JP2009514877A5 - - Google Patents

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Publication number
JP2009514877A5
JP2009514877A5 JP2008539062A JP2008539062A JP2009514877A5 JP 2009514877 A5 JP2009514877 A5 JP 2009514877A5 JP 2008539062 A JP2008539062 A JP 2008539062A JP 2008539062 A JP2008539062 A JP 2008539062A JP 2009514877 A5 JP2009514877 A5 JP 2009514877A5
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JP
Japan
Prior art keywords
composition
chain
nucleotides
duplex region
strand
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2008539062A
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English (en)
Japanese (ja)
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JP2009514877A (ja
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Publication date
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Priority claimed from PCT/US2006/042978 external-priority patent/WO2007056153A2/en
Publication of JP2009514877A publication Critical patent/JP2009514877A/ja
Publication of JP2009514877A5 publication Critical patent/JP2009514877A5/ja
Pending legal-status Critical Current

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JP2008539062A 2005-11-04 2006-11-03 siRNAの送達媒体としてのペプチド−ダイザ基質RNA抱合体 Pending JP2009514877A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US73366505P 2005-11-04 2005-11-04
US82289606P 2006-08-18 2006-08-18
PCT/US2006/042978 WO2007056153A2 (en) 2005-11-04 2006-11-03 Peptide-dicer substrate rna conjugates as delivery vehicles for sirna

Publications (2)

Publication Number Publication Date
JP2009514877A JP2009514877A (ja) 2009-04-09
JP2009514877A5 true JP2009514877A5 (ru) 2009-12-17

Family

ID=37873110

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2008539062A Pending JP2009514877A (ja) 2005-11-04 2006-11-03 siRNAの送達媒体としてのペプチド−ダイザ基質RNA抱合体

Country Status (7)

Country Link
EP (1) EP1942943A2 (ru)
JP (1) JP2009514877A (ru)
KR (1) KR20080066987A (ru)
AU (1) AU2006311912A1 (ru)
CA (1) CA2628113A1 (ru)
IL (1) IL191147A0 (ru)
WO (1) WO2007056153A2 (ru)

Families Citing this family (93)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2576677T3 (es) 2003-03-21 2016-07-08 Roche Innovation Center Copenhagen A/S Análogos de ARN interfirientes cortos
WO2005068616A2 (en) 2004-01-16 2005-07-28 Fraunhofer Gesellschaft zur Förderung der angewandten Forschung e.V. Immunokinases
US20070213293A1 (en) * 2005-04-08 2007-09-13 Nastech Pharmaceutical Company Inc. Rnai therapeutic for respiratory virus infection
EP1800695A1 (en) 2005-12-21 2007-06-27 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. Immuno-RNA-constructs
ES2556128T3 (es) 2006-03-23 2016-01-13 Roche Innovation Center Copenhagen A/S ARN interfiriente pequeño internamente segmentado
CA2663601C (en) * 2006-09-22 2014-11-25 Dharmacon, Inc. Duplex oligonucleotide complexes and methods for gene silencing by rna interference
JP5876637B2 (ja) * 2006-10-18 2016-03-02 マリーナ バイオテック,インコーポレイテッド ニックまたはギャップの入った核酸分子およびそれらの使用
DE102007008596B4 (de) 2007-02-15 2010-09-02 Friedrich-Schiller-Universität Jena Biologisch wirksame Moleküle auf Grundlage von PNA und siRNA, Verfahren zu deren zellspezifischen Aktivierung sowie Applikationskit zur Verabreichung
WO2008109558A2 (en) * 2007-03-02 2008-09-12 Mdrna, Inc. Nucleic acid compounds for inhibiting tlr gene expression and uses thereof
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US20080286866A1 (en) * 2007-03-02 2008-11-20 Nastech Pharmaceutical Company Inc. Nucleic acid compounds for inhibiting vegf gene expression and uses thereof
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WO2008109374A1 (en) * 2007-03-02 2008-09-12 Mdrna, Inc. Nucleic acid compounds for inhibiting mapk gene expression and uses thereof
US20080293136A1 (en) * 2007-03-02 2008-11-27 Nastech Pharmaceutical Company Inc. Nucleic acid compounds for inhibiting akt gene expression and uses thereof
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WO2008109380A2 (en) * 2007-03-02 2008-09-12 Mdrna, Inc. Nucleic acid compounds for inhibiting vegfr family gene expression and uses thereof
JP2010519913A (ja) * 2007-03-02 2010-06-10 エムディーアールエヌエー,インコーポレイテッド Wnt遺伝子の発現を抑制するための核酸化合物およびその使用
WO2008109503A1 (en) * 2007-03-02 2008-09-12 Mdrna, Inc. Nucleic acid compounds for inhibiting ms4a1 gene expression and uses thereof
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EP2126081A2 (en) * 2007-03-02 2009-12-02 MDRNA, Inc. Nucleic acid compounds for inhibiting hif1a gene expression and uses thereof
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WO2008109497A1 (en) * 2007-03-02 2008-09-12 Mdrna, Inc. Nucleic acid compounds for inhibiting folh1 gene expression and uses thereof
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WO2008109369A2 (en) * 2007-03-02 2008-09-12 Mdrna, Inc. Nucleic acid compounds for inhibiting tnf gene expression and uses thereof
JP2010519911A (ja) * 2007-03-02 2010-06-10 エムディーアールエヌエー,インコーポレイテッド Myc遺伝子の発現を抑制するための核酸化合物およびその使用
WO2008109511A1 (en) * 2007-03-02 2008-09-12 Mdrna, Inc. Nucleic acid compounds for inhibiting fcer2 gene expression and uses thereof
WO2008109355A1 (en) * 2007-03-02 2008-09-12 Mdrna, Inc. Nucleic acid compounds for inhibiting srd5a2 gene expression and uses thereof
WO2008109495A2 (en) * 2007-03-02 2008-09-12 Mdrna, Inc. Nucleic acid compounds for inhibiting cd40 gene expression and uses thereof
WO2008109498A2 (en) * 2007-03-02 2008-09-12 Mdrna, Inc. Nucleic acid compounds for inhibiting hdac gene expression and uses thereof
WO2008109492A1 (en) * 2007-03-02 2008-09-12 Mdrna, Inc. Nucleic acid compounds for inhibiting igf1r gene expression and uses thereof
WO2008109372A2 (en) * 2007-03-02 2008-09-12 Mdrna, Inc. Nucleic acid compounds for inhibiting pdgf gene expression and uses thereof
JP2010519912A (ja) * 2007-03-02 2010-06-10 エムディーアールエヌエー,インコーポレイテッド Ras遺伝子の発現を抑制するための核酸化合物およびその使用
WO2008109487A2 (en) * 2007-03-02 2008-09-12 Mdrna, Inc. Nucleic acid compounds for inhibiting mme gene expression and uses thereof
WO2008109547A2 (en) * 2007-03-02 2008-09-12 Mdrna, Inc. Nucleic acid compounds for inhibiting tymp gene expression and uses thereof
EP2226384B1 (en) * 2007-12-18 2016-03-02 Napa Jenomics Co., Ltd. Complex of polysaccharide and double-stranded rna
DE102009043743B4 (de) 2009-03-13 2016-10-13 Friedrich-Schiller-Universität Jena Zellspezifisch wirksame Moleküle auf Grundlage von siRNA sowie Applikationskits zu deren Herstellung und Verwendung
US11414664B2 (en) 2008-12-18 2022-08-16 Dicerna Pharmaceuticals, Inc. Extended dicer substrate agents and methods for the specific inhibition of gene expression
CN102325534B (zh) 2008-12-18 2016-02-17 戴瑟纳制药公司 延长的dicer酶底物和特异性抑制基因表达的方法
WO2010093788A2 (en) * 2009-02-11 2010-08-19 Dicerna Pharmaceuticals, Inc. Multiplex dicer substrate rna interference molecules having joining sequences
US9096850B2 (en) 2009-08-24 2015-08-04 Sirna Therapeutics, Inc. Segmented micro RNA mimetics
US20130079382A1 (en) 2009-10-12 2013-03-28 Larry J. Smith Methods and Compositions for Modulating Gene Expression Using Oligonucleotide Based Drugs Administered in vivo or in vitro
DK2519632T3 (en) * 2009-12-31 2018-07-23 Curna Inc TREATMENT OF INSULIN RECEPTOR SUBSTRATE 2- (IRS2) RELATED DISEASES BY INHIBITION OF NATURAL ANTISENSE TRANSCRIPTION TO IRS2 AND TRANSCRIPTION FACTOR E3 (TFE3)
KR101678876B1 (ko) * 2010-01-15 2016-11-23 한국과학기술원 복합 유전자를 표적하는 siRNA 다중 접합체 및 이의 제조방법
DE102010009445A1 (de) * 2010-02-25 2011-08-25 Universitätsklinikum Jena, 07743 Expressionsvektor zur Enzym-Expression in Zellen und Verfahren zu dessen Verwendung
UY33326A (es) 2010-04-14 2011-12-01 Sanofi Aventis Conjugados de insulina-sirna
WO2012068187A1 (en) * 2010-11-19 2012-05-24 Merck Sharp & Dohme Corp. Poly(amide) polymers for the delivery of oligonucleotides
DK2983706T3 (en) * 2013-04-10 2021-06-14 Univ Aarhus Use of Immune Suppressive Domains as Medicaments
EP3408391A4 (en) 2016-01-31 2019-08-28 University of Massachusetts BRANCHED OLIGONUCLEOTIDES
MX2021001590A (es) 2018-08-10 2021-07-02 Univ Massachusetts Oligonucleótidos modificados dirigidos a snp.
WO2020150636A1 (en) * 2019-01-18 2020-07-23 University Of Massachusetts Dynamic pharmacokinetic-modifying anchors
JP2024523509A (ja) 2021-06-23 2024-06-28 ユニバーシティー オブ マサチューセッツ 子癇前症及び他の血管新生障害の治療のために最適化された抗flt1オリゴヌクレオチド化合物

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP3581877B2 (ja) * 1995-05-12 2004-10-27 独立行政法人産業技術総合研究所 機能性分子輸送体
US20030092180A1 (en) * 2001-08-27 2003-05-15 David Lewis Inhibition of gene expression by delivery of small interfering RNA to post-embryonic animal cells in vivo
JPH1121255A (ja) * 1997-07-02 1999-01-26 Hisamitsu Pharmaceut Co Inc 機能性分子輸送体及びその製造方法
RU2002130203A (ru) * 2000-04-12 2004-03-27 Импликс Лтд. (Gb) Пептидные конъюгаты для доставки лекарственного средства
AU2003217550A1 (en) * 2002-02-20 2003-09-09 Ribozyme Pharmaceuticals, Incorporated RNA INTERFERENCE MEDIATED INHIBITION OF TNF AND TNF RECEPTOR SUPERFAMILY GENE EXPRESSION USING SHORT INTERFERING NUCLEIC ACID (siNA)
WO2003086273A2 (en) * 2002-04-08 2003-10-23 Yissum Research Development Company Of The Hebrew University Of Jerusalem Histone conjugates and uses thereof
EP1527176B2 (en) * 2002-08-05 2017-03-22 Silence Therapeutics GmbH Further novel forms of interfering rna molecules
WO2004028471A2 (en) * 2002-09-28 2004-04-08 Massachusetts Institute Of Technology Influenza therapeutic
AU2003291755A1 (en) * 2002-11-05 2004-06-07 Isis Pharmaceuticals, Inc. Oligomers comprising modified bases for binding cytosine and uracil or thymine and their use
EP1560839A4 (en) * 2002-11-05 2008-04-23 Isis Pharmaceuticals Inc CHIMERIC OLIGOMER COMPOUNDS AND THEIR USE IN GENE MODULATION
DE60332277D1 (de) * 2002-11-26 2010-06-02 Univ Massachusetts Verabreichung von sirnas
MXPA06012605A (es) * 2004-05-04 2006-12-15 Nastech Pharm Co Composiciones y metodos para mejorar el suministro de acidos nucleicos en celulas y para modificar la expresion de genes objetivo en celulas.
US20060040882A1 (en) * 2004-05-04 2006-02-23 Lishan Chen Compostions and methods for enhancing delivery of nucleic acids into cells and for modifying expression of target genes in cells

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