JP2009515996A5 - - Google Patents
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- Publication number
- JP2009515996A5 JP2009515996A5 JP2008541386A JP2008541386A JP2009515996A5 JP 2009515996 A5 JP2009515996 A5 JP 2009515996A5 JP 2008541386 A JP2008541386 A JP 2008541386A JP 2008541386 A JP2008541386 A JP 2008541386A JP 2009515996 A5 JP2009515996 A5 JP 2009515996A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- halo
- cyano
- nitro
- haloalkoxy
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 125000000217 alkyl group Chemical group 0.000 claims 38
- 150000001875 compounds Chemical class 0.000 claims 21
- CYRMSUTZVYGINF-UHFFFAOYSA-N trichlorofluoromethane Chemical compound FC(Cl)(Cl)Cl CYRMSUTZVYGINF-UHFFFAOYSA-N 0.000 claims 21
- -1 —OR 7 Chemical group 0.000 claims 18
- 125000001475 halogen functional group Chemical group 0.000 claims 16
- 125000003342 alkenyl group Chemical group 0.000 claims 15
- 125000003545 alkoxy group Chemical group 0.000 claims 15
- 125000000304 alkynyl group Chemical group 0.000 claims 15
- 125000004438 haloalkoxy group Chemical group 0.000 claims 15
- 125000001188 haloalkyl group Chemical group 0.000 claims 15
- 125000003282 alkyl amino group Chemical group 0.000 claims 14
- 125000004093 cyano group Chemical group *C#N 0.000 claims 14
- 125000004663 dialkyl amino group Chemical group 0.000 claims 13
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims 13
- 125000003710 aryl alkyl group Chemical group 0.000 claims 11
- 125000003118 aryl group Chemical group 0.000 claims 10
- 125000000753 cycloalkyl group Chemical group 0.000 claims 10
- 125000001072 heteroaryl group Chemical group 0.000 claims 10
- 125000000623 heterocyclic group Chemical group 0.000 claims 10
- 125000000392 cycloalkenyl group Chemical group 0.000 claims 8
- 125000004475 heteroaralkyl group Chemical group 0.000 claims 8
- 239000008194 pharmaceutical composition Substances 0.000 claims 8
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 8
- 125000005907 alkyl ester group Chemical group 0.000 claims 7
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 7
- 125000004404 heteroalkyl group Chemical group 0.000 claims 4
- 150000003839 salts Chemical class 0.000 claims 4
- 239000012453 solvate Substances 0.000 claims 4
- 125000004414 alkyl thio group Chemical group 0.000 claims 3
- PXBRQCKWGAHEHS-UHFFFAOYSA-N dichlorodifluoromethane Chemical compound FC(F)(Cl)Cl PXBRQCKWGAHEHS-UHFFFAOYSA-N 0.000 claims 3
- VHSHLMUCYSAUQU-UHFFFAOYSA-N 2-hydroxypropyl methacrylate Chemical compound CC(O)COC(=O)C(C)=C VHSHLMUCYSAUQU-UHFFFAOYSA-N 0.000 claims 2
- HEDRZPFGACZZDS-UHFFFAOYSA-N Chloroform Chemical compound ClC(Cl)Cl HEDRZPFGACZZDS-UHFFFAOYSA-N 0.000 claims 2
- 125000000539 amino acid group Chemical group 0.000 claims 2
- ZUOUZKKEUPVFJK-UHFFFAOYSA-N diphenyl Chemical compound C1=CC=CC=C1C1=CC=CC=C1 ZUOUZKKEUPVFJK-UHFFFAOYSA-N 0.000 claims 2
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 claims 2
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 2
- MQLACMBJVPINKE-UHFFFAOYSA-N 10-[(3-hydroxy-4-methoxyphenyl)methylidene]anthracen-9-one Chemical compound C1=C(O)C(OC)=CC=C1C=C1C2=CC=CC=C2C(=O)C2=CC=CC=C21 MQLACMBJVPINKE-UHFFFAOYSA-N 0.000 claims 1
- 125000000218 acetic acid group Chemical group C(C)(=O)* 0.000 claims 1
- 125000002252 acyl group Chemical group 0.000 claims 1
- 125000002877 alkyl aryl group Chemical group 0.000 claims 1
- 125000002947 alkylene group Chemical group 0.000 claims 1
- 125000001769 aryl amino group Chemical group 0.000 claims 1
- 125000005163 aryl sulfanyl group Chemical group 0.000 claims 1
- 125000004104 aryloxy group Chemical group 0.000 claims 1
- 125000000499 benzofuranyl group Chemical group O1C(=CC2=C1C=CC=C2)* 0.000 claims 1
- 235000010290 biphenyl Nutrition 0.000 claims 1
- 239000004305 biphenyl Substances 0.000 claims 1
- 230000000903 blocking effect Effects 0.000 claims 1
- 230000017531 blood circulation Effects 0.000 claims 1
- 210000004204 blood vessel Anatomy 0.000 claims 1
- 125000004452 carbocyclyl group Chemical group 0.000 claims 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 1
- 125000002795 guanidino group Chemical group C(N)(=N)N* 0.000 claims 1
- 125000005844 heterocyclyloxy group Chemical group 0.000 claims 1
- 125000004468 heterocyclylthio group Chemical group 0.000 claims 1
- 125000001041 indolyl group Chemical group 0.000 claims 1
- 230000002401 inhibitory effect Effects 0.000 claims 1
- 125000002183 isoquinolinyl group Chemical group C1(=NC=CC2=CC=CC=C12)* 0.000 claims 1
- 208000002780 macular degeneration Diseases 0.000 claims 1
- 125000001624 naphthyl group Chemical group 0.000 claims 1
- QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 claims 1
- 125000002971 oxazolyl group Chemical group 0.000 claims 1
- 125000004043 oxo group Chemical group O=* 0.000 claims 1
- 230000002062 proliferating effect Effects 0.000 claims 1
- 125000002098 pyridazinyl group Chemical group 0.000 claims 1
- 125000004076 pyridyl group Chemical group 0.000 claims 1
- 125000000714 pyrimidinyl group Chemical group 0.000 claims 1
- 125000002943 quinolinyl group Chemical group N1=C(C=CC2=CC=CC=C12)* 0.000 claims 1
- 229920003169 water-soluble polymer Polymers 0.000 claims 1
- 0 *c1c(*)[s]nc1* Chemical compound *c1c(*)[s]nc1* 0.000 description 2
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US73834005P | 2005-11-18 | 2005-11-18 | |
| US60/738,340 | 2005-11-18 | ||
| PCT/US2006/044799 WO2007061909A1 (en) | 2005-11-18 | 2006-11-17 | Thiazoles for the treatment of proliferative disorders |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2009515996A JP2009515996A (ja) | 2009-04-16 |
| JP2009515996A5 true JP2009515996A5 (enExample) | 2010-01-14 |
| JP5344923B2 JP5344923B2 (ja) | 2013-11-20 |
Family
ID=37813575
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008541386A Expired - Fee Related JP5344923B2 (ja) | 2005-11-18 | 2006-11-17 | 増殖性疾患の治療のためのチアゾール |
Country Status (7)
| Country | Link |
|---|---|
| US (4) | US7572821B2 (enExample) |
| EP (1) | EP1966172B1 (enExample) |
| JP (1) | JP5344923B2 (enExample) |
| AU (1) | AU2006318709B2 (enExample) |
| CA (1) | CA2628958A1 (enExample) |
| TW (1) | TW200735866A (enExample) |
| WO (1) | WO2007061909A1 (enExample) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TW200735866A (en) | 2005-11-18 | 2007-10-01 | Synta Pharmaceuticals Corp | Compounds for the treatment of proliferative disorders |
| BRPI0910692A2 (pt) * | 2008-04-04 | 2018-03-27 | Lilly Co Eli | 3-indazolil-4-piridilisotiazóis |
| US10801070B2 (en) | 2013-11-25 | 2020-10-13 | The Broad Institute, Inc. | Compositions and methods for diagnosing, evaluating and treating cancer |
| WO2015085147A1 (en) | 2013-12-05 | 2015-06-11 | The Broad Institute Inc. | Polymorphic gene typing and somatic change detection using sequencing data |
| EP3082853A2 (en) | 2013-12-20 | 2016-10-26 | The Broad Institute, Inc. | Combination therapy with neoantigen vaccine |
| JP6524069B2 (ja) * | 2014-04-30 | 2019-06-05 | 日本カーバイド工業株式会社 | オキシラン化合物及びそれを用いた含窒素複素環式化合物を製造する方法 |
| WO2016100977A1 (en) | 2014-12-19 | 2016-06-23 | The Broad Institute Inc. | Methods for profiling the t-cel- receptor repertoire |
| WO2016100975A1 (en) | 2014-12-19 | 2016-06-23 | Massachsetts Institute Ot Technology | Molecular biomarkers for cancer immunotherapy |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5840749A (en) | 1989-08-25 | 1998-11-24 | Hoechst Marion Roussel, Inc. | N-hydroxy-dibenz b,e!oxepinalkylamines, N-hydroxy-dibenz b,e!oxepinalkanoic acid amides and related heterocyclic analogues |
| US5840746A (en) * | 1993-06-24 | 1998-11-24 | Merck Frosst Canada, Inc. | Use of inhibitors of cyclooxygenase in the treatment of neurodegenerative diseases |
| US5474995A (en) | 1993-06-24 | 1995-12-12 | Merck Frosst Canada, Inc. | Phenyl heterocycles as cox-2 inhibitors |
| AU706089B2 (en) * | 1995-07-19 | 1999-06-10 | Merck Frosst Company | Method of treating colonic adenomas |
| AU1131800A (en) * | 1998-10-23 | 2000-05-15 | Dow Agrosciences Llc | 3-(substituted phenyl)-5-(substituted heterocyclyl)-1,2,4-triazole compounds |
| KR100567125B1 (ko) | 2001-11-01 | 2006-03-31 | 주식회사 안지오랩 | 칼콘 또는 이의 유도체를 함유하는 매트릭스메탈로프로테아제 활성 억제용 약학 조성물 |
| KR100484525B1 (ko) * | 2002-10-15 | 2005-04-20 | 씨제이 주식회사 | 이소티아졸 유도체, 그 제조방법 및 약제학적 조성물 |
| WO2005034952A2 (en) * | 2003-10-07 | 2005-04-21 | The Feinstein Institute For Medical Research | Isoxazole and isothiazole compounds useful in the treatment of inflammation |
| TWI262618B (en) * | 2004-11-03 | 2006-09-21 | Tatung Co | A co-precipitation method for Li1+xNi1-yCoyO2-based cathode materials |
| TW200735866A (en) | 2005-11-18 | 2007-10-01 | Synta Pharmaceuticals Corp | Compounds for the treatment of proliferative disorders |
| WO2008033449A2 (en) * | 2006-09-14 | 2008-03-20 | Synta Pharmaceuticals Corp. | Compounds for the treatment of angiogenesis |
-
2006
- 2006-11-16 TW TW095142385A patent/TW200735866A/zh unknown
- 2006-11-17 US US11/601,590 patent/US7572821B2/en not_active Expired - Fee Related
- 2006-11-17 AU AU2006318709A patent/AU2006318709B2/en not_active Ceased
- 2006-11-17 CA CA002628958A patent/CA2628958A1/en not_active Abandoned
- 2006-11-17 EP EP06837993.2A patent/EP1966172B1/en active Active
- 2006-11-17 JP JP2008541386A patent/JP5344923B2/ja not_active Expired - Fee Related
- 2006-11-17 WO PCT/US2006/044799 patent/WO2007061909A1/en not_active Ceased
-
2009
- 2009-07-02 US US12/496,902 patent/US8058297B2/en not_active Expired - Fee Related
-
2011
- 2011-10-07 US US13/269,042 patent/US8399435B2/en not_active Expired - Fee Related
-
2013
- 2013-03-05 US US13/785,724 patent/US20130203824A1/en not_active Abandoned
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