JP2009514507A5 - - Google Patents
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- Publication number
- JP2009514507A5 JP2009514507A5 JP2008522858A JP2008522858A JP2009514507A5 JP 2009514507 A5 JP2009514507 A5 JP 2009514507A5 JP 2008522858 A JP2008522858 A JP 2008522858A JP 2008522858 A JP2008522858 A JP 2008522858A JP 2009514507 A5 JP2009514507 A5 JP 2009514507A5
- Authority
- JP
- Japan
- Prior art keywords
- polypeptide
- nucleic acid
- acid molecule
- seq
- isolated
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- 108090000765 processed proteins & peptides Proteins 0.000 claims 44
- 229920001184 polypeptide Polymers 0.000 claims 39
- 102000004196 processed proteins & peptides Human genes 0.000 claims 39
- 150000007523 nucleic acids Chemical class 0.000 claims 35
- 108020004707 nucleic acids Proteins 0.000 claims 29
- 102000039446 nucleic acids Human genes 0.000 claims 29
- 238000000034 method Methods 0.000 claims 18
- 239000000203 mixture Substances 0.000 claims 9
- 239000000126 substance Substances 0.000 claims 8
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 7
- 150000001875 compounds Chemical class 0.000 claims 7
- 239000012472 biological sample Substances 0.000 claims 6
- 108091028043 Nucleic acid sequence Proteins 0.000 claims 5
- 230000006870 function Effects 0.000 claims 5
- 235000013361 beverage Nutrition 0.000 claims 4
- 235000019658 bitter taste Nutrition 0.000 claims 4
- 239000002537 cosmetic Substances 0.000 claims 4
- 239000000551 dentifrice Substances 0.000 claims 4
- 235000013305 food Nutrition 0.000 claims 4
- 239000002324 mouth wash Substances 0.000 claims 4
- 230000008447 perception Effects 0.000 claims 4
- -1 antibody Proteins 0.000 claims 3
- 108090000623 proteins and genes Proteins 0.000 claims 3
- 102000004169 proteins and genes Human genes 0.000 claims 3
- 150000003384 small molecules Chemical class 0.000 claims 3
- 108020004705 Codon Proteins 0.000 claims 2
- 230000004913 activation Effects 0.000 claims 2
- 239000000556 agonist Substances 0.000 claims 2
- 238000003556 assay Methods 0.000 claims 2
- 235000019611 bitter taste sensations Nutrition 0.000 claims 2
- RRKTZKIUPZVBMF-IBTVXLQLSA-N brucine Chemical compound O([C@@H]1[C@H]([C@H]2C3)[C@@H]4N(C(C1)=O)C=1C=C(C(=CC=11)OC)OC)CC=C2CN2[C@@H]3[C@]41CC2 RRKTZKIUPZVBMF-IBTVXLQLSA-N 0.000 claims 2
- RRKTZKIUPZVBMF-UHFFFAOYSA-N brucine Natural products C1=2C=C(OC)C(OC)=CC=2N(C(C2)=O)C3C(C4C5)C2OCC=C4CN2C5C31CC2 RRKTZKIUPZVBMF-UHFFFAOYSA-N 0.000 claims 2
- 239000003814 drug Substances 0.000 claims 2
- 230000000694 effects Effects 0.000 claims 2
- 230000002068 genetic effect Effects 0.000 claims 2
- 239000003112 inhibitor Substances 0.000 claims 2
- 238000002955 isolation Methods 0.000 claims 2
- 239000003446 ligand Substances 0.000 claims 2
- 239000000463 material Substances 0.000 claims 2
- 229940051866 mouthwash Drugs 0.000 claims 2
- 150000003839 salts Chemical class 0.000 claims 2
- 230000030812 sensory perception of bitter taste Effects 0.000 claims 2
- 239000000243 solution Substances 0.000 claims 2
- 230000027455 binding Effects 0.000 claims 1
- 230000002708 enhancing effect Effects 0.000 claims 1
- 108091005708 gustatory receptors Proteins 0.000 claims 1
- 238000009396 hybridization Methods 0.000 claims 1
- 230000000984 immunochemical effect Effects 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 239000000825 pharmaceutical preparation Substances 0.000 claims 1
- 229940127557 pharmaceutical product Drugs 0.000 claims 1
- 108020003175 receptors Proteins 0.000 claims 1
- 238000003259 recombinant expression Methods 0.000 claims 1
- 239000000523 sample Substances 0.000 claims 1
- 230000009870 specific binding Effects 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US11/182,942 US20060019346A1 (en) | 2002-07-29 | 2005-07-18 | Identification of a novel bitter taste receptor T2R76 that specifically responds to brucine and prop bitter ligands |
| PCT/US2006/027656 WO2007011859A2 (en) | 2005-07-18 | 2006-07-17 | Identification of a novel bitter taste receptor t2r76 that specifically responds to brucine and prop bitter ligands |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2009514507A JP2009514507A (ja) | 2009-04-09 |
| JP2009514507A5 true JP2009514507A5 (https=) | 2009-07-30 |
Family
ID=37669462
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008522858A Withdrawn JP2009514507A (ja) | 2005-07-18 | 2006-07-17 | ブルシンおよびｐｒｏｐ苦味リガンドに特異的に応答する新規苦味受容体ｔ２ｒ７６の同定 |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US20060019346A1 (https=) |
| EP (1) | EP1904527A4 (https=) |
| JP (1) | JP2009514507A (https=) |
| CN (1) | CN101595118A (https=) |
| AU (1) | AU2006270110A1 (https=) |
| CA (1) | CA2610237A1 (https=) |
| IL (1) | IL187827A0 (https=) |
| MX (1) | MX2007015930A (https=) |
| NO (1) | NO20076201L (https=) |
| WO (1) | WO2007011859A2 (https=) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2004011617A2 (en) * | 2002-07-29 | 2004-02-05 | Senomyx, Inc. | Identification of a novel bitter taste receptor, t2r76 |
| WO2006068745A1 (en) | 2004-12-22 | 2006-06-29 | Cargill, Incorporated | Methods for determining cellular response to stimuli |
| WO2008008224A2 (en) | 2006-07-10 | 2008-01-17 | Duke University | Sour taste receptor compositions and methods |
| EP2245171A2 (en) * | 2008-02-01 | 2010-11-03 | Chromocell Corporation | Cell lines and methods for making and using them |
| US8557530B2 (en) | 2008-08-29 | 2013-10-15 | Givaudan Sa | Use of a TAS2R7 nucleic acid sequence to identify modulators |
| CN103068380A (zh) * | 2010-06-17 | 2013-04-24 | 加州理工学院 | 用于调节激素的方法和系统以及相关的方法、剂和组合物 |
| HUE051738T2 (hu) | 2011-01-07 | 2021-03-29 | Anji Pharma Us Llc | Kemoszenzoros receptorligandum-alapú terápiák |
| US9795792B2 (en) | 2011-02-25 | 2017-10-24 | Medtronic, Inc. | Emergency mode switching for non-pacing modes |
| KR20200137035A (ko) | 2012-01-06 | 2020-12-08 | 앤지 파마 유에스 엘엘씨 | 바이구아나이드 조성물 및 대사 장애를 치료하는 방법 |
| EA033067B1 (ru) | 2012-01-06 | 2019-08-30 | Элселикс Терапьютикс, Инк. | Способ лечения метаболических расстройств у пациента, имеющего противопоказание к назначению бигуанидного соединения |
| CA2878625A1 (en) | 2012-07-11 | 2014-01-16 | Elcelyx Therapeutics, Inc. | Compositions comprising statins, biguanides and further agents for reducing cardiometabolic risk |
| CN105101956B (zh) | 2013-01-05 | 2018-12-07 | 埃尔舍利克斯治疗公司 | 包含双胍的延迟释放组合物 |
| EP4566459A3 (en) * | 2018-08-10 | 2025-08-20 | Firmenich Incorporated | Antagonists of t2r54 and compositions and uses thereof |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6004808A (en) * | 1996-06-21 | 1999-12-21 | Aurora Biosciences Corporation | Promiscuous G-protein compositions and their use |
| JP2003057981A (ja) * | 2001-08-17 | 2003-02-28 | Nitto Kogyo Co Ltd | 定着装置 |
| WO2004011617A2 (en) * | 2002-07-29 | 2004-02-05 | Senomyx, Inc. | Identification of a novel bitter taste receptor, t2r76 |
-
2005
- 2005-07-18 US US11/182,942 patent/US20060019346A1/en not_active Abandoned
-
2006
- 2006-07-17 CN CNA2006800235890A patent/CN101595118A/zh active Pending
- 2006-07-17 MX MX2007015930A patent/MX2007015930A/es not_active Application Discontinuation
- 2006-07-17 AU AU2006270110A patent/AU2006270110A1/en not_active Abandoned
- 2006-07-17 CA CA002610237A patent/CA2610237A1/en not_active Abandoned
- 2006-07-17 EP EP06800086A patent/EP1904527A4/en not_active Withdrawn
- 2006-07-17 WO PCT/US2006/027656 patent/WO2007011859A2/en not_active Ceased
- 2006-07-17 JP JP2008522858A patent/JP2009514507A/ja not_active Withdrawn
-
2007
- 2007-12-03 IL IL187827A patent/IL187827A0/en unknown
- 2007-12-03 NO NO20076201A patent/NO20076201L/no not_active Application Discontinuation
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