JP2009513528A - 微粉末形態の送達物質を含む経口投与用医薬組成物 - Google Patents
微粉末形態の送達物質を含む経口投与用医薬組成物 Download PDFInfo
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- JP2009513528A JP2009513528A JP2006518162A JP2006518162A JP2009513528A JP 2009513528 A JP2009513528 A JP 2009513528A JP 2006518162 A JP2006518162 A JP 2006518162A JP 2006518162 A JP2006518162 A JP 2006518162A JP 2009513528 A JP2009513528 A JP 2009513528A
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Abstract
Description
1.発明の分野
本発明は、薬理学的に活性な薬物の送達のための経口組成物、経口投与された薬理学的に活性な薬物のバイオアベイラビリティを増大する方法、および本発明の薬理学的に活性な薬物を経口投与することにより、哺乳動物、特にヒトにおける疾患を処置および/または予防する方法に関する。
薬理学的に活性な薬物の経口送達は一般に、それが便利で、比較的容易で、かつ一般に無痛であり、結果として他の送達方法と比較して患者のコンプライアンスを高めるため、選択される送達経路である。しかしながら、胃腸管内の様々なpH、強力な消化酵素および活性薬物不透過性胃腸膜などの生物学的、化学的および物理的バリアーが、哺乳動物へのいくつかの薬理学的に活性な薬物の経口送達、例えばカルシトニン(それは、哺乳動物における甲状腺の傍濾胞細胞ならびに鳥類および魚類の後鰓の腺から分泌される長鎖ポリペプチドホルモンである)の経口送達を難しい問題としており、それは、少なくとも一部は、胃腸管中カルシトニンの不十分な安定性、ならびにカルシトニンが容易に腸壁を通って血流に移動できないことによることが証明されている。
R1、R2、R3およびR4は、独立して、水素、−OH、−NR6R7、ハロゲン、C1−C4アルキルまたはC1−C4アルコキシであり;
R5は、置換もしくは非置換C2−C16アルキレン、置換もしくは非置換C2−C16アルケニレン、置換もしくは非置換C1−C12アルキル(アリーレン)、または置換もしくは非置換アリール(C1−C12アルキレン)であり;および
R6およびR7は、独立して水素、酸素、またはC1−C4アルキルである]
の二ナトリウム塩;ならびにその水和物および溶媒和物を、カルシトニン、シクロスポリンおよびヘパリンなどの活性薬物の経口送達に特に有効であるとして開示する。
従って、本発明は、非常に驚くほどに、活性薬物、特にペプチドの経口バイオアベイラビリティを大きく高める医薬組成物を対象とする。具体的には、本発明は、
1.治療的有効量の薬理学的に活性な薬物;
2.薬学的に許容される不活性な賦形剤;および
3.該薬理学的に活性な薬物のための送達物質(ここで、該送達物質は、微粉末形態である)
を含む、薬理学的に活性な薬物の経口送達に好適な固形の医薬組成物を提供する。
1.治療的有効量のカルシトニン;
2.薬学的に許容される不活性な賦形剤;および
3.該カルシトニンのための送達物質(ここで該送達物質は、微粉末形態である)
を含む、カルシトニンの経口送達に好適な固形の医薬組成物を提供する。
本発明のさらなる態様にて、経口送達に好適な固形の医薬組成物は、希釈剤も含んでいてよい。
さらなる態様にて、本発明は、薬理学的に活性な薬物の経口バイオアベイラビリティを増大するための方法であって、有効量の本発明の医薬組成物を該薬理学的に活性な薬物を必要とする対象に対して投与することを含む方法を対象とする。
本発明のさらなる特徴および利点は、以下の本発明の詳しい説明により明らかになるであろう。
本発明における使用に好適な前記薬理学的に活性な薬物は、治療的ならびに予防的薬物の両方を含み、そしてそれらだけで胃腸粘膜を通過しないかまたは少量の投与量のみが通過する薬物、および/または胃腸管にて酸および酵素により切断されやすい薬物を特に対象とする。薬理学的に活性な薬物には、タンパク質;ポリペプチド;ホルモン;ムコ多糖の混合物を含む多糖類;炭水化物;脂質;およびその組合せが含まれるが、それらに限定されない。
薬理学的に活性な薬物の量とは一般に、所望の目的を達成するための有効量、例えば、治療的有効量である。しかしながら、その量は、複数の組成物が投与されるとき、すなわち、全有効量が累積的投与量単位で投与され得るとき、より少なくなり得る。活性薬物の量はまた、前記組成物が、薬理学的に活性な薬物の持続的放出を提供するとき、前記有効量より多くなり得る。用いる活性薬物の全量は、当業者に公知の方法により測定され得る。しかしながら、前記組成物が、従前の組成物よりも効果的に活性薬物を送達し得るため、従前の投与量単位形態または送達系に用いられるより少ない活性薬物量が、同じ血液レベルおよび/または治療効果を達成するまでの間、対象に投与され得る。
上記のように、クロスポビドンおよびポビドンは市販されている。あるいは、それらは公知の方法により合成され得る。
R1、R2、R3、およびR4は、独立して、水素、−OH、−NR6R7、ハロゲン、C1−C4アルキル、またはC1−C4アルコキシであり;
R5は、置換もしくは非置換C2−C16アルキレン、置換もしくは非置換C2−C16アルケニレン、置換もしくは非置換C1−C12アルキル(アリーレン)、または置換もしくは非置換アリール(C1−C12アルキレン)であり;および
R6およびR7は独立して、水素、酸素、またはC1−C4アルキルである]
で示される化合物、ならびにその水和物およびアルコール溶媒和物が含まれる。式Iの化合物ならびにその二ナトリウム塩およびそのアルコール溶媒和物および水和物は、その製造方法と一緒に、WO 00/059863に記載されている。
二ナトリウム塩のさらなる製造方法は、送達物質と1モル当量の水酸化ナトリウムとを反応させることにより、二ナトリウム塩を得ることである。
送達物質を、当技術分野で公知の方法、例えば上記のような、米国特許番号第5,773,647号および第5,866,536号に記載の方法により製造することができる。
微粉末化された5−CNACおよびサケカルシトニン+微粉末化された5−CNACの錠剤を、以下のように本発明に従い製造することができる:
粗5−CNAC(微粉末化すべきである)を、約700g/時間の手送りで80セラミックパンケーキ・ジェットミル(直径8cm、6バール N2、0.5mmノズル)を用いて、ジェットミル(エアージェットミル Gem T(登録商標)Copley Scientific, Ltd., Nottingham, UK)に加える。粗5−CNACをジェットミル処理し、そして標準定規測定を有する顕微鏡下で定期的にサンプリングし、いつ所望の微粉末化された粒子サイズ平均が得られるかを同定する。3つの異なるバッチを挽いて、6um、35um、および46umバッチを作成する。その後、別個の微粉末化されたバッチの個々のふるいを、U10、813um 円錐ふるい、円形ビーターを有する円錐ふるいミル(Quadro Comil, Quadro Engineering Incorporated 613 Colby Drive, Waterloo, Ontario, Canada N2V 1A1)を用いて、約150kg/hの処理量で1500upmで行う。
成分 量(mg) 割合(%)
サケ カルシトニン 1 0.25
微粉末化5−CNAC 228 57
アビセルPH 102(登録商標) 147 36.75
クロスポビドン、NF 20 5
ステアリン酸マグネシウム 4 1____
全量 400 100
錠剤の3つの異なるバッチを、微粉末化された5−CNAC二ナトリウムの3つの異なるバッチ(1つ目は、46ミクロンの平均粒子サイズの5−CNAC二ナトリウムを有する錠剤型バッチ(バッチA)であり、2つ目は、6ミクロンの平均粒子サイズの5−CNAC 二ナトリウムを有する錠剤型バッチ(バッチB)であり、3つ目は、35ミクロンの平均粒子サイズの5−CNAC二ナトリウムを有する錠剤型バッチ(バッチC)である)を用いて製造する。
霊長類投与
前記錠剤を、微粉末化された5−CNAC二ナトリウムの3つの異なるバッチ(1つ目は、46ミクロンの平均粒子サイズの5−CNAC二ナトリウムを有する錠剤型バッチ(バッチA)であり、2つ目は、6ミクロンの平均粒子サイズの5−CNAC二ナトリウムを有する錠剤型バッチ(バッチB)であり、3つ目は、35ミクロンの平均粒子サイズの5−CNAC二ナトリウムを有する錠剤型バッチ(バッチC)である)を用いて実施例1に記載のように製造する。3つの異なるバッチのそれぞれから製造された錠剤を、以下のように、異日に同じ4匹のアカゲザルそれぞれに投与する:
上記の態様および実施例は、本発明を単に説明するものとして提供され、限定する物として解釈されてはならない。多くの他の態様および変形は、本発明の範囲内であり、当業者に容易に理解される。
Claims (16)
- a.治療的有効量の薬理学的に活性な薬物;
b.薬学的に許容される不活性な賦形剤、および
c.該薬理学的に活性な薬物のための送達物質(ここで、該送達物質が微粉末形態である)
を含む、薬理学的に活性な薬物の経口送達に適する固形の医薬組成物。 - 前記活性な薬物がペプチドである、請求項1に記載の組成物。
- 前記ペプチドがカルシトニンである、請求項2に記載の組成物。
- 前記カルシトニンがサケカルシトニンである、請求項3に記載の組成物。
- 該不活性な賦形剤が、クロスポビドンおよびポビドンからなる群から選択される、請求項1に記載の組成物。
- 前記送達物質が、5−CNAC、SNADおよびSNACからなる群から選択される、請求項1に記載の組成物。
- 前記送達物質が、5−CNACの二ナトリウム塩、SNADの二ナトリウム塩およびSNACの二ナトリウム塩からなる群から選択される、請求項1に記載の組成物。
- 希釈剤をさらに含む請求項1に記載の組成物。
- 前記希釈剤が微結晶セルロースである、請求項8に記載の組成物。
- 潤滑剤をさらに含む請求項1に記載の組成物。
- 前記潤滑剤がステアリン酸マグネシウムである、請求項10に記載の組成物。
- 有効量の請求項1に記載の医薬組成物を薬理学的に活性な薬物の必要な患者に対して投与することを含む、薬理学的に活性な薬物の経口バイオアベイラビリティを増大するための方法。
- 該薬理学的に活性な薬物が骨活性化薬である、骨関連疾患およびカルシウム障害の処置の方法であって、治療的有効量の請求項1から11に記載の組成物をかかる処置が必要な患者に対して投与することを含む、方法。
- 該薬理学的に活性な薬物がカルシトニンである、請求項13に記載の方法。
- 該カルシトニンがサケカルシトニンである、請求項14に記載の方法。
- 該医薬組成物が骨活性化薬である活性薬物を含む、骨関連疾患の処置のための医薬の製造における請求項1に記載の医薬組成物の使用。
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EP1781257B1 (en) * | 2004-08-13 | 2018-12-19 | Emisphere Technologies, Inc. | Pharmaceutical formulations containing microparticles or nanoparticles of a delivery agent |
WO2007035718A2 (en) * | 2005-09-19 | 2007-03-29 | Emisphere Technologies, Inc. | Crystalline forms of the di-sodium salt of n-(5-chlorosalicyloyl)-8-aminocaprylic acid |
GB0522566D0 (en) * | 2005-11-04 | 2005-12-14 | Novartis Ag | Organic compounds |
AU2007289344B2 (en) | 2006-08-31 | 2011-04-14 | Novartis Ag | Pharmaceutical compositions comprising hGH for oral delivery |
PE20080845A1 (es) * | 2006-09-22 | 2008-08-13 | Novartis Ag | Metodo para fabricar tabletas que contienen agentes farmacologicamente activos |
BRPI0817396C8 (pt) | 2007-11-02 | 2021-05-25 | Emisphere Tech Inc | composição farmacêutica para tratar deficiência de vitamina b¹² |
MX2012009914A (es) * | 2010-02-24 | 2013-03-05 | Emisphere Tech Inc | Terapia oral de b12. |
PT2651398T (pt) | 2010-12-16 | 2018-03-09 | Novo Nordisk As | Composições sólidas compreendendo um agonista de glp-1 e um sal de ácido n-(8-(2-hidroxibenzoil)amino) caprílico |
EP2696687B1 (en) | 2011-04-12 | 2016-10-26 | Novo Nordisk A/S | Double-acylated glp-1 derivatives |
HUE062740T2 (hu) | 2012-03-22 | 2023-12-28 | Novo Nordisk As | GLP-1 peptidek készítményei és elõállításuk |
EP4331667A3 (en) | 2012-03-22 | 2024-05-08 | Novo Nordisk A/S | Compositions comprising a delivery agent and preparation thereof |
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JP6517690B2 (ja) | 2012-06-20 | 2019-05-22 | ノヴォ ノルディスク アー/エス | ペプチド及び送達剤を含む錠剤製剤 |
CN104095828A (zh) * | 2014-07-29 | 2014-10-15 | 中国药科大学 | 一种降钙素口服肠溶组合物及其制备方法 |
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US8748383B2 (en) | 2014-06-10 |
MXPA06000446A (es) | 2006-04-07 |
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US20130230593A1 (en) | 2013-09-05 |
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US20080234179A1 (en) | 2008-09-25 |
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US20070065505A1 (en) | 2007-03-22 |
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