CN101595118A - 鉴定特异应答番木鳖碱和prop苦味配体的新的苦味受体t2r76 - Google Patents

鉴定特异应答番木鳖碱和prop苦味配体的新的苦味受体t2r76 Download PDF

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Publication number
CN101595118A
CN101595118A CNA2006800235890A CN200680023589A CN101595118A CN 101595118 A CN101595118 A CN 101595118A CN A2006800235890 A CNA2006800235890 A CN A2006800235890A CN 200680023589 A CN200680023589 A CN 200680023589A CN 101595118 A CN101595118 A CN 101595118A
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CN
China
Prior art keywords
polypeptide
nucleic acid
acid molecule
seq
isolated nucleic
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
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CNA2006800235890A
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English (en)
Chinese (zh)
Inventor
徐红
李晓东
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Firmenich Inc
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Senomyx Inc
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Publication date
Application filed by Senomyx Inc filed Critical Senomyx Inc
Publication of CN101595118A publication Critical patent/CN101595118A/zh
Pending legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2799/00—Uses of viruses
    • C12N2799/02—Uses of viruses as vector
    • C12N2799/021—Uses of viruses as vector for the expression of a heterologous nucleic acid
    • C12N2799/026—Uses of viruses as vector for the expression of a heterologous nucleic acid where the vector is derived from a baculovirus
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2500/00—Screening for compounds of potential therapeutic value

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Cell Biology (AREA)
  • Zoology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Molecular Biology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Genetics & Genomics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Toxicology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Cosmetics (AREA)
CNA2006800235890A 2005-07-18 2006-07-17 鉴定特异应答番木鳖碱和prop苦味配体的新的苦味受体t2r76 Pending CN101595118A (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US11/182,942 2005-07-18
US11/182,942 US20060019346A1 (en) 2002-07-29 2005-07-18 Identification of a novel bitter taste receptor T2R76 that specifically responds to brucine and prop bitter ligands

Publications (1)

Publication Number Publication Date
CN101595118A true CN101595118A (zh) 2009-12-02

Family

ID=37669462

Family Applications (1)

Application Number Title Priority Date Filing Date
CNA2006800235890A Pending CN101595118A (zh) 2005-07-18 2006-07-17 鉴定特异应答番木鳖碱和prop苦味配体的新的苦味受体t2r76

Country Status (10)

Country Link
US (1) US20060019346A1 (https=)
EP (1) EP1904527A4 (https=)
JP (1) JP2009514507A (https=)
CN (1) CN101595118A (https=)
AU (1) AU2006270110A1 (https=)
CA (1) CA2610237A1 (https=)
IL (1) IL187827A0 (https=)
MX (1) MX2007015930A (https=)
NO (1) NO20076201L (https=)
WO (1) WO2007011859A2 (https=)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN113194742A (zh) * 2018-08-10 2021-07-30 弗门尼舍公司 T2r54的拮抗剂以及它们的组合物及其用途

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004011617A2 (en) * 2002-07-29 2004-02-05 Senomyx, Inc. Identification of a novel bitter taste receptor, t2r76
WO2006068745A1 (en) 2004-12-22 2006-06-29 Cargill, Incorporated Methods for determining cellular response to stimuli
WO2008008224A2 (en) 2006-07-10 2008-01-17 Duke University Sour taste receptor compositions and methods
EP2245171A2 (en) * 2008-02-01 2010-11-03 Chromocell Corporation Cell lines and methods for making and using them
US8557530B2 (en) 2008-08-29 2013-10-15 Givaudan Sa Use of a TAS2R7 nucleic acid sequence to identify modulators
CN103068380A (zh) * 2010-06-17 2013-04-24 加州理工学院 用于调节激素的方法和系统以及相关的方法、剂和组合物
HUE051738T2 (hu) 2011-01-07 2021-03-29 Anji Pharma Us Llc Kemoszenzoros receptorligandum-alapú terápiák
US9795792B2 (en) 2011-02-25 2017-10-24 Medtronic, Inc. Emergency mode switching for non-pacing modes
KR20200137035A (ko) 2012-01-06 2020-12-08 앤지 파마 유에스 엘엘씨 바이구아나이드 조성물 및 대사 장애를 치료하는 방법
EA033067B1 (ru) 2012-01-06 2019-08-30 Элселикс Терапьютикс, Инк. Способ лечения метаболических расстройств у пациента, имеющего противопоказание к назначению бигуанидного соединения
CA2878625A1 (en) 2012-07-11 2014-01-16 Elcelyx Therapeutics, Inc. Compositions comprising statins, biguanides and further agents for reducing cardiometabolic risk
CN105101956B (zh) 2013-01-05 2018-12-07 埃尔舍利克斯治疗公司 包含双胍的延迟释放组合物

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6004808A (en) * 1996-06-21 1999-12-21 Aurora Biosciences Corporation Promiscuous G-protein compositions and their use
JP2003057981A (ja) * 2001-08-17 2003-02-28 Nitto Kogyo Co Ltd 定着装置
WO2004011617A2 (en) * 2002-07-29 2004-02-05 Senomyx, Inc. Identification of a novel bitter taste receptor, t2r76

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN113194742A (zh) * 2018-08-10 2021-07-30 弗门尼舍公司 T2r54的拮抗剂以及它们的组合物及其用途

Also Published As

Publication number Publication date
WO2007011859A2 (en) 2007-01-25
EP1904527A2 (en) 2008-04-02
CA2610237A1 (en) 2007-01-25
MX2007015930A (es) 2008-03-06
EP1904527A4 (en) 2010-05-05
AU2006270110A1 (en) 2007-01-25
JP2009514507A (ja) 2009-04-09
NO20076201L (no) 2008-04-17
WO2007011859A3 (en) 2009-08-27
IL187827A0 (en) 2008-03-20
US20060019346A1 (en) 2006-01-26

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C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
C02 Deemed withdrawal of patent application after publication (patent law 2001)
WD01 Invention patent application deemed withdrawn after publication

Application publication date: 20091202