JP2009516534A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2009516534A5 JP2009516534A5 JP2008539609A JP2008539609A JP2009516534A5 JP 2009516534 A5 JP2009516534 A5 JP 2009516534A5 JP 2008539609 A JP2008539609 A JP 2008539609A JP 2008539609 A JP2008539609 A JP 2008539609A JP 2009516534 A5 JP2009516534 A5 JP 2009516534A5
- Authority
- JP
- Japan
- Prior art keywords
- methacetin
- breath
- derivative
- salt
- subject
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- XVAIDCNLVLTVFM-UHFFFAOYSA-N methacetin Chemical compound COC1=CC=C(NC(C)=O)C=C1 XVAIDCNLVLTVFM-UHFFFAOYSA-N 0.000 claims 46
- 238000000034 method Methods 0.000 claims 26
- 150000003839 salts Chemical class 0.000 claims 25
- WWZKQHOCKIZLMA-UHFFFAOYSA-N octanoic acid Chemical class CCCCCCCC(O)=O WWZKQHOCKIZLMA-UHFFFAOYSA-N 0.000 claims 20
- 238000012544 monitoring process Methods 0.000 claims 16
- 230000005817 liver abnormality Effects 0.000 claims 9
- 208000008338 non-alcoholic fatty liver disease Diseases 0.000 claims 8
- 239000002207 metabolite Substances 0.000 claims 7
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 7
- 206010016654 Fibrosis Diseases 0.000 claims 6
- 230000004761 fibrosis Effects 0.000 claims 6
- OBETXYAYXDNJHR-UHFFFAOYSA-N alpha-ethylcaproic acid Natural products CCCCC(CC)C(O)=O OBETXYAYXDNJHR-UHFFFAOYSA-N 0.000 claims 5
- 239000008280 blood Substances 0.000 claims 4
- 210000004369 blood Anatomy 0.000 claims 4
- 229940079593 drug Drugs 0.000 claims 4
- 239000003814 drug Substances 0.000 claims 4
- 206010053219 non-alcoholic steatohepatitis Diseases 0.000 claims 4
- 230000000155 isotopic effect Effects 0.000 claims 3
- 238000005259 measurement Methods 0.000 claims 3
- 102000004190 Enzymes Human genes 0.000 claims 2
- 108090000790 Enzymes Proteins 0.000 claims 2
- 239000007864 aqueous solution Substances 0.000 claims 2
- 230000008878 coupling Effects 0.000 claims 2
- 238000010168 coupling process Methods 0.000 claims 2
- 238000005859 coupling reaction Methods 0.000 claims 2
- 230000000694 effects Effects 0.000 claims 2
- 208000019423 liver disease Diseases 0.000 claims 2
- 239000000463 material Substances 0.000 claims 2
- 235000012054 meals Nutrition 0.000 claims 2
- OKTJSMMVPCPJKN-OUBTZVSYSA-N Carbon-13 Chemical compound [13C] OKTJSMMVPCPJKN-OUBTZVSYSA-N 0.000 claims 1
- OKTJSMMVPCPJKN-NJFSPNSNSA-N Carbon-14 Chemical compound [14C] OKTJSMMVPCPJKN-NJFSPNSNSA-N 0.000 claims 1
- 230000005856 abnormality Effects 0.000 claims 1
- 238000003745 diagnosis Methods 0.000 claims 1
- 238000001990 intravenous administration Methods 0.000 claims 1
- 210000004185 liver Anatomy 0.000 claims 1
- 230000003908 liver function Effects 0.000 claims 1
- 230000002503 metabolic effect Effects 0.000 claims 1
- 230000004060 metabolic process Effects 0.000 claims 1
- QVGXLLKOCUKJST-NJFSPNSNSA-N oxygen-18 atom Chemical compound [18O] QVGXLLKOCUKJST-NJFSPNSNSA-N 0.000 claims 1
- 238000005070 sampling Methods 0.000 claims 1
- 230000004936 stimulating effect Effects 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US73547905P | 2005-11-11 | 2005-11-11 | |
| PCT/IL2006/001296 WO2007054940A2 (en) | 2005-11-11 | 2006-11-12 | Breath test device and method |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2009516534A JP2009516534A (ja) | 2009-04-23 |
| JP2009516534A5 true JP2009516534A5 (enExample) | 2010-01-07 |
Family
ID=38023667
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008539609A Pending JP2009516534A (ja) | 2005-11-11 | 2006-11-12 | 呼気試験装置および方法 |
Country Status (4)
| Country | Link |
|---|---|
| US (1) | US8622920B2 (enExample) |
| EP (1) | EP1960004A4 (enExample) |
| JP (1) | JP2009516534A (enExample) |
| WO (1) | WO2007054940A2 (enExample) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2006264108B2 (en) | 2005-06-25 | 2012-06-28 | Charite - Universitatsmedizin Berlin | Analysis method for determining a functional parameter of an organ using preferably an aqueous 13C methacetin solution |
| US8512258B2 (en) * | 2005-11-11 | 2013-08-20 | Exalenz Bioscience Ltd. | Breath test device and method |
| DE102006018862A1 (de) * | 2006-03-17 | 2007-09-20 | Charité - Universitätsmedizin Berlin | Vorrichtung zur spektroskopischen Analyse eines Gases |
| JP5887141B2 (ja) * | 2009-02-26 | 2016-03-16 | ユニバーシティ ダンガース | 肝線維症または肝硬変の向上した診断方法 |
| DE102009055320B4 (de) | 2009-12-24 | 2011-09-01 | Humedics Gmbh | Messvorrichtung und Verfahren zur Untersuchung eines Probegases mittels Infrarot-Absorptionsspektroskopie |
| US8753889B1 (en) * | 2010-04-01 | 2014-06-17 | Beverly L. Roeder | Methods for diagnosing and treating disease in animals by the analysis of isotopes in elements such as carbon and nitrogen in animal substrate |
| DE102011007310A1 (de) | 2011-04-13 | 2012-10-18 | Humedics Gmbh | Verfahren zur Bestimmung der metabolischen Leistung mindestens eines Enzyms |
| WO2012140660A1 (en) | 2011-04-14 | 2012-10-18 | Exalenz Bioscience Ltd. | Methods for diagnosis, prognosis, monitoring and treatment of hepatocellular carcinoma |
| US8512676B1 (en) * | 2012-03-07 | 2013-08-20 | Wisconsin Alumni Research Foundation | Detection of rate changes in systematic oscillations of metabolic athways by monitoring isotope ratios |
| US20170181686A1 (en) * | 2014-04-02 | 2017-06-29 | Exalenz Bioscience Ltd. | Breath test for assessing liver disease |
| CN115267100A (zh) * | 2021-04-30 | 2022-11-01 | 北京华亘安邦科技有限公司 | 13c美沙西汀颗粒剂及其制备方法和应用 |
| CN116688160B (zh) * | 2023-07-10 | 2025-07-25 | 北京华亘安邦科技有限公司 | 一种13c美沙西汀口崩片及其制备方法与应用 |
| CN116966323A (zh) * | 2023-07-10 | 2023-10-31 | 北京华亘安邦科技有限公司 | 一种13c美沙西汀注射用冻干粉针剂及其制备方法与应用 |
Family Cites Families (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0584897B1 (de) * | 1992-07-22 | 1996-10-16 | MANNESMANN Aktiengesellschaft | Nichtdispersives Infrarotspektrometer |
| US5386832A (en) * | 1993-06-11 | 1995-02-07 | New England Deaconess Hospital | Liver function breath test using aromatic amino acids |
| US6186958B1 (en) * | 1997-02-26 | 2001-02-13 | Oridion Medical | Breath test analyzer |
| JP3340391B2 (ja) * | 1997-09-11 | 2002-11-05 | 東京瓦斯株式会社 | 肝手術評価用試薬 |
| CN1277545A (zh) | 1997-09-11 | 2000-12-20 | 奥莱登医学有限公司 | 呼吸测试分析仪 |
| USRE38728E1 (en) | 1997-09-11 | 2005-04-19 | Oridion Medical, LTD | Breath test analyzer |
| JP4007669B2 (ja) * | 1997-10-21 | 2007-11-14 | 東京瓦斯株式会社 | 肝機能診断剤 |
| JP4007660B2 (ja) * | 1997-12-11 | 2007-11-14 | 東京瓦斯株式会社 | 肝機能診断剤 |
| CA2249173C (en) | 1997-10-06 | 2008-12-16 | Tokyo Gas Co., Ltd. | Diagnostic agent for liver function |
| JP4007647B2 (ja) * | 1997-10-06 | 2007-11-14 | 東京瓦斯株式会社 | 肝機能診断剤 |
| JP4007664B2 (ja) * | 1998-01-16 | 2007-11-14 | 東京瓦斯株式会社 | 肝機能診断剤 |
| CA2250485C (en) | 1997-10-21 | 2008-04-29 | Tokyo Gas Co., Ltd. | Diagnostic agent for diabetes |
| US6656127B1 (en) | 1999-06-08 | 2003-12-02 | Oridion Breathid Ltd. | Breath test apparatus and methods |
| US6486474B1 (en) | 1999-08-13 | 2002-11-26 | Regents Of The University Of Minnesota | Infrared spectrometer for the measurement of isotopic ratios |
| GB0106923D0 (en) * | 2001-03-20 | 2001-05-09 | Univ Dundee | Liver function test |
| US20040253637A1 (en) | 2001-04-13 | 2004-12-16 | Biosite Incorporated | Markers for differential diagnosis and methods of use thereof |
| JP2005503205A (ja) | 2001-08-23 | 2005-02-03 | オリディオン ブレシド リミティド | 胃腸障害の管理 |
| US6778269B2 (en) | 2001-09-04 | 2004-08-17 | Board Of Regents, The University Of Texas System | Detecting isotopes and determining isotope ratios using raman spectroscopy |
| IL148468A (en) * | 2002-03-03 | 2012-12-31 | Exalenz Bioscience Ltd | Breath collection system |
| US7490085B2 (en) | 2002-12-18 | 2009-02-10 | Ge Medical Systems Global Technology Company, Llc | Computer-assisted data processing system and method incorporating automated learning |
| US8778299B2 (en) * | 2005-01-26 | 2014-07-15 | The Regents Of The University Of Colorado, A Body Corporate | Methods for diagnosis and intervention of hepatic disorders |
| EP1702558A1 (en) | 2005-02-28 | 2006-09-20 | Euro-Celtique S.A. | Method and device for the assessment of bowel function |
| CN101163791A (zh) | 2005-04-16 | 2008-04-16 | 大塚制药株式会社 | 使用呼吸检测来评定细胞色素p450 2d6同工酶活性的方法和组合物 |
| AU2006264108B2 (en) * | 2005-06-25 | 2012-06-28 | Charite - Universitatsmedizin Berlin | Analysis method for determining a functional parameter of an organ using preferably an aqueous 13C methacetin solution |
| US8512258B2 (en) | 2005-11-11 | 2013-08-20 | Exalenz Bioscience Ltd. | Breath test device and method |
| US7662105B2 (en) | 2005-12-14 | 2010-02-16 | Cardiac Pacemakers, Inc. | Systems and methods for determining respiration metrics |
-
2006
- 2006-11-12 US US12/084,629 patent/US8622920B2/en active Active
- 2006-11-12 WO PCT/IL2006/001296 patent/WO2007054940A2/en not_active Ceased
- 2006-11-12 EP EP06809856A patent/EP1960004A4/en not_active Ceased
- 2006-11-12 JP JP2008539609A patent/JP2009516534A/ja active Pending
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| Hallstrand et al. | ERS technical standard on bronchial challenge testing: pathophysiology and methodology of indirect airway challenge testing | |
| Evans | Physiology of equine performance and associated tests of function | |
| US10383546B2 (en) | Oral end tidal carbon dioxide method for diagnosing pulmonary arterial hypertension | |
| JP5732391B2 (ja) | 貯蔵安定なメタセチン組成物 | |
| Poulard et al. | Poor correlation between diaphragm thickening fraction and transdiaphragmatic pressure in mechanically ventilated patients and healthy subjects | |
| Martinez et al. | Graded comprehensive cardiopulmonary exercise testing in the evaluation of dyspnea unexplained by routine evaluation | |
| DuBois et al. | Breath ammonia testing for diagnosis of hepatic encephalopathy | |
| CN102821686B (zh) | 确定受试者排出的总二氧化碳的组成 | |
| JP2009516534A5 (enExample) | ||
| JP6163479B2 (ja) | 肝細胞癌の診断、予後診断、監視および治療方法 | |
| JP2005503205A (ja) | 胃腸障害の管理 | |
| France et al. | Comparison of direct and indirect methods of measuring arterial blood pressure in healthy male rhesus macaques (Macaca mulatta) | |
| US8622920B2 (en) | Breath test device and method | |
| Kirschner et al. | Short-chain fatty acid production in accessible and inaccessible body pools as assessed by novel stable tracer pulse approach is reduced by aging independent of presence of COPD | |
| Desmarchelier et al. | Monitoring of the ventilatory status of anesthetized birds of prey by using end-tidal carbon dioxide measured with a microstream capnometer | |
| JP3911519B2 (ja) | 腸内ガス中の有毒ガスの測定方法及び装置 | |
| Simões et al. | Methods to identify the anaerobic threshold for type-2 diabetic and non-diabetic subjects | |
| Marlin et al. | Respiratory responses of mature horses to intravenous lobeline bolus | |
| WO2007106556A2 (en) | Method for performing a non-invasive blood gas test | |
| Limberg et al. | Effect of obesity and metabolic syndrome on hypoxic vasodilation | |
| Magnin et al. | Indirect assessment of autonomic nervous system balance for prediction of hemorrhage: A preclinical study in a porcine model | |
| O’Neill et al. | Laboratory Setup, Equipment, and Protocols | |
| Lee et al. | Relationship between external jugular and central venous oxygen saturation in anesthetized dogs under varying hemodynamic conditions | |
| Alharbi | The effects of molecular hydrogen supplements on acid-base status and skeletal muscle oxidative metabolism during exercise in humans | |
| Krumbiegel et al. | Towards an Inhalative 13C Breath Test Method |