JP2009514507A5 - - Google Patents

Info

Publication number

JP2009514507A5

JP2009514507A5 JP2008522858A JP2008522858A JP2009514507A5 JP 2009514507 A5 JP2009514507 A5 JP 2009514507A5 JP 2008522858 A JP2008522858 A JP 2008522858A JP 2008522858 A JP2008522858 A JP 2008522858A JP 2009514507 A5 JP2009514507 A5 JP 2009514507A5

Authority

JP

Japan

Prior art keywords

polypeptide

nucleic acid

acid molecule

seq

isolated

Prior art date

2006-07-17

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Withdrawn

Links

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• 108090000765 processed proteins & peptides Proteins 0.000 claims 44
• 229920001184 polypeptide Polymers 0.000 claims 39
• 102000004196 processed proteins & peptides Human genes 0.000 claims 39
• 150000007523 nucleic acids Chemical class 0.000 claims 35
• 108020004707 nucleic acids Proteins 0.000 claims 29
• 102000039446 nucleic acids Human genes 0.000 claims 29
• 238000000034 method Methods 0.000 claims 18
• 239000000203 mixture Substances 0.000 claims 9
• 239000000126 substance Substances 0.000 claims 8
• FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 7
• 150000001875 compounds Chemical class 0.000 claims 7
• 239000012472 biological sample Substances 0.000 claims 6
• 108091028043 Nucleic acid sequence Proteins 0.000 claims 5
• 230000006870 function Effects 0.000 claims 5
• 235000013361 beverage Nutrition 0.000 claims 4
• 235000019658 bitter taste Nutrition 0.000 claims 4
• 239000002537 cosmetic Substances 0.000 claims 4
• 239000000551 dentifrice Substances 0.000 claims 4
• 235000013305 food Nutrition 0.000 claims 4
• 239000002324 mouth wash Substances 0.000 claims 4
• 230000008447 perception Effects 0.000 claims 4
• -1 antibody Proteins 0.000 claims 3
• 108090000623 proteins and genes Proteins 0.000 claims 3
• 102000004169 proteins and genes Human genes 0.000 claims 3
• 150000003384 small molecules Chemical class 0.000 claims 3
• 108020004705 Codon Proteins 0.000 claims 2
• 230000004913 activation Effects 0.000 claims 2
• 239000000556 agonist Substances 0.000 claims 2
• 238000003556 assay Methods 0.000 claims 2
• 235000019611 bitter taste sensations Nutrition 0.000 claims 2
• RRKTZKIUPZVBMF-IBTVXLQLSA-N brucine Chemical compound O([C@@H]1[C@H]([C@H]2C3)[C@@H]4N(C(C1)=O)C=1C=C(C(=CC=11)OC)OC)CC=C2CN2[C@@H]3[C@]41CC2 RRKTZKIUPZVBMF-IBTVXLQLSA-N 0.000 claims 2
• RRKTZKIUPZVBMF-UHFFFAOYSA-N brucine Natural products C1=2C=C(OC)C(OC)=CC=2N(C(C2)=O)C3C(C4C5)C2OCC=C4CN2C5C31CC2 RRKTZKIUPZVBMF-UHFFFAOYSA-N 0.000 claims 2
• 239000003814 drug Substances 0.000 claims 2
• 230000000694 effects Effects 0.000 claims 2
• 230000002068 genetic effect Effects 0.000 claims 2
• 239000003112 inhibitor Substances 0.000 claims 2
• 238000002955 isolation Methods 0.000 claims 2
• 239000003446 ligand Substances 0.000 claims 2
• 239000000463 material Substances 0.000 claims 2
• 229940051866 mouthwash Drugs 0.000 claims 2
• 150000003839 salts Chemical class 0.000 claims 2
• 230000030812 sensory perception of bitter taste Effects 0.000 claims 2
• 239000000243 solution Substances 0.000 claims 2
• 230000027455 binding Effects 0.000 claims 1
• 230000002708 enhancing effect Effects 0.000 claims 1
• 108091005708 gustatory receptors Proteins 0.000 claims 1
• 238000009396 hybridization Methods 0.000 claims 1
• 230000000984 immunochemical effect Effects 0.000 claims 1
• 238000004519 manufacturing process Methods 0.000 claims 1
• 239000000825 pharmaceutical preparation Substances 0.000 claims 1
• 229940127557 pharmaceutical product Drugs 0.000 claims 1
• 108020003175 receptors Proteins 0.000 claims 1
• 238000003259 recombinant expression Methods 0.000 claims 1
• 239000000523 sample Substances 0.000 claims 1
• 230000009870 specific binding Effects 0.000 claims 1