseases 0.000 claims 1
- 208000036142 Viral infection Diseases 0.000 claims 1
- 230000036982 action potential Effects 0.000 claims 1
- 206010002026 amyotrophic lateral sclerosis Diseases 0.000 claims 1
- 208000022400 anemia due to chronic disease Diseases 0.000 claims 1
- 239000008280 blood Substances 0.000 claims 1
- 210000004369 blood Anatomy 0.000 claims 1
- 210000000481 breast Anatomy 0.000 claims 1
- 201000008274 breast adenocarcinoma Diseases 0.000 claims 1
- 239000002299 complementary DNA Substances 0.000 claims 1
- 238000000502 dialysis Methods 0.000 claims 1
- 230000008482 dysregulation Effects 0.000 claims 1
- 229940105423 erythropoietin Drugs 0.000 claims 1
- 210000003527 eukaryotic cell Anatomy 0.000 claims 1
- 229940088597 hormone Drugs 0.000 claims 1
- 239000005556 hormone Substances 0.000 claims 1
- 229940127121 immunoconjugate Drugs 0.000 claims 1
- 102000018358 immunoglobulin Human genes 0.000 claims 1
- 230000000302 ischemic effect Effects 0.000 claims 1
- 208000032839 leukemia Diseases 0.000 claims 1
- 201000006417 multiple sclerosis Diseases 0.000 claims 1
- 210000003205 muscle Anatomy 0.000 claims 1
- 208000010125 myocardial infarction Diseases 0.000 claims 1
- 210000005036 nerve Anatomy 0.000 claims 1
- 208000020470 nervous system symptom Diseases 0.000 claims 1
- 239000002853 nucleic acid probe Substances 0.000 claims 1
- 239000002773 nucleotide Substances 0.000 claims 1
- 125000003729 nucleotide group Chemical group 0.000 claims 1
- 235000016709 nutrition Nutrition 0.000 claims 1
- 230000002669 organ and tissue protective effect Effects 0.000 claims 1
- 208000013371 ovarian adenocarcinoma Diseases 0.000 claims 1
- 210000001672 ovary Anatomy 0.000 claims 1
- 208000027232 peripheral nervous system disease Diseases 0.000 claims 1
- 210000001236 prokaryotic cell Anatomy 0.000 claims 1
- 210000002307 prostate Anatomy 0.000 claims 1
- 201000005825 prostate adenocarcinoma Diseases 0.000 claims 1
- 235000018102 proteins Nutrition 0.000 claims 1
- 102000004169 proteins and genes Human genes 0.000 claims 1
- 108090000623 proteins and genes Proteins 0.000 claims 1
- 238000001959 radiotherapy Methods 0.000 claims 1
- 208000015347 renal cell adenocarcinoma Diseases 0.000 claims 1
- 230000009385 viral infection Effects 0.000 claims 1
- HBOMLICNUCNMMY-XLPZGREQSA-N zidovudine Chemical compound O=C1NC(=O)C(C)=CN1[C@@H]1O[C@H](CO)[C@@H](N=[N+]=[N-])C1 HBOMLICNUCNMMY-XLPZGREQSA-N 0.000 claims 1
- 229960002555 zidovudine Drugs 0.000 claims 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP05111262 | 2005-11-24 | ||
| EP05111265 | 2005-11-24 | ||
| US75370605P | 2005-12-22 | 2005-12-22 | |
| US75366805P | 2005-12-22 | 2005-12-22 | |
| PCT/EP2006/068859 WO2007060213A2 (en) | 2005-11-24 | 2006-11-23 | Erythropoietin polypeptides and uses thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2009517009A JP2009517009A (ja) | 2009-04-30 |
| JP2009517009A5 true JP2009517009A5 (enExample) | 2010-02-04 |
Family
ID=37807876
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008541750A Pending JP2009517009A (ja) | 2005-11-24 | 2006-11-23 | エリスロポエチンポリペプチド及びそれらの使用 |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US20080260746A1 (enExample) |
| EP (1) | EP1966237A2 (enExample) |
| JP (1) | JP2009517009A (enExample) |
| AU (1) | AU2006316450A1 (enExample) |
| CA (1) | CA2621705A1 (enExample) |
| IL (1) | IL191426A (enExample) |
| WO (1) | WO2007060213A2 (enExample) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN100511447C (zh) * | 2004-02-09 | 2009-07-08 | 日本先锋公司 | 光学元件、光学识取器,以及信息记录/重放装置 |
| US7625564B2 (en) | 2006-01-27 | 2009-12-01 | Novagen Holding Corporation | Recombinant human EPO-Fc fusion proteins with prolonged half-life and enhanced erythropoietic activity in vivo |
| US20100115638A1 (en) * | 2006-12-19 | 2010-05-06 | Amina Abina | Method for inhibiting the expression of endogenous erythropoietin (epo) |
| US20100172919A1 (en) * | 2007-06-15 | 2010-07-08 | Jan Grimm | Noveltreatment for neurological disorders |
| US8067548B2 (en) * | 2007-07-26 | 2011-11-29 | Novagen Holding Corporation | Fusion proteins having mutated immunoglobulin hinge region |
| WO2012097256A1 (en) | 2011-01-14 | 2012-07-19 | University Of Tennessee Research Foundation | Therapeutic compositions and methods for disorders associated with neuronal degeneration |
| CN102816853A (zh) * | 2012-08-30 | 2012-12-12 | 山东百福基因科技有限公司 | 运动机能相关基因epo荧光检测试剂盒及检测方法 |
| KR102233664B1 (ko) | 2012-12-05 | 2021-04-02 | 노파르티스 아게 | Epo를 표적화하는 항체에 대한 조성물 및 방법 |
| US20210340241A1 (en) * | 2014-06-12 | 2021-11-04 | Andremacon S.R.L. | Use of negative functional modulators of erythropoietin for therapy |
| CN107922975B (zh) | 2015-08-12 | 2022-06-28 | 诺华股份有限公司 | 治疗眼科病症的方法 |
| EP3587443A4 (en) * | 2017-02-27 | 2021-02-17 | Sylus Co., Ltd. | USE OF ERYTHROPOIETIN PEPTIDE BY EFFECT ON CELL DAMAGE PREVENTION THEREOF |
| WO2022159414A1 (en) | 2021-01-22 | 2022-07-28 | University Of Rochester | Erythropoietin for gastroinfestinal dysfunction |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4558006A (en) * | 1983-02-04 | 1985-12-10 | Kirin-Amgen, Inc. | A.T.C.C. HB8209 and its monoclonal antibody to erythropoietin |
| NZ210501A (en) * | 1983-12-13 | 1991-08-27 | Kirin Amgen Inc | Erythropoietin produced by procaryotic or eucaryotic expression of an exogenous dna sequence |
| DE3923963A1 (de) * | 1989-07-20 | 1991-01-31 | Behringwerke Ag | Muteine des menschlichen erythropoetins, ihre herstellung und ihre verwendung |
| JP4170421B2 (ja) * | 1996-08-06 | 2008-10-22 | 佳子 安田 | 増殖性臓器疾患治療・改善剤 |
| KR20000052807A (ko) * | 1996-10-25 | 2000-08-25 | 윌리암스 로저 에이 | 순환 교환된 에리트로포이에틴 수용체 아고니스트 |
| US7033774B2 (en) * | 1997-04-21 | 2006-04-25 | Glycozyme, Inc. | Determination of recombinant glycosylated proteins and peptides in biological fluids |
| US20040229779A1 (en) * | 1999-05-14 | 2004-11-18 | Ramesh Kekuda | Therapeutic polypeptides, nucleic acids encoding same, and methods of use |
| US6974684B2 (en) * | 2001-08-08 | 2005-12-13 | Curagen Corporation | Therapeutic polypeptides, nucleic acids encoding same, and methods of use |
| JP5424521B2 (ja) * | 2001-12-21 | 2014-02-26 | ヒューマン ジノーム サイエンシーズ, インコーポレイテッド | アルブミン融合タンパク質 |
| MXPA05000063A (es) * | 2002-07-01 | 2005-04-08 | Kenneth S Warren Inst Inc | Citocinas recombinantes protectoras de tejido y acidos nucleicos que las codifican para la proteccion, restauracion y mejora de celulas, tejidos y organos respondedores. |
| AU2003304034A1 (en) * | 2002-08-09 | 2004-11-01 | Curagen Corporation | Therapeutic polypeptides, nucleic acids encoding same, and methods of use |
| US7846466B2 (en) * | 2004-06-10 | 2010-12-07 | Northwestern University | Biodegradable scaffolds and uses thereof |
-
2006
- 2006-11-23 EP EP06830107A patent/EP1966237A2/en not_active Withdrawn
- 2006-11-23 JP JP2008541750A patent/JP2009517009A/ja active Pending
- 2006-11-23 WO PCT/EP2006/068859 patent/WO2007060213A2/en not_active Ceased
- 2006-11-23 US US12/094,869 patent/US20080260746A1/en not_active Abandoned
- 2006-11-23 CA CA002621705A patent/CA2621705A1/en not_active Abandoned
- 2006-11-23 AU AU2006316450A patent/AU2006316450A1/en not_active Abandoned
-
2008
- 2008-05-14 IL IL191426A patent/IL191426A/en not_active IP Right Cessation
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| RU2433181C2 (ru) | Рекомбинантный слитый человеческий белок epo-fc с продленным временем полужизни и повышенной эритропоэтической активностью in vivo (варианты), димерная белковая конструкция, димерный белок, фармацевтическая композиция, последовательность нуклеиновой кислоты (варианты), вектор экспрессии, клетка, способ получения белка и способ стимуляции эритропоэза у млекопитающего | |
| CN110234355B (zh) | 单体人IgG1 Fc和双特异性抗体 | |
| US20190070264A1 (en) | Interleukin 15 protein complex and use thereof | |
| JP2009517009A5 (enExample) | ||
| JP2009517055A (ja) | ニューレグリン変異体、並びにそれをスクリーニングし、及び使用する方法 | |
| US20120083453A1 (en) | Treatment using neublastin polypeptides | |
| US20130096065A1 (en) | Neublastin variants | |
| AU2002250203B2 (en) | Use of neublastin polypeptides for treating neuropathic pain | |
| CN114667298A (zh) | Siglec-9 ecd融合分子及其使用方法 | |
| CN102603886A (zh) | 突变的成纤维细胞生长因子及在治疗内分泌疾病中的用途 | |
| US20220119448A1 (en) | Artificial recombinant protein for improving performance of active protein or polypeptide and use thereof | |
| US10308917B2 (en) | Nucleotide sequences encoding VEGF antagonist compositions of FLT-1 and uses thereof | |
| JP2005519946A (ja) | 発作の処置のためのインターフェロンβ様分子 | |
| JP2009513689A5 (enExample) | ||
| CN117264054B (zh) | 靶向il-6的纳米抗体、组合物、方法及用途 | |
| TW202317176A (zh) | 長效型多肽及其生產和給藥的方法 | |
| Cohan et al. | Design, modeling, expression, and chemoselective PEGylation of a new nanosize cysteine analog of erythropoietin | |
| US20250075003A1 (en) | Nanoparticles comprising fusion protein of single-chain variable fragment and ferritin, and use thereof | |
| US12221488B2 (en) | APJ antibody, fusion protein thereof with Elabela, and pharmaceutical compositions and use thereofus01 | |
| RS52910B (sr) | Polimerni konjugati mutiranog neublastina | |
| WO2025029881A1 (en) | Combination therapy with a sirpa-based chimeric protein and azacitidine | |
| JP2023515825A (ja) | 血管疾患を治療するためのアンジオポエチン模倣物およびtie2アゴニストとしての、c4結合タンパク質c末端セグメントとアンジオポエチン-1フィブリノゲン様ドメインとの間のキメラ融合 | |
| CN120603842A (zh) | Il-2突变体及其用途 | |
| CN120322249A (zh) | 人透明质酸酶1突变体 | |
| JP2023515827A (ja) | 房水流出を高め、眼圧を減少させる方法 |