BRPI0412458A - composições farmacêuticas oralmente dosadas compreendendo um agente de liberação na forma micronizada - Google Patents
composições farmacêuticas oralmente dosadas compreendendo um agente de liberação na forma micronizadaInfo
- Publication number
- BRPI0412458A BRPI0412458A BRPI0412458-8A BRPI0412458A BRPI0412458A BR PI0412458 A BRPI0412458 A BR PI0412458A BR PI0412458 A BRPI0412458 A BR PI0412458A BR PI0412458 A BRPI0412458 A BR PI0412458A
- Authority
- BR
- Brazil
- Prior art keywords
- pharmaceutical compositions
- pharmacologically active
- release agent
- micronized form
- orally dosed
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1617—Organic compounds, e.g. phospholipids, fats
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
- A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/23—Calcitonins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
- A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
- A61K47/183—Amino acids, e.g. glycine, EDTA or aspartame
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2013—Organic compounds, e.g. phospholipids, fats
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Physical Education & Sports Medicine (AREA)
- Immunology (AREA)
- Gastroenterology & Hepatology (AREA)
- Zoology (AREA)
- Endocrinology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Rheumatology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Permanent Magnet Type Synchronous Machine (AREA)
Abstract
"COMPOSIçõES FARMACêUTICAS ORALMENTE DOSADAS COMPREENDENDO UM AGENTE DE LIBERAçãO NA FORMA MICRONIZADA". A presente inenção refere-se a composições farmacêuticas sólidas e métodos para seu uso adequado para a liberação oral de agentes farmacologicamente ativos, por exemplo, peptídeos, compreendendo uma quantidade terapeuticamente eficaz de um agente farmacologicamente ativo; uma crospovidona ou povidona; e um agente de liberação para o referido agente farmacologicamente ativo são descritos. As composições utilizam as formas micronizadas do agente de liberação que fornecem biodisponibilidade realçada de agentes farmacologicamente ativos, particularmente calcitonina.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US48649503P | 2003-07-11 | 2003-07-11 | |
PCT/EP2004/007584 WO2005004900A1 (en) | 2003-07-11 | 2004-07-09 | Orally dosed pharmaceutical compositions comprising a delivery agent in micronized form |
Publications (1)
Publication Number | Publication Date |
---|---|
BRPI0412458A true BRPI0412458A (pt) | 2006-10-17 |
Family
ID=34062133
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BRPI0412458-8A BRPI0412458A (pt) | 2003-07-11 | 2004-07-09 | composições farmacêuticas oralmente dosadas compreendendo um agente de liberação na forma micronizada |
Country Status (15)
Country | Link |
---|---|
US (3) | US20070065505A1 (pt) |
EP (1) | EP1651248B1 (pt) |
JP (1) | JP5032844B2 (pt) |
CN (1) | CN1809377B (pt) |
AT (1) | ATE442158T1 (pt) |
AU (1) | AU2004255458B2 (pt) |
BR (1) | BRPI0412458A (pt) |
CA (1) | CA2529604C (pt) |
DE (1) | DE602004023093D1 (pt) |
ES (1) | ES2330638T3 (pt) |
HK (1) | HK1089950A1 (pt) |
MX (1) | MXPA06000446A (pt) |
PL (1) | PL1651248T3 (pt) |
PT (1) | PT1651248E (pt) |
WO (1) | WO2005004900A1 (pt) |
Families Citing this family (17)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
MXPA04001418A (es) * | 2001-08-17 | 2004-05-27 | Novartis Ag | Acido n-(5-clorosalociloil)-8-aminocaprilico como agente de suministro oral para fragmentos de hormona paratiroides. |
US20060078623A1 (en) * | 2004-08-13 | 2006-04-13 | Emisphere Technologies, Inc. | Pharmaceutical formulations containing microparticles or nanoparticles of a delivery agent |
SG165397A1 (en) | 2005-09-19 | 2010-10-28 | Emisphere Tech Inc | Crystalline forms of the di-sodium salt of n-(5-chlorosalicyloyl)-8- aminocaprylic acid |
GB0522566D0 (en) * | 2005-11-04 | 2005-12-14 | Novartis Ag | Organic compounds |
ES2426485T3 (es) * | 2006-08-31 | 2013-10-23 | Novartis Ag | Composiciones farmacéuticas que comprenden hGH para administración oral |
AR062925A1 (es) * | 2006-09-22 | 2008-12-17 | Novartis Ag | Metodo para fabricar tabletas que contienen agentes farmacologicamente activos |
PT2215047E (pt) | 2007-11-02 | 2014-01-20 | Emisphere Tech Inc | Processo para o tratamento da deficiência de vitamina b12 |
NZ602032A (en) * | 2010-02-24 | 2014-11-28 | Emisphere Tech Inc | Oral b12 therapy |
PT2651398T (pt) | 2010-12-16 | 2018-03-09 | Novo Nordisk As | Composições sólidas compreendendo um agonista de glp-1 e um sal de ácido n-(8-(2-hidroxibenzoil)amino) caprílico |
PL2696687T3 (pl) | 2011-04-12 | 2017-06-30 | Novo Nordisk A/S | Pochodne podwójnie acylowanej GLP-1 |
CA2868188A1 (en) | 2012-03-22 | 2013-09-26 | Novo Nordisk A/S | Compositions of glp-1 peptides and preparation thereof |
HUE042757T2 (hu) | 2012-03-22 | 2019-07-29 | Novo Nordisk As | Szállító szert tartalmazó készítmények és elõállításuk |
EP3542790B1 (en) | 2012-03-22 | 2023-09-13 | Novo Nordisk A/S | Compositions comprising a delivery agent and preparation thereof |
ES2871328T3 (es) | 2012-06-20 | 2021-10-28 | Novo Nordisk As | Formulación de comprimido que comprende un péptido y un agente de suministro |
CN104095828A (zh) * | 2014-07-29 | 2014-10-15 | 中国药科大学 | 一种降钙素口服肠溶组合物及其制备方法 |
CN111683676B (zh) | 2018-02-02 | 2024-06-18 | 诺和诺德股份有限公司 | 包含glp-1激动剂、n-(8-(2-羟基苯甲酰基)氨基)辛酸的盐和润滑剂的固体组合物 |
MX2023012437A (es) | 2021-04-22 | 2023-11-07 | Civi Biopharma Inc | Administracion oral de oligonucleotidos. |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IS1796B (is) * | 1993-06-24 | 2001-12-31 | Ab Astra | Fjölpeptíð lyfjablanda til innöndunar sem einnig inniheldur eykjaefnasamband |
US5866536A (en) * | 1995-03-31 | 1999-02-02 | Emisphere Technologies, Inc. | Compounds and compositions for delivering active agents |
US5650386A (en) * | 1995-03-31 | 1997-07-22 | Emisphere Technologies, Inc. | Compositions for oral delivery of active agents |
US6413546B1 (en) * | 1999-03-18 | 2002-07-02 | Indena, S.P.A. | Tablets incorporating isoflavone plant extracts and methods of manufacturing them |
ES2235854T3 (es) | 1999-04-05 | 2005-07-16 | Emisphere Technologies, Inc. | Sales disodicas, monohidratos y solvatos etanolicos para aportar agentes activos. |
SK285128B6 (sk) * | 1999-12-28 | 2006-07-07 | Zentiva, A. S. | Liečivý prípravok s riadeným uvoľňovaním obsahujúci tramadol hydrochlorid a spôsob jeho prípravy |
US6544553B1 (en) * | 1999-12-28 | 2003-04-08 | Watson Pharmaceuticals, Inc. | Dosage forms and methods for oral delivery of progesterone |
US7049283B2 (en) * | 2000-12-06 | 2006-05-23 | Novartis Ag | Pharmaceutical compositions for the oral delivery of pharmacologically active agents |
-
2004
- 2004-07-09 BR BRPI0412458-8A patent/BRPI0412458A/pt not_active Application Discontinuation
- 2004-07-09 MX MXPA06000446A patent/MXPA06000446A/es active IP Right Grant
- 2004-07-09 DE DE602004023093T patent/DE602004023093D1/de not_active Expired - Lifetime
- 2004-07-09 PL PL04740863T patent/PL1651248T3/pl unknown
- 2004-07-09 CN CN2004800174065A patent/CN1809377B/zh not_active Expired - Fee Related
- 2004-07-09 WO PCT/EP2004/007584 patent/WO2005004900A1/en active Application Filing
- 2004-07-09 AU AU2004255458A patent/AU2004255458B2/en not_active Ceased
- 2004-07-09 CA CA2529604A patent/CA2529604C/en not_active Expired - Fee Related
- 2004-07-09 EP EP04740863A patent/EP1651248B1/en not_active Expired - Lifetime
- 2004-07-09 PT PT04740863T patent/PT1651248E/pt unknown
- 2004-07-09 JP JP2006518162A patent/JP5032844B2/ja not_active Expired - Fee Related
- 2004-07-09 US US10/564,259 patent/US20070065505A1/en not_active Abandoned
- 2004-07-09 AT AT04740863T patent/ATE442158T1/de active
- 2004-07-09 ES ES04740863T patent/ES2330638T3/es not_active Expired - Lifetime
-
2006
- 2006-09-20 HK HK06110477.5A patent/HK1089950A1/xx not_active IP Right Cessation
-
2008
- 2008-06-04 US US12/132,642 patent/US8435946B2/en active Active
-
2013
- 2013-04-15 US US13/862,811 patent/US8748383B2/en not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
CN1809377A (zh) | 2006-07-26 |
US20080234179A1 (en) | 2008-09-25 |
PT1651248E (pt) | 2009-11-10 |
AU2004255458A1 (en) | 2005-01-20 |
US8748383B2 (en) | 2014-06-10 |
US8435946B2 (en) | 2013-05-07 |
ES2330638T3 (es) | 2009-12-14 |
PL1651248T3 (pl) | 2010-02-26 |
CA2529604C (en) | 2012-05-08 |
WO2005004900A1 (en) | 2005-01-20 |
HK1089950A1 (en) | 2006-12-15 |
ATE442158T1 (de) | 2009-09-15 |
JP5032844B2 (ja) | 2012-09-26 |
AU2004255458B2 (en) | 2007-09-13 |
DE602004023093D1 (de) | 2009-10-22 |
US20070065505A1 (en) | 2007-03-22 |
CA2529604A1 (en) | 2005-01-20 |
CN1809377B (zh) | 2010-08-04 |
EP1651248A1 (en) | 2006-05-03 |
MXPA06000446A (es) | 2006-04-07 |
US20130230593A1 (en) | 2013-09-05 |
JP2009513528A (ja) | 2009-04-02 |
EP1651248B1 (en) | 2009-09-09 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
B06F | Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette] | ||
B07D | Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette] | ||
B07E | Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette] | ||
B07A | Application suspended after technical examination (opinion) [chapter 7.1 patent gazette] | ||
B09B | Patent application refused [chapter 9.2 patent gazette] | ||
B12B | Appeal against refusal [chapter 12.2 patent gazette] |