JP2009508476A - 高められたエフェクター機能をもつ抗体定常領域の製造用の宿主細胞株 - Google Patents
高められたエフェクター機能をもつ抗体定常領域の製造用の宿主細胞株 Download PDFInfo
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Classifications
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- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
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- C12N5/0602—Vertebrate cells
- C12N5/0693—Tumour cells; Cancer cells
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
- C07K16/241—Tumor Necrosis Factors
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
- C07K16/2809—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against the T-cell receptor (TcR)-CD3 complex
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/36—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against blood coagulation factors
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/40—Immunoglobulins specific features characterized by post-translational modification
- C07K2317/41—Glycosylation, sialylation, or fucosylation
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/72—Increased effector function due to an Fc-modification
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
- C07K2317/732—Antibody-dependent cellular cytotoxicity [ADCC]
Landscapes
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| US71285805P | 2005-08-31 | 2005-08-31 | |
| PCT/US2006/034382 WO2007028106A2 (en) | 2005-08-31 | 2006-08-31 | Host cell lines for production of antibody constant region with enhanced effector function |
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| JP2009508476A true JP2009508476A (ja) | 2009-03-05 |
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| Country | Link |
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| US (1) | US20090214528A1 (enExample) |
| EP (1) | EP1937313A4 (enExample) |
| JP (1) | JP2009508476A (enExample) |
| KR (1) | KR20080048505A (enExample) |
| AU (1) | AU2006287224A1 (enExample) |
| BR (1) | BRPI0616600A2 (enExample) |
| CA (1) | CA2621236A1 (enExample) |
| MX (1) | MX2008003054A (enExample) |
| WO (1) | WO2007028106A2 (enExample) |
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2012528184A (ja) * | 2009-05-29 | 2012-11-12 | グラクソスミスクライン・リミテッド・ライアビリティ・カンパニー | トロンボポエチンアゴニスト化合物の投与の方法 |
| JP2017517518A (ja) * | 2014-05-27 | 2017-06-29 | アカデミア シニカＡｃａｄｅｍｉａ Ｓｉｎｉｃａ | 増強された抗体の有効性のための普遍的グリコフォームに関する組成物および方法 |
| JP2018525416A (ja) * | 2015-08-25 | 2018-09-06 | アルナイラム ファーマシューティカルズ， インコーポレイテッドＡｌｎｙｌａｍ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ， Ｉｎｃ． | プロタンパク質転換酵素サブチリシン／ケキシン（ｐｃｓｋ９）遺伝子関連障害を治療するための方法および組成物 |
| JP2019509988A (ja) * | 2016-02-05 | 2019-04-11 | ヤンセン バイオテツク，インコーポレーテツド | １型糖尿病の処置又は予防のための抗ｔｎｆ抗体、組成物、方法及び使用 |
| JP2022116272A (ja) * | 2019-05-08 | 2022-08-09 | ノバルティス アーゲー | Ｔ１ｄｍ及び膵島炎の治療に使用するための抗ｃｄ４０抗体 |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2369292C (en) | 1999-04-09 | 2010-09-21 | Kyowa Hakko Kogyo Co. Ltd. | Method of modulating the activity of functional immune molecules |
| FR2807767B1 (fr) * | 2000-04-12 | 2005-01-14 | Lab Francais Du Fractionnement | Anticorps monoclonaux anti-d |
| US6946292B2 (en) | 2000-10-06 | 2005-09-20 | Kyowa Hakko Kogyo Co., Ltd. | Cells producing antibody compositions with increased antibody dependent cytotoxic activity |
| SG10201407983VA (en) * | 2009-12-18 | 2015-01-29 | Csl Ltd | Method of purifying polypeptides |
| GB201003701D0 (en) * | 2010-03-05 | 2010-04-21 | Cilian Ag | System for the expression of a protein |
| WO2013087911A1 (en) | 2011-12-16 | 2013-06-20 | Synthon Biopharmaceuticals B.V. | Compounds and methods for treating inflammatory diseases |
| HUE035887T2 (en) | 2012-12-05 | 2018-05-28 | Alnylam Pharmaceuticals Inc | PCSK9 iRNA preparations and methods for their use |
| US9677105B2 (en) | 2013-03-14 | 2017-06-13 | Momenta Pharmaceuticals, Inc. | Methods of cell culture |
| US8956830B2 (en) | 2013-03-14 | 2015-02-17 | Momenta Pharmaceuticals, Inc. | Methods of cell culture |
| US9217168B2 (en) | 2013-03-14 | 2015-12-22 | Momenta Pharmaceuticals, Inc. | Methods of cell culture |
| IL268007B2 (en) * | 2017-01-30 | 2025-05-01 | Janssen Biotech Inc | Anti-tnf antibodies, compositions, and methods for the treatment of active psoriatic arthritis |
| AU2017398101B2 (en) * | 2017-02-07 | 2025-02-06 | Janssen Biotech, Inc. | Anti-TNF antibodies, compositions, and methods for the treatment of active Ankylosing Spondylitis |
| KR102323342B1 (ko) * | 2019-04-26 | 2021-11-08 | 주식회사 와이바이오로직스 | IL-17A 및 TNF-α에 특이적으로 결합하는 이중표적 항체 |
| CA3138241A1 (en) | 2019-05-23 | 2020-11-26 | Janssen Biotech, Inc. | Method of treating inflammatory bowel disease with a combination therapy of antibodies to il-23 and tnf alpha |
| EP4596046A3 (en) | 2020-05-21 | 2025-10-22 | Janssen Biotech, Inc. | Method of treating inflammatory bowel disease with a combination therapy of antibodies to il-23 and tnf alpha |
Family Cites Families (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US1079704A (en) | 1912-06-19 | 1913-11-25 | Dallas C Hathaway | Combination tire valve-stem and pressure-gage. |
| DE3167442D1 (en) * | 1980-07-07 | 1985-01-10 | Nat Res Dev | Improvements in or relating to cell lines |
| US4816567A (en) | 1983-04-08 | 1989-03-28 | Genentech, Inc. | Recombinant immunoglobin preparations |
| US4816597A (en) * | 1983-10-02 | 1989-03-28 | New Jersey Institute Of Technology | Dental restorative materials based upon blocked isocyanates |
| GB8421551D0 (en) | 1984-08-24 | 1984-09-26 | Ici Plc | Water-soluble dye |
| DE69632465T2 (de) | 1995-06-07 | 2005-06-23 | Ortho-Mcneil Pharmaceutical, Inc. | Cdr-transplantierte antikörper gegen "tissue factor" und verfahren zur deren verwendung |
| DE69823046T2 (de) * | 1997-01-16 | 2005-03-31 | Neose Technologies, Inc. | Praktische in vitro sialylierung von rekombinanten glykpproteinen |
| JP4334141B2 (ja) * | 1998-04-20 | 2009-09-30 | グリカート バイオテクノロジー アクチェンゲゼルシャフト | 抗体依存性細胞傷害性を改善するための抗体のグリコシル化操作 |
| CA2369292C (en) * | 1999-04-09 | 2010-09-21 | Kyowa Hakko Kogyo Co. Ltd. | Method of modulating the activity of functional immune molecules |
| UA81743C2 (uk) | 2000-08-07 | 2008-02-11 | Центокор, Инк. | МОНОКЛОНАЛЬНЕ АНТИТІЛО ЛЮДИНИ, ЩО СПЕЦИФІЧНО ЗВ'ЯЗУЄТЬСЯ З ФАКТОРОМ НЕКРОЗУ ПУХЛИН АЛЬФА (ФНПα), ФАРМАЦЕВТИЧНА КОМПОЗИЦІЯ, ЩО ЙОГО МІСТИТЬ, ТА СПОСІБ ЛІКУВАННЯ РЕВМАТОЇДНОГО АРТРИТУ |
| US6946292B2 (en) * | 2000-10-06 | 2005-09-20 | Kyowa Hakko Kogyo Co., Ltd. | Cells producing antibody compositions with increased antibody dependent cytotoxic activity |
| CA2438148A1 (en) | 2001-02-15 | 2002-08-29 | Centocor, Inc. | Chemically defined medium for cultured mammalian cells |
| CN1930288B (zh) * | 2002-04-09 | 2012-08-08 | 协和发酵麒麟株式会社 | 基因组被修饰的细胞 |
| JPWO2003085118A1 (ja) * | 2002-04-09 | 2005-08-11 | 協和醗酵工業株式会社 | 抗体組成物の製造方法 |
| WO2003084570A1 (en) * | 2002-04-09 | 2003-10-16 | Kyowa Hakko Kogyo Co., Ltd. | DRUG CONTAINING ANTIBODY COMPOSITION APPROPRIATE FOR PATIENT SUFFERING FROM FcϜRIIIa POLYMORPHISM |
| JP2006526641A (ja) | 2003-05-30 | 2006-11-24 | セントカー・インコーポレーテツド | 抗−組織因子抗体を用いる腫瘍成長を抑制する方法 |
| US7605235B2 (en) | 2003-05-30 | 2009-10-20 | Centocor, Inc. | Anti-tissue factor antibodies and compositions |
-
2006
- 2006-08-31 KR KR1020087007406A patent/KR20080048505A/ko not_active Ceased
- 2006-08-31 MX MX2008003054A patent/MX2008003054A/es not_active Application Discontinuation
- 2006-08-31 CA CA002621236A patent/CA2621236A1/en not_active Abandoned
- 2006-08-31 JP JP2008529350A patent/JP2009508476A/ja active Pending
- 2006-08-31 EP EP06814116A patent/EP1937313A4/en not_active Withdrawn
- 2006-08-31 WO PCT/US2006/034382 patent/WO2007028106A2/en not_active Ceased
- 2006-08-31 AU AU2006287224A patent/AU2006287224A1/en not_active Abandoned
- 2006-08-31 BR BRPI0616600-8A patent/BRPI0616600A2/pt not_active Application Discontinuation
- 2006-08-31 US US12/065,178 patent/US20090214528A1/en not_active Abandoned
Cited By (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2012528184A (ja) * | 2009-05-29 | 2012-11-12 | グラクソスミスクライン・リミテッド・ライアビリティ・カンパニー | トロンボポエチンアゴニスト化合物の投与の方法 |
| JP2016020360A (ja) * | 2009-05-29 | 2016-02-04 | ノバルティス アーゲー | トロンボポエチンアゴニスト化合物の投与の方法 |
| JP2017517518A (ja) * | 2014-05-27 | 2017-06-29 | アカデミア シニカＡｃａｄｅｍｉａ Ｓｉｎｉｃａ | 増強された抗体の有効性のための普遍的グリコフォームに関する組成物および方法 |
| JP2018525416A (ja) * | 2015-08-25 | 2018-09-06 | アルナイラム ファーマシューティカルズ， インコーポレイテッドＡｌｎｙｌａｍ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ， Ｉｎｃ． | プロタンパク質転換酵素サブチリシン／ケキシン（ｐｃｓｋ９）遺伝子関連障害を治療するための方法および組成物 |
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Also Published As
| Publication number | Publication date |
|---|---|
| WO2007028106A3 (en) | 2009-06-11 |
| KR20080048505A (ko) | 2008-06-02 |
| EP1937313A2 (en) | 2008-07-02 |
| MX2008003054A (es) | 2008-03-25 |
| CA2621236A1 (en) | 2007-03-08 |
| US20090214528A1 (en) | 2009-08-27 |
| AU2006287224A1 (en) | 2007-03-08 |
| BRPI0616600A2 (pt) | 2011-06-28 |
| WO2007028106A2 (en) | 2007-03-08 |
| EP1937313A4 (en) | 2010-03-24 |
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