JP2009503111A5 - - Google Patents
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- Publication number
- JP2009503111A5 JP2009503111A5 JP2008525234A JP2008525234A JP2009503111A5 JP 2009503111 A5 JP2009503111 A5 JP 2009503111A5 JP 2008525234 A JP2008525234 A JP 2008525234A JP 2008525234 A JP2008525234 A JP 2008525234A JP 2009503111 A5 JP2009503111 A5 JP 2009503111A5
- Authority
- JP
- Japan
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
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Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US70596805P | 2005-08-04 | 2005-08-04 | |
US75282505P | 2005-12-21 | 2005-12-21 | |
PCT/US2006/030481 WO2007019331A2 (en) | 2005-08-04 | 2006-08-04 | Conjugates of a g-csf moiety and a polymer |
Publications (2)
Publication Number | Publication Date |
---|---|
JP2009503111A JP2009503111A (ja) | 2009-01-29 |
JP2009503111A5 true JP2009503111A5 (ja) | 2009-05-21 |
Family
ID=37621974
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2008525234A Withdrawn JP2009503111A (ja) | 2005-08-04 | 2006-08-04 | G−csf部分および重合体の複合体 |
Country Status (11)
Country | Link |
---|---|
US (1) | US20070092482A1 (ja) |
EP (1) | EP2099495A2 (ja) |
JP (1) | JP2009503111A (ja) |
KR (1) | KR20080033439A (ja) |
CN (1) | CN101257926A (ja) |
AU (1) | AU2006278490A1 (ja) |
BR (1) | BRPI0614257A2 (ja) |
CA (1) | CA2617064A1 (ja) |
IL (1) | IL188999A0 (ja) |
MX (1) | MX2008001706A (ja) |
WO (1) | WO2007019331A2 (ja) |
Families Citing this family (33)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU2005318984B2 (en) | 2004-12-21 | 2011-12-01 | Nektar Therapeutics | Stabilized polymeric thiol reagents |
EP1861125A2 (en) * | 2005-03-23 | 2007-12-05 | Nektar Therapeutics Al, Corporation | Conjugates of an hgh moiety and peg derivatives |
EP2279758B1 (en) | 2005-06-16 | 2015-02-25 | Nektar Therapeutics | Conjugates having a degradable linkage and polymeric reagents useful in preparing such conjugates |
CN101534847A (zh) | 2006-08-04 | 2009-09-16 | 普罗龙药品公司 | 修饰型促红细胞生成素 |
CN101588819B (zh) * | 2006-12-27 | 2012-11-21 | 尼克塔治疗公司 | 具有可释放的键合的ix因子部分-聚合物轭合物 |
NZ577728A (en) * | 2006-12-27 | 2012-01-12 | Baxter Int | Von willebrand factor- and factor viii-polymer conjugates having a releasable linkage |
CA2693616A1 (en) * | 2007-07-11 | 2009-01-15 | Enzon Pharmaceuticals, Inc. | Polymeric drug delivery system containing a multi-substituted aromatic moiety |
JP2011507913A (ja) * | 2007-12-29 | 2011-03-10 | バイオスティード ジーン エクスプレッション テック. カンパニー リミテッド | Y型ポリエチレングリコール修飾したg−csfならびにその製造方法および使用 |
ES2523030T3 (es) | 2008-02-18 | 2014-11-20 | Jiangsu Hengrui Medicine Co., Ltd. | Un conjugado del G-CSF modificado por un polímero hidrosoluble |
WO2010014258A2 (en) | 2008-08-01 | 2010-02-04 | Nektar Therapeutics Al, Corporation | Conjugates having a releasable linkage |
RU2011110459A (ru) | 2008-08-21 | 2012-09-27 | Октафарма АГ (CH) | Рекомбинантно полученный человеческий фактор viii и ix |
CN101870728A (zh) * | 2009-04-23 | 2010-10-27 | 派格生物医药(苏州)有限公司 | 新型Exendin变体及其缀合物 |
EP2459227B1 (en) * | 2009-07-31 | 2021-03-17 | Ascendis Pharma A/S | Prodrugs containing an aromatic amine connected by an amide bond to a carrier |
EP2459225A1 (en) * | 2009-07-31 | 2012-06-06 | Ascendis Pharma A/S | Carrier linked pramipexole prodrugs |
TW201138831A (en) * | 2009-09-30 | 2011-11-16 | Prolong Pharmaceuticals Inc | Modified granulocyte colony stimulating factor (G-CSF) |
AU2011244348B2 (en) | 2010-04-20 | 2015-02-12 | Octapharma Ag | New stabilizing agent for pharmaceutical proteins |
WO2012064845A2 (en) * | 2010-11-09 | 2012-05-18 | Nektar Therapeutics | G-csf polymer conjugates having a releasable linkage |
WO2012064867A1 (en) * | 2010-11-09 | 2012-05-18 | Nektar Therapeutics | Pharmacologically active polymer-g-csf conjugates |
HUE054318T2 (hu) * | 2010-11-12 | 2021-08-30 | Nektar Therapeutics | IL-2 molekularész konjugátumai és polimer |
UA116217C2 (uk) | 2012-10-09 | 2018-02-26 | Санофі | Пептидна сполука як подвійний агоніст рецепторів glp1-1 та глюкагону |
BR112015014510A2 (pt) | 2012-12-21 | 2017-11-21 | Sanofi Sa | agonistas de glp1/gip duais ou de glp1/gip/glucagon trigonais |
WO2015086730A1 (en) | 2013-12-13 | 2015-06-18 | Sanofi | Non-acylated exendin-4 peptide analogues |
TW201609795A (zh) | 2013-12-13 | 2016-03-16 | 賽諾菲公司 | 作為雙重glp-1/gip受體促效劑的艾塞那肽-4(exendin-4)胜肽類似物 |
WO2015086729A1 (en) | 2013-12-13 | 2015-06-18 | Sanofi | Dual glp-1/gip receptor agonists |
EP3080149A1 (en) | 2013-12-13 | 2016-10-19 | Sanofi | Dual glp-1/glucagon receptor agonists |
TW201625669A (zh) | 2014-04-07 | 2016-07-16 | 賽諾菲公司 | 衍生自艾塞那肽-4(Exendin-4)之肽類雙重GLP-1/升糖素受體促效劑 |
TW201625670A (zh) | 2014-04-07 | 2016-07-16 | 賽諾菲公司 | 衍生自exendin-4之雙重glp-1/升糖素受體促效劑 |
TW201625668A (zh) | 2014-04-07 | 2016-07-16 | 賽諾菲公司 | 作為胜肽性雙重glp-1/昇糖素受體激動劑之艾塞那肽-4衍生物 |
US9932381B2 (en) | 2014-06-18 | 2018-04-03 | Sanofi | Exendin-4 derivatives as selective glucagon receptor agonists |
JP2016144812A (ja) * | 2015-02-06 | 2016-08-12 | 富士通株式会社 | フラックス及び電子装置の製造方法 |
AR105319A1 (es) | 2015-06-05 | 2017-09-27 | Sanofi Sa | Profármacos que comprenden un conjugado agonista dual de glp-1 / glucagón conector ácido hialurónico |
AU2016277147A1 (en) * | 2015-06-11 | 2018-01-18 | Ambio Pharmaceuticals, Llc | Pegylated granulocyte colony stimulating factor (GCSF) |
AR105284A1 (es) | 2015-07-10 | 2017-09-20 | Sanofi Sa | Derivados de exendina-4 como agonistas peptídicos duales específicos de los receptores de glp-1 / glucagón |
Family Cites Families (31)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4179337A (en) * | 1973-07-20 | 1979-12-18 | Davis Frank F | Non-immunogenic polypeptides |
JPS6023084B2 (ja) * | 1979-07-11 | 1985-06-05 | 味の素株式会社 | 代用血液 |
US5618697A (en) * | 1982-12-10 | 1997-04-08 | Novo Nordisk A/S | Process for preparing a desired protein |
US5206344A (en) * | 1985-06-26 | 1993-04-27 | Cetus Oncology Corporation | Interleukin-2 muteins and polymer conjugation thereof |
US4766106A (en) * | 1985-06-26 | 1988-08-23 | Cetus Corporation | Solubilization of proteins for pharmaceutical compositions using polymer conjugation |
US6004548A (en) * | 1985-08-23 | 1999-12-21 | Amgen, Inc. | Analogs of pluripotent granulocyte colony-stimulating factor |
US4810643A (en) * | 1985-08-23 | 1989-03-07 | Kirin- Amgen Inc. | Production of pluripotent granulocyte colony-stimulating factor |
US5362853A (en) * | 1986-12-23 | 1994-11-08 | Kyowa Hakko Kogyo Co., Ltd. | Polypeptide derivatives of human granulocyte colony stimulating factor |
US5214132A (en) * | 1986-12-23 | 1993-05-25 | Kyowa Hakko Kogyo Co., Ltd. | Polypeptide derivatives of human granulocyte colony stimulating factor |
US5214131A (en) * | 1988-05-06 | 1993-05-25 | Sumitomo Pharmaceuticals Company, Limited | Polyethylene glycol derivatives, modified peptides and production thereof |
JP2958019B2 (ja) * | 1988-05-06 | 1999-10-06 | 住友製薬株式会社 | ポリエチレングリコール誘導体、修飾ペプチドおよびその製造方法 |
US5218092A (en) * | 1988-09-29 | 1993-06-08 | Kyowa Hakko Kogyo Co., Ltd. | Modified granulocyte-colony stimulating factor polypeptide with added carbohydrate chains |
US5349052A (en) * | 1988-10-20 | 1994-09-20 | Royal Free Hospital School Of Medicine | Process for fractionating polyethylene glycol (PEG)-protein adducts and an adduct for PEG and granulocyte-macrophage colony stimulating factor |
US6166183A (en) * | 1992-11-30 | 2000-12-26 | Kirin-Amgen, Inc. | Chemically-modified G-CSF |
US20020177688A1 (en) * | 1988-12-22 | 2002-11-28 | Kirin-Amgen, Inc., | Chemically-modified G-CSF |
US5122614A (en) * | 1989-04-19 | 1992-06-16 | Enzon, Inc. | Active carbonates of polyalkylene oxides for modification of polypeptides |
US5166322A (en) * | 1989-04-21 | 1992-11-24 | Genetics Institute | Cysteine added variants of interleukin-3 and chemical modifications thereof |
US5252714A (en) * | 1990-11-28 | 1993-10-12 | The University Of Alabama In Huntsville | Preparation and use of polyethylene glycol propionaldehyde |
AU1462392A (en) * | 1991-02-22 | 1992-09-15 | Amgen, Inc. | Use of gm-csf and g-csf to promote accelerated wound healing |
US5951974A (en) * | 1993-11-10 | 1999-09-14 | Enzon, Inc. | Interferon polymer conjugates |
US5824784A (en) * | 1994-10-12 | 1998-10-20 | Amgen Inc. | N-terminally chemically modified protein compositions and methods |
US5942253A (en) * | 1995-10-12 | 1999-08-24 | Immunex Corporation | Prolonged release of GM-CSF |
DK1421956T3 (da) * | 1998-04-28 | 2007-10-01 | Applied Research Systems | Polyol-IFN-beta-konjugater |
DK1157037T3 (da) * | 1999-01-29 | 2003-11-24 | Hoffmann La Roche | GCSF-konjugater |
US6646110B2 (en) * | 2000-01-10 | 2003-11-11 | Maxygen Holdings Ltd. | G-CSF polypeptides and conjugates |
MXPA03002046A (es) * | 2000-09-08 | 2003-07-24 | Massachusetts Inst Technology | Composiciones analogos de factor estimulador de colonias de granulocitos y metodos para su elaboracion. |
US7053150B2 (en) * | 2000-12-18 | 2006-05-30 | Nektar Therapeutics Al, Corporation | Segmented polymers and their conjugates |
AU2003210052A1 (en) * | 2002-03-20 | 2003-09-29 | Biopolymed Inc. | Preparation of g-csf stoichiometrically conjugated with biocompatible polymers at cystein residue |
CN1767857A (zh) * | 2003-02-26 | 2006-05-03 | 尼克塔治疗亚拉巴马公司 | 聚合物-因子ⅷ部分共轭物 |
US20040180054A1 (en) * | 2003-03-13 | 2004-09-16 | Hanmi Pharm. Co., Ltd. | Physiologically active polypeptide conjugate having prolonged in vivo half-life |
AU2005318984B2 (en) * | 2004-12-21 | 2011-12-01 | Nektar Therapeutics | Stabilized polymeric thiol reagents |
-
2006
- 2006-08-04 CA CA002617064A patent/CA2617064A1/en not_active Abandoned
- 2006-08-04 US US11/499,115 patent/US20070092482A1/en not_active Abandoned
- 2006-08-04 KR KR1020087004271A patent/KR20080033439A/ko not_active Application Discontinuation
- 2006-08-04 AU AU2006278490A patent/AU2006278490A1/en not_active Abandoned
- 2006-08-04 JP JP2008525234A patent/JP2009503111A/ja not_active Withdrawn
- 2006-08-04 BR BRPI0614257-5A patent/BRPI0614257A2/pt not_active Application Discontinuation
- 2006-08-04 MX MX2008001706A patent/MX2008001706A/es unknown
- 2006-08-04 CN CNA2006800322225A patent/CN101257926A/zh active Pending
- 2006-08-04 WO PCT/US2006/030481 patent/WO2007019331A2/en active Application Filing
- 2006-08-04 EP EP06800776A patent/EP2099495A2/en not_active Withdrawn
-
2008
- 2008-01-24 IL IL188999A patent/IL188999A0/en unknown
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