JP2009504774A - 癌を治療するためにｓａｈａ及びターグレチンの併用方法 - Google Patents

癌を治療するためにｓａｈａ及びターグレチンの併用方法 Download PDF

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Publication number
JP2009504774A
JP2009504774A JP2008527161A JP2008527161A JP2009504774A JP 2009504774 A JP2009504774 A JP 2009504774A JP 2008527161 A JP2008527161 A JP 2008527161A JP 2008527161 A JP2008527161 A JP 2008527161A JP 2009504774 A JP2009504774 A JP 2009504774A
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Japan
Prior art keywords
day
administered
saha
dose
administration
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JP2008527161A
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English (en)
Japanese (ja)
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JP2009504774A5 (enExample
Inventor
リチヨン，ビクトリア・エム
フランケル，スタンリー・アール
アバーブツチ，ステイーブン
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Merck and Co Inc
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Merck and Co Inc
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Application filed by Merck and Co Inc filed Critical Merck and Co Inc
Publication of JP2009504774A publication Critical patent/JP2009504774A/ja
Publication of JP2009504774A5 publication Critical patent/JP2009504774A5/ja
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/192—Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid 
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/216—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acids having aromatic rings, e.g. benactizyne, clofibrate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Emergency Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
JP2008527161A 2005-08-18 2006-08-18 癌を治療するためにｓａｈａ及びターグレチンの併用方法 Withdrawn JP2009504774A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US70959905P 2005-08-18 2005-08-18
US73375205P 2005-11-04 2005-11-04
PCT/US2006/032282 WO2007022408A2 (en) 2005-08-18 2006-08-18 Combination methods of saha and targretin for treating cancer

Publications (2)

Publication Number Publication Date
JP2009504774A true JP2009504774A (ja) 2009-02-05
JP2009504774A5 JP2009504774A5 (enExample) 2009-09-10

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ID=37758430

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2008527161A Withdrawn JP2009504774A (ja) 2005-08-18 2006-08-18 癌を治療するためにｓａｈａ及びターグレチンの併用方法

Country Status (6)

Country Link
US (1) US20090227674A1 (enExample)
EP (1) EP1933825A2 (enExample)
JP (1) JP2009504774A (enExample)
AU (1) AU2006279400A1 (enExample)
CA (1) CA2617623A1 (enExample)
WO (1) WO2007022408A2 (enExample)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2010525042A (ja) * 2007-04-25 2010-07-22 サイクラセル リミテッド 増殖性疾患を治療するためのサパシタビンの使用
JP2018532802A (ja) * 2015-10-31 2018-11-08 アイオー セラピューティクス インコーポレイテッド Ｒｘｒアゴニストおよび甲状腺ホルモンの組み合わせを用いた神経系障害の治療
JP2019507777A (ja) * 2016-03-10 2019-03-22 アイオー セラピューティクス インコーポレイテッド Ｒｘｒアゴニストおよび甲状腺ホルモンの組み合わせでの自己免疫疾患の治療

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2394022C2 (ru) 2002-03-04 2010-07-10 МЕРК ЭйчДиЭйСи Рисерч, ЛЛС Способы индукции конечной дифференцировки
TWI415603B (zh) 2005-05-20 2013-11-21 Merck Sharp & Dohme １，８－辛二醯基苯胺羥胺酸（ｓｕｂｅｒｏｙｌａｎｉｌｉｄｅ ｈｙｄｒｏｘａｍｉｃ ａｃｉｄ）之調配物及其製配方法
AU2006299645B2 (en) 2005-09-30 2011-02-03 Io Therapeutics, Llc Treatment of cancer with specific RXR agonists
CN110151745A (zh) 2011-12-13 2019-08-23 Io治疗公司 使用rxr激动剂的自身免疫紊乱的治疗
US10653650B2 (en) 2011-12-13 2020-05-19 Io Therapeutics, Inc. Treatment of diseases by concurrently eliciting remyelination effects and immunomodulatory effects using selective RXR agonists
US9949972B2 (en) 2013-12-03 2018-04-24 Acetylon Pharmaceuticals, Inc Combinations of histone deacetylase inhibitors and immunomodulatory drugs
RU2016150116A (ru) * 2014-05-21 2018-06-22 Нэшнл Инститьют Оф Адванст Индастриал Сайенс Энд Текнолоджи Ингибитор пролиферации раковых стволовых клеток
AU2016245984B2 (en) * 2015-04-10 2021-03-25 Bioresponse, L.L.C. Self-emulsifying formulations of DIM-related indoles
DK3426303T3 (da) * 2016-03-10 2022-09-19 Io Therapeutics Inc Behandling af muskellidelser med kombinationer af rxr-agonister og thyroideahormoner
WO2018089861A1 (en) * 2016-11-11 2018-05-17 The Regents Of The University Of California Methods and compositions for the treatment of cancer and metabolic diseases
WO2019060600A1 (en) 2017-09-20 2019-03-28 Io Therapeutics, Inc. TREATMENT OF DISEASE WITH ESTERS OF SELECTIVE RXR AGONISTS
WO2020232399A1 (en) * 2019-05-16 2020-11-19 The Regents Of The University Of California Compositions comprising hdac inhibitors and retinoids
US10966950B2 (en) 2019-06-11 2021-04-06 Io Therapeutics, Inc. Use of an RXR agonist in treating HER2+ cancers
AU2022407454A1 (en) 2021-12-07 2024-06-06 Board Of Regents, The University Of Texas System Use of an rxr agonist in treating drug resistant her2+ cancers
KR20240119103A (ko) 2021-12-07 2024-08-06 아이오 테라퓨틱스, 인크. Her2+ 암 치료에서의 rxr 작용제 및 탁산의 용도

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002060430A1 (en) * 2001-02-01 2002-08-08 Cornell Research Foundation, Inc. Use of retinoids plus histone deacetylase inhibitors to inhibit the growth of solid tumors

Cited By (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2010525042A (ja) * 2007-04-25 2010-07-22 サイクラセル リミテッド 増殖性疾患を治療するためのサパシタビンの使用
JP2015013877A (ja) * 2007-04-25 2015-01-22 サイクラセル リミテッド 増殖性疾患を治療するためのサパシタビンの使用
JP2018532802A (ja) * 2015-10-31 2018-11-08 アイオー セラピューティクス インコーポレイテッド Ｒｘｒアゴニストおよび甲状腺ホルモンの組み合わせを用いた神経系障害の治療
JP2021063116A (ja) * 2015-10-31 2021-04-22 アイオー セラピューティクス インコーポレイテッド Ｒｘｒアゴニストおよび甲状腺ホルモンの組み合わせを用いた神経系障害の治療
JP7368859B2 (ja) 2015-10-31 2023-10-25 アイオー セラピューティクス インコーポレイテッド Ｒｘｒアゴニストおよび甲状腺ホルモンの組み合わせを用いた神経系障害の治療
JP2023171942A (ja) * 2015-10-31 2023-12-05 アイオー セラピューティクス インコーポレイテッド Ｒｘｒアゴニストおよび甲状腺ホルモンの組み合わせを用いた神経系障害の治療
JP2019507777A (ja) * 2016-03-10 2019-03-22 アイオー セラピューティクス インコーポレイテッド Ｒｘｒアゴニストおよび甲状腺ホルモンの組み合わせでの自己免疫疾患の治療
JP7169646B2 (ja) 2016-03-10 2022-11-11 アイオー セラピューティクス インコーポレイテッド Ｒｘｒアゴニストおよび甲状腺ホルモンの組み合わせでの自己免疫疾患の治療

Also Published As

Publication number Publication date
AU2006279400A1 (en) 2007-02-22
EP1933825A2 (en) 2008-06-25
WO2007022408A2 (en) 2007-02-22
US20090227674A1 (en) 2009-09-10
WO2007022408A3 (en) 2007-09-27
CA2617623A1 (en) 2007-02-22

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